SA518390881B1 - Sirp-alpha أجزاء منشأة تتضمن نطاق أو صورة متغيرة منها - Google Patents
Sirp-alpha أجزاء منشأة تتضمن نطاق أو صورة متغيرة منهاInfo
- Publication number
- SA518390881B1 SA518390881B1 SA518390881A SA518390881A SA518390881B1 SA 518390881 B1 SA518390881 B1 SA 518390881B1 SA 518390881 A SA518390881 A SA 518390881A SA 518390881 A SA518390881 A SA 518390881A SA 518390881 B1 SA518390881 B1 SA 518390881B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- sirp
- variant
- constructs
- cell
- cells
- Prior art date
Links
- 101150036449 SIRPA gene Proteins 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 2
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
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Abstract
يتعلق الاختراع الحالي ببولي ببتيدات بروتين تنظيم لإشارة α (SIRP-α) وأجزاء منشاة مفيدة، على سبيل المثال، في استهداف خلية (على سبيل المثال، خلية سرطان أو خلية الجهاز المناعي)، لزيادة الالتهام الخلوي للخلية المستهدفة، للتخلص من خلايا مناعية مثل الخلايا التائية المنظمة، لقتل الخلايا السرطانية، لعلاج مرض (على سبيل المثال، السرطان) لدى خاضع للعلاج، أو أي توليفة منها. تتضمن الأجزاء المنشأة SIRP-α نطاق SIRP-α D1 عالي الألفة أو صورة متغيرة منه ترتبط بـ CD47 بألفة أعلى من SIRP-α من النمط البري. تتضمن بولي ببتيدات SIRP-α أو الأجزاء المنشأة صورة متغيرة SIRP-α D1 ملتحمة بمونومر نطاق Fc، ألبومين مصل بشري (HSA)، ببتيد ربط ألبومين، أو بوليمر بولي إيثيلين جليكول (PEG). تتضمن التركيبات المبينة هنا (i) بولي ببتيد يتضمن صورة متغيرة لبروتين تنظيم إشارة مفرد α (SIRP- α) D1 و(ii) جسم مضاد. شكل 3.
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