TR201900695T4 - Hpv/cyaa-bazli ki̇meri̇k protei̇nler ve bunlarin hpv enfeksi̇yonuna ve hpv i̇le i̇ndüklenen rahatsizliklara karşi i̇mmün yanit i̇ndüklemedeki̇ kullanimlari. - Google Patents

Hpv/cyaa-bazli ki̇meri̇k protei̇nler ve bunlarin hpv enfeksi̇yonuna ve hpv i̇le i̇ndüklenen rahatsizliklara karşi i̇mmün yanit i̇ndüklemedeki̇ kullanimlari. Download PDF

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Publication number
TR201900695T4
TR201900695T4 TR2019/00695T TR201900695T TR201900695T4 TR 201900695 T4 TR201900695 T4 TR 201900695T4 TR 2019/00695 T TR2019/00695 T TR 2019/00695T TR 201900695 T TR201900695 T TR 201900695T TR 201900695 T4 TR201900695 T4 TR 201900695T4
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TR
Turkey
Prior art keywords
hpv
cyaa
immune response
response against
based chemical
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TR2019/00695T
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English (en)
Inventor
Misseri Yolande
Bridonneau Philippe
Goubier Anne
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Genkyotex
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Publication of TR201900695T4 publication Critical patent/TR201900695T4/tr

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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    • C12N2710/00011—Details
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01001—Aodenylate cyclase (4.6.1.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Buluş, N-terminalden C-terminale, (a) bir Bordetella CyaA proteininin bir N-terminal parçasını, (b) farklı HPV antijenleri içeren bir heterolog polipeptidi ve (c) bir Bordetella CyaA proteininin bir C-terminal parçasını içeren veya bunlardan oluşan bir kimerik protein ile ilgilidir. Buluş aynı zamanda, bu kimerik proteini kodlayan bir polinükleotid ile ilgilidir. Buluşun en az bir kimerik proteinini(proteinlerini) içeren bir bileşim ve söz konusu bileşimin profilaktik ve/veya terapötik kullanımları da aynı zamanda, buluşun bir parçasıdır.
TR2019/00695T 2012-07-23 2013-07-23 Hpv/cyaa-bazli ki̇meri̇k protei̇nler ve bunlarin hpv enfeksi̇yonuna ve hpv i̇le i̇ndüklenen rahatsizliklara karşi i̇mmün yanit i̇ndüklemedeki̇ kullanimlari. TR201900695T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12305898.4A EP2689786A1 (en) 2012-07-23 2012-07-23 HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders

Publications (1)

Publication Number Publication Date
TR201900695T4 true TR201900695T4 (tr) 2019-03-21

Family

ID=48832935

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/00695T TR201900695T4 (tr) 2012-07-23 2013-07-23 Hpv/cyaa-bazli ki̇meri̇k protei̇nler ve bunlarin hpv enfeksi̇yonuna ve hpv i̇le i̇ndüklenen rahatsizliklara karşi i̇mmün yanit i̇ndüklemedeki̇ kullanimlari.

Country Status (21)

Country Link
US (1) US9827302B2 (tr)
EP (2) EP2689786A1 (tr)
JP (1) JP6466328B2 (tr)
KR (1) KR20150031487A (tr)
CN (1) CN104736173B (tr)
AU (1) AU2013295047B2 (tr)
CA (1) CA2879999A1 (tr)
DK (1) DK2874657T3 (tr)
ES (1) ES2712647T3 (tr)
HK (1) HK1208822A1 (tr)
HR (1) HRP20190108T1 (tr)
HU (1) HUE042808T2 (tr)
LT (1) LT2874657T (tr)
MX (1) MX2015001021A (tr)
PL (1) PL2874657T3 (tr)
PT (1) PT2874657T (tr)
RS (1) RS58313B1 (tr)
RU (1) RU2015100212A (tr)
SI (1) SI2874657T1 (tr)
TR (1) TR201900695T4 (tr)
WO (1) WO2014016312A1 (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2690172A1 (en) * 2012-07-23 2014-01-29 Genticel CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses
EP3037103A1 (en) 2014-12-23 2016-06-29 Genticel Immunotherapeutic vaccine comprising E7 proteins of HPV16 and HPV18 fused with CyaA, for use in subjects infected with HPV
EP3323424A1 (en) * 2016-11-17 2018-05-23 Cyanimal IP Cyaa polypeptides as immune enhancer
CN112912097A (zh) * 2018-08-23 2021-06-04 葛兰素史密丝克莱恩生物有限公司 免疫原性蛋白和组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01209817A (ja) 1988-02-17 1989-08-23 Yamaha Corp 浮動少数点形ディジタル・アナログ変換器
PT1188446E (pt) 2000-09-15 2009-11-10 Pasteur Institut Vectores proteinácios para a distribuição da molécula a células que expressam cd11b
EP1489092A1 (en) 2003-06-18 2004-12-22 Institut Pasteur Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof
ES2293178T3 (es) * 2004-03-18 2008-03-16 Institut Pasteur Proteina recombinante que contiene epitopos del papilomavirus humano insertados en un proteina adenilato ciclasa o un fragmento de la misma y usos terapeuticos de la misma.
CN103983634A (zh) 2008-07-22 2014-08-13 普罗美加公司 基于adp检测的发光磷酸转移酶或atp水解酶测定
EP2478915A1 (en) * 2011-01-24 2012-07-25 Genticel CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses

Also Published As

Publication number Publication date
EP2874657B1 (en) 2018-10-17
RU2015100212A (ru) 2016-09-10
CN104736173B (zh) 2019-02-05
KR20150031487A (ko) 2015-03-24
RS58313B1 (sr) 2019-03-29
DK2874657T3 (en) 2019-02-11
MX2015001021A (es) 2015-08-05
US9827302B2 (en) 2017-11-28
EP2689786A1 (en) 2014-01-29
AU2013295047B2 (en) 2018-02-22
JP2015524420A (ja) 2015-08-24
CA2879999A1 (en) 2014-01-30
JP6466328B2 (ja) 2019-02-13
PL2874657T3 (pl) 2019-05-31
CN104736173A (zh) 2015-06-24
AU2013295047A1 (en) 2015-02-05
US20150250867A1 (en) 2015-09-10
ES2712647T3 (es) 2019-05-14
EP2874657A1 (en) 2015-05-27
LT2874657T (lt) 2019-02-25
HUE042808T2 (hu) 2019-07-29
WO2014016312A1 (en) 2014-01-30
HK1208822A1 (en) 2016-03-18
SI2874657T1 (sl) 2019-03-29
PT2874657T (pt) 2019-02-18
HRP20190108T1 (hr) 2019-03-22

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