HRP20211167T1 - Konstrukcije koje imaju sirp-alfa domenu ili njihove varijante - Google Patents
Konstrukcije koje imaju sirp-alfa domenu ili njihove varijante Download PDFInfo
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- HRP20211167T1 HRP20211167T1 HRP20211167TT HRP20211167T HRP20211167T1 HR P20211167 T1 HRP20211167 T1 HR P20211167T1 HR P20211167T T HRP20211167T T HR P20211167TT HR P20211167 T HRP20211167 T HR P20211167T HR P20211167 T1 HRP20211167 T1 HR P20211167T1
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- cancer
- polypeptide
- pharmaceutical preparation
- leukemia
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Claims (12)
1. Polipeptid, koji sadrži signalno-regulacijski protein α (SIRP-α) D1 varijantu i Fc varijantu, pri čemu polipeptid sadrži sekvencu odabranu iz grupe koju čine: SEQ ID NO: 98-104, 107-113, 116-122 i 135-136.
2. Dimer koji se sastoji od dvije kopije polipeptida prema zahtjevu 1.
3. Nukleinska kiselina koja kodira polipeptid prema zahtjevu 1.
4. Vektor koji sadrži nukleinsku kiselinu prema zahtjevu 3.
5. Stanica domaćina koja sadrži nukleinsku kiselinu prema zahtjevu 3 ili vektor prema zahtjevu 4.
6. Postupak za proizvodnju polipeptida prema zahtjevu 1 sadrži uzgoj stanice domaćina prema zahtjevu 5 pod odgovarajućim uvjetima da bi se izazvala ekspresija polipeptida, i obnavljanje polipeptida.
7. Farmaceutski pripravak sadrži polipeptid prema zahtjevu 1, ili dimer prema zahtjevu 2, i farmaceutski prihvatljiv nosač.
8. Farmaceutski pripravak sadrži 7 za uporabu u postupku za liječenje raka.
9. Farmaceutski pripravak za uporabu prema zahtjevu 8, naznačen time što je rak solidni tumor raka, hematološki rak, akutna mijeloična leukemija, kronična limfocitna leukemija, kronična mijeloična leukemija, akutna limfoblastna leukemija, ne-Hodgkinov limfom, Hodgkinov limfom, multipli mijelom, rak mokraćnog mjehura, rak gušterače, rak vrata maternice, rak endometrija, rak pluća, rak bronha, rak jetre, rak jajnika, rak debelog crijeva i rektuma, rak želuca, gastrični rak, rak žučnog mjehura, rak gastrointestinalnog stromalnog tumora, rak štitnjače, rak glave i vrata, orofaringealni rak, rak jednjaka, melanom, nemelanomski rak kože, karcinom Merkelovih stanica, virusno inducirani rak, neuroblastom, rak dojke, rak prostate, rak bubrega, rak bubrežnih stanica, rak bubrežne zdjelice, leukemija, limfom, sarkom, gliom, tumor na mozgu, ili karcinom.
10. Farmaceutski pripravak za uporabu prema zahtjevu 8 ili 9, naznačen time što postupak uključuje primjenu farmaceutskog pripravka i terapijskog antitijela.
11. Farmaceutski pripravak za uporabu prema zahtjevu 10, naznačen time što se terapijsko antitijelo veže na 4-1BB, 5T4, ALK1, ANG-2, B7-H3, B7-H4, c-Met, CA6, CCR4, CD123, CD19, CD20, CD22, CD27, EpCAM, CD30, CD32b, CD33, CD37, CD38, CD40, CD52, CD70, CD74, CD79b, CD98, CEA, CEACAM5, CLDN18.2, CLDN6, CS1, CTLA-4, CXCR4, DLL-4, EGFR, EGP-1, ENPP3, EphA3, ETBR, FGFR2, fibronektin, FR-alfa, iskrivljeni receptor, GCC, GD2, glipican-3, GPNMB, HER2, HER3, HLA-DR, ICAM-1, IGF-1R, IL-3R, LIV-1, mezotelin, MUC16, MUC1, NaPi2b, nektin-4, usjek 2, usjek 1, OX-40, PD-1, PD-L1, PD-L2, PDGFR-α, PS, PSMA, SLTRK6, STEAP1, TEM1, VEGFR, CD25, DKK-1 ili CSF-1R.
12. Farmaceutski pripravak za uporabu prema zahtjevu 10, naznačen time što je terapijsko antitijelo cetuksimab, necitumumab, pembrolizumab, nivolumab, pidilizumab, MEDI0680, atezolizumab, avelumab, durvalumab, MEDI6383, MEDI6469, RG7888, ipilimumab, tremelimumab, urelumab, PF-05082566, enoblituzumab, vantictumab, varlilumab, mogamulizumab, SAR650984, daratumumab, trastuzumab, trastuzumab emtansin, pertuzumab, elotuzumab, rituksimab, ofatumumab, RG7155, FPA008, panitumumab, ili brentuksimab vedotin.
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EP16835723.4A EP3331902B1 (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
PCT/US2016/045914 WO2017027422A1 (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
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US10053513B2 (en) * | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
RS62151B1 (sr) | 2015-08-07 | 2021-08-31 | Alx Oncology Inc | Konstrukti koji sadrže sirp-alfa domen ili njegovu varijantu |
AU2016310348B2 (en) | 2015-08-26 | 2023-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced depletion of targeted cells with CD47 blockade and an immune costimulatory agonist |
KR20180051651A (ko) | 2015-10-01 | 2018-05-16 | 히트 바이오로직스, 인코퍼레이티드 | 비상동성 키메라 단백질로서의 i형 및 ii형 세포외 도메인을 인접시키기 위한 조성물 및 방법 |
ES2796378T3 (es) | 2016-01-11 | 2020-11-26 | Forty Seven Inc | Anticuerpos monoclonales anti-cd47 humanizados, de ratón o químicos |
US11560433B2 (en) | 2016-05-27 | 2023-01-24 | Albert Einstein College Of Medicine | Methods of treatment by targeting VCAM1 and MAEA |
US10696722B2 (en) | 2016-08-10 | 2020-06-30 | Ajou University Industry-Academic Cooperation Foundation | Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same |
WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
KR102597943B1 (ko) | 2017-01-05 | 2023-11-06 | 카 메디컬 리미티드 | Pd1-41bbl 융합 단백질 및 이의 이용 방법 |
IL267862B2 (en) | 2017-01-05 | 2024-05-01 | Kahr Medical Ltd | SIRPalpha-41BBL conjugate protein and methods of using it |
US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
EP3577133A1 (en) | 2017-02-06 | 2019-12-11 | Orionis Biosciences NV | Targeted chimeric proteins and uses thereof |
WO2018157164A1 (en) | 2017-02-27 | 2018-08-30 | Shattuck Labs, Inc. | Csf1r-based chimeric proteins |
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