AU2006290433B2 - Modified antigen binding molecules with altered cell signaling activity - Google Patents

Modified antigen binding molecules with altered cell signaling activity Download PDF

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Publication number
AU2006290433B2
AU2006290433B2 AU2006290433A AU2006290433A AU2006290433B2 AU 2006290433 B2 AU2006290433 B2 AU 2006290433B2 AU 2006290433 A AU2006290433 A AU 2006290433A AU 2006290433 A AU2006290433 A AU 2006290433A AU 2006290433 B2 AU2006290433 B2 AU 2006290433B2
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Australia
Prior art keywords
antibody
antigen binding
binding fragment
modified
region
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AU2006290433A
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AU2006290433A1 (en
Inventor
Ekkehard Mossner
Pablo Umana
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Roche Glycart AG
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Roche Glycart AG
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Application filed by Roche Glycart AG filed Critical Roche Glycart AG
Publication of AU2006290433A1 publication Critical patent/AU2006290433A1/en
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Publication of AU2006290433B2 publication Critical patent/AU2006290433B2/en
Assigned to ROCHE GLYCART AG reassignment ROCHE GLYCART AG Alteration of Name(s) of Applicant(s) under S113 Assignors: GLYCART BIOTECHNOLOGY AG
Priority to AU2012216702A priority Critical patent/AU2012216702B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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AU2006290433A 2005-08-26 2006-08-25 Modified antigen binding molecules with altered cell signaling activity Active AU2006290433B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012216702A AU2012216702B2 (en) 2005-08-26 2012-09-06 Modified antigen binding molecules with altered cell signaling activity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71145405P 2005-08-26 2005-08-26
US60/711,454 2005-08-26
PCT/IB2006/003294 WO2007031875A2 (en) 2005-08-26 2006-08-25 Modified antigen binding molecules with altered cell signaling activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012216702A Division AU2012216702B2 (en) 2005-08-26 2012-09-06 Modified antigen binding molecules with altered cell signaling activity

Publications (2)

Publication Number Publication Date
AU2006290433A1 AU2006290433A1 (en) 2007-03-22
AU2006290433B2 true AU2006290433B2 (en) 2012-06-07

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ID=37865318

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AU2006290433A Active AU2006290433B2 (en) 2005-08-26 2006-08-25 Modified antigen binding molecules with altered cell signaling activity

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US (2) US20070071745A1 (enExample)
EP (3) EP2395024B1 (enExample)
JP (3) JP5373396B2 (enExample)
KR (2) KR101460932B1 (enExample)
CN (2) CN101291954B (enExample)
AR (1) AR055137A1 (enExample)
AU (1) AU2006290433B2 (enExample)
BR (2) BRPI0615397B1 (enExample)
CA (1) CA2619298C (enExample)
CL (2) CL2010000823A1 (enExample)
IL (1) IL189756A (enExample)
NO (2) NO345919B1 (enExample)
PH (1) PH12012502376B1 (enExample)
RU (2) RU2547931C2 (enExample)
SG (1) SG192479A1 (enExample)
TW (2) TWI615407B (enExample)
WO (1) WO2007031875A2 (enExample)
ZA (1) ZA200802500B (enExample)

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KR20100018071A (ko) 2001-08-03 2010-02-16 글리카트 바이오테크놀로지 아게 항체 의존적 세포 독성이 증가된 항체 글리코실화 변이체
JP2007535895A (ja) 2003-05-01 2007-12-13 イムクローン システムズ インコーポレイティド ヒトインシュリン様成長因子−１受容体に対する完全ヒト抗体
RS54450B1 (sr) 2003-11-05 2016-06-30 Roche Glycart Ag Molekuli koji se vezuju za antigen sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
NZ556286A (en) 2005-02-07 2010-11-26 Glycart Biotechnology Ag Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
PL2100618T3 (pl) 2005-06-17 2014-07-31 Imclone Llc Przeciwciało anty-PDGFR alfa do zastosowania w leczeniu przerzutowego raka kości
TWI615407B (zh) * 2005-08-26 2018-02-21 羅齊克雷雅公司 具有經改變細胞傳訊活性之改質抗原結合分子
AP2008004569A0 (en) 2006-02-03 2008-08-31 Imclone Systems Inc IGR-IR antagonists as adjuvants for treatment of prostrate cancer
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
PL2158315T3 (pl) 2007-06-25 2016-10-31 Sposoby modyfikowania przeciwciał i zmodyfikowane przeciwciała o ulepszonych właściwościach funkcjonalnych
BRPI0816458A2 (pt) 2007-09-05 2013-03-12 Hoffmann La Roche terapia combinada com anticorpos anti-cd20 tipo i e tipo ii
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090110688A1 (en) * 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
JP2011507897A (ja) * 2007-12-21 2011-03-10 ジェネンテック， インコーポレイテッド リツキシマブ抵抗性関節リウマチ患者の治療
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
AU2009235622C9 (en) * 2008-03-13 2015-07-02 Biotest Ag Agent for treating disease
AU2009231325B2 (en) * 2008-03-13 2014-09-18 Biotest Ag Agent for treating disease
CA2717812A1 (en) * 2008-03-13 2009-09-17 Biotest Ag Agent for treating disease
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