MX2022004713A - Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos. - Google Patents

Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos.

Info

Publication number
MX2022004713A
MX2022004713A MX2022004713A MX2022004713A MX2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A MX 2022004713 A MX2022004713 A MX 2022004713A
Authority
MX
Mexico
Prior art keywords
application
xanthine oxidase
oxidase inhibitors
thiophene derivatives
inhibitors
Prior art date
Application number
MX2022004713A
Other languages
English (en)
Inventor
Wentao Wu
Yang Zhang
Shuhui Chen
Wenyuan Zhu
Original Assignee
Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd filed Critical Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd
Publication of MX2022004713A publication Critical patent/MX2022004713A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Una clase de inhibidores de xantina oxidasa (XO), y aplicación de los mismos en la preparación de fármacos para tratar enfermedades relacionadas con XO. Se describe específicamente un compuesto representado por la fórmula (I) y una sal farmacéuticamente aceptable del mismo. (ver Fórmula).
MX2022004713A 2019-10-30 2020-10-30 Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos. MX2022004713A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911049951 2019-10-30
CN202010110482 2020-02-21
PCT/CN2020/125191 WO2021083319A1 (zh) 2019-10-30 2020-10-30 作为黄嘌呤氧化酶抑制剂的噻吩衍生物及其应用

Publications (1)

Publication Number Publication Date
MX2022004713A true MX2022004713A (es) 2022-05-11

Family

ID=75714861

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004713A MX2022004713A (es) 2019-10-30 2020-10-30 Derivados de tiofeno como inhibidores de xantina oxidasa y aplicacion de los mismos.

Country Status (8)

Country Link
US (1) US20230322703A1 (es)
EP (1) EP4053114A4 (es)
JP (1) JP7362916B2 (es)
CN (1) CN114555578B (es)
AU (1) AU2020374919B9 (es)
BR (1) BR112022007543A2 (es)
MX (1) MX2022004713A (es)
WO (1) WO2021083319A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022228280A1 (zh) * 2021-04-29 2022-11-03 东宝紫星(杭州)生物医药有限公司 噻吩衍生物的晶型及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5222561B2 (ja) * 2005-10-07 2013-06-26 キッセイ薬品工業株式会社 含窒素芳香族複素環化合物およびそれを含有する医薬組成物
JP4930008B2 (ja) 2006-11-22 2012-05-09 いすゞ自動車株式会社 車両用動力伝達装置の制御装置
BRPI0810524B8 (pt) * 2007-04-11 2021-05-25 Kissei Pharmaceutical derivado de (aza)indol, inibidor de xantina oxidase e composição farmacêutica compreendendo o dito derivado
CN101679244B (zh) * 2007-04-11 2014-01-01 橘生药品工业株式会社 5元杂环衍生物及其医药用途
JPWO2010044403A1 (ja) * 2008-10-15 2012-03-15 キッセイ薬品工業株式会社 ５員環ヘテロアリール誘導体及びその医薬用途
US9115144B2 (en) * 2011-08-24 2015-08-25 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative and pharmaceutical use thereof
EP3344604B1 (en) * 2015-09-02 2020-11-04 Sunshine Lake Pharma Co., Ltd. Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
AU2017270858B2 (en) 2016-05-23 2019-09-19 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. Thiophene, manufacturing method thereof, and pharmaceutical application of same

Also Published As

Publication number Publication date
JP7362916B2 (ja) 2023-10-17
JP2022553682A (ja) 2022-12-26
CN114555578B (zh) 2024-03-26
AU2020374919B2 (en) 2024-02-22
AU2020374919A1 (en) 2022-04-21
BR112022007543A2 (pt) 2022-07-12
EP4053114A1 (en) 2022-09-07
CN114555578A (zh) 2022-05-27
AU2020374919B9 (en) 2024-02-29
WO2021083319A1 (zh) 2021-05-06
EP4053114A4 (en) 2023-10-25
US20230322703A1 (en) 2023-10-12

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