CN109526226A - 与表达外源rna的治疗性细胞体系有关的组合物和方法 - Google Patents
与表达外源rna的治疗性细胞体系有关的组合物和方法 Download PDFInfo
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- CN109526226A CN109526226A CN201780044400.4A CN201780044400A CN109526226A CN 109526226 A CN109526226 A CN 109526226A CN 201780044400 A CN201780044400 A CN 201780044400A CN 109526226 A CN109526226 A CN 109526226A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N5/0644—Platelets; Megakaryocytes
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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- C12N2330/00—Production
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
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- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201662359416P | 2016-07-07 | 2016-07-07 | |
US62/359,416 | 2016-07-07 | ||
PCT/US2017/041155 WO2018009838A1 (en) | 2016-07-07 | 2017-07-07 | Compositions and methods related to therapeutic cell systems expressing exogenous rna |
Publications (1)
Publication Number | Publication Date |
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CN109526226A true CN109526226A (zh) | 2019-03-26 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201780044400.4A Pending CN109526226A (zh) | 2016-07-07 | 2017-07-07 | 与表达外源rna的治疗性细胞体系有关的组合物和方法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20190161730A1 (ja) |
EP (1) | EP3481943A1 (ja) |
JP (2) | JP2019520829A (ja) |
KR (1) | KR20190026819A (ja) |
CN (1) | CN109526226A (ja) |
AU (1) | AU2017293931A1 (ja) |
BR (1) | BR112019000195A2 (ja) |
CA (1) | CA3029906A1 (ja) |
MX (1) | MX2019000205A (ja) |
WO (1) | WO2018009838A1 (ja) |
Cited By (4)
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CN111647660A (zh) * | 2020-07-09 | 2020-09-11 | 河南省人民医院 | Linc01559在胃癌诊断及治疗中的应用 |
CN112852741A (zh) * | 2019-11-28 | 2021-05-28 | 华东师范大学 | 一种嵌合抗原受体t细胞及其制备方法和细胞药物 |
CN115247176A (zh) * | 2022-01-17 | 2022-10-28 | 郑州大学第一附属医院 | 一种长链非编码rna及其应用 |
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EP3703751A2 (en) | 2017-11-03 | 2020-09-09 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
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WO2019133881A1 (en) | 2017-12-29 | 2019-07-04 | Rubius Therapeutics, Inc. | Gene editing and targeted transcriptional modulation for enginerering erythroid cells |
WO2019140116A2 (en) | 2018-01-10 | 2019-07-18 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
CN108192975B (zh) * | 2018-03-02 | 2021-06-04 | 中南大学湘雅医院 | 长链非编码rna linc00559作为生物标志物在制备肺鳞癌预后检测制剂中的应用 |
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CN111647660B (zh) * | 2020-07-09 | 2021-03-16 | 河南省人民医院 | Linc01559在胃癌诊断及治疗中的应用 |
CN115247176A (zh) * | 2022-01-17 | 2022-10-28 | 郑州大学第一附属医院 | 一种长链非编码rna及其应用 |
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KR20190026819A (ko) | 2019-03-13 |
WO2018009838A1 (en) | 2018-01-11 |
JP2019520829A (ja) | 2019-07-25 |
AU2017293931A1 (en) | 2019-01-17 |
JP2021191304A (ja) | 2021-12-16 |
MX2019000205A (es) | 2019-09-23 |
CA3029906A1 (en) | 2018-01-11 |
EP3481943A1 (en) | 2019-05-15 |
US20190161730A1 (en) | 2019-05-30 |
BR112019000195A2 (pt) | 2019-04-24 |
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