CO2018002471A2 - Constructos de anticuerpos con un dominio sirp-alfa y sus variantes - Google Patents
Constructos de anticuerpos con un dominio sirp-alfa y sus variantesInfo
- Publication number
- CO2018002471A2 CO2018002471A2 CONC2018/0002471A CO2018002471A CO2018002471A2 CO 2018002471 A2 CO2018002471 A2 CO 2018002471A2 CO 2018002471 A CO2018002471 A CO 2018002471A CO 2018002471 A2 CO2018002471 A2 CO 2018002471A2
- Authority
- CO
- Colombia
- Prior art keywords
- sirp
- constructs
- cell
- variant
- domain
- Prior art date
Links
- 101150036449 SIRPA gene Proteins 0.000 abstract 7
- 210000004027 cell Anatomy 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 2
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 102000034356 gene-regulatory proteins Human genes 0.000 abstract 2
- 108091006104 gene-regulatory proteins Proteins 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
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Abstract
La presente descripción presenta construcciones y polipéptidos de la proteína reguladora de señales (SIRP-α) que son útiles, p. ej., para dirigirse a una célula (p. ej., una célula cancerosa o una célula del sistema inmunitario), aumentar la fagocitosis de la célula diana, eliminar células inmunitarias tales como linfocitos T reguladores, destruir células cancerosas, tratar una enfermedad (p. ej., un cáncer) en un sujeto, o cualquier combinación de estas opciones. Las construcciones de SIRP-α incluyen un dominio D1 de SIRP-α de afinidad alta o una variante de este que se une a CD47 con una afinidad más alta que la de una SIRP-α de tipo salvaje. Las construcciones o los polipéptidos de SIRP-α incluyen una variante D1 de SIRP-α fusionada a un monómero del dominio de Fc, una albúmina sérica humana (HSA), un péptido de unión a albúmina o un polímero de polietilenglicol (PEG). Las composiciones que se proporcionan en la presente incluyen (i) un polipéptido que incluye una variante D1 de la proteína reguladora de señales α (SIRP- α) y (ii) un anticuerpo.
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PCT/US2016/045914 WO2017027422A1 (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11208459B2 (en) | 2015-08-07 | 2021-12-28 | ALX Oncology Inc. | Constructs having a SIRP-alpha domain or variant thereof |
US11639376B2 (en) | 2015-08-07 | 2023-05-02 | ALX Oncology Inc. | Constructs having a SIRP-α domain or variant thereof |
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