BR112023018839A2 - Composto de glutarimida substituído por anel fundido com furano - Google Patents
Composto de glutarimida substituído por anel fundido com furanoInfo
- Publication number
- BR112023018839A2 BR112023018839A2 BR112023018839A BR112023018839A BR112023018839A2 BR 112023018839 A2 BR112023018839 A2 BR 112023018839A2 BR 112023018839 A BR112023018839 A BR 112023018839A BR 112023018839 A BR112023018839 A BR 112023018839A BR 112023018839 A2 BR112023018839 A2 BR 112023018839A2
- Authority
- BR
- Brazil
- Prior art keywords
- furan
- ring fused
- compound replaced
- glutarimide
- glutarimide compound
- Prior art date
Links
- -1 GLUTARIMIDE COMPOUND Chemical class 0.000 title abstract 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical class O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
composto de glutarimida substituído por anel fundido com furano. é divulgada uma série de compostos de glutarimida substituídos por anel fundido com furano e uma aplicação dos mesmos na preparação de um medicamento para o tratamento de doenças relacionadas. em particular, é divulgado um composto representado pela fórmula (ii) ou um sal farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110286500 | 2021-03-17 | ||
| CN202110712765 | 2021-06-25 | ||
| CN202111314330 | 2021-11-08 | ||
| CN202210187905 | 2022-02-28 | ||
| PCT/CN2022/081261 WO2022194221A1 (zh) | 2021-03-17 | 2022-03-16 | 呋喃稠环取代的戊二酰亚胺类化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023018839A2 true BR112023018839A2 (pt) | 2023-12-26 |
Family
ID=83322066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023018839A BR112023018839A2 (pt) | 2021-03-17 | 2022-03-16 | Composto de glutarimida substituído por anel fundido com furano |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240190851A1 (pt) |
| EP (1) | EP4310083A1 (pt) |
| JP (1) | JP2024511342A (pt) |
| KR (1) | KR20230154953A (pt) |
| CN (1) | CN116940568A (pt) |
| AU (1) | AU2022240688B2 (pt) |
| BR (1) | BR112023018839A2 (pt) |
| CA (1) | CA3212104A1 (pt) |
| TW (1) | TWI807697B (pt) |
| WO (1) | WO2022194221A1 (pt) |
| ZA (1) | ZA202309588B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202409025A (zh) * | 2022-08-19 | 2024-03-01 | 大陸商正大天晴藥業集團股份有限公司 | 包含環己基的化合物、包含其的藥物組合物及其用途 |
| WO2024055994A1 (zh) * | 2022-09-14 | 2024-03-21 | 南京明德新药研发有限公司 | 萘并呋喃取代的戊二酰亚胺类化合物的晶型、制备方法及其应用 |
| WO2024114639A1 (en) * | 2022-11-28 | 2024-06-06 | Shanghai Degron Biomedical Technology Co., Ltd. | Compounds for modulating hur (elavl1) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10584101B2 (en) * | 2016-10-11 | 2020-03-10 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| EP3848371A4 (en) * | 2018-09-07 | 2022-06-08 | Medshine Discovery Inc. | TRICYCLIC FURAN-SUBSTITUTED PIPERIDONEE COMPOUND |
| WO2020048546A1 (zh) * | 2018-09-07 | 2020-03-12 | 南京明德新药研发有限公司 | 三环取代哌啶二酮类化合物 |
| CN115380026B (zh) * | 2020-03-17 | 2023-11-07 | 南京明德新药研发有限公司 | 蛋白降解调节剂与其使用方法 |
-
2022
- 2022-03-16 WO PCT/CN2022/081261 patent/WO2022194221A1/zh active Application Filing
- 2022-03-16 KR KR1020237034055A patent/KR20230154953A/ko unknown
- 2022-03-16 JP JP2023556819A patent/JP2024511342A/ja active Pending
- 2022-03-16 US US18/549,186 patent/US20240190851A1/en active Pending
- 2022-03-16 CA CA3212104A patent/CA3212104A1/en active Pending
- 2022-03-16 EP EP22770574.6A patent/EP4310083A1/en active Pending
- 2022-03-16 TW TW111109709A patent/TWI807697B/zh active
- 2022-03-16 BR BR112023018839A patent/BR112023018839A2/pt unknown
- 2022-03-16 CN CN202280018997.6A patent/CN116940568A/zh active Pending
- 2022-03-16 AU AU2022240688A patent/AU2022240688B2/en active Active
-
2023
- 2023-10-13 ZA ZA2023/09588A patent/ZA202309588B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4310083A1 (en) | 2024-01-24 |
| JP2024511342A (ja) | 2024-03-13 |
| AU2022240688A1 (en) | 2023-11-02 |
| WO2022194221A1 (zh) | 2022-09-22 |
| TW202241404A (zh) | 2022-11-01 |
| ZA202309588B (en) | 2024-06-26 |
| CN116940568A (zh) | 2023-10-24 |
| KR20230154953A (ko) | 2023-11-09 |
| AU2022240688B2 (en) | 2024-07-11 |
| TWI807697B (zh) | 2023-07-01 |
| US20240190851A1 (en) | 2024-06-13 |
| CA3212104A1 (en) | 2022-09-22 |
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