CN114712308A - 药物制剂 - Google Patents
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Abstract
本发明涉及制剂领域,公开了一种制剂,该制剂中包含主表面活性剂、母育酚磷酸酯、水、活性剂以及任选的油,其中,所述活性剂和/或所述任选的油中含有疏水相。所述制剂具有较好的药物递送效果。
Description
本申请是申请号为201680072343.6、申请日为2016年12月9日、发明名称为“药物制剂”的中国发明专利申请的分案申请。
在本文引用或讨论知识的文件、法令或条款的情况下,该引用或讨论并不是承认该知识的文件、法令或条款或其任意组合在优先权日时是公众可获得的、公众所知的、公知常识的一部分;或者已知与试图解决本文所涉及的任何问题有关。
技术领域
本发明涉及一种制剂,更具体地,涉及一种药物制剂。
背景技术
已经开发药物递送技术来提高活性剂的生物利用度、安全性、持续时间、起效(onset)或释放。
在开发药物递送技术时,可能遇到的问题包括药物递送系统与活性剂的相容性、维持足够和有效的持续时间、潜在的副作用,以及满足患者的便利性和依从性。因此,许多药物递送技术达不到期望的改善和需求。有必要改进或改变药物技术。
发明内容
因此,本发明的第一方面提供了一种制剂,该制剂中包含主表面活性剂、母育酚磷酸酯(tocol phosphate)、水、活性剂以及任选的油,其中,所述活性剂和/或所述任选的油中含有疏水相。
第二方面,本发明提供了一种制剂,该制剂中包含10mg/mL的丙泊酚、20%的聚氧乙烯脱水山梨糖醇单油酸酯、0.05%的单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物的乙醇溶液,余量为水。
第三方面,本发明提供了一种制剂,该制剂中包含10mg/mL的丙泊酚、10%的聚氧乙烯脱水山梨糖醇单油酸酯、0.05%的单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物的乙醇溶液,余量为水。
具体实施方式
本发明涉及一种制剂,该制剂中包含主表面活性剂、母育酚磷酸酯、水、活性剂以及任选的油,其中,所述活性剂和/或所述任选的油中含有疏水相。
活性剂
术语“活性剂”是指为了医疗、治疗、美容和兽医目的而对人或动物具有作用的化学物质,并且包括药物、医药品(pharmaceuticals)、药物化妆品(cosmeceuticals)、营养制品(nutraceuticals)和营养剂。应该理解地是,一些活性剂可归类到这些类别中的不止一种。
在某些实施方式中,所述活性剂不溶于水或微溶于水。
在一些实施方式中,所述活性剂选自由安泼那韦、贝沙罗汀、骨化三醇、氯苯吩嗪、环孢霉素(cyclosporine,或环孢菌素(cyclosporin))、地高辛、度骨化醇、屈大麻酚、度他雄胺、依托泊苷、异维甲酸、伊曲康唑、洛匹那韦、利托那韦、氯雷他定、硝苯吡啶、尼莫地平、苯巴比妥、孕甾酮(progesterone)、利哌利酮(risperidone)、沙奎那韦、西罗莫司、维甲酸、丙戊酸、盐酸胺碘酮(amiodarone HCl)、盐酸氯氮卓(chlordiazepoxide HCl)、地西泮、双氢麦角胺甲磺酸盐、非诺多泮、土霉素、帕立骨化醇、戊巴比妥钠、苯妥英钠、植物甲萘醌、丙泊酚、甲磺酸齐拉西酮、多西他奇(docetaxel)、依托泊苷、氟维司群、癸氟哌啶醇、醋酸亮丙瑞林、醋酸亮丙瑞林植入剂(viadur)、劳拉西泮、紫杉醇、他克莫司、替尼泊苷、庚酸睾酮、环戊丙酸睾酮、环戊丙酸雌二醇和戊柔比星组成的组。
在一种实施方式中,所述活性剂为丙泊酚。
在一些实施方式中,所述制剂适用于被认为是油的活性剂。在其它实施方式中,所述制剂适用于被认为不是油的活性剂。
在一些实施方式中,所述活性剂可以以所述制剂总量的约1mg/mL至约20mg/mL范围内的量存在。在一些实施方式中,所述活性剂可以以所述制剂总量的约1mg/mL至约10mg/mL范围内的量存在。在另一些其它实施方式中,所述活性剂可以以所述制剂总量的约5mg/mL至约10mg/mL范围内的量存在。在一种实施方式中,所述活性剂是以所述制剂总量的约10mg/mL的量存在。在另一种实施方式中,所述活性剂是以所述制剂总量的约5mg/mL的量存在。在又一种实施方式中,所述活性剂是以所述制剂总量的约2mg/mL的量存在。在又一种实施方式中,所述活性剂是以所述制剂总量的约1mg/mL的量存在。
表面活性剂
所述主表面活性剂可以为非离子型表面活性剂、阴离子型表面活性剂、阳离子型表面活性剂或两性离子型表面活性剂。
在一些实施方式中,所述主表面活性剂为非离子型表面活性剂。合适的非离子型表面活性剂包括但不限于,聚乙二醇、丙二醇、蓖麻油聚氧乙烯醚(例如EL)、氢化蓖麻油(例如RH 60)、2-羟基乙基12-羟基硬脂酸酯(2-hydroxyethyl12-hydroxyoctadecanoate)(例如HS 15)、聚氧乙烯单油酸酯(例如PEG单油酸酯)、聚氧乙烯单硬脂酸酯(例如PEG400单硬脂酸酯)、聚氧乙烯单月桂酸酯(例如PEG400单月桂酸酯)、失水山梨糖醇单月桂酸酯(例如20)、油酸三乙醇胺、聚氧乙烯山梨糖醇酐单月桂酸酯(例如20,吐温21)、聚氧乙烯山梨糖醇酐单棕榈酸酯(例如40)、聚氧乙烯山梨糖醇酐单硬脂酸酯(例如60、61)、聚氧乙烯脱水山梨糖醇三硬脂酸酯(例如65)、聚氧乙烯脱水山梨糖醇单油酸酯(例如80、81)和聚氧乙烯脱水山梨糖醇三油酸酯(例如85)。
在一些实施方式中,所述主表面活性剂的HLB值为8-18。在另一些实施方式中,所述主表面活性剂的HLB值为8-14。具有该范围内HLB值的表面活性剂的实例包括但不限于,聚乙二醇、丙二醇、蓖麻油聚氧乙烯醚(例如EL)、氢化蓖麻油(例如RH 60)、2-羟基乙基12-羟基硬脂酸酯(例如HS 15)、油酸钠、聚氧乙烯单油酸酯(例如PEG单油酸酯)、聚氧乙烯单硬脂酸酯(例如PEG400单硬脂酸酯)、聚氧乙烯单月桂酸酯(例如PEG400单月桂酸酯)、失水山梨糖醇单月桂酸酯(例如20)、油酸三乙醇胺、聚氧乙烯山梨糖醇酐单月桂酸酯(例如20,吐温21)、聚氧乙烯山梨糖醇酐单棕榈酸酯(例如40)、聚氧乙烯山梨糖醇酐单硬脂酸酯(例如60、61)、聚氧乙烯脱水山梨糖醇三硬脂酸酯(例如65)、聚氧乙烯脱水山梨糖醇单油酸酯(例如80、81)和聚氧乙烯脱水山梨糖醇三油酸酯(例如 85)。
所述主表面活性剂可以以所述制剂总量的约1重量%至约30重量%范围内的量存在。在一些实施方式中,所述主表面活性剂可以以所述制剂总量的约1重量%至约20重量%范围内的量存在。在其它实施方式中,所述主表面活性剂可以以所述制剂总量的约1重量%至约10重量%范围内的量存在。在又一些实施方式中,所述主表面活性剂可以以所述制剂总量的约10重量%至约20重量%范围内的量存在。在一种实施方式中,所述主表面活性剂可以以所述制剂总量的约20重量%的量存在。在另一种实施方式中,所述主表面活性剂可以以所述制剂总量的约10重量%的量存在。
在一种实施方式中,表面活性剂与所述活性剂的比例大于10:1。已经发现,在这些具体实施方式中这样的比例产生了清澈的溶液。
母育酚磷酸酯
所述母育酚磷酸酯可以选自由生育酚磷酸酯(tocopheryl phosphates)和/或生育三烯酚磷酸酯(tocotrienol phosphates)及其盐组成的组。在本发明的制剂中,所述母育酚磷酸酯可以当作通常形成微乳液所需的助表面活性剂。
母育酚磷酸酯的实例包括但不限于,单-(生育酚基)磷酸酯(mono-(tocopheryl)phosphate)、单-(生育酚基)磷酸酯单钠盐、单-(生育酚基)磷酸酯二钠盐、二-(生育酚基)磷酸酯、二-(生育酚基)磷酸酯单钠盐、单-(生育三烯酚)磷酸酯、单-(生育三烯酚)磷酸酯单钠盐、单-(生育三烯酚)磷酸酯二钠盐、二-(生育三烯酚)磷酸酯、二-(生育三烯酚)磷酸酯单钠盐。所述母育酚磷酸酯也可以为生育酚磷酸酯和/或生育三烯酚磷酸酯的混合物。例如,为单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物(“TPM”)。
所述“盐”可以包括如碱金属盐或碱土金属盐的金属盐,例如钠盐、镁盐、钾盐和钙盐。优选为钠盐和钾盐。
所述母育酚磷酸酯可以被中和,也可以不被中和。如果被中和,则将其中和至接近中性的pH,更优选中和至5-7的pH范围内。
在被包含在所述制剂中之前,所述母育酚磷酸酯可以先制成溶液。合适的溶剂包括任何与水混溶的溶剂,例如醇溶剂。合适的醇溶剂包括C1-C6的醇,优选乙醇或异丙醇。在一些实施方式中,可以使用高达2.5%的醇溶剂来制备母育酚磷酸酯溶液。
所述制剂中可以含有占所述制剂总量约0.01重量%至约5重量%范围内的量的母育酚磷酸酯。在一些实施方式中,所述制剂中可以含有占所述制剂总量约0.03重量%至约0.15重量%范围内的量的母育酚磷酸酯。在一种实施方式中,所述制剂中可以含有占所述制剂总量约0.03重量%的量的母育酚磷酸酯。在另一种实施方式中,所述制剂中可以含有占所述制剂总量约0.125重量%的量的母育酚磷酸酯。
任选的油
本发明的制剂还可以包含任选的油。所述油可以为任意的适合于医药产品的油。
在一些实施方式中,所述油为植物油或蔬菜油,例如芥花籽油、棉籽油、芝麻油、玉米油、葵花油、红花油和大豆油。
所述油还可以选自矿物油或合成油,例如脂肪酸的单甘油酯或二甘油酯和中链甘油三酯。
赋形剂
本发明的制剂可以任选地进一步包含一种或多种赋形剂。本发明领域的技术人员会理解可包含在本发明制剂中的合适的赋形剂,例如,一种或多种稳定剂。赋形剂的选择和量取决于制剂的预期用途、施用方式和/或剂型。
制备
所述制剂可以通过多种技术制备。例如,所述制剂可以通过制药领域中公知的任何方法制备,例如Remington J.P.,The Science and Practice of Pharmacy,ed.A.R.Gennaro,20th edition,Lippincott,Williams and Wilkins Baltimore,Md.(2000)中描述的方法。
一种制备所述制剂的方法涉及将所述活性剂和/或任选的油与所述主表面活性剂和母育酚磷酸酯或母育酚磷酸酯在醇溶剂中的溶液结合,然后加入水。
所述制剂可以任选地还包含本领域公知的一种或多种赋形剂(例如稳定剂)。
所述制剂的pH可以任选地用合适的酸或碱,或通过使用在水相中的缓冲剂来调节。用于调节pH的合适碱的实例为NaOH。合适的缓冲剂的实例包括磷酸盐缓冲液和柠檬酸盐缓冲液。在一种实施方式中,所述制剂的pH通过加入水相后被立即调节。
在一些实施方式中,所述制剂的pH为或被调节至4-10的范围内。
然后将组分混合,可能形成乳液。在一些实施方式中,使用标准混合设备混合所述组分。在其它实施方式中,使用高剪切混合设备来混合所述组分。
如果所述活性剂被认为是油,其可以含有或可以是所述疏水相。在这些实施方式中,所述疏水相也可以不包含所述任选的油。如果所述活性剂被认为不是油,则所述制剂还可以包含油。所述任选的油可以含有或可以是所述疏水相。在这种实施方式中,所述疏水相也可以包含所述活性剂。所述活性剂可以替代地或额外地存在于水相中。
包含油和水的组合物通常产生乳液。因此,本发明所述的制剂可以是乳液。然而,已经发现,母育酚磷酸酯的存在可以将油-水(oil-and-water)转变成微乳液或纳米乳液。因此,在一些实施方式中,所述乳液可以是微乳液或纳米乳液。
通常,“微乳液”是热力学稳定的。本发明所述的微乳液是透明的,因此粒度会低于可见范围。根据本领域的文献,不可见的粒径在5-50nm的范围内,且可见的粒径在50-200nm的范围内。与浑浊制剂相比,清澈制剂可以认为在美学上是优越的。此外,作为微乳液,本发明所述的制剂不太可能需要稳定剂的存在。然而,在一些实施方式中,所述制剂还可以包含稳定剂。
给药途径
根据效果可将给药途径大致分为三类,即:“局部”,其期望的效果是局部的,所以物质直接应用于需要其作用的地方;“肠内”,其期望的效果是系统性的(非局部),因此物质是通过消化道被给予的;以及“肠胃外”,其所需效果是系统性的,因此物质是通过消化道以外的途径被给予的。
本发明所述的制剂适用于局部、肠内或肠胃外给药。
据认为,所述制剂最适合肠胃外给药,尤其是作为可注射制剂。
具有局部效果的局部给药途径的实例包括表皮(epicutaneous)(在皮肤上)。
具有系统性(非局部)效果的肠内给药途径的实例包括涉及胃肠道任何部位的任何形式的给药,例如口服(进入口腔)、鼻内(进入鼻腔)、直肠内(进入直肠),以及阴道内(进入阴道)。口服给药包括口腔给药(通过牙龈附近的脸颊吸收)和舌下给药(在舌头下)。
通过具有系统性效果的注射、输注或扩散的肠胃外给药途径的实例包括静脉内(进入静脉)、动脉内(进入动脉)、肌内(进入肌肉)、心内(进入心脏)、皮下(在皮肤之下)、经皮(通过针刺进入皮肤)、皮内(进入皮肤本身)、鞘内(进入椎管)、腹膜内(输注或注射入腹膜)、膀胱内输注(输注至膀胱内)、硬膜外(注射或输注至硬膜外腔)、透皮(transdermal)或经皮(transcutaneous)(通过完整皮肤扩散)、经粘膜(通过粘膜扩散)、吹入(通过鼻腔扩散)、吸入(通过口腔扩散),以及乳房内(进入乳房组织)。
在本文中,除上下文另有要求外,词语“包括(comprise)”、“含有(comprises)”和“包含(comprising)”分别表示“包括(include)”、“含有(includes)”和“包含(including)”,即当本发明被描述或定义为包含指定的特征时,相同发明的各种实施方式还可以包括附加特征。
实施例
现参考以下非限制性实施例来描述本发明的各实施方式或方面。
实施例1
通过向活性剂中加入母育酚磷酸酯,然后加入主表面活性剂,再加入水,接着搅拌5-10分钟并几乎不摇动来制备以下微乳液。
在上述每种制剂中,母育酚磷酸酯(即,单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物)以2.5%的最终浓度提供在乙醇或异丙醇中。
实施例2
通过将单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物(TPM)溶解在乙醇(EtOH)中,加入80(T-80)并混合来制备以下微乳液。然后加入水并根据需要调节pH。将所述制剂混合24小时。结果见表1。
表1
最初认为,将pH调节至7会使制剂澄清(因此上述测量)。然而,观察到保持其天然pH对于维持透明制剂是有效的。
选择制剂B1、E1和H1以制备更大规模(100g)。
实施例3
通过将2.5克TPM与10克EtOH溶解在20mL的玻璃闪烁瓶(glass scintillationvial)中来制备所述TPM在EtOH中的原料浓缩物。通过在40℃磁热板上搅拌过夜来使TPM/EtOH原料浓缩物溶液溶解。
根据表2中规定的量应用以下方法(见下文)。
将“x”克TPM/EtOH储备液(stock solution)(上述制备的)移入100mL的玻璃瓶中,然后加入“x”克T-80。
然后在TPM/EtOH/T-80制备液(preparation)中加入“x”克丙泊酚,并在40℃的热板上搅拌至均匀。
添加足够量的MilliQ水以使得最终制剂为100克。
在磁力板上搅拌过夜。
表2:制剂组分
<u>B1</u> | <u>E1</u> | <u>H1</u> | <u>Z1</u> | |
TPM/EtOH储备液 | 0.5克 | 0.5克 | 0.5克 | 0.5克 |
T-80 | 10克 | 20克 | 10克 | 20克 |
丙泊酚 | 1克 | 2克 | 2克 | 1克 |
QS MilliQ水 | 88.5克 | 77.5克 | 87.5克 | 78.5克 |
结果
在100mL玻璃瓶中配制后,将各20mL分装到小瓶中。
根据肉眼观察,制剂B1显示最清晰,而制剂H1显示最不清晰。结果见表3所示。
表3
<u>B1</u> | <u>E1</u> | <u>H1</u> | <u>Z1</u> | |
外观 | 清澈 | 黄色 | 乳白色 | 黄色 |
结论
考虑到不透明的问题并通过TPM的作用解决了这一问题,因为TPM使丙泊酚保持悬浮状态,且最重要的是防止所述制剂中形成油滴。这被认为是制剂B1的情况,因为事实上该制剂的外观是清澈的。
尽管已经通过实施例并参照其可能的实施方式描述了本发明,但是应该理解在不脱离本发明的范围的情况下,可以对本发明进行修改或改进。
Claims (19)
1.一种制剂,其特征在于,该制剂中包含主表面活性剂、母育酚磷酸酯、水、活性剂以及任选的油,其中,所述活性剂和/或所述任选的油中含有疏水相。
2.根据权利要求1所述的制剂,其中,所述制剂为乳液。
3.根据权利要求2所述的制剂,其中,所述乳液为微乳液或纳米乳液。
4.根据前述任意一项权利要求所述的制剂,其中,所述母育酚磷酸酯为生育酚磷酸酯。
5.根据前述任意一项权利要求所述的制剂,其中,所述母育酚磷酸酯为单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物。
6.根据前述任意一项权利要求所述的制剂,其中,所述主表面活性剂为非离子型表面活性剂、阴离子型表面活性剂、阳离子型表面活性剂或两性离子型表面活性剂。
7.根据权利要求6所述的制剂,其中,所述主表面活性剂为非离子型表面活性剂。
8.根据权利要求7所述的制剂,其中,所述非离子型表面活性剂选自由聚乙二醇、丙二醇、蓖麻油聚氧乙烯醚、氢化蓖麻油、2-羟基乙基12-羟基硬脂酸酯、聚氧乙烯单油酸酯、聚氧乙烯单硬脂酸酯、聚氧乙烯单月桂酸酯、失水山梨糖醇单月桂酸酯、油酸三乙醇胺、聚氧乙烯山梨糖醇酐单月桂酸酯、聚氧乙烯山梨糖醇酐单棕榈酸酯、聚氧乙烯山梨糖醇酐单硬脂酸酯、聚氧乙烯脱水山梨糖醇三硬脂酸酯、聚氧乙烯脱水山梨糖醇单油酸酯和聚氧乙烯脱水山梨糖醇三油酸酯组成的组。
9.根据权利要求6所述的制剂,其中,所述主表面活性剂的HLB值为8-18。
10.根据权利要求9所述的制剂,其中,所述主表面活性剂的HLB值为8-14。
11.根据前述任意一项权利要求所述的制剂,其中,所述主表面活性剂为聚氧乙烯脱水山梨糖醇单油酸酯。
12.根据前述任意一项权利要求所述的制剂,其中,该制剂中包含一种主表面活性剂。
13.根据前述任意一项权利要求所述的制剂,其中,该制剂中包含主表面活性剂的组合。
14.根据前述任意一项权利要求所述的制剂,其中,所述活性剂不溶于水或微溶于水。
15.根据前述任意一项权利要求所述的制剂,其中,所述活性剂选自由安泼那韦、贝沙罗汀、骨化三醇、氯苯吩嗪、环孢霉素(或环孢菌素)、地高辛、度骨化醇、屈大麻酚、度他雄胺、依托泊苷、异维甲酸、伊曲康唑、洛匹那韦、利托那韦、氯雷他定、硝苯吡啶、尼莫地平、苯巴比妥、孕甾酮、利哌利酮、沙奎那韦、西罗莫司、维甲酸、丙戊酸、盐酸胺碘酮、盐酸氯氮卓、地西泮、双氢麦角胺甲磺酸盐、非诺多泮、土霉素、帕立骨化醇、戊巴比妥钠、苯妥英钠、植物甲萘醌、丙泊酚、甲磺酸齐拉西酮、多西他奇、依托泊苷、氟维司群、安度利可、醋酸亮丙瑞林、醋酸亮丙瑞林植入剂、劳拉西泮、紫杉醇、他克莫司、替尼泊苷、庚酸睾酮、环戊丙酸睾酮、环戊丙酸雌二醇和戊柔比星组成的组。
16.根据前述任意一项权利要求所述的制剂,其中,所述活性剂为丙泊酚。
17.根据前述任意一项权利要求所述的制剂,其中,所述疏水相中不包含所述任选的油。
18.一种制剂,其特征在于,该制剂中包含10mg/mL的丙泊酚、20%的聚氧乙烯脱水山梨糖醇单油酸酯、0.05%的单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物的乙醇溶液,余量为水。
19.一种制剂,其特征在于,该制剂中包含10mg/mL的丙泊酚、10%的聚氧乙烯脱水山梨糖醇单油酸酯、0.05%的单-(生育酚基)磷酸酯和二-(生育酚基)磷酸酯的混合物的乙醇溶液,余量为水。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1143436A (ja) * | 1997-07-25 | 1999-02-16 | Showa Denko Kk | 末梢血流障害予防・治療剤 |
EP1264595A1 (en) * | 2001-06-05 | 2002-12-11 | Pacific Corporation | Use of tocopherol derivatives for stabilizing nano-sized emulsion particles containing lecithin and their external application to the skin |
CN1917858A (zh) * | 2004-02-13 | 2007-02-21 | 生物药效率有限公司 | 麻醉用高浓度异丙酚微乳制剂 |
CN101247834A (zh) * | 2005-06-17 | 2008-08-20 | 生命健康科学公司 | 包含一种或多种二-和/或单-(电子转移剂)磷酸酯衍生物或其络合物的载体 |
CN102686279A (zh) * | 2009-12-23 | 2012-09-19 | 磷肌酸有限公司 | 载体组合物 |
Family Cites Families (294)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2457932A (en) | 1949-01-04 | Salts of tocopheryl phosphoric | ||
US2407823A (en) | 1946-09-17 | Antihemorrhagic esters and methods | ||
US2667479A (en) | 1951-01-30 | 1954-01-26 | Merck & Co Inc | Benzimidazole phosphate |
GB778142A (en) | 1953-11-20 | 1957-07-03 | Leo Ab | High-molecular weight derivatives of hydroxyl group-containing steroids and a method of producing them |
US2913477A (en) | 1957-03-22 | 1959-11-17 | Merck & Co Inc | Antihemorrhagic compounds and processes for preparing the same |
US3127434A (en) | 1959-10-20 | 1964-03-31 | Hoffmann La Roche | Dihydrovitamin k monophosphate compounds and preparation thereof |
US3212901A (en) | 1961-06-07 | 1965-10-19 | Eastman Kodak Co | Stabilized tocopherol concentrates and process for preparing the same |
US3331896A (en) | 1964-09-15 | 1967-07-18 | Gen Aniline & Film Corp | Method of preparing alkali soluble phosphate esters of hydroxylic organic compounds |
US3607765A (en) | 1968-11-29 | 1971-09-21 | Colgate Polmolive Co | Detergent softener compositions |
JPS5132700B2 (zh) | 1973-05-02 | 1976-09-14 | ||
JPS5022535A (zh) | 1973-06-27 | 1975-03-11 | ||
DE2526938C2 (de) | 1975-02-14 | 1982-04-22 | F. Hoffmann-La Roche & Co. AG, 4002 Basel | Vitaminpräparate |
JPS521858A (en) | 1975-06-24 | 1977-01-08 | Hitachi Metals Ltd | Steel pipe transfer apparatus |
JPS5239013A (en) | 1975-09-23 | 1977-03-26 | Shintaro Yamada | Forced draft diesel engine |
JPS6035347B2 (ja) | 1976-07-26 | 1985-08-14 | エーザイ株式会社 | α−トコフエロ−ルの合成法 |
US4141938A (en) | 1976-10-07 | 1979-02-27 | Hoechst Aktiengesellschaft | Production of acid orthophosphoric acid ester mixtures |
US4444755A (en) | 1978-01-23 | 1984-04-24 | Efamol Limited | Treatment for skin disorders |
US4299906A (en) | 1979-06-01 | 1981-11-10 | American Hoechst Corporation | Light-sensitive color proofing film with surfactant in a light-sensitive coating |
SU925961A1 (ru) | 1980-08-15 | 1982-05-07 | Московский ордена Трудового Красного Знамени технологический институт пищевой промышленности | Способ получени фосфорилированных глицеридов высших жирных кислот |
US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
IT1157269B (it) | 1982-03-19 | 1987-02-11 | Seuref Ag | Nuove formulazioni farmaceutiche contenenti il coenzima q10 adatte per la somministrazione topica |
JPS58180410A (ja) | 1982-04-16 | 1983-10-21 | Shiseido Co Ltd | 化粧料 |
JPS5944375A (ja) * | 1982-09-06 | 1984-03-12 | Senjiyu Seiyaku Kk | α−トコフエロ−ルリン酸エステルの安定な水溶液 |
JPH0247997B2 (ja) | 1983-02-25 | 1990-10-23 | Sanyo Chemical Ind Ltd | Rinsanesuterunoseizoho |
JPS6048962A (ja) | 1983-08-26 | 1985-03-16 | Chisso Corp | スルファミン酸グアニジンの製造方法 |
JPS6056699A (ja) | 1983-09-08 | 1985-04-02 | 三菱重工業株式会社 | 半暖水双銅船 |
JPS60197621A (ja) | 1984-03-19 | 1985-10-07 | Hohnen Oil Co Ltd | コレステロ−ル低下剤 |
CH661438A5 (it) | 1984-04-09 | 1987-07-31 | Seuref Ag | Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. |
US4977282A (en) | 1984-04-17 | 1990-12-11 | Henkel Corporation | Production of d-alpha-tocopherol from natural plant sources |
US4603142A (en) | 1984-06-01 | 1986-07-29 | Wisconsin Alumni Research Foundation | Cholesterol lowering method of use |
DE3582904D1 (de) | 1984-08-02 | 1991-06-27 | Henkel Corp | Reinigung von tocopherolen durch extraktion. |
JPS6186940A (ja) | 1984-10-02 | 1986-05-02 | Kao Corp | 水中油型乳化組成物 |
JPS6191137A (ja) | 1984-10-11 | 1986-05-09 | Kao Corp | 外用薬剤組成物 |
JPS61176535A (ja) | 1985-01-31 | 1986-08-08 | Morishita Jintan Kk | 腸溶性製剤 |
JP2540294B2 (ja) | 1985-04-09 | 1996-10-02 | 花王株式会社 | 経皮吸収製剤 |
JPS62195393A (ja) | 1986-02-21 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造方法 |
JPS6393791A (ja) | 1986-10-08 | 1988-04-25 | Nippon Shokubai Kagaku Kogyo Co Ltd | リン酸エステルおよびその製法 |
JPH0781138B2 (ja) | 1986-12-02 | 1995-08-30 | 株式会社資生堂 | 抗酸化剤 |
DE3702766A1 (de) | 1987-01-30 | 1988-08-11 | Henkel Kgaa | Verfahren zur herstellung und isolierung von monoalkylphosphorsaeureestern |
JP3070744B2 (ja) | 1987-04-10 | 2000-07-31 | 株式会社日立製作所 | ベクトル処理装置 |
US4952495A (en) | 1987-06-08 | 1990-08-28 | Eastman Kodak Company | Hydrolyzable compounds which release electron transfer agents and analytical use of same |
PH25859A (en) | 1988-01-11 | 1991-12-02 | Takeda Chemical Industries Ltd | Composition for treatment of ischemic disorder |
US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5234957A (en) | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
JPH01228920A (ja) | 1988-03-09 | 1989-09-12 | Kuraray Co Ltd | 吸収促進剤 |
DE3813624A1 (de) | 1988-04-22 | 1989-11-02 | Basf Ag | Verfahren zur herstellung von d-(alpha)-tocopherol aus natuerlichen vorprodukten |
JPH01274830A (ja) | 1988-04-28 | 1989-11-02 | Asahi Denka Kogyo Kk | 安全で且つ高度な界面活性を有する脂質組成物 |
CA2007643A1 (en) | 1989-02-01 | 1990-08-01 | Donald S. Karanewsky | Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination |
US6028105A (en) | 1989-04-06 | 2000-02-22 | Nigra; Thomas P. | Topical drug delivery composition and method |
JP3040427B2 (ja) | 1989-05-18 | 2000-05-15 | 帝國製薬株式会社 | 神経痛治療用アスピリン含有軟膏組成物 |
US5053222A (en) | 1989-06-07 | 1991-10-01 | Shiseido Company Ltd. | Hair cosmetic composition |
US5094848A (en) | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
DE3927113C2 (de) | 1989-08-17 | 1993-11-25 | Dolorgiet Gmbh & Co Kg | Mittel zur Behandlung von schweren Schmerzzuständen und Verfahren zu ihrer Herstellung |
JPH03120230A (ja) | 1989-10-04 | 1991-05-22 | Nippon Mining Co Ltd | 薬効成分の経皮吸収促進剤及び経皮吸収型製剤 |
JP2854631B2 (ja) | 1989-11-21 | 1999-02-03 | 千寿製薬株式会社 | 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤 |
IT1236843B (it) | 1989-11-22 | 1993-04-21 | Simes | Processo per la preparazione di 4-0-fosfati di dopamina o suoi derivati |
JPH03206089A (ja) | 1990-01-05 | 1991-09-09 | Eisai Co Ltd | 新規ビタミンe誘導体及びその製造方法 |
US5374645A (en) | 1990-01-22 | 1994-12-20 | Ciba-Geigy Corporation | Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol |
FR2657526B1 (fr) | 1990-01-31 | 1994-10-28 | Lvmh Rech | Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues. |
US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
US5114957A (en) | 1990-05-08 | 1992-05-19 | Biodor U.S. Holding | Tocopherol-based antiviral agents and method of using same |
AU642743B2 (en) | 1990-05-21 | 1993-10-28 | Smith Kline & French Laboratories Limited | Phenol and pyridinol derivatives as pharmaceuticals |
WO1993009777A1 (en) | 1991-11-22 | 1993-05-27 | Lipogenics, Inc. | Tocotrienols and tocotrienol-like compounds and methods for their use |
CA2067754C (en) | 1990-08-24 | 2002-06-04 | Gregor Cevc | Preparation for the application of agents in mini-droplets |
DE69024370T2 (de) | 1990-10-26 | 1996-06-20 | Senju Pharma Co | Hautpräparat zur äusserlichen anwendung |
SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
JP3035742B2 (ja) | 1990-11-30 | 2000-04-24 | 昭和電工株式会社 | 化粧品 |
JP2983311B2 (ja) | 1991-02-26 | 1999-11-29 | 株式会社資生堂 | 皮膚外用剤 |
US5646190A (en) | 1991-03-01 | 1997-07-08 | Warner-Lambert Company | Acne treating-wound healing compositions and methods for preparing and using same |
