BR112022007543A2 - Derivados de tiofeno como inibidores de xantina oxidase e aplicação dos mesmos - Google Patents

Derivados de tiofeno como inibidores de xantina oxidase e aplicação dos mesmos

Info

Publication number
BR112022007543A2
BR112022007543A2 BR112022007543A BR112022007543A BR112022007543A2 BR 112022007543 A2 BR112022007543 A2 BR 112022007543A2 BR 112022007543 A BR112022007543 A BR 112022007543A BR 112022007543 A BR112022007543 A BR 112022007543A BR 112022007543 A2 BR112022007543 A2 BR 112022007543A2
Authority
BR
Brazil
Prior art keywords
application
thiophene derivatives
oxidase inhibitors
xantine
inhibitors
Prior art date
Application number
BR112022007543A
Other languages
English (en)
Inventor
Chen Shuhui
Zhu Wenyuan
Wu Wentao
Zhang Yang
Original Assignee
Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd, Medshine Discovery Inc filed Critical Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Publication of BR112022007543A2 publication Critical patent/BR112022007543A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DERIVADOS DE TIOFENO COMO INIBIDORES DE XANTINA OXIDASE E APLICAÇÃO DOS MESMOS. Uma classe de inibidores de xantina oxidase (XO) e aplicação da mesma na preparação de fármacos para tratar doenças relacionadas a XO. Um composto representado pela fórmula (I) e um sal farmaceuticamente aceitável do mesmo são especificamente revelados.
BR112022007543A 2019-10-30 2020-10-30 Derivados de tiofeno como inibidores de xantina oxidase e aplicação dos mesmos BR112022007543A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911049951 2019-10-30
CN202010110482 2020-02-21
PCT/CN2020/125191 WO2021083319A1 (zh) 2019-10-30 2020-10-30 作为黄嘌呤氧化酶抑制剂的噻吩衍生物及其应用

Publications (1)

Publication Number Publication Date
BR112022007543A2 true BR112022007543A2 (pt) 2022-07-12

Family

ID=75714861

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022007543A BR112022007543A2 (pt) 2019-10-30 2020-10-30 Derivados de tiofeno como inibidores de xantina oxidase e aplicação dos mesmos

Country Status (8)

Country Link
US (1) US20230322703A1 (pt)
EP (1) EP4053114A4 (pt)
JP (1) JP7362916B2 (pt)
CN (1) CN114555578B (pt)
AU (1) AU2020374919B9 (pt)
BR (1) BR112022007543A2 (pt)
MX (1) MX2022004713A (pt)
WO (1) WO2021083319A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022265937A1 (en) * 2021-04-29 2023-12-14 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. Crystal form of thiophene derivative and preparation method therefor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1932833B1 (en) * 2005-10-07 2012-08-01 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
JP4930008B2 (ja) 2006-11-22 2012-05-09 いすゞ自動車株式会社 車両用動力伝達装置の制御装置
MX337527B (es) * 2007-04-11 2016-03-09 Kissei Pharmaceutical Derivado de (aza)indol y su uso para propositos medicos.
CA2682393C (en) * 2007-04-11 2015-03-17 Kissei Pharmaceutical Co., Ltd. 5-membered heterocyclic derivative and use thereof for medical purposes
WO2010044403A1 (ja) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 ５員環ヘテロアリール誘導体及びその医薬用途
EP2749562A4 (en) * 2011-08-24 2015-01-07 Kissei Pharmaceutical CONDENSED HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL USE
KR102635986B1 (ko) * 2015-09-02 2024-02-08 선샤인 레이크 파르마 컴퍼니 리미티드 카르복시 치환된 (헤테로) 방향족 고리 유도체 및 이의 제조 방법과 용도
NZ749427A (en) 2016-05-23 2019-11-29 Cstone Pharmaceutical Suzhou Co Ltd Thiophene, manufacturing method thereof, and pharmaceutical application of same

Also Published As

Publication number Publication date
CN114555578A (zh) 2022-05-27
US20230322703A1 (en) 2023-10-12
CN114555578B (zh) 2024-03-26
EP4053114A4 (en) 2023-10-25
AU2020374919B2 (en) 2024-02-22
JP7362916B2 (ja) 2023-10-17
AU2020374919A1 (en) 2022-04-21
AU2020374919B9 (en) 2024-02-29
WO2021083319A1 (zh) 2021-05-06
MX2022004713A (es) 2022-05-11
EP4053114A1 (en) 2022-09-07
JP2022553682A (ja) 2022-12-26

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: DONGBAO PURPLE STAR (HANGZHOU) BIOPHARMACEUTICAL CO., LTD. (CN)