WO2008114506A1 - ４－アミノメチル安息香酸の製造方法 - Google Patents

４－アミノメチル安息香酸の製造方法 Download PDF

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Publication number
WO2008114506A1
WO2008114506A1 PCT/JP2008/000621 JP2008000621W WO2008114506A1 WO 2008114506 A1 WO2008114506 A1 WO 2008114506A1 JP 2008000621 W JP2008000621 W JP 2008000621W WO 2008114506 A1 WO2008114506 A1 WO 2008114506A1
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WO
WIPO (PCT)
Prior art keywords
producing
formula
compound represented
aminomethylbenzoic acid
aqueous ammonia
Prior art date
Application number
PCT/JP2008/000621
Other languages
English (en)
French (fr)
Inventor
Yukio Sato
Akinori Hatanaka
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of WO2008114506A1 publication Critical patent/WO2008114506A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

　トラネキサム酸やセトラキセートの製造中間体である４－アミノメチル安息香酸の安価で効率のよい製造方法を提供することを目的とする。 　下記の式（１）で表される化合物をＣ1～Ｃ6－アルコール中で加熱して、下記の式（２）（式中、ＲはＣ1～Ｃ6－アルキル基を示す。）で表される化合物を得、次いでアンモニア水溶液又はアンモニア水溶液と有機溶剤との混合液中で金属触媒の存在下接触還元することを特徴とする、下記の式（３）で表される化合物の製造方法。
PCT/JP2008/000621 2007-03-19 2008-03-18 ４－アミノメチル安息香酸の製造方法 WO2008114506A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-070142 2007-03-19
JP2007070142 2007-03-19

Publications (1)

Publication Number Publication Date
WO2008114506A1 true WO2008114506A1 (ja) 2008-09-25

Family

ID=39765624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000621 WO2008114506A1 (ja) 2007-03-19 2008-03-18 ４－アミノメチル安息香酸の製造方法

Country Status (2)

Country Link
TW (1) TW200900376A (ja)
WO (1) WO2008114506A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011087211A3 (ko) * 2010-01-14 2011-11-17 주식회사 네이퓨 4-아미노메틸벤조산의 제조방법
US8597683B2 (en) 2010-11-30 2013-12-03 Watson Pharmaceuticals, Inc. Modified release tranexamic acid formulation
KR101359230B1 (ko) 2012-02-29 2014-02-07 한국화학연구원 4-아미노메틸사이클로헥산 카르복실산의 제조방법
CN108484426A (zh) * 2018-05-15 2018-09-04 常州兰陵制药有限公司 氨甲苯酸的合成方法
WO2021107047A1 (ja) * 2019-11-29 2021-06-03 株式会社Ｄｎｐファインケミカル ４－（アミノメチル）シクロヘキサンカルボン酸の製造方法
CN113717054A (zh) * 2020-05-25 2021-11-30 中国科学院大连化学物理研究所 一种醛还原胺化制备伯胺的方法
WO2023037992A1 (ja) * 2021-09-07 2023-03-16 三菱瓦斯化学株式会社 化合物の製造方法
WO2023080106A1 (ja) * 2021-11-08 2023-05-11 三菱瓦斯化学株式会社 芳香環を含むアミンの製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111790444B (zh) * 2020-06-18 2022-11-22 安徽禾宸化学科技有限公司 一种离子树脂基催化剂及其催化合成氨甲苯酸的方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
JPS5088042A (ja) * 1973-12-07 1975-07-15
JPS59190954A (ja) * 1983-04-13 1984-10-29 メルク　エンド　カムパニー　インコーポレーテッド 抗炎症剤としてのヒドロキシベンジルアミノ誘導体
WO2005025504A2 (en) * 2003-09-12 2005-03-24 Kemia, Inc. Modulators of calcitonin and amylin activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5088042A (ja) * 1973-12-07 1975-07-15
JPS59190954A (ja) * 1983-04-13 1984-10-29 メルク　エンド　カムパニー　インコーポレーテッド 抗炎症剤としてのヒドロキシベンジルアミノ誘導体
WO2005025504A2 (en) * 2003-09-12 2005-03-24 Kemia, Inc. Modulators of calcitonin and amylin activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLERICI A. ET AL.: "Efficient Acetalisation of Aldehyde Catalyzed by Titanium Tetrachloride in a Basic Medium", TETRAHEDRON, vol. 54, no. 51, 1998, pages 15679 - 15690, XP004144145 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011087211A3 (ko) * 2010-01-14 2011-11-17 주식회사 네이퓨 4-아미노메틸벤조산의 제조방법
CN102791677A (zh) * 2010-01-14 2012-11-21 Naf株式会社 4-氨基甲基苯甲酸的制备方法
CN102791677B (zh) * 2010-01-14 2014-12-03 Naf株式会社 4-氨基甲基苯甲酸的制备方法
US8907127B2 (en) 2010-01-14 2014-12-09 Naf Co Ltd Preparation method of 4-aminomethylbenzoic acid
US8597683B2 (en) 2010-11-30 2013-12-03 Watson Pharmaceuticals, Inc. Modified release tranexamic acid formulation
US9387178B2 (en) 2010-11-30 2016-07-12 Actavis, Inc. Modified release tranexamic acid formulation
KR101359230B1 (ko) 2012-02-29 2014-02-07 한국화학연구원 4-아미노메틸사이클로헥산 카르복실산의 제조방법
CN108484426A (zh) * 2018-05-15 2018-09-04 常州兰陵制药有限公司 氨甲苯酸的合成方法
WO2021107047A1 (ja) * 2019-11-29 2021-06-03 株式会社Ｄｎｐファインケミカル ４－（アミノメチル）シクロヘキサンカルボン酸の製造方法
CN113717054A (zh) * 2020-05-25 2021-11-30 中国科学院大连化学物理研究所 一种醛还原胺化制备伯胺的方法
WO2023037992A1 (ja) * 2021-09-07 2023-03-16 三菱瓦斯化学株式会社 化合物の製造方法
WO2023080106A1 (ja) * 2021-11-08 2023-05-11 三菱瓦斯化学株式会社 芳香環を含むアミンの製造方法

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Publication number Publication date
TW200900376A (en) 2009-01-01

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