CL2010000823A1 - Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). - Google Patents
Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06).Info
- Publication number
- CL2010000823A1 CL2010000823A1 CL2010000823A CL2010000823A CL2010000823A1 CL 2010000823 A1 CL2010000823 A1 CL 2010000823A1 CL 2010000823 A CL2010000823 A CL 2010000823A CL 2010000823 A CL2010000823 A CL 2010000823A CL 2010000823 A1 CL2010000823 A1 CL 2010000823A1
- Authority
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- Chile
- Prior art keywords
- antibody
- vector
- pharmaceutical composition
- producing
- div
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71145405P | 2005-08-26 | 2005-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2010000823A1 true CL2010000823A1 (es) | 2011-01-07 |
Family
ID=37865318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2010000823A CL2010000823A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). |
| CL2010000822A CL2010000822A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2010000822A CL2010000822A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06). |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20070071745A1 (enExample) |
| EP (3) | EP1931712B1 (enExample) |
| JP (3) | JP5373396B2 (enExample) |
| KR (2) | KR101460932B1 (enExample) |
| CN (2) | CN101291954B (enExample) |
| AR (1) | AR055137A1 (enExample) |
| AU (1) | AU2006290433B2 (enExample) |
| BR (2) | BRPI0615397B1 (enExample) |
| CA (1) | CA2619298C (enExample) |
| CL (2) | CL2010000823A1 (enExample) |
| IL (1) | IL189756A (enExample) |
| NO (2) | NO345919B1 (enExample) |
| PH (1) | PH12012502376B1 (enExample) |
| RU (2) | RU2547931C2 (enExample) |
| SG (1) | SG192479A1 (enExample) |
| TW (2) | TWI478940B (enExample) |
| WO (1) | WO2007031875A2 (enExample) |
| ZA (1) | ZA200802500B (enExample) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1423510A4 (en) | 2001-08-03 | 2005-06-01 | Glycart Biotechnology Ag | ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY |
| EP2365001A3 (en) | 2003-05-01 | 2012-03-28 | Imclone LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| HUE038955T2 (hu) * | 2003-11-05 | 2018-12-28 | Roche Glycart Ag | Antigén-kötõ molekulák fokozott Fc receptor-kötõ affinitással és effektor funkcióval |
| BRPI0607315B1 (pt) | 2005-02-07 | 2022-05-17 | Roche Glycart Ag | Molécula de ligação ao antígeno anti-egfr humanizada e seus usos, composição farmacêutica, e método para detectar a presença de egfr em uma amostra |
| CA2678008C (en) | 2005-06-17 | 2013-07-30 | Imclone Systems Incorporated | Methods of treating a secondary bone tumor with anti-pdgfralpha antibodies |
| AU2006290433B2 (en) * | 2005-08-26 | 2012-06-07 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
| AU2007212447B2 (en) | 2006-02-03 | 2013-02-21 | Imclone Llc | IGF-IR antagonists as adjuvants for treatment of prostate cancer |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| NZ581468A (en) | 2007-06-25 | 2012-09-28 | Esbatech Alcon Biomed Res Unit | Methods of modifying antibodies, and modified antibodies with improved functional properties |
| US20110243931A1 (en) * | 2007-09-02 | 2011-10-06 | Thomas Friess | Combination therapy with type i and type ii anti-cd20 antibodies |
| US20090098118A1 (en) | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| US20090110688A1 (en) * | 2007-10-24 | 2009-04-30 | Georg Fertig | Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor |
| KR20100102172A (ko) * | 2007-12-21 | 2010-09-20 | 제넨테크, 인크. | 리툭시마브-난치성 류마티스성 관절염 환자의 요법 |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| MX2010010027A (es) * | 2008-03-13 | 2011-05-02 | Biotest Ag | Agente para tratar enfermedad. |
| EP2262838B1 (en) * | 2008-03-13 | 2016-04-13 | Biotest AG | Agent for treating disease |
| RU2539110C2 (ru) * | 2008-03-13 | 2015-01-10 | Биотест Аг | Способ лечения аутоиммунного заболевания (варианты) |
| BRPI0909227B8 (pt) * | 2008-03-25 | 2021-05-25 | Roche Glycart Ag | uso de um anticorpo b-ly1 humanizado e um ou mais agentes quimioterápicos selecionados do grupo consistindo em ciclofosfamida,vincristina e doxorubicina para a fabricação de um medicamento para o tratamento de um linfoma não hodgkin de células b (nhl) |
| EP2282769A4 (en) * | 2008-04-29 | 2012-04-25 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
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