CN1101810C - 盐酸乐卡地平的制备方法 - Google Patents

盐酸乐卡地平的制备方法 Download PDF

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Publication number
CN1101810C
CN1101810C CN96193842A CN96193842A CN1101810C CN 1101810 C CN1101810 C CN 1101810C CN 96193842 A CN96193842 A CN 96193842A CN 96193842 A CN96193842 A CN 96193842A CN 1101810 C CN1101810 C CN 1101810C
Authority
CN
China
Prior art keywords
dimethyl
diphenylpropyl
crystallization
solvent
aprotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96193842A
Other languages
English (en)
Chinese (zh)
Other versions
CN1184468A (zh
Inventor
A·莱奥纳蒂
G·莫塔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati Ireland Ltd
Original Assignee
Recordati SA
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA, Recordati Ireland Ltd filed Critical Recordati SA
Publication of CN1184468A publication Critical patent/CN1184468A/zh
Application granted granted Critical
Publication of CN1101810C publication Critical patent/CN1101810C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96193842A 1995-05-12 1996-05-09 盐酸乐卡地平的制备方法 Expired - Lifetime CN1101810C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI95A000957 1995-05-12
ITMI950957A IT1274480B (it) 1995-05-12 1995-05-12 Procedimento migliorato per la preparazione della lercanidipina cloridrato

Publications (2)

Publication Number Publication Date
CN1184468A CN1184468A (zh) 1998-06-10
CN1101810C true CN1101810C (zh) 2003-02-19

Family

ID=11371581

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96193842A Expired - Lifetime CN1101810C (zh) 1995-05-12 1996-05-09 盐酸乐卡地平的制备方法

Country Status (37)

Country Link
EP (1) EP0824517B1 (OSRAM)
JP (1) JP4038622B2 (OSRAM)
KR (1) KR100395441B1 (OSRAM)
CN (1) CN1101810C (OSRAM)
AR (1) AR002739A1 (OSRAM)
AT (1) ATE221050T1 (OSRAM)
AU (1) AU694046B2 (OSRAM)
BG (1) BG62400B1 (OSRAM)
BR (1) BR9608374A (OSRAM)
CA (1) CA2217849C (OSRAM)
CZ (1) CZ288634B6 (OSRAM)
DE (1) DE69622552T2 (OSRAM)
DK (1) DK0824517T3 (OSRAM)
DZ (1) DZ2032A1 (OSRAM)
EA (1) EA000346B1 (OSRAM)
EE (1) EE03351B1 (OSRAM)
EG (1) EG21755A (OSRAM)
ES (1) ES2179942T3 (OSRAM)
HU (1) HU226709B1 (OSRAM)
IL (1) IL118143A (OSRAM)
IN (1) IN188486B (OSRAM)
IT (1) IT1274480B (OSRAM)
MA (1) MA23858A1 (OSRAM)
MX (1) MX9708662A (OSRAM)
MY (1) MY113802A (OSRAM)
NO (1) NO309423B1 (OSRAM)
NZ (1) NZ309059A (OSRAM)
PL (1) PL185260B1 (OSRAM)
PT (1) PT824517E (OSRAM)
RO (1) RO119616B1 (OSRAM)
SA (1) SA96170216B1 (OSRAM)
SK (1) SK283321B6 (OSRAM)
TN (1) TNSN96069A1 (OSRAM)
TW (1) TW404940B (OSRAM)
UA (1) UA46769C2 (OSRAM)
WO (1) WO1996035668A1 (OSRAM)
ZA (1) ZA963716B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
JP2006504800A (ja) * 2002-10-16 2006-02-09 レコーダチ アイルランド リミテッド リシノプリル／レルカニジピンの組み合わせ治療
AR052918A1 (es) * 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
KR100713136B1 (ko) * 2005-05-04 2007-05-02 주식회사 대희화학 무수 레르카니디핀 염화수소 결정다형의 개선된 신규결정화 방법
PL1891009T3 (pl) 2005-06-15 2010-03-31 Hetero Drugs Ltd Nowy sposób wytwarzania lerkanidypiny
EP1940790B1 (en) 2005-09-16 2015-09-02 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
KR100811497B1 (ko) * 2005-10-19 2008-03-07 신풍제약주식회사 무수 염산 1,4-디하이드로피리딘 유도체의 제조 방법
ATE415389T1 (de) * 2006-05-24 2008-12-15 Cf Pharma Ltd Verfahren zur herstellung von lercanipidin
KR100808281B1 (ko) * 2006-06-30 2008-03-03 주식회사 하원정밀화학 레르카니디핀 및 그 산부가염의 제조방법
CN102020602B (zh) * 2009-09-18 2013-12-25 深圳信立泰药业股份有限公司 盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物
SI2585051T2 (sl) 2010-06-23 2020-07-31 Krka, D.D., Novo Mesto Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli
EA023996B1 (ru) 2010-12-24 2016-08-31 КРКА, д.д., НОВО МЕСТО Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой
CN102516160B (zh) * 2011-12-16 2014-04-02 华润赛科药业有限责任公司 一种高纯盐酸乐卡地平的合成工艺
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN109956943B (zh) * 2019-04-18 2021-07-20 合肥合源药业有限公司 一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (en) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (en) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid

