CN114805533A - 修饰的fgf-21多肽及其用途 - Google Patents

修饰的fgf-21多肽及其用途 Download PDF

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Publication number
CN114805533A
CN114805533A CN202210088433.1A CN202210088433A CN114805533A CN 114805533 A CN114805533 A CN 114805533A CN 202210088433 A CN202210088433 A CN 202210088433A CN 114805533 A CN114805533 A CN 114805533A
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Prior art keywords
polypeptide
amino acid
seq
fgf
modified fgf
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CN202210088433.1A
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Chinese (zh)
Inventor
P·E·莫林
D·科恩
R·慕克吉
T·P·赖利
R·C·克里斯汀
D·利波夫斯基
R·坎普豪森
J·克鲁平斯基
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN114805533A publication Critical patent/CN114805533A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202210088433.1A 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途 Pending CN114805533A (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201462068514P 2014-10-24 2014-10-24
US201462068526P 2014-10-24 2014-10-24
US201462068296P 2014-10-24 2014-10-24
US201462068523P 2014-10-24 2014-10-24
US201462068534P 2014-10-24 2014-10-24
US62/068,534 2014-10-24
US62/068,296 2014-10-24
US62/068,526 2014-10-24
US62/068,523 2014-10-24
US62/068,514 2014-10-24
US201562141337P 2015-04-01 2015-04-01
US201562141383P 2015-04-01 2015-04-01
US62/141,337 2015-04-01
US62/141,383 2015-04-01
CN201580070276.XA CN107108710B (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
PCT/US2015/057228 WO2016065326A2 (en) 2014-10-24 2015-10-23 Modified fgf-21 polypeptides and uses thereof

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CN114805533A true CN114805533A (zh) 2022-07-29

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Application Number Title Priority Date Filing Date
CN202210088408.3A Pending CN114805532A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN201580070276.XA Active CN107108710B (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN202210088395.XA Pending CN114853868A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN202210088433.1A Pending CN114805533A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN201811440663.XA Active CN110078814B (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN202210087736.1A Pending CN114805531A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途

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CN202210088408.3A Pending CN114805532A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN201580070276.XA Active CN107108710B (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN202210088395.XA Pending CN114853868A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途

Family Applications After (2)

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CN201811440663.XA Active CN110078814B (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途
CN202210087736.1A Pending CN114805531A (zh) 2014-10-24 2015-10-23 修饰的fgf-21多肽及其用途

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US (6) US9434778B2 (enExample)
EP (3) EP3909596A1 (enExample)
JP (2) JP6702962B2 (enExample)
KR (2) KR102854572B1 (enExample)
CN (6) CN114805532A (enExample)
AU (3) AU2015335603B2 (enExample)
BR (1) BR112017008157A2 (enExample)
CA (1) CA2965502A1 (enExample)
CL (1) CL2017000999A1 (enExample)
CO (1) CO2017004489A2 (enExample)
CY (1) CY1124309T1 (enExample)
DK (1) DK3412302T3 (enExample)
EA (1) EA036697B1 (enExample)
ES (1) ES2874331T3 (enExample)
HR (1) HRP20211053T1 (enExample)
HU (1) HUE055311T2 (enExample)
IL (2) IL251795B (enExample)
LT (1) LT3412302T (enExample)
MX (1) MX2017004947A (enExample)
PE (1) PE20170950A1 (enExample)
PL (1) PL3412302T3 (enExample)
PT (1) PT3412302T (enExample)
SG (2) SG11201702824UA (enExample)
SI (1) SI3412302T1 (enExample)
SM (1) SMT202100388T1 (enExample)
TW (2) TW202124419A (enExample)
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KR102854572B1 (ko) 2014-10-24 2025-09-02 브리스톨-마이어스 스큅 컴퍼니 변형된 fgf-21 폴리펩티드 및 그의 용도
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102668200B1 (ko) 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
KR102670157B1 (ko) 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
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CN111518770B (zh) 2017-12-19 2023-01-06 北京吉源生物科技有限公司 一种表达glp1和fgf21的干细胞及其用途
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CN108434441A (zh) * 2018-04-17 2018-08-24 哈尔滨博翱生物医药技术开发有限公司 新型成纤维细胞生长因子-21类似物在治疗弥漫性间质性肺脏疾病中的应用
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US20180243375A1 (en) 2018-08-30
SG11201702824UA (en) 2017-05-30
TWI705071B (zh) 2020-09-21
EP3909596A1 (en) 2021-11-17
CO2017004489A2 (es) 2017-09-20
PE20170950A1 (es) 2017-07-13
MX2017004947A (es) 2017-06-29
CN107108710A (zh) 2017-08-29
EA201790895A1 (ru) 2017-10-31
SI3412302T1 (sl) 2021-09-30
US20220185856A1 (en) 2022-06-16
WO2016065326A2 (en) 2016-04-28
BR112017008157A2 (pt) 2017-12-19
EP3412302A1 (en) 2018-12-12
TW202124419A (zh) 2021-07-01
CN114805532A (zh) 2022-07-29
SMT202100388T1 (it) 2021-09-14
CN114853868A (zh) 2022-08-05
CA2965502A1 (en) 2016-04-28
CN107108710B (zh) 2022-02-15
KR20170070227A (ko) 2017-06-21
KR20240024362A (ko) 2024-02-23
ES2874331T3 (es) 2021-11-04
JP2017537612A (ja) 2017-12-21
JP6702962B2 (ja) 2020-06-03
EP3209316A2 (en) 2017-08-30
AU2020210152B2 (en) 2022-07-21

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