CN1071118C - 用于治疗阳萎的吡唑并嘧啶酮类 - Google Patents
用于治疗阳萎的吡唑并嘧啶酮类 Download PDFInfo
- Publication number
- CN1071118C CN1071118C CN94192386A CN94192386A CN1071118C CN 1071118 C CN1071118 C CN 1071118C CN 94192386 A CN94192386 A CN 94192386A CN 94192386 A CN94192386 A CN 94192386A CN 1071118 C CN1071118 C CN 1071118C
- Authority
- CN
- China
- Prior art keywords
- alkyl
- optionally substituted
- methyl
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paper (AREA)
- Hydroponics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9311920.4 | 1993-06-09 | ||
GB939311920A GB9311920D0 (en) | 1993-06-09 | 1993-06-09 | Therapeutic agents |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN011112603A Division CN1742731B (zh) | 1993-06-09 | 1994-05-13 | 治疗雌性性机能障碍的吡唑并嘧啶酮类 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1124926A CN1124926A (zh) | 1996-06-19 |
CN1071118C true CN1071118C (zh) | 2001-09-19 |
Family
ID=10736901
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN011112603A Expired - Lifetime CN1742731B (zh) | 1993-06-09 | 1994-05-13 | 治疗雌性性机能障碍的吡唑并嘧啶酮类 |
CN94192386A Expired - Lifetime CN1071118C (zh) | 1993-06-09 | 1994-05-13 | 用于治疗阳萎的吡唑并嘧啶酮类 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN011112603A Expired - Lifetime CN1742731B (zh) | 1993-06-09 | 1994-05-13 | 治疗雌性性机能障碍的吡唑并嘧啶酮类 |
Country Status (28)
Country | Link |
---|---|
US (2) | US6469012B1 (zh) |
EP (1) | EP0702555B1 (zh) |
JP (4) | JP2925034B2 (zh) |
KR (2) | KR100262926B1 (zh) |
CN (2) | CN1742731B (zh) |
AT (1) | ATE163852T1 (zh) |
AU (1) | AU676571C (zh) |
CA (1) | CA2163446C (zh) |
CY (1) | CY2099B1 (zh) |
CZ (1) | CZ284946B6 (zh) |
DE (1) | DE69408981T2 (zh) |
DK (1) | DK0702555T3 (zh) |
EC (1) | ECSP941102A (zh) |
ES (1) | ES2113656T3 (zh) |
FI (1) | FI955911A0 (zh) |
GB (2) | GB9301192D0 (zh) |
GR (1) | GR3026520T3 (zh) |
HU (1) | HU227877B1 (zh) |
IL (3) | IL121836A (zh) |
LV (1) | LV12269B (zh) |
MY (1) | MY111446A (zh) |
NO (3) | NO309227B3 (zh) |
NZ (2) | NZ314110A (zh) |
PL (1) | PL311948A1 (zh) |
RU (1) | RU2373938C9 (zh) |
TW (1) | TW292971B (zh) |
WO (1) | WO1994028902A1 (zh) |
ZA (1) | ZA944018B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005058899A1 (fr) * | 2003-12-18 | 2005-06-30 | The Institute Of Radiation Medicine, Academy Of Miilitary Medical Sciences, Pla | Derives pyrazolopyrimidinethione, sels, solvates, et procedes d'elaboration et d'utilisation correspondants |
CN101891747A (zh) * | 2010-07-02 | 2010-11-24 | 苏州麦迪仙医药科技有限公司 | 抑制5型磷酸二酯酶的化合物及制备方法 |
CN104650093A (zh) * | 2015-02-02 | 2015-05-27 | 王靖林 | 一种西地那非类似物的合成方法 |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060222647A1 (en) * | 1993-05-27 | 2006-10-05 | Beavo Joseph A | Methods and compositions for modulating the activity of PDE5 |
GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
GB9423911D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
GB9514464D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
WO1997043287A1 (en) | 1996-05-10 | 1997-11-20 | Icos Corporation | Carboline derivatives |
GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
DE19642284A1 (de) * | 1996-10-14 | 1998-04-16 | Merck Patent Gmbh | Pyrazolinone zur Behandlung von Potenzstörungen |
TR199902646T2 (xx) | 1997-04-25 | 2000-05-22 | Pfizer Inc. | Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar. |
CN1309561A (zh) * | 1997-05-29 | 2001-08-22 | 持田制药株式会社 | 勃起机能障碍治疗剂 |
CA2295595A1 (en) | 1997-07-09 | 1999-01-21 | Androsolutions, Inc. | Improved methods and compositions for treating male erectile dysfunction |
US6399618B1 (en) | 1997-07-09 | 2002-06-04 | Cardiome Pharma Corp | Compositions and methods for modulating sexual activity |
US20020025969A1 (en) * | 1997-07-09 | 2002-02-28 | Wolf-Georg Forssmann | Use of phosphordiesterase inhibitors in the treatment of prostatic diseases |
US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
US6593369B2 (en) | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
GB9722520D0 (en) | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
JP2003525845A (ja) * | 1997-10-28 | 2003-09-02 | ヴィヴァス・インコーポレイテッド | 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与 |
US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
US6156753A (en) * | 1997-10-28 | 2000-12-05 | Vivus, Inc. | Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction |
US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
US6127363A (en) * | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
JP2001520999A (ja) | 1997-10-28 | 2001-11-06 | アシビ, エルエルシー | 女性の性的機能不全の処置 |
US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
GB2346877B (en) * | 1997-11-12 | 2001-12-05 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
AU759825B2 (en) * | 1997-12-16 | 2003-05-01 | Pfizer Products Inc. | Combination effective for the treatment of impotence |
TW542719B (en) * | 1998-02-23 | 2003-07-21 | Pfizer Res & Dev | Method of treating impotence due to spinal cord injury |
JP3721077B2 (ja) * | 1998-04-20 | 2005-11-30 | ファイザー・インク | 性的不全を治療するためのピラゾロピリミジノンcGMPPDE5阻害剤 |
DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
US6187790B1 (en) | 1999-03-04 | 2001-02-13 | Neal R. Cutler | Use of cilostazol for treatment of sexual dysfunction |
US6541487B1 (en) | 1998-05-01 | 2003-04-01 | R.T. Alamo Ventures I, Llc | PDE III inhibitors for treating sexual dysfunction |
US6132753A (en) * | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6426084B1 (en) | 2000-06-19 | 2002-07-30 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6110489A (en) * | 1998-05-01 | 2000-08-29 | Cutler; Neal R. | Use of quinolines and quinolones to treat male erectile dysfunction |
WO1999056666A1 (en) * | 1998-05-01 | 1999-11-11 | Rt Alamo Ventures, Inc. | The treatment of sexual dysfunction in certain patient groups |
US6132757A (en) * | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6194433B1 (en) | 1998-10-05 | 2001-02-27 | Neal R. Cutler | Sexual dysfunction in females |
AU4068599A (en) * | 1998-05-20 | 1999-12-06 | Schering Corporation | Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction |
EP0967284A1 (en) * | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterases |
TWI223598B (en) * | 1998-06-22 | 2004-11-11 | Pfizer Ireland Pharmaceuticals | An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate |
US7087240B1 (en) | 1998-06-25 | 2006-08-08 | Lavipharm Laboratories Inc. | Device and method for the treatment of erectile dysfunction |
EP1089679B1 (en) | 1998-06-25 | 2005-09-07 | Lavipharm Laboratories, Inc. | A device and method for the treatment of erectile dysfunction |
AU4717299A (en) * | 1998-06-26 | 2000-01-17 | Nastech Pharmaceutical Company, Inc | Nasal delivery of sildenafil citrate |
DE19837067A1 (de) | 1998-08-17 | 2000-02-24 | Bayer Ag | Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern |
US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
CA2342830C (en) * | 1998-09-04 | 2008-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction |
WO2000020033A1 (fr) | 1998-10-05 | 2000-04-13 | Eisai Co., Ltd. | Comprimes se delitant immediatement dans la cavite buccale |
JP2000178204A (ja) * | 1998-10-05 | 2000-06-27 | Eisai Co Ltd | ホスフォジエステラ―ゼ阻害剤を含有する口腔内速崩壊性錠剤 |
JP2000191518A (ja) * | 1998-10-19 | 2000-07-11 | Eisai Co Ltd | 溶解性の改善された口腔内速崩壊性錠剤 |
GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823102D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
GB9823101D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
US6225315B1 (en) | 1998-11-30 | 2001-05-01 | Pfizer Inc | Method of treating nitrate-induced tolerance |
GB9828340D0 (en) * | 1998-12-22 | 1999-02-17 | Novartis Ag | Organic compounds |
US6455564B1 (en) | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
AU3210500A (en) * | 1999-01-22 | 2000-08-07 | Selectus Pharmaceuticals, Inc. | Controlling heart rate or blood pressure in patients co-medicated with phosphodiesterase inhibitors for treatment of impotence |
WO2000053148A2 (en) * | 1999-03-08 | 2000-09-14 | Merck & Co., Inc. | Methods and compositions for treating erectile dysfunction |
JP2002540102A (ja) | 1999-03-22 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | cGMPホスホジエステラーゼの縮合ピリドピリダジン阻害剤 |
US6214849B1 (en) | 1999-04-29 | 2001-04-10 | Lupin Laboratories Limited | Use of nicorandil in treatment of sexual dysfunction or for enhancement of sexual function in mammals including humans |
HUP0001632A3 (en) * | 1999-04-30 | 2001-12-28 | Lilly Icos Llc Wilmington | Pharmaceutical compositions comprising selective phosphodiestherase inhibitors |
US6451807B1 (en) * | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
US7258850B2 (en) * | 1999-05-04 | 2007-08-21 | Aradigm Corporation | Methods and compositions for treating erectile dysfunction |
US6242444B1 (en) | 1999-06-04 | 2001-06-05 | The Jordanian Pharmaceutical Manufacturing And Medical Equipment Co., Ltd. | Compounds and pharmaceutical compositions containing the same |
AU5204800A (en) * | 1999-06-21 | 2001-01-09 | Biochemical Pharmaceutical Factory of Zhuhai Sez, The | Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine |
US6303135B1 (en) | 1999-07-08 | 2001-10-16 | Neal R. Cutler | Use of quinolines and quinolones to treat male erectile dysfunction |
CN1077108C (zh) * | 1999-07-13 | 2002-01-02 | 成都地奥制药集团有限公司 | 用于制备药物昔多芬的前体化合物 |
IL130968A (en) * | 1999-07-15 | 2002-12-01 | Shmuel Simon | Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss |
US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
DE19944161A1 (de) * | 1999-09-15 | 2001-03-22 | Bayer Ag | Neue Kombination zur Behandlung von sexueller Dysfunktion |
EP1219609B1 (en) | 1999-09-16 | 2007-04-04 | Tanabe Seiyaku Co., Ltd. | Aromatic nitrogenous six-membered ring compounds |
US6436944B1 (en) | 1999-09-30 | 2002-08-20 | Pfizer Inc. | Combination effective for the treatment of impotence |
CZ20021151A3 (cs) * | 1999-10-11 | 2003-03-12 | Pfizer Inc. | 5-(2-substituovaný-5-heterocyklylsulfonylpyrid-3-yl)-dihydropyrazolo[4,3-d]-pyrimidin-7-ony jako inhibitory fosfodiesterasy |
TWI265925B (en) | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
US20050020547A1 (en) * | 1999-11-08 | 2005-01-27 | Pfizer Inc. | Compounds for the treatment of female sexual dysfunction |
US6803365B2 (en) | 1999-12-24 | 2004-10-12 | Bayer Aktlengesellschaft | Imidazo[1,3,5]triazinones and the use thereof |
KR100358083B1 (ko) * | 2000-02-17 | 2002-10-25 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도 |
DE10010067A1 (de) * | 2000-03-02 | 2001-09-06 | Bayer Ag | Neue Imidazotriazinone und ihre Verwendung |
GB0008694D0 (en) * | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
US7019136B2 (en) | 2000-04-07 | 2006-03-28 | Novartis, Ag | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
DE10017947A1 (de) * | 2000-04-11 | 2001-10-25 | Merck Patent Gmbh | Verfahren zur Herstellung benzo-annelierter Heterocyclen |
CN1440393A (zh) | 2000-04-28 | 2003-09-03 | 田边制药株式会社 | 环状化合物 |
US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
WO2001087888A1 (en) * | 2000-05-17 | 2001-11-22 | Sk Chemicals Co., Ltd. | Pyrazolopyrimidinone derivatives, process for their preparation and their use |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
US6730786B2 (en) | 2000-06-22 | 2004-05-04 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
US6667398B2 (en) | 2000-06-22 | 2003-12-23 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
DE10031585A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
DE10031584A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
AU2001276403A1 (en) * | 2000-07-12 | 2002-01-21 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Use of inhibitors to multidrug resistance protein 5 (mrp5) to enhance intracellular levels of cyclic nucleotides |
BRPI0003386B8 (pt) * | 2000-08-08 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas |
PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
AU2000267375A1 (en) * | 2000-08-23 | 2002-03-04 | Lg Life Sciences Ltd. | Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
AU2001284444B2 (en) | 2000-09-06 | 2006-05-25 | Mitsubishi Tanabe Pharma Corporation | Preparations for oral administration |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
GB0025782D0 (en) * | 2000-10-20 | 2000-12-06 | Pfizer Ltd | Use of inhibitors |
US6548508B2 (en) * | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
DE60005024T2 (de) * | 2000-10-23 | 2004-06-24 | The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co. Ltd. | Verwendung von Sulfadiazin und Sulfadimidine zur Behandlung der erektilen Dysfunktion |
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
CA2437085A1 (en) * | 2001-02-02 | 2002-08-15 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pharmaceutical formulation comprising pyrazolo[4,3-d]pyrimidines and endothelin receptor antagonists or thienopyrimidines and endothelin receptor antagonists |
DE60236850D1 (de) | 2001-02-15 | 2010-08-12 | Mitsubishi Tanabe Pharma Corp | Tabletten, die in der mundhöhle schnell zerfallen |
DE10107639A1 (de) * | 2001-02-15 | 2002-08-22 | Bayer Ag | 2-Alkoxyphenyl-substituierte Imidazotriazinone |
KR100540623B1 (ko) | 2001-02-26 | 2006-01-11 | 다나베 세이야꾸 가부시키가이샤 | 피리도피리미딘 또는 나프틸리딘 유도체 |
US6784185B2 (en) | 2001-03-16 | 2004-08-31 | Pfizer Inc. | Pharmaceutically active compounds |
BR0208078A (pt) * | 2001-03-16 | 2004-03-02 | Pfizer | Compostos pirazol[4,3-d]pirimidinona como inibidores de cgmp pde |
US20030054531A1 (en) * | 2001-03-19 | 2003-03-20 | Decode Genetics Ehf, | Human stroke gene |
US20040014099A1 (en) * | 2001-03-19 | 2004-01-22 | Decode Genetics Ehf. | Susceptibility gene for human stroke; methods of treatment |
WO2004028341A2 (en) * | 2001-03-19 | 2004-04-08 | Decode Genetics Ehf. | Susceptibility gene for human stroke; methods of treatment |
US20050164220A1 (en) * | 2001-03-19 | 2005-07-28 | Decode Genetics Ehf. | Susceptibility gene for human stroke: method of treatment |
US6794387B2 (en) | 2001-03-28 | 2004-09-21 | Pfizer Inc. | Pharmaceutically active compounds |
GB0107751D0 (en) * | 2001-03-28 | 2001-05-16 | Pfizer Ltd | Pharmaceutically active compounds |
DE10118306A1 (de) | 2001-04-12 | 2002-10-17 | Bayer Ag | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
WO2002083631A1 (en) | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
KR100393160B1 (ko) * | 2001-06-14 | 2003-07-31 | 한국과학기술연구원 | 신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도 |
EP1404336A1 (en) * | 2001-06-14 | 2004-04-07 | Sampad Bhattacharya | Compositions comprising cgmppde5 inhibitor for transdermal delivery to the erectile tissue of the penis |
CN1127506C (zh) * | 2001-06-29 | 2003-11-12 | 刘宝顺 | 一种治疗阳痿的新化合物 |
DE10135815A1 (de) | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
EP1790652A1 (en) * | 2001-08-28 | 2007-05-30 | Schering Corporation | Polycyclic guanine phosphodiesterase V inhibitors |
ATE395349T1 (de) * | 2001-08-28 | 2008-05-15 | Schering Corp | Polycyclische guanin phosphodiesterase inhibitoren |
US20030087963A1 (en) | 2001-09-13 | 2003-05-08 | Senanayake Chris H. | Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites |
US6943171B2 (en) | 2001-11-09 | 2005-09-13 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase V inhibitors |
WO2003053975A1 (fr) * | 2001-12-13 | 2003-07-03 | Daiichi Suntory Pharma Co., Ltd. | Derives de pyrazolopyrimidinone possedant une activite inhibitrice de pde7 |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
DE60319980T2 (de) * | 2002-05-31 | 2009-04-16 | Schering Corporation | Xanthin-phosphodiesterase-v-hemmer polymorphe |
EP1719772A1 (en) | 2002-05-31 | 2006-11-08 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
DE60317684D1 (de) | 2002-06-19 | 2008-01-03 | Janssen Pharmaceutica Nv | SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
WO2004072079A1 (en) * | 2003-02-11 | 2004-08-26 | Pfizer Limited | Hydrated and anhydrous sildenafil hemi-citrate compound |
DE10325813B4 (de) | 2003-06-06 | 2007-12-20 | Universitätsklinikum Freiburg | Prophylaxe und/oder Therapie bei der portalen Hypertonie |
CN100374441C (zh) | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途 |
CA2529307C (en) | 2003-06-13 | 2013-12-24 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
WO2005053790A1 (ja) * | 2003-12-02 | 2005-06-16 | Hakuju Institute For Health Science Company, Ltd. | 非薬理的な生殖機能の制御方法及びその装置 |
WO2005102282A1 (en) * | 2004-04-19 | 2005-11-03 | Strategic Science & Technologies, Llc | Transdermal delivery of beneficial substances effected by a hostile biophysical environment |
US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
NZ551356A (en) | 2004-05-11 | 2009-09-25 | Emotional Brain Bv | Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
US20060030574A1 (en) | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
EP1781254A2 (en) * | 2004-08-23 | 2007-05-09 | Mannkind Corporation | Pulmonary delivery of inhibitors of phosphodiesterase type 5 |
CN100347174C (zh) * | 2004-09-10 | 2007-11-07 | 上海特化医药科技有限公司 | 杂环并嘧啶酮衍生物、制备方法和用途 |
DK1802277T3 (da) | 2004-10-18 | 2010-05-17 | Polymun Scient Immunbio Forsch | Liposomal sammensætning indeholdende en aktiv bestanddel til relaksation af glat muskulatur og terapeutisk anvendelse af sammensætningen |
DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
US20060235005A1 (en) * | 2005-04-14 | 2006-10-19 | Oak Labs, Corp. | Use of phosphodiesterase 5 (PDE5) inhibitors in the treatment of schizophrenia |
UA84688C2 (uk) * | 2005-04-15 | 2008-11-25 | Виктор Павлович Кутняк | Засіб для лікування еректильної дисфункції |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
RU2008122978A (ru) | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
CN1966506A (zh) | 2005-11-17 | 2007-05-23 | 上海特化医药科技有限公司 | 吡唑并嘧啶酮衍生物及其制备方法和用途 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20080027072A1 (en) * | 2006-04-20 | 2008-01-31 | Ampla Pharmaceuticals, Inc. | Potentiation of MC4 receptor activity |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
CN101495122B (zh) * | 2006-05-15 | 2011-10-05 | 联合治疗公司 | 使用定量吸入器给予曲前列尼 |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
US7910597B2 (en) | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
WO2008074194A1 (fr) | 2006-12-21 | 2008-06-26 | Topharman Shanghai Co., Ltd. | Procédé de préparation du sildénafil et de ses intermédiaires |
US20080194529A1 (en) * | 2007-02-12 | 2008-08-14 | Auspex Pharmaceuticals, Inc. | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS |
EP2486921A1 (en) * | 2007-02-12 | 2012-08-15 | DMI Biosciences, Inc. | Reducing Side Effects of Tramadol |
KR20140054312A (ko) * | 2007-02-12 | 2014-05-08 | 디엠아이 바이오사이언시스 인코포레이티드 | 조루 및 발기부전을 동시에 치료하는 방법 |
ES2310144B1 (es) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5. |
DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
WO2009091777A1 (en) * | 2008-01-15 | 2009-07-23 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
PL2296633T3 (pl) | 2008-05-02 | 2016-03-31 | Gilead Sciences Inc | Zastosowanie cząsteczek stałych nośników dla udoskonalenia przetwarzalności środka farmaceutycznego |
EP2305237B1 (en) | 2008-05-14 | 2014-04-30 | SBI Pharmaceuticals Co., Ltd. | Therapeutic agent for male sterility |
CN101747282A (zh) | 2008-12-10 | 2010-06-23 | 上海特化医药科技有限公司 | 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途 |
EP2374460A4 (en) * | 2008-12-12 | 2013-08-21 | Rhein Siegfried Sa De Cv | SILDENAFIL COMPOSITION WITH PULSED RELEASE AND METHOD FOR PRODUCING THIS COMPOSITION |
WO2010070617A1 (en) | 2008-12-19 | 2010-06-24 | Shimoda Biotech (Pty) Ltd | Inclusion complexes of alpha-cyclodextrin and sildenafil salt |
DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20100261737A1 (en) * | 2009-04-10 | 2010-10-14 | Medtronic Vascular, Inc. | Method of Treating Erectile Dysfunction |
AU2010261510A1 (en) | 2009-06-19 | 2012-02-09 | Nanoform Hungary Ltd. | Nanostructured Sildenafil base, its pharmaceutically acceptable salts and co-crystals, compositions of them, process for the preparation thereof and pharmaceutical compositions containing them |
US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
DE102009035211A1 (de) | 2009-07-29 | 2011-02-17 | Ratiopharm Gmbh | Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung |
WO2011051928A1 (en) | 2009-10-30 | 2011-05-05 | Medispec Ltd | Method and apparatus for treatment of erectile dysfunction with extracorporeal shockwaves |
UY33041A (es) | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico |
CU24084B1 (es) | 2009-11-27 | 2015-03-30 | Bayer Ip Gmbh | Procedimiento para la preparación de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}metilcarbamato de metilo y su purificación para uso como principio activo farmacéutico |
US8829049B2 (en) | 2009-12-21 | 2014-09-09 | Acef S.A. | Medicinal composition intended for the treatment of erectile dysfunction in mammals and use of the composition |
EP2539326B1 (de) | 2010-02-27 | 2017-05-03 | Bayer Intellectual Property GmbH | Bis-arylverknüpfte aryltriazolone und ihre verwendung |
CA2791081C (en) * | 2010-03-15 | 2015-08-25 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
WO2012000634A1 (de) | 2010-06-29 | 2012-01-05 | Georg Bambach | Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion |
TW201210584A (en) | 2010-08-18 | 2012-03-16 | Alcon Res Ltd | Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma |
DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
JP2014504592A (ja) | 2010-12-29 | 2014-02-24 | ストラテジック サイエンス アンド テクノロジーズ, エルエルシー | 勃起不全および他の適応症の処置 |
KR101521861B1 (ko) | 2011-02-02 | 2015-05-21 | 노파르티스 아게 | Alk 억제제의 사용 방법 |
US8623924B2 (en) | 2011-07-15 | 2014-01-07 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
WO2013067309A1 (en) | 2011-11-04 | 2013-05-10 | Xion Pharmaceutical Corporation | Methods and compositions for oral administration of melanocortin receptor agonist compounds |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
EP2821066B1 (en) | 2012-02-28 | 2018-04-25 | Seoul Pharma. Co. Ltd. | High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
AU2013344753B2 (en) | 2012-11-13 | 2018-09-27 | Nusirt Sciences, Inc. | Compositions and methods for increasing energy metabolism |
EP2929886B1 (en) | 2012-12-04 | 2021-11-24 | Aribio Inc. | Composition comprising phosphodiesterase type 5 inhibitor for inhibiting apoptosis of nerve cells |
KR101953735B1 (ko) | 2012-12-14 | 2019-03-04 | 한미약품 주식회사 | 포스포다이에스터라제-5 억제제를 포함하는 츄정 |
MX2015010725A (es) | 2013-02-21 | 2016-05-31 | Adverio Pharma Gmbh | Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato. |
CA2902879C (en) | 2013-03-15 | 2023-09-26 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
SG11201607075TA (en) | 2014-02-27 | 2016-09-29 | Nusirt Sciences Inc | Compositions and methods for the reduction or prevention of hepatic steatosis |
KR101645652B1 (ko) | 2014-11-03 | 2016-08-08 | (주)퓨젠바이오농업회사법인 | 세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물 |
AU2015342017B2 (en) | 2014-11-03 | 2020-02-06 | Bayer Pharma Aktiengesellschaft | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
US10568847B2 (en) * | 2016-12-13 | 2020-02-25 | James J. Caprio | Compositions and methods for treatment of erectile dysfunction |
WO2018134848A1 (en) | 2017-01-20 | 2018-07-26 | Laila Nutraceuticals | Dietary supplements for inhibiting pde5 and increasing cgmp levels |
JP7334124B2 (ja) | 2017-06-21 | 2023-08-28 | トランジェーヌ | 個別化ワクチン |
EP3650444B8 (en) * | 2017-07-07 | 2023-10-18 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences | Salt and polymorph of benzopyrimidinone compound and pharmaceutical composition and use thereof |
MX2020009262A (es) | 2018-03-07 | 2021-01-08 | Transgene | Vectores de parapoxvirus. |
EP3807896A1 (en) * | 2018-06-14 | 2021-04-21 | AstraZeneca UK Limited | Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition |
EP3807897A1 (en) | 2018-06-14 | 2021-04-21 | AstraZeneca UK Limited | Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition |
SE542968C2 (en) | 2018-10-26 | 2020-09-22 | Lindahl Anders | Treatment of osteoarthritis |
CA3124773A1 (en) | 2018-12-28 | 2020-07-02 | Transgene | M2-defective poxvirus |
CN113493459B (zh) * | 2020-04-07 | 2022-12-13 | 广州白云山医药集团股份有限公司白云山制药总厂 | Pde5抑制剂化合物及其制备方法和应用 |
CN111732593A (zh) * | 2020-07-07 | 2020-10-02 | 黄泳华 | 哌嗪氧化物衍生物及其组合物、制备方法与用途 |
CN115785101B (zh) * | 2022-11-23 | 2023-10-13 | 西安市食品药品检验所 | 一种含有苯基哌嗪结构的那非类化合物及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1068329A (zh) * | 1991-07-09 | 1993-01-27 | 美国辉瑞有限公司 | 吡唑并嘧啶酮抗心绞痛剂 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1338235A (en) | 1970-12-15 | 1973-11-21 | May & Baker Ltd | Azapurinones |
JPS5310599A (en) | 1976-07-15 | 1978-01-31 | Harinton Ando Richiyaadoson In | Safety device for firearm |
FR2547501A1 (fr) | 1983-06-15 | 1984-12-21 | Opochimiotherapie Lab | Excipient effervescent, sans alcalino-terreux, contenant des composes carbonates de l'arginine et un acide, et comprimes effervescents correspondants |
US4521421A (en) * | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
EP0143357B1 (en) | 1983-10-31 | 1988-06-08 | Matsushita Electric Industrial Co., Ltd. | Optical device and document reader using the same |
US4666908A (en) | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
IT1217190B (it) | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
IE61928B1 (en) | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
FR2649613B1 (fr) | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
CA2034171A1 (en) | 1990-01-22 | 1991-07-23 | Gorm Wagner | Method of treating erectile dysfunction |
JP3044324B2 (ja) | 1990-02-15 | 2000-05-22 | サカタインクス株式会社 | すべり止めニス及びそれを用いたすべり止め加工方法並びにすべり止め加工を施した段ボールの製造方法 |
US5270323A (en) | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
