BR0208265A - Redução estereosseletiva de acetofenona substituìda - Google Patents

Redução estereosseletiva de acetofenona substituìda

Info

Publication number
BR0208265A
BR0208265A BR0208265-9A BR0208265A BR0208265A BR 0208265 A BR0208265 A BR 0208265A BR 0208265 A BR0208265 A BR 0208265A BR 0208265 A BR0208265 A BR 0208265A
Authority
BR
Brazil
Prior art keywords
stereoselective reduction
substituted acetophenone
useful
stereoselective
substituted
Prior art date
Application number
BR0208265-9A
Other languages
English (en)
Inventor
Ramesh Patel
Animesh Goswami
Linda Chu
Venkata Nanduri
Steven Goldberg
Robert Johnston
Mary Jo Donovan
K David Mirfakhrae
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0208265A publication Critical patent/BR0208265A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/938—Pichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"REDUçãO ESTEREOSSELETIVA DE ACETOFENONA SUBSTITUìDA". A presente invenção refere-se a processos estereosseletivos inovadores para a preparação de (S) -aril-etanóis pela redução dos compostos correspondentes que contêm o grupo ceto, por microorganismos. Os (S)-aril-etanóis são úteis como intermediários na síntese de compostos que são inibidores de <sym>-secretase, úteis no tratamento da doença de Alzheimer.
BR0208265-9A 2001-03-22 2002-03-06 Redução estereosseletiva de acetofenona substituìda BR0208265A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27802501P 2001-03-22 2001-03-22
PCT/US2002/006783 WO2002077258A1 (en) 2001-03-22 2002-03-06 Stereoselective reduction of substituted acetophenone

Publications (1)

Publication Number Publication Date
BR0208265A true BR0208265A (pt) 2004-03-02

Family

ID=23063377

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208265-9A BR0208265A (pt) 2001-03-22 2002-03-06 Redução estereosseletiva de acetofenona substituìda

Country Status (13)

Country Link
US (1) US6800477B2 (pt)
EP (1) EP1370677A1 (pt)
JP (1) JP2004532017A (pt)
KR (1) KR20030085012A (pt)
CN (1) CN1498273A (pt)
BR (1) BR0208265A (pt)
CA (1) CA2441267A1 (pt)
CZ (1) CZ20032496A3 (pt)
HU (1) HUP0400261A3 (pt)
IL (1) IL157386A0 (pt)
MX (1) MXPA03008437A (pt)
PL (1) PL364577A1 (pt)
WO (1) WO2002077258A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003032994A2 (de) * 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
JP2008510791A (ja) * 2004-08-26 2008-04-10 ファイザー・インク プロテインチロシンキナーゼ阻害薬中間体の調製のためのエナンチオ選択性生体内変換
WO2007084625A2 (en) * 2006-01-19 2007-07-26 Mount Sinai School Of Medicine Novel compounds and methods for inhibiting p53 activity
EP2066788B1 (en) 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
KR101502634B1 (ko) * 2007-02-08 2015-03-16 코덱시스, 인코포레이티드 케토 환원 효소 및 이의 용도
EP2195443B1 (en) 2007-08-24 2015-01-07 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
JP5973131B2 (ja) 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
KR20100061571A (ko) * 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
SI2205727T1 (sl) 2007-10-01 2015-09-30 Codexis, Inc. Polipeptidi ketoreduktaze za izdelavo azetidinona
WO2010027710A2 (en) * 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
EP2329014B1 (en) 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
ES2541590T3 (es) * 2009-06-22 2015-07-22 Sk Biopharmaceuticals Co., Ltd. Método para la preparación de éster (R)-1-aril-2-tetrazolil-etílico de ácido carbámico
EP2446025B1 (en) * 2009-06-22 2018-08-08 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
SG10201405022PA (en) 2009-08-19 2014-10-30 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en) * 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
US20130289276A1 (en) * 2010-10-08 2013-10-31 Cadila Healthcare Limited Process for preparing an intermediate of sitagliptin via enzymatic conversion
EP2780448B1 (en) 2011-11-18 2019-09-11 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
EP3615058A4 (en) 2017-04-27 2021-06-02 Codexis, Inc. KETOREDUCTASE-POLYPEPTIDES AND POLYNUCLEOTIDES
CN107686447A (zh) * 2017-08-25 2018-02-13 许昌恒生制药有限公司 一种替格瑞洛中间体的制备方法
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
MX2023011482A (es) 2021-04-02 2023-10-03 Genentech Inc Proceso para preparar compuestos de cetona biciclicos.
WO2024150146A1 (en) 2023-01-12 2024-07-18 Novartis Ag Engineered ketoreductase polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538693A3 (en) 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
DE59306681D1 (de) * 1992-03-13 1997-07-10 Forschungszentrum Juelich Gmbh Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
WO1999023242A1 (en) 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast

Also Published As

Publication number Publication date
US6800477B2 (en) 2004-10-05
CA2441267A1 (en) 2002-10-03
HUP0400261A3 (en) 2005-11-28
MXPA03008437A (es) 2004-01-29
KR20030085012A (ko) 2003-11-01
PL364577A1 (en) 2004-12-13
EP1370677A1 (en) 2003-12-17
CN1498273A (zh) 2004-05-19
CZ20032496A3 (cs) 2003-12-17
JP2004532017A (ja) 2004-10-21
HUP0400261A2 (hu) 2004-09-28
WO2002077258A1 (en) 2002-10-03
US20030068811A1 (en) 2003-04-10
IL157386A0 (en) 2004-02-19

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010.