SI2874657T1 - Himerni proteini na osnovi-HPV/CYAA in njihove uporabe v indukciji imunskih odzivov proti infekciji HPV in HPV-induciranih motnjah - Google Patents

Himerni proteini na osnovi-HPV/CYAA in njihove uporabe v indukciji imunskih odzivov proti infekciji HPV in HPV-induciranih motnjah

Info

Publication number
SI2874657T1
SI2874657T1 SI201331327T SI201331327T SI2874657T1 SI 2874657 T1 SI2874657 T1 SI 2874657T1 SI 201331327 T SI201331327 T SI 201331327T SI 201331327 T SI201331327 T SI 201331327T SI 2874657 T1 SI2874657 T1 SI 2874657T1
Authority
SI
Slovenia
Prior art keywords
hpv
cyaa
induction
immune responses
chimeric proteins
Prior art date
Application number
SI201331327T
Other languages
English (en)
Inventor
Yolande Misseri
Philippe Bridonneau
Anne Goubier
Original Assignee
Genkyotex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyotex filed Critical Genkyotex
Publication of SI2874657T1 publication Critical patent/SI2874657T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01001—Aodenylate cyclase (4.6.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201331327T 2012-07-23 2013-07-23 Himerni proteini na osnovi-HPV/CYAA in njihove uporabe v indukciji imunskih odzivov proti infekciji HPV in HPV-induciranih motnjah SI2874657T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305898.4A EP2689786A1 (en) 2012-07-23 2012-07-23 HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders
PCT/EP2013/065549 WO2014016312A1 (en) 2012-07-23 2013-07-23 Hpv/cyaa-based chimeric proteins and their uses in the induction of immune responses against hpv infection and hpv-induced disorders
EP13739725.3A EP2874657B1 (en) 2012-07-23 2013-07-23 Hpv/cyaa-based chimeric proteins and their uses in the induction of immune responses against hpv infection and hpv-induced disorders

Publications (1)

Publication Number Publication Date
SI2874657T1 true SI2874657T1 (sl) 2019-03-29

Family

ID=48832935

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201331327T SI2874657T1 (sl) 2012-07-23 2013-07-23 Himerni proteini na osnovi-HPV/CYAA in njihove uporabe v indukciji imunskih odzivov proti infekciji HPV in HPV-induciranih motnjah

Country Status (21)

Country Link
US (1) US9827302B2 (sl)
EP (2) EP2689786A1 (sl)
JP (1) JP6466328B2 (sl)
KR (1) KR20150031487A (sl)
CN (1) CN104736173B (sl)
AU (1) AU2013295047B2 (sl)
CA (1) CA2879999A1 (sl)
DK (1) DK2874657T3 (sl)
ES (1) ES2712647T3 (sl)
HK (1) HK1208822A1 (sl)
HR (1) HRP20190108T1 (sl)
HU (1) HUE042808T2 (sl)
LT (1) LT2874657T (sl)
MX (1) MX2015001021A (sl)
PL (1) PL2874657T3 (sl)
PT (1) PT2874657T (sl)
RS (1) RS58313B1 (sl)
RU (1) RU2015100212A (sl)
SI (1) SI2874657T1 (sl)
TR (1) TR201900695T4 (sl)
WO (1) WO2014016312A1 (sl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2690172A1 (en) * 2012-07-23 2014-01-29 Genticel CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses
EP3037103A1 (en) 2014-12-23 2016-06-29 Genticel Immunotherapeutic vaccine comprising E7 proteins of HPV16 and HPV18 fused with CyaA, for use in subjects infected with HPV
EP3323424A1 (en) * 2016-11-17 2018-05-23 Cyanimal IP Cyaa polypeptides as immune enhancer
CN112912097A (zh) * 2018-08-23 2021-06-04 葛兰素史密丝克莱恩生物有限公司 免疫原性蛋白和组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01209817A (ja) 1988-02-17 1989-08-23 Yamaha Corp 浮動少数点形ディジタル・アナログ変換器
PT1188446E (pt) 2000-09-15 2009-11-10 Pasteur Institut Vectores proteinácios para a distribuição da molécula a células que expressam cd11b
EP1489092A1 (en) 2003-06-18 2004-12-22 Institut Pasteur Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof
ES2293178T3 (es) * 2004-03-18 2008-03-16 Institut Pasteur Proteina recombinante que contiene epitopos del papilomavirus humano insertados en un proteina adenilato ciclasa o un fragmento de la misma y usos terapeuticos de la misma.
CN103983634A (zh) 2008-07-22 2014-08-13 普罗美加公司 基于adp检测的发光磷酸转移酶或atp水解酶测定
EP2478915A1 (en) * 2011-01-24 2012-07-25 Genticel CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses

Also Published As

Publication number Publication date
EP2874657B1 (en) 2018-10-17
RU2015100212A (ru) 2016-09-10
CN104736173B (zh) 2019-02-05
KR20150031487A (ko) 2015-03-24
RS58313B1 (sr) 2019-03-29
DK2874657T3 (en) 2019-02-11
MX2015001021A (es) 2015-08-05
US9827302B2 (en) 2017-11-28
EP2689786A1 (en) 2014-01-29
TR201900695T4 (tr) 2019-03-21
AU2013295047B2 (en) 2018-02-22
JP2015524420A (ja) 2015-08-24
CA2879999A1 (en) 2014-01-30
JP6466328B2 (ja) 2019-02-13
PL2874657T3 (pl) 2019-05-31
CN104736173A (zh) 2015-06-24
AU2013295047A1 (en) 2015-02-05
US20150250867A1 (en) 2015-09-10
ES2712647T3 (es) 2019-05-14
EP2874657A1 (en) 2015-05-27
LT2874657T (lt) 2019-02-25
HUE042808T2 (hu) 2019-07-29
WO2014016312A1 (en) 2014-01-30
HK1208822A1 (en) 2016-03-18
PT2874657T (pt) 2019-02-18
HRP20190108T1 (hr) 2019-03-22

Similar Documents

Publication Publication Date Title
HK1211607A1 (en) Chimeric fibroblast growth factor 21 proteins and methods of use 21
HRP20190108T1 (hr) Kimerni proteini na bazi hpv/cyaa i njihova upotreba u izazivanju imunosnih odgovora protiv infekcije hpv-om i poremećaja izazvanih hpv-om
HK1206370A1 (en) Charged nutritive proteins and methods
HK1206764A1 (en) Nutritive proteins and methods
ZA201405858B (en) Recombinant microorganisms and methods of use thereof
EP2911473A4 (en) INDUCTION COOKER
GB2526400B (en) Induction heating cooker
HK1190863A1 (zh) 感應加熱烹調器
HK1204929A1 (en) Timothy grass allergens and methods and uses for immune response modulation
GB2489815B (en) Produced fluid heating and separation
GB2520887B (en) Induction heating cooker
HUE037157T2 (hu) Vakcinavektorok, és eljárások immunválaszok fokozására
HK1209326A1 (en) Reassortant btv and ahsv vaccines btv hpv
HK1208048A1 (en) Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses cyaa
EP2804624A4 (en) VACCINES AGAINST ANTIGENS RELATED TO THERAPY RESISTANCE AND METHOD OF USE THEREOF
EP2892554A4 (en) HIV IMMUNOSTIMULATING COMPOSITIONS WITH RECOMBINANT EXPRESSED PILI ON BACTERIA AND CORRESPONDING METHODS
EP2900036A4 (en) HIGH FREQUENCY INDUCTION HEATING DEVICE AND PROCESSING DEVICE
HK1204285A1 (en) Immune tolerance inducer
EP2814839A4 (en) ANTAGONISTS OF BCL-2 AND USES THEREOF IN THE INDUCTION OF APOPTOSIS
SG11201601263WA (en) Recombinant microorganisms and methods of use thereof
EP2930183A4 (en) RECOMBINANT PROTEIN AND USES FOR DIAGNOSIS OF MULTIPLE SCLEROSIS
EP2920312A4 (en) ONCOLYTIC HSV1 VECTORS AND METHODS OF USING SAME
GB201318220D0 (en) Battery powered food or beverage induction heater
EP3018976A4 (en) Induction heating cooker
AU2012901301A0 (en) Treatment of inflammatory and immune disorders