US5399581A (en) | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
US5278192A (en) | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
US5891904A (en) | 1992-09-14 | 1999-04-06 | Wolf-Georg Forssmann | Use of inhibitors of phosphodiesterase IV |
DE4230755A1 (de) | 1992-09-14 | 1994-03-17 | Schering Ag | Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen |
GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
US5565466A (en) | 1993-08-13 | 1996-10-15 | Zonagen, Inc. | Methods for modulating the human sexual response |
GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
US6037346A (en) | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
JP2001520999A (ja) | 1997-10-28 | 2001-11-06 | アシビ, エルエルシー | 女性の性的機能不全の処置 |
AU4663100A (en) | 1999-04-30 | 2000-11-17 | Lilly Icos Llc | Treatment of female arousal disorder |
-
1993
- 1993-06-09 GB GB939301192A patent/GB9301192D0/en active Pending
- 1993-06-09 GB GB939311920A patent/GB9311920D0/en active Pending
-
1994
- 1994-05-13 US US08/549,792 patent/US6469012B1/en not_active Expired - Lifetime
- 1994-05-13 PL PL94311948A patent/PL311948A1/xx unknown
- 1994-05-13 NZ NZ314110A patent/NZ314110A/en not_active IP Right Cessation
- 1994-05-13 JP JP7501234A patent/JP2925034B2/ja not_active Expired - Lifetime
- 1994-05-13 AT AT94916236T patent/ATE163852T1/de not_active IP Right Cessation
- 1994-05-13 AU AU199467973A patent/AU676571C/xx active Active
- 1994-05-13 HU HU9501933A patent/HU227877B1/hu unknown
- 1994-05-13 CA CA002163446A patent/CA2163446C/en not_active Expired - Lifetime
- 1994-05-13 CZ CZ953242A patent/CZ284946B6/cs not_active IP Right Cessation
- 1994-05-13 DK DK94916236.6T patent/DK0702555T3/da active
- 1994-05-13 WO PCT/EP1994/001580 patent/WO1994028902A1/en not_active Application Discontinuation
- 1994-05-13 RU RU96100543/63A patent/RU2373938C9/ru active IP Right Maintenance
- 1994-05-13 CN CN011112603A patent/CN1742731B/zh not_active Expired - Lifetime
- 1994-05-13 ES ES94916236T patent/ES2113656T3/es not_active Expired - Lifetime
- 1994-05-13 EP EP94916236A patent/EP0702555B1/en not_active Revoked
- 1994-05-13 NZ NZ266463A patent/NZ266463A/en not_active IP Right Cessation
- 1994-05-13 DE DE69408981T patent/DE69408981T2/de not_active Revoked
- 1994-05-13 CN CN94192386A patent/CN1071118C/zh not_active Expired - Lifetime
- 1994-05-13 KR KR1019997001541A patent/KR100262926B1/ko not_active IP Right Cessation
- 1994-05-14 TW TW083104365A patent/TW292971B/zh active
- 1994-06-02 IL IL12183694A patent/IL121836A/en not_active IP Right Cessation
- 1994-06-02 IL IL10987394A patent/IL109873A/en not_active IP Right Cessation
- 1994-06-07 MY MYPI94001445A patent/MY111446A/en unknown
- 1994-06-08 ZA ZA944018A patent/ZA944018B/xx unknown
- 1994-06-09 EC EC1994001102A patent/ECSP941102A/es unknown
-
1995
- 1995-11-24 NO NO19954757A patent/NO309227B3/no not_active IP Right Cessation
- 1995-12-08 KR KR1019950705553A patent/KR960702751A/ko active Search and Examination
- 1995-12-08 FI FI955911A patent/FI955911A0/fi not_active Application Discontinuation
-
1997
- 1997-09-25 IL IL12183697A patent/IL121836A0/xx unknown
-
1998
- 1998-04-03 GR GR980400704T patent/GR3026520T3/el unknown
- 1998-08-11 CY CY9800022A patent/CY2099B1/xx unknown
-
1999
- 1999-01-29 JP JP11021945A patent/JPH11263728A/ja not_active Withdrawn
- 1999-01-29 JP JP11021939A patent/JPH11286444A/ja active Pending
- 1999-02-15 LV LVP-99-22A patent/LV12269B/en unknown
-
2000
- 2000-02-11 NO NO20000702A patent/NO325558B1/no not_active IP Right Cessation
- 2000-02-11 NO NO20000703A patent/NO321622B1/no not_active IP Right Cessation
-
2002
- 2002-07-24 US US10/202,962 patent/US20030027824A1/en not_active Abandoned
-
2004
- 2004-09-17 JP JP2004270712A patent/JP2005097304A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1068329A (zh) * | 1991-07-09 | 1993-01-27 | 美国辉瑞有限公司 | 吡唑并嘧啶酮抗心绞痛剂 |
Non-Patent Citations (1)
Title |
---|
AM.J.PHSIOL.VOL.264 1993.2.1 F.TRIGO-ROCHA ET AL"NITRIC OXIDE AND CGMP:MEDIATORS OF PELVIC MERVE-STIIMULATED ERECTION IN DOGS" * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005058899A1 (fr) * | 2003-12-18 | 2005-06-30 | The Institute Of Radiation Medicine, Academy Of Miilitary Medical Sciences, Pla | Derives pyrazolopyrimidinethione, sels, solvates, et procedes d'elaboration et d'utilisation correspondants |
EA011091B1 (ru) * | 2003-12-18 | 2008-12-30 | ДЗЕ ИНСТИТЬЮТ ОФ РАДИЭЙШН МЕДСИН, ЭКЕДЕМИ ОФ МИЛИТАРИ МЕДИКАЛ САЙЕНСИЗ, ПиЭлЭй | Производные пиразолопиримидинтиона, их соли и сольваты, способы их получения и использования |
CN101891747A (zh) * | 2010-07-02 | 2010-11-24 | 苏州麦迪仙医药科技有限公司 | 抑制5型磷酸二酯酶的化合物及制备方法 |
CN101891747B (zh) * | 2010-07-02 | 2012-04-25 | 张南 | 抑制5型磷酸二酯酶的化合物及制备方法 |
CN104650093A (zh) * | 2015-02-02 | 2015-05-27 | 王靖林 | 一种西地那非类似物的合成方法 |
CN104650093B (zh) * | 2015-02-02 | 2017-01-25 | 王靖林 | 一种西地那非类似物的合成方法 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1071118C (zh) | 用于治疗阳萎的吡唑并嘧啶酮类 | |
JP3221611B2 (ja) | 物質乱用障害の治療用医薬組成物 | |
US20090325923A1 (en) | New method for the treatment of inflammatory diseases | |
TW201811798A (zh) | sGC 刺激劑 | |
WO2005012485A3 (en) | Methods for treating diabetes and related disorders using pde10a inhibitors | |
KR20040025915A (ko) | 디펩티딜 펩티다아제 iv의 저해제를 이용한 2형당뇨병의 치료 | |
JP2003525240A (ja) | 糖尿病性腎障害の処置のためのpdgf受容体チロシンキナーゼ阻害剤の使用 | |
WO2000028993A1 (en) | Serotonin ligands as pro-erectile compounds | |
AU755402B2 (en) | Method of treating impotence due to spinal cord injury | |
EP2029139B1 (en) | Use of a p38 kinase inhibitor for treating psychiatric disorders | |
JP2000198734A (ja) | 胃運動性減弱および関連疾患の治療のための運動性増強薬 | |
US20020147199A1 (en) | Process for the treatment of erectile dysfunction and product therefor | |
US20210401838A1 (en) | Identification of agents displaying functional activation of dopamine d2 and d4 receptors | |
Pissarnitski et al. | SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction | |
US20210106581A1 (en) | Treatment Of Liver Diseases | |
WO2002011729A1 (en) | Novel compositions and methods for treatment of male erectile dysfunction | |
JP2007512267A (ja) | 高尿酸血症の治療のためのペンタジエン酸誘導体の使用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: PFIZER Free format text: FORMER OWNER: PFIZER RESEARCH AND DEVELOPMENT COMPANY Effective date: 20040109 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20040109 Address after: Dublin, Ireland Patentee after: Pfizer Ireland Pharmaceuticals Address before: Dublin, Ireland Patentee before: PFIZER LTD. |
|
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Pfizer Pharmaceuticals Limited Assignor: Pfizer Ireland Pharmaceuticals Contract fulfillment period: From January 28, 2005 to May 13, 2014 Contract record no.: 051000030033 Denomination of invention: A pyrazole group used in the treatment of impotence Granted publication date: 20010919 License type: General permission Record date: 20050221 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: COMMON LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2005.1.28 TO 2014.5.13 Name of requester: PFIZER(WARNER-LAMBERT) PHARMACEUTICAL CO., LTD. Effective date: 20050221 |
|
ASS | Succession or assignment of patent right |
Owner name: PFIZER IRELAND PHARMACEUTICALS CO. Free format text: FORMER OWNER: PFIZER MANUFACTURING IRELAND CO. Effective date: 20110920 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: PFIZER OVERSEAS PHARMACEUTICALS CO. Free format text: FORMER NAME: PFIZER Owner name: PFIZER IRELAND PHARMACEUTICALS CO. Free format text: FORMER NAME: PFIZER OVERSEAS PHARMACEUTICALS CO. Owner name: PFIZER MANUFACTURING IRELAND CO. Free format text: FORMER NAME: PFIZER IRELAND PHARMACEUTICALS CO. |
|
CP01 | Change in the name or title of a patent holder |
Address after: Dublin, Ireland Patentee after: Pfizer manufacturing Ireland Address before: Dublin, Ireland Patentee before: PFIZER IRELAND PHARMACEUTICALS Address after: Dublin, Ireland Patentee after: PFIZER IRELAND PHARMACEUTICALS Address before: Dublin, Ireland Patentee before: Pfizer overseas pharmaceuticals Address after: Dublin, Ireland Patentee after: Pfizer overseas pharmaceuticals Address before: Dublin, Ireland Patentee before: Pfizer Ireland Pharmaceuticals |
|
TR01 | Transfer of patent right |
Effective date of registration: 20110920 Address after: The Irish Village Patentee after: PFIZER IRELAND PHARMACEUTICALS Address before: Dublin, Ireland Patentee before: Pfizer manufacturing Ireland |
|
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20140513 Granted publication date: 20010919 |