CN101861308B - 用于制备苯并呋喃类化合物的方法 - Google Patents

用于制备苯并呋喃类化合物的方法 Download PDF

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Publication number
CN101861308B
CN101861308B CN2008801163899A CN200880116389A CN101861308B CN 101861308 B CN101861308 B CN 101861308B CN 2008801163899 A CN2008801163899 A CN 2008801163899A CN 200880116389 A CN200880116389 A CN 200880116389A CN 101861308 B CN101861308 B CN 101861308B
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compound
formula
preparation
salt
reaction
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Expired - Fee Related
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CN2008801163899A
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Chinese (zh)
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CN101861308A (zh
Inventor
拉斯·埃克隆德
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Nobel Chemicals AB
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Cambrex Karlskoga AB
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Priority to CN201310195267.6A priority Critical patent/CN103342633B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2008801163899A 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法 Expired - Fee Related CN101861308B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310195267.6A CN103342633B (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0719180.2A GB0719180D0 (en) 2007-10-02 2007-10-02 New process
GB0719180.2 2007-10-02
PCT/GB2008/003341 WO2009044143A2 (en) 2007-10-02 2008-10-02 Process for preparing benzofurans

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2011102205750A Division CN102382086A (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法
CN201310195267.6A Division CN103342633B (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法

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CN101861308A CN101861308A (zh) 2010-10-13
CN101861308B true CN101861308B (zh) 2013-06-19

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CN2011102205750A Pending CN102382086A (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法
CN201310195267.6A Expired - Fee Related CN103342633B (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法
CN2008801163899A Expired - Fee Related CN101861308B (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法

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CN2011102205750A Pending CN102382086A (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法
CN201310195267.6A Expired - Fee Related CN103342633B (zh) 2007-10-02 2008-10-02 用于制备苯并呋喃类化合物的方法

Country Status (9)

Country Link
US (2) US8519165B2 (enExample)
EP (3) EP2200993B1 (enExample)
JP (2) JP5577252B2 (enExample)
CN (3) CN102382086A (enExample)
BR (1) BRPI0817423A2 (enExample)
ES (3) ES2589011T3 (enExample)
GB (1) GB0719180D0 (enExample)
PL (3) PL2636670T3 (enExample)
WO (1) WO2009044143A2 (enExample)

Families Citing this family (34)

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GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
EP2684564A1 (en) 2008-04-17 2014-01-15 Sanofi Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or in the prevention of atrial fibrillation
CN102171200B (zh) * 2008-10-02 2015-09-30 坎布雷卡尔斯库加公司 用于制备二酮类和药物的方法
EA201100620A1 (ru) * 2008-10-10 2011-12-30 Лонца Лтд Способ получения 2-алкил-3-ароил-5-нитробензофуранов
RU2520748C2 (ru) 2008-12-04 2014-06-27 Санофи Способы и применения, включающие гемсвязывающий белок 1
WO2010096871A1 (en) 2009-02-25 2010-09-02 Applied Hybrid Energy Pty Ltd Carbon capture
CN102459154B (zh) * 2009-04-08 2015-12-02 坎布雷卡尔斯库加公司 用于制备羟胺类和药物的新方法
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
UY32657A (es) * 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
FR2957079B1 (fr) * 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
US20120005128A1 (en) * 2010-06-29 2012-01-05 Sanofi Methods for reducing the risk of an adverse dronedarone / calcium channel blockers interaction in a patient suffering from atrial fibrilation
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
FR2962731B1 (fr) * 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
CN102070580B (zh) * 2011-01-19 2015-05-20 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-取代氨基苯并呋喃的制备
CN102070581B (zh) * 2011-01-19 2015-11-25 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-氨基苯并呋喃的制备
CN102070577B (zh) * 2011-01-19 2016-03-09 上海医药工业研究院 2-正丁基-3-(4-取代丙氧基苯甲酰基)-5-取代氨基苯并呋喃及其应用
CN102070578B (zh) * 2011-01-19 2015-10-14 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-烷酰基氨基苯并呋喃的制备方法
WO2012120544A2 (en) 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) * 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2013014480A1 (en) * 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
CN102690250A (zh) * 2012-05-08 2012-09-26 郑州明泽医药科技有限公司 决奈达隆中间体及其制备方法
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction

Citations (2)

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CN1479735A (zh) * 2000-12-11 2004-03-03 ʥŵ��-�ϳ�ʵ���ҹ�˾ 甲基磺酰胺基-苯并呋喃衍生物,它的制备方法与它作为合成中间体的应用

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EP0270342A2 (en) * 1986-12-02 1988-06-08 Tanabe Seiyaku Co., Ltd. A benzo-furan (or -thiophene) derivative and processes for preparing the same
CN1479735A (zh) * 2000-12-11 2004-03-03 ʥŵ��-�ϳ�ʵ���ҹ�˾ 甲基磺酰胺基-苯并呋喃衍生物,它的制备方法与它作为合成中间体的应用

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Also Published As

Publication number Publication date
CN102382086A (zh) 2012-03-21
PL2388256T3 (pl) 2016-06-30
ES2589011T3 (es) 2016-11-08
EP2388256A1 (en) 2011-11-23
JP2010540608A (ja) 2010-12-24
EP2388256B1 (en) 2015-11-25
JP5943965B2 (ja) 2016-07-05
JP2014208660A (ja) 2014-11-06
WO2009044143A2 (en) 2009-04-09
PL2200993T3 (pl) 2013-01-31
EP2200993B1 (en) 2012-08-29
CN103342633A (zh) 2013-10-09
HK1185611A1 (en) 2014-02-21
US8779201B2 (en) 2014-07-15
US8519165B2 (en) 2013-08-27
ES2559939T3 (es) 2016-02-16
GB0719180D0 (en) 2007-11-14
CN103342633B (zh) 2016-05-04
BRPI0817423A2 (pt) 2015-06-16
JP5577252B2 (ja) 2014-08-20
EP2200993A2 (en) 2010-06-30
WO2009044143A4 (en) 2009-09-11
ES2395174T3 (es) 2013-02-08
HK1145684A1 (en) 2011-04-29
US20130338398A1 (en) 2013-12-19
CN101861308A (zh) 2010-10-13
EP2636670B1 (en) 2016-06-01
HK1164303A1 (en) 2012-09-21
PL2636670T3 (pl) 2016-12-30
WO2009044143A3 (en) 2009-06-25
US20100292319A1 (en) 2010-11-18
EP2636670A1 (en) 2013-09-11
EP2388256A3 (en) 2012-03-21

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