CL2020000530A1 - Construcciones con un dominio sirp-alfa o sus variantes. (divisional solicitud 201800340). - Google Patents
Construcciones con un dominio sirp-alfa o sus variantes. (divisional solicitud 201800340).Info
- Publication number
- CL2020000530A1 CL2020000530A1 CL2020000530A CL2020000530A CL2020000530A1 CL 2020000530 A1 CL2020000530 A1 CL 2020000530A1 CL 2020000530 A CL2020000530 A CL 2020000530A CL 2020000530 A CL2020000530 A CL 2020000530A CL 2020000530 A1 CL2020000530 A1 CL 2020000530A1
- Authority
- CL
- Chile
- Prior art keywords
- sirp
- variant
- cell
- cancer
- polipeptides
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 2
- 108010088751 Albumins Proteins 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000034356 gene-regulatory proteins Human genes 0.000 abstract 1
- 108091006104 gene-regulatory proteins Proteins 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
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- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
LA PRESENTE DESCRIPCIÓN PRESENTA CONSTRUCCIONES Y POLIPÉPTIDOS DE LA PROTEÍNA REGULADORA DE SEÑALES (SIRP-(X) QUE SON ÚTILES, P. EJ., PARA DIRIGIRSE A UNA CÉLULA (P. EJ., UNA CÉLULA CANCEROSA O UNA CÉLULA DEL SISTEMA INMUNITARIO), AUMENTAR LA FAGOCITOSIS DE LA CÉLULA DIANA, ELIMINAR CÉLULAS INMUNITARIAS TALES COMO LINFOCITOS T REGULADORES, DESTRUIR CÉLULAS CANCEROSAS, TRATAR UNA ENFERMEDAD (P. EJ., UN CÁNCER) EN UN SUJETO, O CUALQUIER COMBINACIÓN DE ESTAS OPCIONES. LAS CONSTRUCCIONES DE SIRP-A INCLUYEN UN DOMINIO DL DE SIRP-A DE AFINIDAD ALTA A UNA VARIANTE DE ESTE QUE SE UNE A CD47 CON UNA AFINIDAD MÁS ALTA QUE IA DE UNA SIRP-A DE TIPO SALVAJE. LAS CONSTRUCCIONES A LOS POLIPÉPTIDOS DE SIRP-A INCLUYEN UNA VARIANTE DL DE SIRP-A FUSIONADA A UN MONÓMERO DEL DOMINIO DE FC, UNA ALBUMINA SÉRICA HUMANA (HSA), UN PÉPTIDO DE UNIÓN A ALBUMINA O UN POLÍMERO DE POLIETILENGLICOL (PEG). LAS COMPOSICIONES QUE SE PROPORCIONAN EN LA PRESENTE INCLUYEN (I) UN POLIPÉPTIDO QUE INCLUYE UNA VARIANTE DL DE LA PROTEÍNA REGULADORA DE SEÑALES A (SIRP- A) Y (II) UN ANTICUERPO.
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