CN104781400A - 包含嗜热菌蛋白酶变体的组合物和方法 - Google Patents

包含嗜热菌蛋白酶变体的组合物和方法 Download PDF

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Publication number
CN104781400A
CN104781400A CN201380057595.8A CN201380057595A CN104781400A CN 104781400 A CN104781400 A CN 104781400A CN 201380057595 A CN201380057595 A CN 201380057595A CN 104781400 A CN104781400 A CN 104781400A
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China
Prior art keywords
thermolysin
modification
amino acid
equal
parent
Prior art date
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Pending
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CN201380057595.8A
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English (en)
Chinese (zh)
Inventor
V·Y·阿莱克塞耶夫
L·M·巴别
D·A·埃斯特尔
F·格德盖布
H·穆尔德
D·E·托雷斯帕兹米诺
J·姚
R·R·博特
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Danisco USA Inc
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Danisco USA Inc
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Publication of CN104781400A publication Critical patent/CN104781400A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24027—Thermolysin (3.4.24.27)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
CN201380057595.8A 2012-11-05 2013-11-05 包含嗜热菌蛋白酶变体的组合物和方法 Pending CN104781400A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722660P 2012-11-05 2012-11-05
US61/722,660 2012-11-05
PCT/US2013/068590 WO2014071410A1 (en) 2012-11-05 2013-11-05 Compositions and methods comprising thermolysin protease variants

Publications (1)

Publication Number Publication Date
CN104781400A true CN104781400A (zh) 2015-07-15

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Family Applications (1)

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CN201380057595.8A Pending CN104781400A (zh) 2012-11-05 2013-11-05 包含嗜热菌蛋白酶变体的组合物和方法

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Country Link
US (1) US20160060611A1 (enExample)
EP (1) EP2914720B1 (enExample)
JP (3) JP6858487B2 (enExample)
KR (1) KR20150082502A (enExample)
CN (1) CN104781400A (enExample)
AU (1) AU2013337255A1 (enExample)
BR (1) BR112015010104A2 (enExample)
CA (1) CA2889864C (enExample)
MX (1) MX382899B (enExample)
WO (1) WO2014071410A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108676787A (zh) * 2018-05-28 2018-10-19 湖北大学 一种比酶活提高的嗜热嗜碱木聚糖酶突变体及其在工业中的应用
CN111479912A (zh) * 2017-11-30 2020-07-31 荷兰联合利华有限公司 包含蛋白酶的洗涤剂组合物
CN113474355A (zh) * 2019-02-14 2021-10-01 诺尔玛克制药有限公司 从i型胶原酶、ii型胶原酶、中性蛋白酶和梭菌蛋白酶选出的至少一种酶的色谱纯化
CN114317341A (zh) * 2021-12-27 2022-04-12 宁波希诺亚海洋生物科技有限公司 一株可产乳糖酶的哈维氏弧菌变种及其应用
CN114540329A (zh) * 2020-11-25 2022-05-27 潍坊康地恩生物科技有限公司 乳糖酶突变体
CN114934038A (zh) * 2022-05-05 2022-08-23 安徽丰原发酵技术工程研究有限公司 天冬氨酸酶突变体及其应用

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104781400A (zh) * 2012-11-05 2015-07-15 丹尼斯科美国公司 包含嗜热菌蛋白酶变体的组合物和方法
WO2014194034A2 (en) 2013-05-29 2014-12-04 Danisco Us Inc. Novel metalloproteases
US9267096B2 (en) * 2013-10-29 2016-02-23 Ecolab USA, Inc. Use of amino carboxylate for enhancing metal protection in alkaline detergents
WO2015193488A1 (en) * 2014-06-20 2015-12-23 Novozymes A/S Metalloprotease from kribbella aluminosa and detergent compositions comprising the metalloprotease
EP3224357A1 (en) 2014-10-27 2017-10-04 Danisco US Inc. Serine proteases of bacillus species
EP4403631A3 (en) 2014-10-27 2024-10-30 Danisco US Inc. Serine proteases
US20170335306A1 (en) 2014-10-27 2017-11-23 Danisco Us Inc. Serine proteases
DK3212662T3 (da) 2014-10-27 2020-07-20 Danisco Us Inc Serinproteaser
WO2016069569A2 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases
EP3034590A1 (en) 2014-12-17 2016-06-22 The Procter and Gamble Company Method of automatic dishwashing
EP3034592A1 (en) 2014-12-17 2016-06-22 The Procter and Gamble Company Method of automatic dishwashing
PL3034588T3 (pl) 2014-12-17 2019-09-30 The Procter And Gamble Company Kompozycja detergentu
EP3034596B2 (en) * 2014-12-17 2021-11-10 The Procter & Gamble Company Detergent composition
EP3034591A1 (en) 2014-12-17 2016-06-22 The Procter and Gamble Company Method of automatic dishwashing
EP3034597A1 (en) * 2014-12-17 2016-06-22 The Procter and Gamble Company Detergent composition
EP3034589A1 (en) 2014-12-17 2016-06-22 The Procter and Gamble Company Detergent composition
EP3050955B2 (en) * 2015-02-02 2023-11-08 The Procter & Gamble Company Detergent pack
ES2714130T3 (es) * 2015-02-02 2019-05-27 Procter & Gamble Composición detergente
CN104894081B (zh) * 2015-04-15 2018-07-06 云南师范大学 一种碱性热稳定SGNH家族酯酶EstD1及其基因
CN107835855B (zh) 2015-05-13 2022-05-13 丹尼斯科美国公司 AprL-进化枝蛋白酶变体及其用途
EP3098296A1 (en) 2015-05-29 2016-11-30 The Procter and Gamble Company Process for making a multi-compartment pouch
EP3098295A1 (en) 2015-05-29 2016-11-30 The Procter and Gamble Company Process for making a single or multi-compartment pouch
JP7015695B2 (ja) 2015-06-17 2022-02-03 ダニスコ・ユーエス・インク バチルス・ギブソニイ（Ｂａｃｉｌｌｕｓ ｇｉｂｓｏｎｉｉ）クレードセリンプロテアーゼ
US20190153417A1 (en) 2015-11-05 2019-05-23 Danisco Us Inc Paenibacillus sp. mannanases
JP7364330B2 (ja) 2015-11-05 2023-10-18 ダニスコ・ユーエス・インク パエニバチルス（Ｐａｅｎｉｂａｃｉｌｌｕｓ）属種及びバチルス（Ｂａｃｉｌｌｕｓ）属種のマンナナーゼ
EP3181678A1 (en) 2015-12-17 2017-06-21 The Procter and Gamble Company Process for making a detergent powder
EP3181672A1 (en) 2015-12-17 2017-06-21 The Procter and Gamble Company Automatic dishwashing detergent composition
EP3181676B1 (en) 2015-12-17 2019-03-13 The Procter and Gamble Company Automatic dishwashing detergent composition
EP3181670B1 (en) 2015-12-17 2019-01-30 The Procter and Gamble Company Automatic dishwashing detergent composition
EP3181675B2 (en) 2015-12-17 2022-12-07 The Procter & Gamble Company Automatic dishwashing detergent composition
EP3181679A1 (en) 2015-12-17 2017-06-21 The Procter and Gamble Company Process for making an automatic dishwashing product
EP3181671B1 (en) 2015-12-17 2024-07-10 The Procter & Gamble Company Automatic dishwashing detergent composition
EP3390625B1 (en) 2015-12-18 2023-09-06 Danisco US Inc. Polypeptides with endoglucanase activity and uses thereof
EP3184622A1 (en) 2015-12-22 2017-06-28 The Procter and Gamble Company Automatic dishwashing composition
BR112018072530A2 (pt) 2016-05-03 2019-03-26 Danisco Us Inc variantes de protease e usos das mesmas
BR112018072586A2 (pt) 2016-05-05 2019-02-19 Danisco Us Inc variantes de protease e usos das mesmas
EP3464599A1 (en) 2016-05-31 2019-04-10 Danisco US Inc. Protease variants and uses thereof
EP3257928B1 (en) 2016-06-17 2019-12-11 The Procter and Gamble Company Automatic dishwashing detergent composition
EP3257923B1 (en) 2016-06-17 2020-04-08 The Procter and Gamble Company Automatic dishwashing detergent composition
EP3257930A1 (en) 2016-06-17 2017-12-20 The Procter and Gamble Company Cleaning pouch
WO2017219011A1 (en) 2016-06-17 2017-12-21 Danisco Us Inc Protease variants and uses thereof
EP3257931A1 (en) 2016-06-17 2017-12-20 The Procter and Gamble Company Detergent composition
EP3257929B1 (en) 2016-06-17 2022-03-09 The Procter & Gamble Company Automatic dishwashing detergent composition
CN109563452B (zh) 2016-09-07 2021-11-30 埃科莱布美国股份有限公司 含有由膦酸稳定的酶的洗涤剂组合物
EP3301169A1 (en) * 2016-10-03 2018-04-04 The Procter & Gamble Company Laundry detergent composition
US20190264138A1 (en) 2016-11-07 2019-08-29 Danisco Us Inc. Laundry detergent composition
EP3559227B1 (en) 2016-12-21 2025-02-19 Danisco US Inc. Protease variants and uses thereof
WO2018118950A1 (en) 2016-12-21 2018-06-28 Danisco Us Inc. Bacillus gibsonii-clade serine proteases
EP3339419A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3339413A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3339417A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3339415A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3339422B1 (en) 2016-12-22 2020-10-21 The Procter & Gamble Company Laundry detergent composition
EP3339418A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3339407A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
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EP3339421A1 (en) 2016-12-22 2018-06-27 The Procter & Gamble Company Laundry detergent composition
EP3583210B1 (en) 2017-03-15 2021-07-07 Danisco US Inc. Trypsin-like serine proteases and uses thereof
EP3601553B1 (en) 2017-03-31 2025-12-03 Danisco US Inc. Alpha-amylase combinatorial variants
EP3388507B1 (en) * 2017-04-12 2025-02-19 The Procter & Gamble Company Fabric softening compositions
CN111212906B (zh) 2017-08-18 2024-02-02 丹尼斯科美国公司 α-淀粉酶变体
WO2019108599A1 (en) 2017-11-29 2019-06-06 Danisco Us Inc Subtilisin variants having improved stability
US11162055B2 (en) 2018-06-14 2021-11-02 Ecolab Usa Inc. Compositions comprising cellulase with quaternary ammonium compounds
EP3799601A1 (en) 2018-06-19 2021-04-07 Danisco US Inc. Subtilisin variants
US12415996B2 (en) 2018-06-19 2025-09-16 Danisco Us Inc. Subtilisin variants
MX2021001213A (es) 2018-07-31 2021-08-24 Danisco Us Inc Variantes de alfa-amilasas que tienen sustituciones de aminoácidos que bajan el pka del ácido general.
WO2020057845A1 (en) * 2018-09-17 2020-03-26 Unilever Plc Composition
EP3856882A1 (en) 2018-09-27 2021-08-04 Danisco US Inc. Compositions for medical instrument cleaning
CA3116128A1 (en) 2018-10-12 2020-04-16 Danisco Us Inc Alpha-amylases with mutations that improve stability in the presence of chelants
EP3887515A1 (en) 2018-11-28 2021-10-06 Danisco US Inc. Subtilisin variants having improved stability
US20220056379A1 (en) * 2018-12-03 2022-02-24 Novozymes A/S Powder Detergent Compositions
US12460304B2 (en) * 2019-04-04 2025-11-04 Chemetall Gmbh Phosphate-free cleaner for metallic surfaces with reduced pickling erosion
US20220220419A1 (en) 2019-05-24 2022-07-14 Danisco Us Inc Subtilisin variants and methods of use
US20220306968A1 (en) * 2019-06-06 2022-09-29 Danisco Us Inc Methods and compositions for cleaning
EP4048683A2 (en) 2019-10-24 2022-08-31 Danisco US Inc Variant maltopentaose/maltohexaose-forming alpha-amylases
WO2021092331A1 (en) * 2019-11-06 2021-05-14 Ohio State Innovation Foundation Targeting circular pcmtd1 in leukemias with p53 mutations and/or bcr/abl fusions
US20240034960A1 (en) 2020-08-27 2024-02-01 Danisco Us Inc Enzymes and enzyme compositions for cleaning
CN116997642A (zh) 2021-01-29 2023-11-03 丹尼斯科美国公司 清洁组合物及其相关的方法
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CN117916354A (zh) 2021-09-03 2024-04-19 丹尼斯科美国公司 用于清洁的衣物洗涤组合物
CA3241094A1 (en) 2021-12-16 2023-06-22 Jonathan LASSILA Variant maltopentaose/maltohexaose-forming alpha-amylases
WO2023114932A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114939A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114936A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023168234A1 (en) 2022-03-01 2023-09-07 Danisco Us Inc. Enzymes and enzyme compositions for cleaning
EP4544016A1 (en) * 2022-06-21 2025-04-30 Danisco US Inc. Methods and compositions for cleaning comprising a polypeptide having thermolysin activity
JP2025529133A (ja) 2022-09-02 2025-09-04 ダニスコ・ユーエス・インク サブチリシン変異体及びそれに関連する方法
CN119816592A (zh) 2022-09-02 2025-04-11 丹尼斯科美国公司 甘露聚糖酶变体和使用方法
CA3265943A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. DETERGENT COMPOSITIONS AND ASSOCIATED PROCESSES
WO2024102698A1 (en) 2022-11-09 2024-05-16 Danisco Us Inc. Subtilisin variants and methods of use
CN120677237A (zh) 2023-02-01 2025-09-19 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
CN120712348A (zh) 2023-03-06 2025-09-26 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
CN120813242A (zh) 2023-03-16 2025-10-17 营养与生物科学美国第四公司 用于清洁和臭味控制的短芽孢杆菌发酵物提取物及其用途
WO2025072144A1 (en) * 2023-09-27 2025-04-03 Osprey Biopharmaceuticals, Inc. Polypeptides having human igg cleavage activity
WO2025071996A1 (en) 2023-09-28 2025-04-03 Danisco Us Inc. Variant cutinase enzymes with improved solubility and uses thereof
WO2025085351A1 (en) 2023-10-20 2025-04-24 Danisco Us Inc. Subtilisin variants and methods of use
CN119391658B (zh) * 2024-10-30 2025-10-10 天津凯莱英生物科技有限公司 多肽连接酶突变体及多肽的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101341248A (zh) * 2005-10-12 2009-01-07 金克克国际有限公司 储存稳定的中性金属蛋白酶的用途和制备
CN101868538A (zh) * 2007-11-01 2010-10-20 丹尼斯科美国公司 嗜热菌蛋白酶及其变体的生产和在液体洗涤剂中的用途
WO2012110563A1 (en) * 2011-02-16 2012-08-23 Novozymes A/S Detergent compositions comprising metalloproteases

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296839A (enExample) 1969-05-29 1972-11-22
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
GB2048606B (en) 1979-02-28 1983-03-16 Barr & Stroud Ltd Optical scanning system
US4302544A (en) 1979-10-15 1981-11-24 University Of Rochester Asporogenous mutant of B. subtilis for use as host component of HV1 system
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
GR76237B (enExample) 1981-08-08 1984-08-04 Procter & Gamble
US4450235A (en) 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system
US4561998A (en) 1982-05-24 1985-12-31 The Procter & Gamble Company Near-neutral pH detergents containing anionic surfactant, cosurfactant and fatty acid
US4550862A (en) 1982-11-17 1985-11-05 The Procter & Gamble Company Liquid product pouring and measuring package with self draining feature
US4597898A (en) 1982-12-23 1986-07-01 The Proctor & Gamble Company Detergent compositions containing ethoxylated amines having clay soil removal/anti-redeposition properties
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4515707A (en) 1983-06-27 1985-05-07 The Chemithon Corporation Intermediate product for use in producing a detergent bar and method for producing same
IE58014B1 (en) 1983-07-06 1993-06-16 Gist Brocades Nv Molecular cloning and expression in industrial microorganism species
US4515705A (en) 1983-11-14 1985-05-07 The Procter & Gamble Company Compositions containing odor purified proteolytic enzymes and perfumes
US4537706A (en) 1984-05-14 1985-08-27 The Procter & Gamble Company Liquid detergents containing boric acid to stabilize enzymes
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
US5801038A (en) 1984-05-29 1998-09-01 Genencor International Inc. Modified subtilisins having amino acid alterations
US5972682A (en) 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
DK154572C (da) 1985-08-07 1989-04-24 Novo Industri As Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler
US4933287A (en) 1985-08-09 1990-06-12 Gist-Brocades N.V. Novel lipolytic enzymes and their use in detergent compositions
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
ATE110768T1 (de) 1986-08-29 1994-09-15 Novo Nordisk As Enzymhaltiger reinigungsmittelzusatz.
GB8629837D0 (en) 1986-12-13 1987-01-21 Interox Chemicals Ltd Bleach activation
US4765916A (en) 1987-03-24 1988-08-23 The Clorox Company Polymer film composition for rinse release of wash additives
US4972017A (en) 1987-03-24 1990-11-20 The Clorox Company Rinse soluble polymer film composition for wash additives
WO1988009367A1 (en) 1987-05-29 1988-12-01 Genencor, Inc. Cutinase cleaning composition
DE3854249T2 (de) 1987-08-28 1996-02-29 Novonordisk As Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen.
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
DE68924654T2 (de) 1988-01-07 1996-04-04 Novonordisk As Spezifische Protease.
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
US4977252A (en) 1988-03-11 1990-12-11 National Starch And Chemical Investment Holding Corporation Modified starch emulsifier characterized by shelf stability
US4968451A (en) 1988-08-26 1990-11-06 The Procter & Gamble Company Soil release agents having allyl-derived sulfonated end caps
WO1990009446A1 (en) 1989-02-17 1990-08-23 Plant Genetic Systems N.V. Cutinase
DE4111321A1 (de) 1990-04-14 1991-10-17 Kali Chemie Ag Alkalische bacillus-lipasen, hierfuer codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren
US5354559A (en) 1990-05-29 1994-10-11 Grain Processing Corporation Encapsulation with starch hydrolyzate acid esters
ATE219136T1 (de) 1991-01-16 2002-06-15 Procter & Gamble Kompakte waschmittelzusammensetzungen mit hochaktiven cellulasen
GB9108136D0 (en) 1991-04-17 1991-06-05 Unilever Plc Concentrated detergent powder compositions
US5340735A (en) 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
JPH05199873A (ja) * 1991-11-28 1993-08-10 Tosoh Corp 新規プロテア−ゼ
ATE237681T1 (de) 1992-12-01 2003-05-15 Novozymes As Beschleunigung von enzymreaktionen
WO1994016048A1 (en) 1993-01-18 1994-07-21 The Procter & Gamble Company Machine dishwashing detergent compositions
CZ287850B6 (en) 1993-05-08 2001-02-14 Henkel Kgaa Use of organic redox-active substances in dishwashing preparations and slightly alkaline preparation for machine washing of dishes
JPH08509777A (ja) 1993-05-08 1996-10-15 ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチェン 銀腐食保護剤（▲ｉ▼）
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
US5698504A (en) 1993-07-01 1997-12-16 The Procter & Gamble Company Machine dishwashing composition containing oxygen bleach and paraffin oil and benzotriazole compound silver tarnishing inhibitors
US5486303A (en) 1993-08-27 1996-01-23 The Procter & Gamble Company Process for making high density detergent agglomerates using an anhydrous powder additive
DE4342680A1 (de) 1993-12-15 1995-06-22 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
ES2364776T3 (es) 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
EP0701605B2 (en) 1994-02-24 2017-02-22 Basf Se Improved enzymes and detergents containing them
US5691295A (en) 1995-01-17 1997-11-25 Cognis Gesellschaft Fuer Biotechnologie Mbh Detergent compositions
JPH07250679A (ja) * 1994-03-14 1995-10-03 Daiwa Kasei Kk 変異型サーモリシンｔｙ１４０及びその遺伝子
US5686014A (en) 1994-04-07 1997-11-11 The Procter & Gamble Company Bleach compositions comprising manganese-containing bleach catalysts
PE6995A1 (es) 1994-05-25 1995-03-20 Procter & Gamble Composicion que comprende un polimero de polialquilenoamina etoxilado propoxilado como agente de separacion de sucio
