CL2011003244A1 - Procedimiento para preparar el ester aril-2-tetrazolil etilico de acido carbamico que comprende una etapa de reduccion asimetrica (r), una etapa de carbamatacion y una etapa de cristalizacion. - Google Patents

Procedimiento para preparar el ester aril-2-tetrazolil etilico de acido carbamico que comprende una etapa de reduccion asimetrica (r), una etapa de carbamatacion y una etapa de cristalizacion.

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Publication number
CL2011003244A1
CL2011003244A1 CL2011003244A CL2011003244A CL2011003244A1 CL 2011003244 A1 CL2011003244 A1 CL 2011003244A1 CL 2011003244 A CL2011003244 A CL 2011003244A CL 2011003244 A CL2011003244 A CL 2011003244A CL 2011003244 A1 CL2011003244 A1 CL 2011003244A1
Authority
CL
Chile
Prior art keywords
formula
asymmetric reduction
configuration
compound
aryl
Prior art date
Application number
CL2011003244A
Other languages
English (en)
Inventor
Nahm Ryune Cho
Dae Won Lee
Ju Young Lee
Hui Ho Kim
Dong Ho Lee
Hyun Seok Lee
Se Ii Lee
Moo Yong Uhm
Sang Chul Lim
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of CL2011003244A1 publication Critical patent/CL2011003244A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN MÉTODO PARA PREPARAR EL ÉSTER ARIL-2-TETRAZOLIL ETILICO DE ÁCIDO CARBÁMICO, REPRESENTADO POR LA FÓRMULA I, QUE COMPRENDE: SOMETER UNA ARILETONA, REPRESENTADA POR LA FÓRMULA 2, A LA REDUCCIÓN ASIMÉTRICA SELECTIVA (R) PARA FORMAR UN COMPUESTO DE ALCOHOL DE CONFIGURACIÓN (R), REPRESENTADO POR LA FÓRMULA 5; Y CARBAMATAR EL ALCOHOL: DONDE LA REDUCCIÓN ASIMÉTRICA SELECTIVA (R) SE LOGRA MEDIANTE REDUCCIÓN ASIMÉTRICA BIOLÓGICA; O REDUCCIÓN<br /> ASIMÉTRICA QUÍMICA QUE SE LOGRA CON UN REDUCTOR DE BORANO QUIRAL DE (-)-B-CLORODÜSOPINOCANFEILBORANO O MEDIANTE HIDROGENACIÓN CATALÍTICA SIMÉTRICA; Y LA ETAPA DE CARBAMATACIÓN SE LLEVA A CABO AL HACER REACCIONAR EL COMPUESTO DE ALCOHOL DE CONFIGURACIÓN (R) DE LA FÓRMULA 5 CON CIANATO INORGÁNICO Y UN ÁCIDO ORGÁNICO;<br /> HIDROLIZAR UN PRODUCTO QUE RESULTA DE LA REACCIÓN ENTRE EL COMPUESTO DE ALCOHOL DE CONFIGURACIÓN (R) DE LA FÓRMULA 5 Y UN COMPUESTO ISOCIANATO; O INTRODUCIR AMONÍACO EN UN PRODUCTO QUE RESULTA DE LA REACCIÓN ENTRE EL COMPUESTO DE ALCOHOL DE CONFIGURACIÓN (R) DE LA FÓRMULA 5 Y UN COMPUESTO CARBONILO.  
CL2011003244A 2009-06-22 2011-12-21 Procedimiento para preparar el ester aril-2-tetrazolil etilico de acido carbamico que comprende una etapa de reduccion asimetrica (r), una etapa de carbamatacion y una etapa de cristalizacion. CL2011003244A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20090055576 2009-06-22

Publications (1)

Publication Number Publication Date
CL2011003244A1 true CL2011003244A1 (es) 2012-08-10

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CL2011003244A CL2011003244A1 (es) 2009-06-22 2011-12-21 Procedimiento para preparar el ester aril-2-tetrazolil etilico de acido carbamico que comprende una etapa de reduccion asimetrica (r), una etapa de carbamatacion y una etapa de cristalizacion.

Country Status (17)

Country Link
US (1) US8501436B2 (es)
EP (1) EP2445890B1 (es)
JP (1) JP5683580B2 (es)
KR (1) KR101708433B1 (es)
CN (1) CN102803233B (es)
AU (1) AU2009348523B2 (es)
BR (1) BRPI0924997B1 (es)
CA (1) CA2765566C (es)
CL (1) CL2011003244A1 (es)
ES (1) ES2541590T3 (es)
IL (1) IL216786A (es)
MX (1) MX2011013982A (es)
MY (1) MY155662A (es)
PL (1) PL2445890T3 (es)
RU (1) RU2508290C2 (es)
WO (1) WO2010150946A1 (es)
ZA (1) ZA201109362B (es)

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MY155662A (en) 2015-11-13
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