CN110506039A - 用于雄激素受体靶向降解的化合物和方法 - Google Patents

用于雄激素受体靶向降解的化合物和方法 Download PDF

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Publication number
CN110506039A
CN110506039A CN201780076646.XA CN201780076646A CN110506039A CN 110506039 A CN110506039 A CN 110506039A CN 201780076646 A CN201780076646 A CN 201780076646A CN 110506039 A CN110506039 A CN 110506039A
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alkyl
optionally substituted
chloro
group
dioxopiperidin
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Chinese (zh)
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安德鲁·P·克鲁
基思·R·霍恩伯格
劳伦斯·B·斯奈德
库尔特·齐默尔曼
J·王
迈克尔·贝尔林
克雷格·M·克鲁斯
H·董
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Arvinas Inc
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Arvinas Inc
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Priority to CN202010284436.3A priority Critical patent/CN111892577B/zh
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CN201780076646.XA 2016-10-11 2017-10-11 用于雄激素受体靶向降解的化合物和方法 Pending CN110506039A (zh)

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PCT/US2017/056234 WO2018071606A1 (en) 2016-10-11 2017-10-11 Compounds and methods for the targeted degradation of androgen receptor

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Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110357889A (zh) * 2018-04-09 2019-10-22 上海科技大学 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
WO2021129653A1 (zh) 2019-12-23 2021-07-01 上海济煜医药科技有限公司 一种蛋白降解剂化合物的制备方法和应用
CN113387930A (zh) * 2020-03-11 2021-09-14 苏州开拓药业股份有限公司 一种双官能化合物及其制备方法和用途
CN113582974A (zh) * 2020-04-30 2021-11-02 江西济民可信集团有限公司 一类作为蛋白降解剂的化合物及其制备方法和医药用途
CN113620931A (zh) * 2021-09-13 2021-11-09 中国海洋大学 一种雄激素受体抑制剂及其用途
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