JPH05946A (ja) | 1991-06-27 | 1993-01-08 | Nichiban Co Ltd | ケトチフエン含有経皮吸収製剤 |
FR2679904A1 (fr) | 1991-08-01 | 1993-02-05 | Lvmh Rech | Utilisation d'un phosphate de tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, ou pharmaceutiques et compositions ainsi obtenues. |
US5643597A (en) | 1991-08-01 | 1997-07-01 | Lvmh Recherche | Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained |
EP0535283A1 (en) | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Cardioprotective tocopherol analogs |
US5474891A (en) | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
US5519046A (en) | 1991-11-11 | 1996-05-21 | Hisamitsu Pharmaceutical Co., Inc. | Ketorolac-containing fomentation |
US5282312A (en) | 1991-12-31 | 1994-02-01 | Tessera, Inc. | Multi-layer circuit construction methods with customization features |
WO1993015731A1 (en) | 1992-02-14 | 1993-08-19 | Robert Lamb | Phosphate derivatives of vitamin e to protect cells from effects of aging and injury |
JP3207494B2 (ja) | 1992-04-02 | 2001-09-10 | ロート製薬株式会社 | 水性懸濁製剤 |
JPH05286848A (ja) | 1992-04-10 | 1993-11-02 | Senju Pharmaceut Co Ltd | 浴用剤 |
US5731299A (en) | 1992-05-29 | 1998-03-24 | The Procter & Gamble Company | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
GB9212450D0 (en) | 1992-06-11 | 1992-07-22 | Indena Spa | New derivatives of non-steroidal anti-inflammatory,analgesic and/or antipyretic substances,their use and pharmaceutical formulations containing them |
US5741518A (en) | 1992-08-03 | 1998-04-21 | L'oreal | Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids |
US5773457A (en) | 1995-02-15 | 1998-06-30 | Cesar Roberto Dias Nahoum | Compositions |
AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
US6384043B1 (en) | 1993-02-01 | 2002-05-07 | Gholam A. Peyman | Methods of alleviating pain sensations of the denuded eye with opioid analgesics |
TW252918B (zh) | 1993-03-31 | 1995-08-01 | Senju Pharma Co | |
DE4336557C2 (de) | 1993-05-06 | 1997-07-17 | Lohmann Therapie Syst Lts | Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
JP3179629B2 (ja) | 1993-06-24 | 2001-06-25 | 花王株式会社 | 液体洗浄剤組成物 |
CN1077800C (zh) | 1993-07-01 | 2002-01-16 | 韩美药品工业株式会社 | 环孢菌素软胶囊组合物 |
GB9318271D0 (en) | 1993-09-03 | 1993-10-20 | Scotia Holdings Plc | Tocopherols |
CA2129509A1 (en) | 1993-09-10 | 1995-03-11 | Kazumi Ogata | Pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis |
WO1995014457A1 (en) | 1993-11-27 | 1995-06-01 | Knoll Ag | Compositions comprising iminium ion scavengers and/or nitrite scavengers |
JPH07196516A (ja) | 1993-12-29 | 1995-08-01 | Senju Pharmaceut Co Ltd | 痔疾患治療剤 |
FR2714595B1 (fr) | 1993-12-30 | 1996-02-02 | Oreal | Emulsion eau dans huile contenant du rétinol, son utilisation et son conditionnement. |
FR2715565B1 (fr) | 1994-01-31 | 1996-03-15 | Oreal | Composition cosmétique ou dermatologique stabilisée contenant plusieurs précurseurs d'un même actif pour maximaliser sa libération, son utilisation. |
EP0669132A1 (en) | 1994-02-23 | 1995-08-30 | van der Kraaij, Antonius Marinus Maria | Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis |
CA2145229A1 (en) | 1994-03-29 | 1995-09-30 | Tetsuya Toge | Suppressory compositions against hepatic metastases of tumors |
US5554781A (en) | 1994-03-30 | 1996-09-10 | Reierson; Robert L. | Monoalkyl phosphonic acid ester production process |
JPH07277988A (ja) | 1994-04-05 | 1995-10-24 | Senju Pharmaceut Co Ltd | 局所用掻痒除去、治療剤 |
JPH07278587A (ja) | 1994-04-06 | 1995-10-24 | Kao Corp | 洗浄剤組成物 |
TW287103B (zh) | 1994-04-22 | 1996-10-01 | Senju Pharma Co | |
JP3362501B2 (ja) | 1994-04-28 | 2003-01-07 | 千寿製薬株式会社 | 角膜障害治療剤 |
JP3396953B2 (ja) | 1994-05-10 | 2003-04-14 | 千寿製薬株式会社 | 網膜疾患予防・治療剤 |
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
JPH07316170A (ja) | 1994-05-24 | 1995-12-05 | Kao Corp | リン酸モノエステルの製造法 |
WO1995034303A1 (en) | 1994-06-13 | 1995-12-21 | Arcturus Pharmaceutical Corporation | Method for the treatment, prevention or minimization of hair loss |
US5589504A (en) | 1994-07-26 | 1996-12-31 | Cornell Research Foundation, Inc. | Treatment of newborn jaundice |
CA2152693A1 (en) | 1994-08-05 | 1996-02-06 | Kazumi Ogata | Therapeutic composition for pancreatitis |
IT1274734B (it) | 1994-08-25 | 1997-07-24 | Prospa Bv | Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti |
JPH0873338A (ja) | 1994-09-02 | 1996-03-19 | Noevir Co Ltd | 皮膚外用剤 |
HU215966B (hu) | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
DE69532295T2 (de) | 1994-12-09 | 2004-09-23 | Kao Corp. | Verfahren zur herstellung von phosphorsäuremonoestern |
DE4444238A1 (de) | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
SE9404568L (sv) | 1994-12-30 | 1996-07-01 | Perstorp Ab | Användning av inositoltrisfosfat för beredning av läkemedel |
AU4515996A (en) | 1995-01-09 | 1996-07-31 | Alpha-Therapeutics, Inc. | Methods for increasing the bioavailability of biological active agents |
JP3526940B2 (ja) | 1995-01-11 | 2004-05-17 | 花王株式会社 | リン酸エステルの製造法 |
FR2730928B1 (fr) | 1995-02-23 | 1997-04-04 | Oreal | Composition a base de vesicules lipidiques a ph acide et son utilisation en application topique |
JPH08231564A (ja) | 1995-02-28 | 1996-09-10 | Nippon Shokubai Co Ltd | リン酸エステルおよびその製造方法並びにリン酸エステル重合体 |
GB9505025D0 (en) | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
ATE249819T1 (de) | 1995-04-21 | 2003-10-15 | Seikisui Chemical Co Ltd | Präparate zur äusserlichen anwendung zur behandlung von dermatosen |
JP3197787B2 (ja) | 1995-05-17 | 2001-08-13 | 花王株式会社 | 分岐二量化アルキルリン酸塩基性アミノ酸塩の製造方法 |
JPH08311489A (ja) | 1995-05-19 | 1996-11-26 | Nippon Oil & Fats Co Ltd | 洗浄剤組成物 |
US5665389A (en) | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
JP3622267B2 (ja) | 1995-05-31 | 2005-02-23 | 日本油脂株式会社 | 洗浄剤組成物 |
US5607968A (en) | 1995-06-07 | 1997-03-04 | Avon Products, Inc. | Topical alkyl-2-O-L-ascorbyl-phosphates |
JPH097298A (ja) | 1995-06-21 | 1997-01-10 | Victor Co Of Japan Ltd | 情報信号記録装置及び情報信号再生装置 |
KR100423458B1 (ko) | 1995-07-12 | 2004-05-17 | 가부시키가이샤 시세이도 | 피부외용제 |
JPH0944375A (ja) | 1995-07-26 | 1997-02-14 | Hitachi Ltd | テストプログラムの自動テスト項目選択方式 |
DE69637277T2 (de) | 1995-10-17 | 2008-05-08 | Showa Denko K.K. | Hochreine tocopherolphosphate, verfahren zu ihrer herstellung und analyse, und kosmetika |
FR2741263B1 (fr) | 1995-11-22 | 1997-12-26 | Oreal | Composition comprenant une dispersion aqueuse de vesicules lipidiques encapsulant un filtre uv a fonction acide et utilisations en application topique |
AU727314B2 (en) | 1996-03-27 | 2000-12-07 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
US6077828A (en) | 1996-04-25 | 2000-06-20 | Abbott Laboratories | Method for the prevention and treatment of cachexia and anorexia |
US5885595A (en) | 1996-05-13 | 1999-03-23 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic composition with a retinol fatty acid ester |
JPH09309813A (ja) | 1996-05-22 | 1997-12-02 | Nonogawa Shoji Kk | 皮膚外用剤 |
JPH1045783A (ja) | 1996-07-29 | 1998-02-17 | Showa Denko Kk | ヒドロキシクロマン誘導体リン酸エステルの製造方法 |
CA2209690A1 (en) | 1996-07-31 | 1998-01-31 | Sachiko Matsuura | Therapeutic drug for acne vulgaris |
JPH1067639A (ja) | 1996-08-26 | 1998-03-10 | Shiseido Co Ltd | ビタミンe−ビタミンcリン酸ジエステル/シクロデキストリン包接物及び該包接物を配合した皮膚外用剤 |
JPH10155429A (ja) | 1996-11-27 | 1998-06-16 | Showa Denko Kk | 動物に対するビタミンe供給方法および動物用トコフェロールリン酸エステル又はその塩類組成物 |
US6022867A (en) | 1996-11-27 | 2000-02-08 | Showa Denko Kabushiki Kaisha | Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals |
US6727280B2 (en) | 1997-01-07 | 2004-04-27 | Sonus Pharmaceuticals, Inc. | Method for treating colorectal carcinoma using a taxane/tocopherol formulation |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US5804168A (en) | 1997-01-29 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for protecting and treating sun damaged skin |
EP0965328B1 (en) | 1997-01-29 | 2009-03-04 | Kao Corporation | Cosmetic |
US6248758B1 (en) | 1997-03-13 | 2001-06-19 | Hexal Ag | Pharmaceutical antacid |
US7179486B1 (en) | 1997-04-01 | 2007-02-20 | Nostrum Pharmaceuticals, Inc. | Process for preparing sustained release tablets |
JP2926046B2 (ja) | 1997-06-04 | 1999-07-28 | 株式会社太平洋 | 水安定型l−アスコルビン酸誘導体とその製造方法及びこれを含有する美白化粧料組成物 |
US5928631A (en) | 1997-06-09 | 1999-07-27 | The Procter & Gamble Company | Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins |
US5906811A (en) | 1997-06-27 | 1999-05-25 | Thione International, Inc. | Intra-oral antioxidant preparations |
US5776915A (en) | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
US6096326A (en) | 1997-08-15 | 2000-08-01 | Scandinavian-American Import/Export Corporation | Skin care compositions and use |
IT1294748B1 (it) | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
JP3950216B2 (ja) | 1997-12-26 | 2007-07-25 | 日本メナード化粧品株式会社 | 皮膚外用剤 |
CA2317008C (en) | 1997-12-31 | 2009-01-20 | The University Of Kansas | Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof |
JPH11199465A (ja) | 1998-01-07 | 1999-07-27 | Nonogawa Shoji Kk | 皮膚外用剤 |
AU2455199A (en) | 1998-01-12 | 1999-07-26 | Betagene, Inc. | Compositions and methods for regulated secretion from neuroendocrine cell lines |
CA2319020A1 (en) | 1998-02-03 | 1999-08-12 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical compositions for prevention and treatment of neurodegenarative diseases |
FR2777179A1 (fr) | 1998-04-09 | 1999-10-15 | Lvmh Rech | Compositions cosmetiques ou dermatologiques comprenant un vehicule a base d'un liquide hydrophobe |
US6461623B2 (en) | 1998-04-13 | 2002-10-08 | Kao Corporation | Cosmetic composition |
US6254853B1 (en) | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
US6121249A (en) | 1998-07-01 | 2000-09-19 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases with help of aspirin, antioxidants, niacin, and certain B vitamins |
JP2002519366A (ja) | 1998-07-07 | 2002-07-02 | トランスダーマル・テクノロジーズ・インコーポレーテツド | 医薬的に活性な作用物質を迅速かつ非刺激的に経皮送達するための組成物、およびそのような組成物の調剤法およびそれらの送達 |
US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
US6770672B1 (en) | 1998-09-23 | 2004-08-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
NZ510732A (en) | 1998-09-23 | 2004-01-30 | Res Dev Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
IT1303787B1 (it) | 1998-11-25 | 2001-02-23 | Maria Rosa Gasco | "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule" |
US6048891A (en) | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
AUPP829399A0 (en) | 1999-01-25 | 1999-02-18 | Swig Pty Ltd | Recovery for chroman derivatives |
AUPQ037499A0 (en) | 1999-05-14 | 1999-06-10 | Swig Pty Ltd | Improved process for phosphorylation and compounds produced by this method |
JP2000212082A (ja) | 1999-01-26 | 2000-08-02 | Showa Denko Kk | 皮膚用剤 |
US6156354A (en) | 1999-01-29 | 2000-12-05 | Brandeis University | Hyper-absorption of vitamin E dispersed in milks |
NZ527924A (en) | 1999-01-29 | 2005-01-28 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
DE19912798C1 (de) | 1999-03-10 | 2000-02-17 | Andreas Jordan | Verfahren zur Kultivierung von Krebszellen aus Humangewebe und Vorrichtung zur Aufbereitung von Gewebeproben |
AU3913800A (en) | 1999-03-26 | 2000-10-16 | Lipogenics, Inc. | Novel antioxidant formulations and methods for using them |
US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
CA2372066C (en) | 1999-05-14 | 2006-01-31 | Simon Michael West | Process for phosphorylation of primary fatty alcohols,secondary alcohols and aromatic alcohols using p4o10 in the absence of solvent |
DE19923551A1 (de) | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
US6184247B1 (en) | 1999-05-21 | 2001-02-06 | Amway Corporation | Method of increasing cell renewal rate |
US6641847B1 (en) | 1999-06-01 | 2003-11-04 | Ocean Spray Cranberries, Inc. | Cranberry seed oil extract and compositions containing components thereof |
WO2000074684A1 (en) | 1999-06-04 | 2000-12-14 | The General Hospital Corporation | Pharmaceutical formulations for treating postmenopausal and perimenopausal women, and their use |
EP1210079A2 (en) | 1999-08-20 | 2002-06-05 | Ferrosan A/S | A pharmaceutical delivery system for vitamin c and vitamin e and use of a combination of vitamin c and e for preventing or treating conditions involving oxidative stress |
US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
WO2001015593A2 (en) | 1999-09-02 | 2001-03-08 | Drake Larson | Compositions for reducing vascular plaque formation and methods of using same |
GB9921960D0 (en) | 1999-09-16 | 1999-11-17 | Pharmacia & Upjohn Spa | Formulations for parenteral use of estramustine phosphate and amino acids |
JP2003513019A (ja) | 1999-09-27 | 2003-04-08 | ソーナス ファーマシューティカルス,インコーポレイテッド | トコール可溶性治療剤の組成物 |
EP1265638A1 (en) | 1999-11-12 | 2002-12-18 | Pharmaderm Laboratories Ltd. | Compositions for transdermal and transmucosal administration of therapeutic agents |
WO2001035883A1 (en) | 1999-11-19 | 2001-05-25 | Xel Herbaceuticals | Transdermal delivery system for alkaloids of aconitum species |
JP2001169731A (ja) | 1999-12-17 | 2001-06-26 | Showa Denko Kk | 動物体の脂質代謝改善剤 |
CA2393359A1 (en) | 1999-12-22 | 2001-06-28 | Merck Frosst Canada & Co. | Aromatic phosphonates as protein tyrosine phosphatase 1b (ptp-1b) inhibitors |
IT1317736B1 (it) | 2000-01-26 | 2003-07-15 | A C R Applied Coating Res S A | Cerotto per la somministrazione locale e transdermica di principiattivi dotati di gruppi anionici ed elettronattrattori. |
CA2399802C (en) | 2000-02-11 | 2009-12-08 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US20030035812A1 (en) | 2000-02-29 | 2003-02-20 | Shinobu Ito | Immune enhancement compositions and use thereof |
US6346544B2 (en) | 2000-03-02 | 2002-02-12 | Oklahoma Medical Research Foundation | Desmethyl tocopherols for protecting cardiovascular tissue |
JP2001247585A (ja) | 2000-03-03 | 2001-09-11 | Nof Corp | トコフェロール誘導体、その中間体、その製造方法及び用途 |
US6444220B2 (en) | 2000-03-16 | 2002-09-03 | Teresa S. Wiley | Method and compositions for changing the contour of skin |
AR027715A1 (es) | 2000-03-24 | 2003-04-09 | Baker Norton Pharma | Composiciones basadas en taxanos y metodos de uso de las mismas |
US6361800B1 (en) | 2000-04-13 | 2002-03-26 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
DE10032301A1 (de) | 2000-07-04 | 2002-01-17 | Rbs Netkom Gmbh | Fahrdatengewinnungs-, übermittlungs- und ausgabesystem |
WO2002003996A1 (en) | 2000-07-12 | 2002-01-17 | RAJKUMAR, Sujatha | Use of dammarane-type tritepenoid saporins |
FR2811546B1 (fr) | 2000-07-13 | 2003-09-26 | Oreal | Kit et procede de maquillage longue tenue |
US6485950B1 (en) | 2000-07-14 | 2002-11-26 | Council Of Scientific And Industrial Research | Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions |
US6362234B1 (en) | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
KR100365070B1 (ko) | 2000-08-29 | 2002-12-16 | 주식회사 태평양 | 토코페롤 유도체 및 그의 제조방법 |
JP4818500B2 (ja) | 2000-09-05 | 2011-11-16 | 株式会社ペンタプラストア | トコトリエノール誘導体及びその製造方法 |
WO2002026238A1 (en) | 2000-09-26 | 2002-04-04 | Vital Health Sciences Pty Ltd. | Phosphate derivative supplements |
US6660306B2 (en) | 2000-10-12 | 2003-12-09 | Mickey L. Peshoff | Wound healing compound |
US20030206972A1 (en) | 2000-10-13 | 2003-11-06 | Babish John G. | Compositions containing carotenoids and tocotrienols and having synergistic antioxidant effect |
AU2002220021A1 (en) | 2000-11-02 | 2002-05-15 | The Regents Of The University Of California | Alpha-tocopherol transfer protein knockout animals |
AU2002214820B2 (en) | 2000-11-14 | 2003-08-14 | Vital Health Sciences Pty Ltd | Formulation containing phosphate derivatives of electron transfer agents |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
WO2002040034A1 (en) | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd. | Complexes of phosphate derivatives |
IN188917B (zh) * | 2000-12-07 | 2002-11-23 | Bharat Surums & Vaccines Ltd | |
AU2002239748A1 (en) | 2000-12-15 | 2002-06-24 | Galileo Laboratories, Inc. | Use of tocopherol, metabolites or derivatives thereof or flavonoid metabolites or derivatives thereof in the manufacture of a medicament for the treatment of tissue ischemia |
US20020151467A1 (en) | 2000-12-21 | 2002-10-17 | Leung Frank K. | Methods and compositions for oral insulin delivery |
