MX2022004713A - Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos. - Google Patents

Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos.

Info

Publication number
MX2022004713A
MX2022004713A MX2022004713A MX2022004713A MX2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A
Authority
MX
Mexico
Prior art keywords
application
xanthine oxidase
oxidase inhibitors
thiophene derivatives
inhibitors
Prior art date
Application number
MX2022004713A
Other languages
English (en)
Inventor
Wentao Wu
Yang Zhang
Shuhui Chen
Wenyuan Zhu
Original Assignee
Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd filed Critical Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Publication of MX2022004713A publication Critical patent/MX2022004713A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Una clase de inhibidores de xantina oxidasa (XO), y aplicación de los mismos en la preparación de fármacos para tratar enfermedades relacionadas con XO. Se describe específicamente un compuesto representado por la fórmula (I) y una sal farmacéuticamente aceptable del mismo. (ver Fórmula).
MX2022004713A 2019-10-30 2020-10-30 Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos. MX2022004713A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911049951 2019-10-30
CN202010110482 2020-02-21
PCT/CN2020/125191 WO2021083319A1 (zh) 2019-10-30 2020-10-30 作为黄嘌呤氧化酶抑制剂的噻吩衍生物及其应用

Publications (1)

Publication Number Publication Date
MX2022004713A true MX2022004713A (es) 2022-05-11

Family

ID=75714861

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004713A MX2022004713A (es) 2019-10-30 2020-10-30 Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos.

Country Status (8)

Country Link
US (1) US20230322703A1 (es)
EP (1) EP4053114A4 (es)
JP (1) JP7362916B2 (es)
CN (1) CN114555578B (es)
AU (1) AU2020374919B9 (es)
BR (1) BR112022007543A2 (es)
MX (1) MX2022004713A (es)
WO (1) WO2021083319A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240004711A (ko) * 2021-04-29 2024-01-11 둥바오 퍼플 스타 (항저우) 바이오파마슈티컬 컴퍼니 리미티드 티오펜 유도체의 결정형 및 이의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2623327A1 (en) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
JP4930008B2 (ja) 2006-11-22 2012-05-09 いすゞ自動車株式会社 車両用動力伝達装置の制御装置
PL2133332T3 (pl) * 2007-04-11 2014-02-28 Kissei Pharmaceutical Pochodna aza(indolu) i jej zastosowanie do celów medycznych
RU2515968C2 (ru) * 2007-04-11 2014-05-20 Киссеи Фармасьютикал Ко., Лтд. 5-членное гетероциклическое соединение и его применение для лекарственных целей
JPWO2010044403A1 (ja) * 2008-10-15 2012-03-15 キッセイ薬品工業株式会社 5員環ヘテロアリール誘導体及びその医薬用途
KR20140060535A (ko) * 2011-08-24 2014-05-20 깃세이 야쿠힌 고교 가부시키가이샤 축합 헤테로환 유도체 및 그 의약용도
EP3344604B1 (en) * 2015-09-02 2020-11-04 Sunshine Lake Pharma Co., Ltd. Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
WO2017202291A1 (zh) * 2016-05-23 2017-11-30 南京明德新药研发股份有限公司 噻吩化合物及其合成方法和其在医药上的应用

Also Published As

Publication number Publication date
JP2022553682A (ja) 2022-12-26
AU2020374919B9 (en) 2024-02-29
US20230322703A1 (en) 2023-10-12
CN114555578B (zh) 2024-03-26
BR112022007543A2 (pt) 2022-07-12
JP7362916B2 (ja) 2023-10-17
AU2020374919B2 (en) 2024-02-22
EP4053114A4 (en) 2023-10-25
AU2020374919A1 (en) 2022-04-21
EP4053114A1 (en) 2022-09-07
WO2021083319A1 (zh) 2021-05-06
CN114555578A (zh) 2022-05-27

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