DE69825048D1 - Analoga von duocarmycin and cc-1065 - Google Patents
Analoga von duocarmycin and cc-1065Info
- Publication number
- DE69825048D1 DE69825048D1 DE69825048T DE69825048T DE69825048D1 DE 69825048 D1 DE69825048 D1 DE 69825048D1 DE 69825048 T DE69825048 T DE 69825048T DE 69825048 T DE69825048 T DE 69825048T DE 69825048 D1 DE69825048 D1 DE 69825048D1
- Authority
- DE
- Germany
- Prior art keywords
- duocarmycin
- analog
- analogs
- antitumor antibiotics
- field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4850597P | 1997-05-22 | 1997-05-22 | |
PCT/US1998/010535 WO1998052925A1 (en) | 1997-05-22 | 1998-05-22 | Analogs of duocarmycin and cc-1065 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69825048D1 true DE69825048D1 (de) | 2004-08-19 |
Family
ID=21954939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69825048T Expired - Lifetime DE69825048D1 (de) | 1997-05-22 | 1998-05-22 | Analoga von duocarmycin and cc-1065 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6281354B1 (de) |
EP (1) | EP0983248B1 (de) |
JP (1) | JP2002503228A (de) |
AT (1) | ATE271041T1 (de) |
AU (1) | AU754083B2 (de) |
CA (1) | CA2290789A1 (de) |
DE (1) | DE69825048D1 (de) |
NZ (1) | NZ500789A (de) |
WO (1) | WO1998052925A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002068412A1 (en) * | 2001-02-22 | 2002-09-06 | School Of Pharmacy, University Of London | Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment |
ES2552281T3 (es) | 2001-05-11 | 2015-11-26 | Ludwig Institute For Cancer Research Ltd. | Proteínas de unión específica y usos de las mismas |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
US7129261B2 (en) | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
DE10147672A1 (de) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
JP2006505571A (ja) * | 2002-10-15 | 2006-02-16 | リゲル ファーマシューテイカルズ、インコーポレイテッド | 置換されたインドール及びhcv阻害剤としてのその使用 |
US20060167271A1 (en) * | 2002-11-14 | 2006-07-27 | Mark Ginsberg | Purified compounds that inhibit intracellular alphax4/paxillin binding |
CN100519555C (zh) * | 2004-03-13 | 2009-07-29 | Tmrc株式会社 | 将dna的特定碱基序列烷基化的新吲哚衍生物和使用其的烷基化剂以及药剂 |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
EP1747021B1 (de) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Selbstimmolative verbinder und arzneimittelkonjugate |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
CN101312748A (zh) * | 2005-09-26 | 2008-11-26 | 梅达莱克斯公司 | 抗体-药物轭合物和使用方法 |
EP1934261B1 (de) | 2005-09-26 | 2014-10-29 | Medarex, L.L.C. | Humane monoklonale antikörper gegen cd70 |
ES2375843T3 (es) | 2005-10-26 | 2012-03-06 | Medarex, Inc. | Procedimientos y compuestos para la preparación de an�?logos de cc-1065. |
WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
DK1957539T3 (da) | 2005-12-08 | 2013-05-06 | Medarex Inc | Humane monoklonale antistoffer til proteintyrosinkinase 7 (ptk7) og deres anvendelse |
PT1960434E (pt) | 2005-12-08 | 2012-10-02 | Medarex Inc | Anticorpos monoclonais humanos para fucosil-gm1 e métodos para a utilização de anti-fucosil-gm1 |
US20090175886A1 (en) | 2006-01-17 | 2009-07-09 | Medarex, Inc. | Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues |
US20110182904A1 (en) | 2006-09-05 | 2011-07-28 | Deborah Zimmerman | Antibodies to bone morphogenic proteins and receptors therefor and methods for their use |
MX2009005776A (es) | 2006-12-01 | 2009-06-10 | Medarex Inc | Anticuerpos humanos que se enlazan al cd 22 y sus usos. |
CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
WO2008074004A2 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
WO2008103693A2 (en) | 2007-02-21 | 2008-08-28 | Medarex, Inc. | Chemical linkers with single amino acids and conjugates thereof |
MX2009009782A (es) | 2007-03-15 | 2010-09-10 | Ludwig Inst Cancer Res | Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
HUE035798T2 (en) | 2008-11-03 | 2018-05-28 | Syntarga Bv | CC-1065 analogues and conjugates |
BRPI1009232B1 (pt) | 2009-03-05 | 2022-05-03 | E.R. Squibb & Sons, Llc. | Anticorpo monoclonal isolado ou uma porção de ligação de antígeno do mesmo, ou um fragmento de anticorpo, composição que os compreende, molécula de ácido nucleico, hibridoma e métodos para a preparação de um anticorpo anti-cadm1 |
SG10201401604VA (en) | 2009-04-20 | 2014-08-28 | Oxford Biotherapeutics Ltd | Antibodies Specific To Cadherin-17 |
EP2470569A1 (de) | 2009-10-13 | 2012-07-04 | Oxford Biotherapeutics Ltd. | Antikörper gegen epha10 |
CN102933231B (zh) | 2010-02-10 | 2015-07-29 | 伊缪诺金公司 | Cd20抗体及其用途 |
UA112291C2 (uk) | 2010-04-21 | 2016-08-25 | Синтарґа Б.В. | Кон'югати аналогів cc-1065 і біфункціональні лінкери |
PE20140756A1 (es) | 2011-06-28 | 2014-07-04 | Oxford Biotherapeutics Ltd | Anticuerpos que se unen a bst1 |
US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
JP6482471B2 (ja) | 2012-12-21 | 2019-03-13 | バイオアライアンス コマンディテール フェンノートシャップ | 親水性の自壊性リンカー及びそのコンジュゲート |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
SG11201605605SA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Method for purifying cys-linked antibody-drug conjugates |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
CN113350518A (zh) | 2015-07-12 | 2021-09-07 | 杭州多禧生物科技有限公司 | 与细胞结合分子的共轭偶联的桥连接体 |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
US10472422B2 (en) | 2016-01-08 | 2019-11-12 | Abgenomics International Inc. | Tetravalent anti-PSGL-1 antibodies and uses thereof |
KR102493853B1 (ko) | 2016-08-19 | 2023-01-30 | 브리스톨-마이어스 스큅 컴퍼니 | 세코-시클로프로파피롤로인돌 화합물, 그의 항체-약물 접합체, 및 제조 및 사용 방법 |
WO2018064094A1 (en) | 2016-09-28 | 2018-04-05 | Bristol-Myers Squibb Company | Enantioselective synthesis of pyrroloindole compounds |
NZ752394A (en) | 2016-11-14 | 2021-07-30 | Hangzhou Dac Biotech Co Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1238907A (en) * | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
US5008271A (en) * | 1988-10-21 | 1991-04-16 | Kyowa Hakko Kogyo Co., Ltd. | DC-88A derivatives |
US5214065A (en) * | 1990-06-11 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivatives |
NZ332960A (en) * | 1996-05-31 | 2000-05-26 | Scripps Research Inst | tetrahydro-cyclopropan[c]benz[e]-indol-4-one and tetrahydro-cyclopropan[c]benzo[e]-indole derivatives and medicaments |
-
1998
- 1998-05-22 JP JP55069798A patent/JP2002503228A/ja not_active Ceased
- 1998-05-22 AT AT98924851T patent/ATE271041T1/de not_active IP Right Cessation
- 1998-05-22 DE DE69825048T patent/DE69825048D1/de not_active Expired - Lifetime
- 1998-05-22 CA CA002290789A patent/CA2290789A1/en not_active Abandoned
- 1998-05-22 WO PCT/US1998/010535 patent/WO1998052925A1/en active IP Right Grant
- 1998-05-22 NZ NZ500789A patent/NZ500789A/en unknown
- 1998-05-22 EP EP98924851A patent/EP0983248B1/de not_active Expired - Lifetime
- 1998-05-22 AU AU76927/98A patent/AU754083B2/en not_active Ceased
-
1999
- 1999-11-09 US US09/423,576 patent/US6281354B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6281354B1 (en) | 2001-08-28 |
EP0983248B1 (de) | 2004-07-14 |
ATE271041T1 (de) | 2004-07-15 |
EP0983248A1 (de) | 2000-03-08 |
NZ500789A (en) | 2002-05-31 |
AU754083B2 (en) | 2002-11-07 |
CA2290789A1 (en) | 1998-11-26 |
EP0983248A4 (de) | 2000-09-13 |
WO1998052925A1 (en) | 1998-11-26 |
AU7692798A (en) | 1998-12-11 |
JP2002503228A (ja) | 2002-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |