DE69121334T2 - DC-89-Derivate als Antitumor-Wirkstoffe - Google Patents
DC-89-Derivate als Antitumor-WirkstoffeInfo
- Publication number
- DE69121334T2 DE69121334T2 DE69121334T DE69121334T DE69121334T2 DE 69121334 T2 DE69121334 T2 DE 69121334T2 DE 69121334 T DE69121334 T DE 69121334T DE 69121334 T DE69121334 T DE 69121334T DE 69121334 T2 DE69121334 T2 DE 69121334T2
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- tumor agents
- tumor
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19874790 | 1990-07-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69121334D1 DE69121334D1 (de) | 1996-09-19 |
DE69121334T2 true DE69121334T2 (de) | 1997-03-20 |
Family
ID=16396296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69121334T Expired - Fee Related DE69121334T2 (de) | 1990-07-26 | 1991-07-22 | DC-89-Derivate als Antitumor-Wirkstoffe |
Country Status (3)
Country | Link |
---|---|
US (1) | US5332740A (de) |
EP (1) | EP0468400B1 (de) |
DE (1) | DE69121334T2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258383A (en) * | 1991-06-28 | 1993-11-02 | Kyowa Hakko Kogyo Co., Ltd. | DC-89 derivatives |
JPH0597853A (ja) * | 1991-10-07 | 1993-04-20 | Kyowa Hakko Kogyo Co Ltd | Dc−89誘導体の臭化水素酸塩 |
CN1463270A (zh) | 2001-05-31 | 2003-12-24 | 梅达莱克斯公司 | 细胞毒素、其有用的前体药物、连接基团和稳定剂 |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
NZ550934A (en) * | 2004-05-19 | 2010-05-28 | Medarex Inc | Chemical linkers and conjugates thereof |
DK1851250T3 (da) * | 2005-02-18 | 2012-07-09 | Medarex Inc | Humant monoklonalt antistof mod prostataspecifikt membranantigen (psma) |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
AU2006294554B2 (en) * | 2005-09-26 | 2013-03-21 | E. R. Squibb & Sons, L.L.C. | Antibody-drug conjugates and methods of use |
KR20080068084A (ko) | 2005-10-26 | 2008-07-22 | 메다렉스, 인코포레이티드 | 씨씨-1065 유사체를 제조하기 위한 방법 및 화합물 |
WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
CN101616911A (zh) * | 2007-02-21 | 2009-12-30 | 梅达莱克斯公司 | 具有单个氨基酸的化学连接物及其偶联物 |
ES2701076T3 (es) | 2012-11-24 | 2019-02-20 | Hangzhou Dac Biotech Co Ltd | Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células |
CN114262344A (zh) | 2014-02-28 | 2022-04-01 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
KR20220147721A (ko) | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006265A1 (en) * | 1986-04-17 | 1987-10-22 | Kyowa Hakko Kogyo Co., Ltd. | Novel compounds dc-88a and dc-89a1 and process for their preparation |
EP0318056A3 (de) * | 1987-11-27 | 1990-12-19 | Meiji Seika Kaisha Ltd. | Antibiotika und Verfahren zu deren Herstellung |
JP2642165B2 (ja) * | 1988-07-22 | 1997-08-20 | 協和醗酵工業株式会社 | 新規dc−89化合物およびその製造法 |
US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
US5008271A (en) * | 1988-10-21 | 1991-04-16 | Kyowa Hakko Kogyo Co., Ltd. | DC-88A derivatives |
-
1991
- 1991-07-22 DE DE69121334T patent/DE69121334T2/de not_active Expired - Fee Related
- 1991-07-22 EP EP91112235A patent/EP0468400B1/de not_active Expired - Lifetime
-
1993
- 1993-04-13 US US08/046,365 patent/US5332740A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0468400B1 (de) | 1996-08-14 |
US5332740A (en) | 1994-07-26 |
DE69121334D1 (de) | 1996-09-19 |
EP0468400A1 (de) | 1992-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69119329T2 (de) | Actinonin-Derivate | |
FI925523A0 (fi) | Hydroxi- och alkoxipyridinderivat | |
IT9022240A1 (it) | Complesso di sostegno di condotti | |
FI932535A (fi) | Tryckoeverfoerare med en djupning foer spaenningsisolering | |
FI932669A (fi) | Flerpoligt skaermat kontaktdon med gemensam jord | |
IT9019537A0 (it) | Agenti scivolanti | |
DE69125099T2 (de) | Indolderivate | |
ATE144765T1 (de) | Hiv-hemmende benzenacetamidderivate | |
DE69121334T2 (de) | DC-89-Derivate als Antitumor-Wirkstoffe | |
ATE171449T1 (de) | Oxadolderivate | |
DK0472733T3 (da) | Phenantrenderivater | |
TR26336A (tr) | SüBSTITüE EDILMIS PIRAZOLIN TüREVLERI | |
LV11176A (lv) | Uracila atvasinajumi | |
FI930560A (fi) | Naetdriven med fasskaerningskontroll utrustad koppling | |
DE69116887D1 (de) | Ortungsbestimmung | |
FI930132A (fi) | Avboejningssystem med en kontrollerad straolpunkt | |
FI931625A0 (fi) | Kromaner och tiokromaner med retinoidlik aktivitet | |
DE69316018T2 (de) | Carbostyrilderivate als antiarrhytmika | |
BR9105770A (pt) | Encosto | |
FI932076A0 (fi) | Haevsystem med en inbyggd gasfjaeder | |
BR9104543A (pt) | Derivados de triazolpiridazina | |
DK0487759T3 (da) | Kredsløbsindretning | |
FI924296A (fi) | Rengoeringsprodukter i vaetskeform | |
DK16391A (da) | Styrehus | |
KR930700523A (ko) | 뉴클레오티드 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |