HRP20230414T1 - Spojevi i postupci za ciljanu razgradnju androgenog receptora - Google Patents
Spojevi i postupci za ciljanu razgradnju androgenog receptora Download PDFInfo
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- HRP20230414T1 HRP20230414T1 HRP20230414TT HRP20230414T HRP20230414T1 HR P20230414 T1 HRP20230414 T1 HR P20230414T1 HR P20230414T T HRP20230414T T HR P20230414TT HR P20230414 T HRP20230414 T HR P20230414T HR P20230414 T1 HRP20230414 T1 HR P20230414T1
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- 150000001875 compounds Chemical class 0.000 title claims 22
- 102000001307 androgen receptors Human genes 0.000 title claims 3
- 108010080146 androgen receptors Proteins 0.000 title claims 3
- 230000015556 catabolic process Effects 0.000 title 1
- 238000006731 degradation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 2
- 229960002066 vinorelbine Drugs 0.000 claims 2
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 2
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 2
- 229960000237 vorinostat Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
Classifications
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
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- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Claims (26)
1. Spoj koji ima strukturu:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
ili
[image]
ili farmaceutski prihvatljiva sol, enantiomer, stereoizomer ili izotopni derivat bilo kojeg od prethodno navedenih.
2. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
ili
[image]
3. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
ili njegova farmaceutski prihvatljiva sol, enantiomer, stereoizomer ili izotopni derivat.
4. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
5. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
ili njegova farmaceutski prihvatljiva sol, enantiomer, stereoizomer ili izotopni derivat.
6. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
ili njegova farmaceutski prihvatljiva sol.
7. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
8. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
ili njegova farmaceutski prihvatljiva sol, enantiomer, stereoizomer ili izotopni derivat.
9. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
10. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
ili njegova farmaceutski prihvatljiva sol, enantiomer, stereoizomer ili izotopni derivat.
11. Spoj prema zahtjevu 1, naznačen time što ima strukturu:
[image]
12. Farmaceutski pripravak, naznačen time što sadrži spoj prema bilo kojem od zahtjeva 1-11, i farmaceutski prihvatljiv nosač.
13. Farmaceutski pripravak prema zahtjevu 12, naznačen time što nadalje sadrži učinkovitu količinu dodatnog sredstva protiv raka.
14. Farmaceutski pripravak prema zahtjevu 13, naznačen time što je dodatno sredstvo protiv raka inhibitor FLT-3, inhibitor androgenog receptora, inhibitor VEGFR, inhibitor EGFR TK, inhibitor aurora kinaze, modulator PIK-1, inhibitor Bcl-2, inhibitor HDAC , inhibitor c-MET, inhibitor PARP, inhibitor CDK, anti-HGF protutijelo, inhibitor IGFR TK, inhibitor PI3 kinaze, inhibitor AKT, inhibitor JAK/STAT, inhibitor kontrolne točke 1, inhibitor kontrolne točke 2, inhibitor kinaze žarišne adhezije, inhibitor kinaze MAP , ili protutijelo VEGF klopka.
15. Farmaceutski pripravak prema zahtjevu 13, naznačen time što je dodatno sredstvo protiv raka estramustin, docetaksel, ketokonazol, goserelin acetat, histrelin, buserelin, ciproteron, flutamid, bikalutamid, nilutamid, pamidronat, zolendronat, mitoksantron, pemetreksed, ipilimumab, vorinostat, etopozid, gemcitabin, doksorubicin, vinkristin, temozolomid, kapecitabin, irinotekan označen PEG-om, tamoksifen, anastrazol, eksemestan, letrozol, dietilstilbestrol, estradiol, estrogen, bevacizumab, leuprolid acetat, triptorelin pamoat, medroksiprogesteron acetat, hidroksiprogesteron kaproat, raloksifen, megestrol acetat, karboplatin, cisplatin, dakarbazin, metotreksat, vinblastin, vinorelbin, topotekan, finasterid, arzoksifen, fulvestrant ili prednizon.
16. Farmaceutski pripravak prema zahtjevu 15, naznačen time što:
(a) dodatno sredstvo protiv raka je estramustin, docetaksel, ketokonazol, goserelin acetat, histrelin, triptorelin pamoat, buserelin, ciproteron, flutamid, bikalutamid, nilutamid, pamidronat ili zolendronat; ili
(b) dodatno sredstvo protiv raka je docetaksel, mitoksantron, estramustin ili leuprolid acetat.
