ZA200200390B - Use of interleukin-18 inhibitors to inhibit tumor metastasis. - Google Patents

Use of interleukin-18 inhibitors to inhibit tumor metastasis.

Info

Publication number
ZA200200390B
ZA200200390B ZA200200390A ZA200200390A ZA200200390B ZA 200200390 B ZA200200390 B ZA 200200390B ZA 200200390 A ZA200200390 A ZA 200200390A ZA 200200390 A ZA200200390 A ZA 200200390A ZA 200200390 B ZA200200390 B ZA 200200390B
Authority
ZA
South Africa
Prior art keywords
interleukin
inhibitors
tumor metastasis
inhibit tumor
inhibit
Prior art date
Application number
ZA200200390A
Other languages
English (en)
Inventor
Charles Dinarello
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of ZA200200390B publication Critical patent/ZA200200390B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200200390A 1999-07-22 2002-01-16 Use of interleukin-18 inhibitors to inhibit tumor metastasis. ZA200200390B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors

Publications (1)

Publication Number Publication Date
ZA200200390B true ZA200200390B (en) 2003-04-30

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200200390A ZA200200390B (en) 1999-07-22 2002-01-16 Use of interleukin-18 inhibitors to inhibit tumor metastasis.

Country Status (31)

Country Link
US (1) US7741276B2 (enExample)
EP (1) EP1206274B1 (enExample)
JP (1) JP4827352B2 (enExample)
KR (1) KR100682219B1 (enExample)
CN (1) CN1173736C (enExample)
AR (1) AR024907A1 (enExample)
AT (1) ATE363288T1 (enExample)
AU (1) AU782478B2 (enExample)
BG (1) BG65800B1 (enExample)
BR (1) BR0012675A (enExample)
CA (1) CA2380216C (enExample)
CY (1) CY1107932T1 (enExample)
CZ (1) CZ302114B6 (enExample)
DE (2) DE1206274T1 (enExample)
DK (1) DK1206274T3 (enExample)
EA (1) EA005419B1 (enExample)
EE (1) EE04838B1 (enExample)
ES (1) ES2186596T3 (enExample)
HK (1) HK1048248B (enExample)
HU (1) HU228780B1 (enExample)
IL (2) IL131047A0 (enExample)
MX (1) MXPA02000838A (enExample)
NO (1) NO329827B1 (enExample)
NZ (1) NZ516535A (enExample)
PL (1) PL202477B1 (enExample)
PT (1) PT1206274E (enExample)
SK (1) SK287522B6 (enExample)
TR (1) TR200200169T2 (enExample)
UA (1) UA73745C2 (enExample)
WO (1) WO2001007480A2 (enExample)
ZA (1) ZA200200390B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206277A (zh) * 2000-02-10 2011-10-05 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
CA2424983A1 (en) 2000-10-11 2002-04-18 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
IL158866A0 (en) * 2001-05-16 2004-05-12 Yeda Res & Dev Use of il-18 inhibitors for the treatment or prevention of sepsis
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
EP1572291B1 (en) * 2002-10-08 2013-04-03 Ares Trading S.A. The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
PL1885753T3 (pl) 2005-06-03 2011-12-30 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
ATE529433T1 (de) 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
IL314346A (en) 2022-03-15 2024-09-01 Compugen Ltd Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE231915T1 (de) * 1992-09-02 2003-02-15 Isis Pharmaceuticals Inc Beeinflussing der zelladhäsie durch oligonukleotide
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
WO1998041232A2 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
PL202477B1 (pl) 2009-06-30
AU5843200A (en) 2001-02-13
IL147675A (en) 2009-05-04
KR100682219B1 (ko) 2007-02-12
KR20020027493A (ko) 2002-04-13
BG65800B1 (bg) 2009-12-31
WO2001007480A3 (en) 2001-05-10
CN1173736C (zh) 2004-11-03
EP1206274A2 (en) 2002-05-22
EA200200189A1 (ru) 2002-12-26
HK1048248B (zh) 2005-04-22
BG106311A (en) 2002-08-30
BRPI0012675B1 (pt) 2001-02-01
BRPI0012675B8 (enExample) 2021-05-25
PT1206274E (pt) 2007-07-06
CA2380216C (en) 2012-01-31
CZ2002195A3 (cs) 2002-06-12
CA2380216A1 (en) 2001-02-01
CN1364086A (zh) 2002-08-14
DE1206274T1 (de) 2002-11-14
HUP0202107A2 (en) 2002-10-28
JP2003505472A (ja) 2003-02-12
HU228780B1 (en) 2013-05-28
SK287522B6 (sk) 2011-01-04
EP1206274B1 (en) 2007-05-30
MXPA02000838A (es) 2002-07-30
EE04838B1 (et) 2007-06-15
ES2186596T1 (es) 2003-05-16
AU782478B2 (en) 2005-08-04
NO20020153L (no) 2002-03-11
HUP0202107A3 (en) 2005-01-28
CY1107932T1 (el) 2013-09-04
BR0012675A (pt) 2002-04-09
DE60035049D1 (de) 2007-07-12
ES2186596T3 (es) 2007-11-16
DE60035049T2 (de) 2007-09-27
JP4827352B2 (ja) 2011-11-30
IL131047A0 (en) 2001-01-28
HK1048248A1 (en) 2003-03-28
AR024907A1 (es) 2002-10-30
US20080003216A1 (en) 2008-01-03
EA005419B1 (ru) 2005-02-24
NO20020153D0 (no) 2002-01-11
EE200200032A (et) 2003-02-17
SK882002A3 (en) 2002-07-02
US7741276B2 (en) 2010-06-22
PL353732A1 (en) 2003-12-01
UA73745C2 (en) 2005-09-15
NZ516535A (en) 2004-04-30
DK1206274T3 (da) 2007-08-13
ATE363288T1 (de) 2007-06-15
WO2001007480A2 (en) 2001-02-01
CZ302114B6 (cs) 2010-10-20
NO329827B1 (no) 2011-01-03
TR200200169T2 (tr) 2002-06-21

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