Also Published As

Publication number Publication date
SK283321B6 (sk) 2003-06-03
PT824517E (pt) 2002-12-31
IL118143A (en) 2001-06-14
MY113802A (en) 2002-05-31
JPH11504932A (ja) 1999-05-11
KR19990008378A (ko) 1999-01-25
MA23858A1 (fr) 1996-12-31
HUP9801913A3 (en) 1999-01-28
BG102034A (en) 1998-04-30
EG21755A (en) 2002-02-27
SK151497A3 (en) 1998-05-06
CZ288634B6 (cs) 2001-08-15
SA96170216B1 (ar) 2005-12-21
NO975176D0 (no) 1997-11-11
TNSN96069A1 (fr) 2005-03-15
AU5898596A (en) 1996-11-29
MX9708662A (es) 1998-08-30
DE69622552D1 (de) 2002-08-29
DE69622552T2 (de) 2003-01-23
NZ309059A (en) 1998-10-28
UA46769C2 (uk) 2002-06-17
EA000346B1 (ru) 1999-04-29
TW404940B (en) 2000-09-11
EA199700374A1 (ru) 1998-10-29
IT1274480B (it) 1997-07-17
CA2217849C (en) 2007-09-11
ES2179942T3 (es) 2003-02-01
HUP9801913A2 (hu) 1998-12-28
ZA963716B (en) 1996-11-20
NO975176L (no) 1997-11-11
EP0824517A1 (en) 1998-02-25
PL323236A1 (en) 1998-03-16
AU694046B2 (en) 1998-07-09
JP4038622B2 (ja) 2008-01-30
IL118143A0 (en) 1996-09-12
IN188486B (OSRAM) 2002-10-05
AR002739A1 (es) 1998-04-29
RO119616B1 (ro) 2005-01-28
DZ2032A1 (fr) 2002-07-21
BG62400B1 (bg) 1999-10-29
NO309423B1 (no) 2001-01-29
ATE221050T1 (de) 2002-08-15
CA2217849A1 (en) 1996-11-14
BR9608374A (pt) 1999-08-24
HU226709B1 (en) 2009-07-28
WO1996035668A1 (en) 1996-11-14
ITMI950957A1 (it) 1996-11-12
DK0824517T3 (da) 2002-11-18
EE03351B1 (et) 2001-02-15
PL185260B1 (pl) 2003-04-30
KR100395441B1 (ko) 2004-02-05
CN1184468A (zh) 1998-06-10
EP0824517B1 (en) 2002-07-24
CZ356797A3 (cs) 1998-04-15
ITMI950957A0 (it) 1995-05-12

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: CARESSDAARY IRELAND CO., LTD.

Free format text: FORMER OWNER: RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA

Effective date: 20030124

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20030124

Address after: Limerick

Patentee after: Recordati Ireland Ltd.

Address before: Swiss Express

Patentee before: Recordati S. A., Chemical & Pharmaceutical Co.

CX01 Expiry of patent term

Granted publication date: 20030219

EXPY Termination of patent right or utility model