AU704022B2 (en) 1994-06-17 1999-04-15 Genencor International, Inc. Cleaning compositions containing plant cell wall degrading enzymes and their use in cleaning methods
GB2294268A (en) 1994-07-07 1996-04-24 Procter & Gamble Bleaching composition for dishwasher use
US5879584A (en) 1994-09-10 1999-03-09 The Procter & Gamble Company Process for manufacturing aqueous compositions comprising peracids
US5691297A (en) 1994-09-20 1997-11-25 The Procter & Gamble Company Process for making a high density detergent composition by controlling agglomeration within a dispersion index
US5516448A (en) 1994-09-20 1996-05-14 The Procter & Gamble Company Process for making a high density detergent composition which includes selected recycle streams for improved agglomerate
US5489392A (en) 1994-09-20 1996-02-06 The Procter & Gamble Company Process for making a high density detergent composition in a single mixer/densifier with selected recycle streams for improved agglomerate properties
JPH11501501A (ja) * 1994-12-06 1999-02-09 財団法人 相模中央化学研究所 バチルス由来の熱安定中性プロテアーゼの変異体
WO1996017921A1 (en) 1994-12-09 1996-06-13 The Procter & Gamble Company Automatic dishwashing composition containing particles of diacyl peroxides
US5534179A (en) 1995-02-03 1996-07-09 Procter & Gamble Detergent compositions comprising multiperacid-forming bleach activators
US5574005A (en) 1995-03-07 1996-11-12 The Procter & Gamble Company Process for producing detergent agglomerates from high active surfactant pastes having non-linear viscoelastic properties
JPH09255A (ja) * 1995-04-20 1997-01-07 Daiwa Kasei Kk 変異型サーモリシンｙｔ７３及びその遺伝子
US5569645A (en) 1995-04-24 1996-10-29 The Procter & Gamble Company Low dosage detergent composition containing optimum proportions of agglomerates and spray dried granules for improved flow properties
ATE203051T1 (de) 1995-06-16 2001-07-15 Procter & Gamble Maschinengeschirrspülmittel, die kobaltkatalysatoren enthalten
US5597936A (en) 1995-06-16 1997-01-28 The Procter & Gamble Company Method for manufacturing cobalt catalysts
US5565422A (en) 1995-06-23 1996-10-15 The Procter & Gamble Company Process for preparing a free-flowing particulate detergent composition having improved solubility
US5576282A (en) 1995-09-11 1996-11-19 The Procter & Gamble Company Color-safe bleach boosters, compositions and laundry methods employing same
HUP9802268A3 (en) 1995-09-18 2000-03-28 Procter And Gamble Company Cin Delivery systems for detergent comprising glass-stage granules
MA24136A1 (fr) 1996-04-16 1997-12-31 Procter & Gamble Fabrication d'agents de surface .
US5929022A (en) 1996-08-01 1999-07-27 The Procter & Gamble Company Detergent compositions containing amine and specially selected perfumes
US6306812B1 (en) 1997-03-07 2001-10-23 Procter & Gamble Company, The Bleach compositions containing metal bleach catalyst, and bleach activators and/or organic percarboxylic acids
DE69830574T2 (de) 1997-03-07 2006-05-04 The Procter & Gamble Company, Cincinnati Verbesserte verfahren zur herstellung von vernetzt verbrückten macropolycyclen
GB2327947A (en) 1997-08-02 1999-02-10 Procter & Gamble Detergent tablet
US6376445B1 (en) 1997-08-14 2002-04-23 Procter & Gamble Company Detergent compositions comprising a mannanase and a protease
AR015977A1 (es) 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