17. Spoj prema bilo kojem od zahtjeva 1-11 ili farmaceutski pripravak prema zahtjevu 12 za upotrebu u liječenju raka prostate kod subjekta.
18. Spoj prema zahtjevu 6 za upotrebu u liječenju raka prostate kod subjekta.
19. Spoj prema zahtjevu 7 za upotrebu u liječenju raka prostate kod subjekta.
20. Spoj ili farmaceutski pripravak za upotrebu prema zahtjevu 17, naznačen time što liječenje nadalje uključuje upotrebu učinkovite količine dodatnog sredstva protiv raka.
21. Spoj za upotrebu prema zahtjevu 18, naznačen time što liječenje nadalje uključuje upotrebu učinkovite količine dodatnog sredstva protiv raka.
22. Spoj za upotrebu prema zahtjevu 19, naznačen time što liječenje nadalje uključuje upotrebu učinkovite količine dodatnog sredstva protiv raka.
23. Spoj ili farmaceutski pripravak za upotrebu prema bilo kojem od zahtjeva 20-22, naznačen time što je dodatno sredstvo protiv raka inhibitor FLT-3, inhibitor androgenog receptora, inhibitor VEGFR, inhibitor EGFR TK, inhibitor aurora kinaze, modulator PIK-1, inhibitor Bcl-2, inhibitor HDAC , inhibitor c-MET, inhibitor PARP, inhibitor CDK, anti-HGF protutijelo, inhibitor IGFR TK, inhibitor PI3 kinaze, inhibitor AKT, inhibitor JAK/STAT, inhibitor kontrolne točke 1, inhibitor kontrolne točke 2, inhibitor kinaze žarišne adhezije, inhibitor kinaze MAP , ili protutijelo VEGF klopka.
24. Spoj ili farmaceutski pripravak za upotrebu prema bilo kojem od zahtjeva 20-22, naznačen time što je dodatno sredstvo protiv raka estramustin, docetaksel, ketokonazol, goserelin acetat, histrelin, buserelin, ciproteron, flutamid, bikalutamid, nilutamid, pamidronat, zolendronat, mitoksantron, pemetreksed, ipilimumab, vorinostat, etopozid, gemcitabin, doksorubicin, vinkristin, temozolomid, kapecitabin, irinotekan označen PEG-om, tamoksifen, anastrazol, eksemestan, letrozol, dietilstilbestrol, estradiol, estrogen, bevacizumab, leuprolid acetat, triptorelin pamoat, medroksiprogesteron acetat, hidroksiprogesteron kaproat, raloksifen, megestrol acetat, karboplatin, cisplatin, dakarbazin, metotreksat, vinblastin, vinorelbin, topotekan, finasterid, arzoksifen, fulvestrant ili prednizon.
25. Spoj ili farmaceutski pripravak za upotrebu prema zahtjevu 24, naznačen time što:
(a) dodatno sredstvo protiv raka je estramustin, docetaksel, ketokonazol, goserelin acetat, histrelin, triptorelin pamoat, buserelin, ciproteron, flutamid, bikalutamid, nilutamid, pamidronat ili zolendronat; ili
(b) dodatno sredstvo protiv raka je docetaksel, mitoksantron, estramustin ili leuprolid acetat.
26. Farmaceutski pripravak prema bilo kojem od zahtjeva 13-16, naznačen time što se koristi u liječenju raka prostate kod subjekta.
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US20210113557A1 (en) * | 2019-10-22 | 2021-04-22 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
BR112022022753A2 (pt) | 2020-05-09 | 2023-02-14 | Arvinas Operations Inc | Métodos de fabricação de um composto bifuncional, formas ultrapuras do composto bifuncional e formas de dosagem compreendendo o mesmo |
US20210353621A1 (en) * | 2020-05-12 | 2021-11-18 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
AU2021365850A1 (en) * | 2020-10-21 | 2023-06-08 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor protein |
CA3204819A1 (en) * | 2020-12-11 | 2022-06-16 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
WO2023205481A1 (en) | 2022-04-21 | 2023-10-26 | Arvinas Operations, Inc. | A combination for use in treating prostate cancer comprising arv-100 and abiraterone |
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