CN101795711A - 化学连接物与可切割的底物以及它们的偶联物 - Google Patents

化学连接物与可切割的底物以及它们的偶联物 Download PDF

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CN101795711A
CN101795711A CN200780051809A CN200780051809A CN101795711A CN 101795711 A CN101795711 A CN 101795711A CN 200780051809 A CN200780051809 A CN 200780051809A CN 200780051809 A CN200780051809 A CN 200780051809A CN 101795711 A CN101795711 A CN 101795711A
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B·苏菲
V·古尔拉维斯
陈良
S·甘格沃
张谦
D·B·帕斯摩
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ER Squibb and Sons LLC
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Medarex LLC
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
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  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CN200780051809A 2006-12-28 2007-12-28 化学连接物与可切割的底物以及它们的偶联物 Pending CN101795711A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88246106P 2006-12-28 2006-12-28
US60/882,461 2006-12-28
US99130007P 2007-11-30 2007-11-30
US60/991,300 2007-11-30
PCT/US2007/089100 WO2008083312A2 (en) 2006-12-28 2007-12-28 Chemical linkers and cleavable substrates and conjugates thereof

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CN101795711A true CN101795711A (zh) 2010-08-04

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US (1) US8461117B2 (enExample)
EP (1) EP2114454A2 (enExample)
JP (1) JP2010522693A (enExample)
KR (1) KR20090098901A (enExample)
CN (1) CN101795711A (enExample)
AR (1) AR067837A1 (enExample)
AU (1) AU2007342052A1 (enExample)
BR (1) BRPI0719626A2 (enExample)
CA (1) CA2674055C (enExample)
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EA (1) EA019962B1 (enExample)
IL (1) IL199416A0 (enExample)
MX (1) MX2009007147A (enExample)
NO (1) NO20092733L (enExample)
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SG (1) SG170070A1 (enExample)
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WO (1) WO2008083312A2 (enExample)

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CN104356048A (zh) * 2014-11-02 2015-02-18 浙江医药高等专科学校 环己烷羧酸酰胺类衍生物、其制备方法和用途
CN110087691A (zh) * 2016-10-17 2019-08-02 辉瑞公司 抗-edb抗体和抗体-药物缀合物
CN112255908A (zh) * 2020-11-16 2021-01-22 西安轻工业钟表研究所有限公司 一种指针式卫星光伏时钟
CN112553274A (zh) * 2020-12-02 2021-03-26 江南大学 大豆提取物Bowman-Birk inhibitor切割DNA的方法
CN114181216A (zh) * 2021-12-27 2022-03-15 苏州新药篮生物医药科技有限公司 一种3,6-二氢吡咯并[3,2-e]吲哚-2-甲酸甲酯的制备方法
CN114341154A (zh) * 2019-09-05 2022-04-12 国立大学法人东京农工大学 类胰蛋白酶活性测定用底物
CN114685661A (zh) * 2015-01-20 2022-07-01 西托姆克斯治疗公司 基质金属蛋白酶可切割且丝氨酸蛋白酶可切割底物及其使用方法
CN115038699A (zh) * 2020-01-30 2022-09-09 (株)爱恩德生物 苯并硒吩系化合物、包含其的药物组合物及抗体-药物缀合物
CN116727114A (zh) * 2023-07-19 2023-09-12 昆明理工大学 一种短流程浮选回收锂云母的方法
WO2025185559A1 (zh) * 2024-03-04 2025-09-12 杭州中美华东制药有限公司 抗FGFR2b抗体、其抗体药物偶联物及其用途

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US8865875B2 (en) * 2007-08-22 2014-10-21 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
US8268970B2 (en) 2007-10-01 2012-09-18 Bristol-Myers Squibb Company Human antibodies that bind mesothelin, and uses thereof
WO2009073533A2 (en) * 2007-11-30 2009-06-11 Medarex, Inc. Anti-b7h4 monoclonal antibody-drug conjugate and methods of use
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
JP5677970B2 (ja) 2008-11-03 2015-02-25 シンタルガ・ビーブイ 新規ｃｃ−１０６５類似体およびその複合体
UA102891C2 (uk) 2009-03-05 2013-08-27 Медарекс, Інк. Повні людські антитіла, специфічні до cadm1
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
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WO2011034668A1 (en) 2009-08-07 2011-03-24 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
HRP20130953T1 (hr) * 2010-04-15 2013-11-22 Spirogen Sàrl Pirolobenzodiazepini i njihovi konjugati
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US8501930B2 (en) * 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
US8852599B2 (en) * 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
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CA2860739A1 (en) 2012-01-09 2013-07-18 Ohmx Corporation Enzyme cascade methods for e-trace assay signal amplification
HRP20170334T1 (hr) 2012-02-13 2017-04-21 Bristol-Myers Squibb Company Spojevi enedina, njihovi konjugati, primjene i metode
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