CL2010000823A1 - Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). - Google Patents
Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06).Info
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract
UN ANTICUERPO ANTI-CD20 MODIFICADO, QUE COMPRENDE UNA REGIÓN VARIABLE DE CADENA PESADA QUE CONTIENE AL MENOS UNA SUSTITUCIÓN EN LA REGIÓN FR1 DE LA REGIÓN VARIABLE DE CADENA PESADA DONDE DICHO FR1 COMPRENDE UNA SECUENCIA DE AMINOÁCIDOS EN LAS POSICIONES KABAT 8 A 13 DE LA SEQ ID NO: 63, Y DONDE DICHO ANTICUERPO MODIFICADO INDUCE MAYORES NIVELES DE APOPTOSIS CUANDO FORMA UN COMPLEJO CON CD20 RESPECTO DEL COMPLEJO CON EL ANTICUERPO MURINO B-LY1, Y DONDE DICHO ANTICUERPO MODIFICADO COMPRENDE: UN PRIMER Y SEGUNDO POLIPÉPTIDOS AISLADOS DEFINIDOS EN EL PLIEGO DE REIVINDICACIONES. UNA CÉLULA HUÉSPED QUE LO PRODUCE. UNA<br /> COMPOSICIÓN FARMACÉUTICA, QUE COMPRENDE A DICHO ANTICUERPO, ÚTIL PARA TRATAR DESÓRDENES QUE RESPONDEN AL AGOTAMIENTO DE CÉLULAS B. UN POLINUCLEÓTIDO AISLADO QUE CODIFICA LA SECUENCIA DE REGIÓN VARIABLE DE CADENA LIVIANA DEL ANTICUERPO, UN VECTOR DE EXPRESIÓN Y UNA CÉLULA HUÉSPED QUE COMPRENDE A DICHO VECTOR. UN MÉTODO PARA PRODUCIR EL ANTICUERPO EN UNA CÉLULA HUÉSPED QUE COMPRENDE CULTIVAR UNA CÉLULA HUÉSPED GENÉTICAMENTE MODIFICADA Y AISLAR DICHO ANTICUERPO.<br />
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71145405P | 2005-08-26 | 2005-08-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2010000823A1 true CL2010000823A1 (es) | 2011-01-07 |
Family
ID=37865318
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2010000822A CL2010000822A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06). |
CL2010000823A CL2010000823A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo anti-cd-20 con actividad apoptotica; polinucleotido, vector y celula huesped que expresa el anticuerpo; composicion farmaceutica que lo comprende; usos en la preparacion de un medicamento para tratar cancer o una enfermedad autoinmune; metodo para producir dicho anticuerpo (div. sol. n°2246-06). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2010000822A CL2010000822A1 (es) | 2005-08-26 | 2010-07-30 | Anticuerpo humanizado anti-cd20 el cual induce mayores niveles de apoptosis cuando esta formando un complejo con cd20, en comparacion al anticuerpo parental; composición farmaceutica; uso para tratar desordenes que responden a la eliminación de células b; polinucleotido codificante; vector, célula huésped; método de producción. (divisional solicitud n° 2246-06). |
Country Status (19)
Country | Link |
---|---|
US (2) | US20070071745A1 (es) |
EP (3) | EP2395023B1 (es) |
JP (3) | JP5373396B2 (es) |
KR (2) | KR101460932B1 (es) |
CN (2) | CN101291954B (es) |
AR (1) | AR055137A1 (es) |
AU (1) | AU2006290433B2 (es) |
BR (2) | BR122020020335B1 (es) |
CA (1) | CA2619298C (es) |
CL (2) | CL2010000822A1 (es) |
HK (1) | HK1185357A1 (es) |
IL (1) | IL189756A (es) |
NO (2) | NO345919B1 (es) |
PH (1) | PH12012502376A1 (es) |
RU (2) | RU2482132C2 (es) |
SG (1) | SG192479A1 (es) |
TW (2) | TWI615407B (es) |
WO (1) | WO2007031875A2 (es) |
ZA (1) | ZA200802500B (es) |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA04001072A (es) | 2001-08-03 | 2005-02-17 | Glycart Biotechnology Ag | Variantes de glicosilacion de anticuerpos que tienen citotoxicidad celulares dependiente de anticuerpos incrementada. |
US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
CA2544865C (en) * | 2003-11-05 | 2019-07-09 | Glycart Biotechnology Ag | Cd20 antibodies with increased fc receptor binding affinity and effector function |
KR101569300B1 (ko) | 2005-02-07 | 2015-11-13 | 로슈 글리카트 아게 | Egfr 에 결합하는 항원 결합 분자, 이를 코딩하는 벡터, 및 그의 용도 |
RU2502523C2 (ru) | 2005-06-17 | 2013-12-27 | Имклоун Элэлси | АНТИТЕЛА ПРОТИВ PDGFRα ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОЙ ОПУХОЛИ КОСТИ |
RU2482132C2 (ru) * | 2005-08-26 | 2013-05-20 | Роше Гликарт Аг | Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью |
EA017265B1 (ru) | 2006-02-03 | 2012-11-30 | Имклоун Элэлси | Применение антитела imc-a12, которое является ингибитором igf-ir, для лечения рака предстательной железы |
AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
CN102838673B (zh) | 2007-06-25 | 2016-05-11 | 艾斯巴技术-诺华有限责任公司 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
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