US5935826A (en) 1997-10-31 1999-08-10 National Starch And Chemical Investment Holding Corporation Glucoamylase converted starch derivatives and their use as emulsifying and encapsulating agents
US6287839B1 (en) 1997-11-19 2001-09-11 Genencor International, Inc. Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same
KR100762164B1 (ko) 1997-11-21 2007-10-01 노보자임스 에이/에스 프로테아제 변이체 및 조성물
WO1999034011A2 (en) 1997-12-24 1999-07-08 Genencor International, Inc. Method of assaying for a preferred enzyme and/or detergent
CN101024826B (zh) 1998-06-10 2014-09-03 诺沃奇梅兹有限公司 新的甘露聚糖酶
US6376450B1 (en) 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
US6294514B1 (en) 1998-11-24 2001-09-25 The Procter & Gamble Company Process for preparing mono-long chain amine oxide surfactants with low nitrite, nitrosamine and low residual peroxide
CA2348893A1 (en) 1998-11-30 2000-06-08 The Procter & Gamble Company Process for preparing cross-bridged tetraaza macrocycles
US6440991B1 (en) 2000-10-02 2002-08-27 Wyeth Ethers of 7-desmethlrapamycin
US6582914B1 (en) 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations
GB0114847D0 (en) 2001-06-18 2001-08-08 Unilever Plc Water soluble package and liquid contents thereof
KR20050052666A (ko) * 2002-10-10 2005-06-03 다이버사 코포레이션 프로테아제, 이를 암호화하는 핵산, 및 이를 제조하고사용하는 방법
DE60319347T2 (de) 2003-05-23 2009-02-19 The Procter & Gamble Company, Cincinnati Waschmittelzusammensetzung zum Gebrauch in einer Textilwasch- oder Geschirrspülmaschine
US20080113917A1 (en) 2003-11-06 2008-05-15 Day Anthony G Tgfbeta Supported and Binding Peptides
CN1981035B (zh) 2003-12-03 2011-06-08 金克克国际有限公司 过水解酶
CA2652678A1 (en) 2006-06-05 2007-12-21 The Procter & Gamble Company Detergent compositions comprising polysaccharides as enzyme stabilizers
CN101511998A (zh) 2006-07-18 2009-08-19 丹尼斯科美国公司 在宽温度范围内具有活性的蛋白酶变体
EP2100947A1 (en) 2008-03-14 2009-09-16 The Procter and Gamble Company Automatic dishwashing detergent composition
CN104781400A (zh) * 2012-11-05 2015-07-15 丹尼斯科美国公司 包含嗜热菌蛋白酶变体的组合物和方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101341248A (zh) * 2005-10-12 2009-01-07 金克克国际有限公司 储存稳定的中性金属蛋白酶的用途和制备
CN101868538A (zh) * 2007-11-01 2010-10-20 丹尼斯科美国公司 嗜热菌蛋白酶及其变体的生产和在液体洗涤剂中的用途
WO2012110563A1 (en) * 2011-02-16 2012-08-23 Novozymes A/S Detergent compositions comprising metalloproteases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIYOSHI YASUKAWA等: "Improving the activity and stability of thermolysin by site-directed mutagenesis", 《SCIENCEDIRECT》 *
MASAYUKI KUSANO等: "Effects of the mutaional combinations on the activity and stability of thermolysin", 《JOURNAL OF BIOTECHNOLOGY》 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111479912A (zh) * 2017-11-30 2020-07-31 荷兰联合利华有限公司 包含蛋白酶的洗涤剂组合物
CN111479912B (zh) * 2017-11-30 2021-08-10 联合利华知识产权控股有限公司 包含蛋白酶的洗涤剂组合物
CN108676787A (zh) * 2018-05-28 2018-10-19 湖北大学 一种比酶活提高的嗜热嗜碱木聚糖酶突变体及其在工业中的应用
CN108676787B (zh) * 2018-05-28 2022-01-28 湖北大学 一种比酶活提高的嗜热嗜碱木聚糖酶突变体及其在工业中的应用
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CN114317341A (zh) * 2021-12-27 2022-04-12 宁波希诺亚海洋生物科技有限公司 一株可产乳糖酶的哈维氏弧菌变种及其应用
CN114317341B (zh) * 2021-12-27 2024-01-09 宁波希诺亚海洋生物科技有限公司 一株可产乳糖酶的哈维氏弧菌变种及其应用
CN114934038A (zh) * 2022-05-05 2022-08-23 安徽丰原发酵技术工程研究有限公司 天冬氨酸酶突变体及其应用
CN114934038B (zh) * 2022-05-05 2023-09-12 安徽丰原发酵技术工程研究有限公司 天冬氨酸酶突变体及其应用

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