US20020131994A1 (en) | 2001-01-10 | 2002-09-19 | Schur Henry B. | Non-irritating formulation for the transdermal delivery of substances |
US6849271B2 (en) | 2001-04-27 | 2005-02-01 | Verion, Inc. | Microcapsule matrix microspheres, absorption-enhancing pharmaceutical compositions and methods |
TW576859B (en) | 2001-05-11 | 2004-02-21 | Shipley Co Llc | Antireflective coating compositions |
KR100428702B1 (ko) | 2001-05-26 | 2004-04-28 | 주식회사 엘지생명과학 | 폴리에톡실화 알파 토코페롤 에스테르 유도체를 함유하는동물용 사료첨가제 조성물 |
JP4745608B2 (ja) | 2001-07-27 | 2011-08-10 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 電子伝達剤のリン酸誘導体を用いた皮膚治療 |
AUPR684801A0 (en) | 2001-08-06 | 2001-08-30 | Vital Health Sciences Pty Ltd | Supplement therapy |
PL205576B1 (pl) | 2001-09-04 | 2010-05-31 | Trommsdorff Arzneimittel | Zastosowanie warstwy przeznaczonej do pozostawania w bezpośrednim kontakcie z paznokciem i ewentualnie z otaczającą skórą, do wytwarzania plastra |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
AU2002951045A0 (en) | 2002-08-27 | 2002-09-12 | Vital Health Sciences Pty Ltd | Method of supplementing nascent endogenous storage forms |
CA2458279A1 (en) | 2001-09-26 | 2003-04-03 | Vital Health Sciences Pty Ltd. | Modulation of vitamin storage |
JP4370451B2 (ja) | 2001-09-28 | 2009-11-25 | 大塚製薬株式会社 | 医薬組成物 |
JP2003128531A (ja) | 2001-10-17 | 2003-05-08 | Nonogawa Shoji Kk | 皮膚外用剤 |
EP1450787A4 (en) | 2001-11-15 | 2006-01-25 | Galileo Pharmaceuticals Inc | FORMULATIONS AND METHODS FOR THE TREATMENT OR AMELIORATION OF INFLAMMATORY CONDITIONS |
DE60238276D1 (de) | 2001-12-13 | 2010-12-23 | Vital Health Sciences Pty Ltd | Transdermaler transport von verbindungen |
CN100515497C (zh) | 2001-12-19 | 2009-07-22 | 研究发展基金会 | 脂质体输送以维生素e为基础的化合物 |
DE10200578A1 (de) | 2002-01-09 | 2003-07-10 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme |
WO2003063860A1 (fr) | 2002-01-31 | 2003-08-07 | Kansai Technology Licensing Organization Co., Ltd. | Composition et procede pour la prevention du cancer chez des sujets humains |
WO2003068209A1 (en) | 2002-02-14 | 2003-08-21 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
US7074825B2 (en) | 2002-03-07 | 2006-07-11 | Huanbiao Mo | Composition and method for treating cancer |
WO2003094882A1 (en) | 2002-05-09 | 2003-11-20 | Showa Denko K.K. | Skin whitening external preparation |
EP1507813A4 (en) | 2002-05-20 | 2005-11-23 | Ranbaxy Lab Ltd | FAT BINDING USING AN INTERPOLYMER COMPLEX OF GLUCOSAMINE AND POLYACRYLIC ACID |
US20040018237A1 (en) | 2002-05-31 | 2004-01-29 | Perricone Nicholas V. | Topical drug delivery using phosphatidylcholine |
CA2494297C (en) | 2002-07-29 | 2011-10-18 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
US20040067890A1 (en) | 2002-10-04 | 2004-04-08 | Gupta Shyam K. | Ascorbic acid salts of organic bases with enhanced bioavailability for synergictic anti-aging and skin protective cosmetic compositions |
FR2846651B1 (fr) | 2002-10-30 | 2006-06-16 | Rhodia Polyamide Intermediates | Procede de fabrication d'acides carboxyliques |
US7399784B2 (en) | 2002-11-26 | 2008-07-15 | Children's Hospital & Research Center At Oakland | Tocopherol and tocotrienol anti-obesity medicaments |
US6645514B1 (en) | 2002-12-19 | 2003-11-11 | Access Business Group International, Llc | Increasing skin cell renewal with water-soluble Vitamin E |
EP1578325B1 (en) | 2002-12-31 | 2011-04-27 | Transdermal Biotechnology, Inc. | Stable topical drug delivery compositions |
JP4690305B2 (ja) | 2003-01-17 | 2011-06-01 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 抗増殖性質を有する化合物 |
US7033998B2 (en) | 2003-04-11 | 2006-04-25 | All Natural Fmg, Inc. | Alcohol-free transdermal insulin composition and processes for manufacture and use thereof |
AU2003901812A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphates of secondary alcohols |
AU2003901813A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Pharmaceutical derivatives |
AU2003901815A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
US20050152858A1 (en) | 2003-07-11 | 2005-07-14 | Isp Investments Inc. | Solubilizing agents for active or functional organic compounds |
US8546453B2 (en) * | 2003-08-14 | 2013-10-01 | Rensheng Zhang | Propofol compositions and methods for reducing pain associated with propofol injection |
JP2006199589A (ja) | 2003-09-03 | 2006-08-03 | Ltt Bio-Pharma Co Ltd | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
CN100536845C (zh) | 2003-09-23 | 2009-09-09 | 中国医学科学院药物研究所 | 氯雷他定透皮贴片 |
US7207669B2 (en) | 2003-12-19 | 2007-04-24 | Arizona Chemical Company | Jet printing inks containing polymerized fatty acid-based polyamides |
CN110522717A (zh) | 2004-01-22 | 2019-12-03 | 迈阿密大学 | 局部辅酶q10制剂及其使用方法 |
NZ549576A (en) | 2004-02-23 | 2010-04-30 | Euro Celtique Sa | Abuse resistance opioid transdermal delivery device using microspheres of opiate antagonist |
CA2557354C (en) | 2004-03-03 | 2013-05-07 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
CN1946401B (zh) * | 2004-03-03 | 2011-11-02 | 生命健康科学有限公司 | 生物碱制剂 |
EP1783209B1 (en) | 2004-06-29 | 2010-04-14 | Japan Science and Technology Agency | Selective culture method and separation method for small hepatocytes with the use of hyaluronic acid |
EP2269650A3 (en) | 2004-08-03 | 2012-05-16 | Vital Health Sciences Pty Ltd. | Carrier for enteral administration |
JP4523388B2 (ja) | 2004-11-19 | 2010-08-11 | 日本メナード化粧品株式会社 | コラーゲン合成促進剤及び皮膚外用剤 |
