TW202124419A - 經修飾之fgf-21多肽及其用途 - Google Patents

經修飾之fgf-21多肽及其用途 Download PDF

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TW202124419A
TW202124419A TW109129002A TW109129002A TW202124419A TW 202124419 A TW202124419 A TW 202124419A TW 109129002 A TW109129002 A TW 109129002A TW 109129002 A TW109129002 A TW 109129002A TW 202124419 A TW202124419 A TW 202124419A
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polypeptide
amino acid
seq
modified fgf
kda
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TW109129002A
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Chinese (zh)
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保羅 Ｅ 莫林
羅伯 寇漢
嵐真 莫克吉
提摩西 雷利
蘿絲 克莉斯汀
達沙 力珀薩
雷 坎佛森
約翰 庫賓斯基
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美商必治妥美雅史谷比公司
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109129002A 2014-10-24 2015-10-23 經修飾之fgf-21多肽及其用途 TW202124419A (zh)

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Application Number Priority Date Filing Date Title
US201462068534P 2014-10-24 2014-10-24
US201462068523P 2014-10-24 2014-10-24
US201462068296P 2014-10-24 2014-10-24
US201462068514P 2014-10-24 2014-10-24
US201462068526P 2014-10-24 2014-10-24
US62/068,523 2014-10-24
US62/068,296 2014-10-24
US62/068,534 2014-10-24
US62/068,514 2014-10-24
US62/068,526 2014-10-24
US201562141337P 2015-04-01 2015-04-01
US201562141383P 2015-04-01 2015-04-01
US62/141,337 2015-04-01
US62/141,383 2015-04-01

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