US20060120979A1 (en) | 2004-12-02 | 2006-06-08 | Joel Rubin | Skin care composition comprising hydroquinone and a substantially anhydrous base |
US20090239827A1 (en) | 2005-03-03 | 2009-09-24 | Esra Ogru | Compounds having lipid lowering properties |
CN101132789A (zh) | 2005-03-03 | 2008-02-27 | 生命健康科学有限公司 | 具有降脂性能的化合物 |
RU2435580C2 (ru) | 2005-03-03 | 2011-12-10 | Вайтал Хэлф Сайнсис Пти Лтд | Составы, обладающие антиканцерогенными свойствами |
US20060228395A1 (en) | 2005-04-11 | 2006-10-12 | Robert Lamb | Vitamin E phosphate/phosphatidylcholine liposomes to protect from or ameliorate cell damage |
JP5221343B2 (ja) | 2005-06-17 | 2013-06-26 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 担体 |
KR100764679B1 (ko) | 2005-07-22 | 2007-10-09 | 익수제약 주식회사 | 파록세틴을 함유하는 경피투여용 패취제 |
US20070110739A1 (en) | 2005-11-11 | 2007-05-17 | Logsdon Lawrence M | Wipe away pain |
US7446096B2 (en) | 2005-12-19 | 2008-11-04 | Industrial Technology Research Institute | Glutathione based delivery system |
TW200800223A (en) | 2005-12-21 | 2008-01-01 | Shire Pharmaceuticals Inc | Transdermal delivery of meptazinol |
RU2008123556A (ru) | 2005-12-23 | 2010-01-27 | Вайтал Хэлф Сайнсис Пти Лтд (Au) | Составы, имеющие цитокин модулирующие свойства |
DE102006023336A1 (de) | 2006-05-18 | 2007-11-22 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole II |
WO2008034178A1 (en) | 2006-09-21 | 2008-03-27 | Salvatore Iemma | Topical depilating composition |
RU2373957C2 (ru) | 2006-10-13 | 2009-11-27 | Александр Метталинович Тишин | Носитель для лекарственных средств и биологически активных веществ для лечения и диагностики и применение его для создания лекарственных средств и способа регулируемой управляемой доставки лекарственного средства или биологически активного вещества с регулируемой десорбцией его |
MX2009005947A (es) | 2006-12-05 | 2009-06-17 | Novartis Ag | Formas de dosificacion en microemulsion de valsartan, y metodos para elaborarlas. |
IL181217A0 (en) * | 2007-02-08 | 2007-07-04 | Haim Levy | Pharmaceuticalcompositions based on a microemulsion |
FR2921259B1 (fr) | 2007-09-26 | 2015-02-13 | Lvmh Rech | Utilisation cosmetique du phosphate de tocopherol comme agent anti-vieillissement de la peau |
EP2113242A1 (en) | 2008-05-02 | 2009-11-04 | Pangaea Laboratories Limited | Antioxidant for use in cosmetic, medicated and pharmaceutical preparations |
US20090297591A1 (en) | 2008-05-30 | 2009-12-03 | Orient Pharma Co., Ltd. | Compositions And Methods For The Transdermal Delivery Of Pharmaceutical Compounds |
AR072008A1 (es) | 2008-06-13 | 2010-07-28 | Merck & Co Inc | Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38 |
US20090319191A1 (en) | 2008-06-24 | 2009-12-24 | Rivas Ariel L | Method for diagnosis of an infectious disease stage and determination of treatment |
CN101524330B (zh) * | 2009-04-20 | 2013-01-09 | 重庆莱美药业股份有限公司 | 一种微乳载药系统及制备方法 |
RU2012133467A (ru) | 2010-02-05 | 2014-02-10 | Фосфейдженикс Лимитед | Композиция носителя |
AU2011213557B2 (en) | 2010-02-05 | 2015-05-07 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
JP5132700B2 (ja) | 2010-02-22 | 2013-01-30 | 三菱電機株式会社 | 手乾燥装置 |
RU2553350C2 (ru) | 2010-03-30 | 2015-06-10 | Фосфейдженикс Лимитед | Трансдермальные пластыри |
AU2011340797B2 (en) * | 2010-12-10 | 2017-08-10 | Ns Technologies Pty Ltd | Methods for forming miniemulsions and use thereof for delivering bioactive agents |
CN102079756B (zh) | 2010-12-27 | 2012-09-12 | 锦州惠发天合化学有限公司 | 一种全氟烷基聚氧乙烯基磷酸酯含氟表面活性剂的合成方法 |
EP2685992A4 (en) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | AMINO-QUINOLINES AS KINASE INHIBITORS |
US9328317B2 (en) | 2011-11-04 | 2016-05-03 | The Chemours Company Fc, Llc | Fluorophosphate surfactants |
KR101542541B1 (ko) | 2014-10-07 | 2015-08-06 | 주식회사 대동요업 | 역류 방지가 가능한 기와 |
-
2016
- 2016-12-09 CN CN201680072343.6A patent/CN108601732A/zh active Pending
- 2016-12-09 WO PCT/AU2016/051209 patent/WO2017096427A1/en active Application Filing
- 2016-12-09 EP EP16871823.7A patent/EP3383371B1/en active Active
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- 2016-12-09 JP JP2018549368A patent/JP6882321B2/ja active Active
- 2016-12-09 AU AU2016367708A patent/AU2016367708B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1143436A (ja) * | 1997-07-25 | 1999-02-16 | Showa Denko Kk | 末梢血流障害予防・治療剤 |
EP1264595A1 (en) * | 2001-06-05 | 2002-12-11 | Pacific Corporation | Use of tocopherol derivatives for stabilizing nano-sized emulsion particles containing lecithin and their external application to the skin |
CN1917858A (zh) * | 2004-02-13 | 2007-02-21 | 生物药效率有限公司 | 麻醉用高浓度异丙酚微乳制剂 |
CN101247834A (zh) * | 2005-06-17 | 2008-08-20 | 生命健康科学公司 | 包含一种或多种二-和/或单-(电子转移剂)磷酸酯衍生物或其络合物的载体 |
CN102686279A (zh) * | 2009-12-23 | 2012-09-19 | 磷肌酸有限公司 | 载体组合物 |
Non-Patent Citations (1)
Title |
---|
刘丽萍 等主编, 北京:中国中医药出版社 * |
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EP3383371B1 (en) | 2024-05-01 |
CA3007587A1 (en) | 2017-06-15 |
JP6882321B2 (ja) | 2021-06-02 |
JP2018537534A (ja) | 2018-12-20 |
AU2016367708B2 (en) | 2022-07-14 |
WO2017096427A1 (en) | 2017-06-15 |
US20190015329A1 (en) | 2019-01-17 |
CN108601732A (zh) | 2018-09-28 |
EP3383371A4 (en) | 2019-07-24 |
AU2016367708A1 (en) | 2018-06-21 |
US10973761B2 (en) | 2021-04-13 |
EP3383371A1 (en) | 2018-10-10 |
CA3007587C (en) | 2023-12-05 |
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