CH626045A5 - - Google Patents

Download PDF

Info

Publication number
CH626045A5
CH626045A5 CH32779A CH32779A CH626045A5 CH 626045 A5 CH626045 A5 CH 626045A5 CH 32779 A CH32779 A CH 32779A CH 32779 A CH32779 A CH 32779A CH 626045 A5 CH626045 A5 CH 626045A5
Authority
CH
Switzerland
Prior art keywords
formula
spiro
amine
group
carbon atoms
Prior art date
Application number
CH32779A
Other languages
German (de)
English (en)
Inventor
Barbro Ka Goeransson-Dahlander
Nils Ake Joensson
Ferenc Merenyi
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of CH626045A5 publication Critical patent/CH626045A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/675Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having three rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
CH32779A 1972-03-24 1979-01-12 CH626045A5 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7203905A SE371190B (fi) 1972-03-24 1972-03-24

Publications (1)

Publication Number Publication Date
CH626045A5 true CH626045A5 (fi) 1981-10-30

Family

ID=20263107

Family Applications (4)

Application Number Title Priority Date Filing Date
CH428173A CH621110A5 (fi) 1972-03-24 1973-03-23
CH32579A CH626044A5 (fi) 1972-03-24 1979-01-12
CH32679A CH622769A5 (fi) 1972-03-24 1979-01-12
CH32779A CH626045A5 (fi) 1972-03-24 1979-01-12

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CH428173A CH621110A5 (fi) 1972-03-24 1973-03-23
CH32579A CH626044A5 (fi) 1972-03-24 1979-01-12
CH32679A CH622769A5 (fi) 1972-03-24 1979-01-12

Country Status (12)

Country Link
US (1) US4172093A (fi)
JP (1) JPS599540B2 (fi)
AT (1) AT329045B (fi)
CA (1) CA1032165A (fi)
CH (4) CH621110A5 (fi)
DE (1) DE2314636C2 (fi)
DK (1) DK138598B (fi)
FI (1) FI57253C (fi)
FR (1) FR2177929B1 (fi)
GB (1) GB1421208A (fi)
NO (1) NO138628C (fi)
SE (1) SE371190B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000825B1 (en) * 1977-08-05 1982-04-14 Kabi AB Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them
CH641147A5 (de) * 1979-01-17 1984-02-15 Sandoz Ag 3-amino-2-hydroxypropoxyaryl-derivat, seine herstellung und dieses enthaltende heilmittel.
CH647235A5 (de) * 1980-02-13 1985-01-15 Sandoz Ag 4-(2,2-dialkylindan-1-yliden)piperidin derivate, ihre herstellung und verwendung.
IL103106A (en) * 1991-09-25 1998-06-15 Sanofi Elf Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them
GB9309621D0 (en) * 1993-05-11 1993-06-23 Wellcome Found Amide derivatives and their therapeutic use
US5877218A (en) * 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
MY113062A (en) * 1994-05-10 2001-11-30 The Wellcome Foundation Ltd Amide derivatives and their therapeutic use
EP1535902B1 (en) 1996-12-18 2007-11-07 Teva Pharmaceutical Industries, Ltd. Aminoindan derivatives
US6124284A (en) * 1998-07-16 2000-09-26 Glaxo Wellcome Inc. Bicyclic amide derivatives and their use as muscle relaxants
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
GB0328906D0 (en) 2003-12-12 2004-01-14 Syngenta Participations Ag Chemical compounds
US20070135518A1 (en) * 2005-12-09 2007-06-14 Marta Weinstock-Rosin Use of low-dose ladostigil for neuroprotection
EP1956904B1 (en) * 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1007323B (de) * 1956-04-13 1957-05-02 Schering Ag Verfahren zur Herstellung von 1-Aminoindanen mit coronargefaesserweiternder Wirkung
US3308157A (en) * 1964-08-07 1967-03-07 Colgate Palmolive Co N-(benzocyclobutene-1-loweralkyl)-carboxylic acid amides
US3360435A (en) * 1964-09-15 1967-12-26 Mead Johnson & Co Treatment of depressed states
US3553093A (en) * 1965-03-19 1971-01-05 Xerox Corp Color photoelectrophoretic imaging process
GB1139135A (en) * 1965-10-01 1969-01-08 Kefalas As Aminoalkyl-substituted indanes and pharmaceutical compositions containing them
US3657440A (en) * 1968-04-23 1972-04-18 Ciba Geigy Corp Aminoalkyl-spirocycloalkanes as analgetic agents
CH529097A (de) * 1968-04-23 1972-10-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Aminoalkylspirocycloalkanen

Also Published As

Publication number Publication date
JPS599540B2 (ja) 1984-03-03
FR2177929A1 (fi) 1973-11-09
JPS495957A (fi) 1974-01-19
CA1032165A (en) 1978-05-30
NO138628B (no) 1978-07-03
SE371190B (fi) 1974-11-11
DE2314636C2 (de) 1986-09-11
AT329045B (de) 1976-04-26
AU5365173A (en) 1974-09-26
GB1421208A (en) 1976-01-14
DK138598B (da) 1978-10-02
DE2314636A1 (de) 1973-10-04
FR2177929B1 (fi) 1976-10-22
CH626044A5 (fi) 1981-10-30
DK138598C (fi) 1979-03-26
FI57253C (fi) 1980-07-10
NO138628C (no) 1978-10-11
FI57253B (fi) 1980-03-31
CH622769A5 (fi) 1981-04-30
CH621110A5 (fi) 1981-01-15
US4172093A (en) 1979-10-23
ATA255373A (de) 1975-07-15

Similar Documents

Publication Publication Date Title
CH626045A5 (fi)
CH621115A5 (fi)
DE2047658C3 (de) 2-Styryl- und 2-Phenyläthinylbenzylaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DD149511A5 (de) Verfahren zur herstellung von 9-aminoalkylfluorenen
DE3103372A1 (de) Neue indanyl-derivate, ihre herstellung und verwendung
DE2314639A1 (de) Pharmakodynamisch aktive aminoalkyloximaether
DE2633931A1 (de) Pyrazolderivate, deren salze mit saeuren, verfahren zu ihrer herstellung und arzneipraeparate
AT333743B (de) Verfahren zur herstellung von neuen, basisch substituierten indanderivaten
DE1695962A1 (de) (2-Aminocycloalkyl)hydrochinone und Derivate derselben sowie Verfahren zu ihrer Herstellung
AT333744B (de) Verfahren zur herstellung von neuen, basisch substituierten indenderivaten
DE1151509B (de) Verfahren zur Herstellung von Phenthiazinderivaten
DE1695963A1 (de) Cycloalkenamin-p-benzochinonaddukte und Verfahren zu ihrer Herstellung
DE3718892A1 (de) Polyhydrobenz(c,d)indol-sulfonamide
CH455754A (de) Verfahren zur Herstellung von N-substituierten 1-Phenyl-2-aminopropanen
DE2729817C2 (de) Verfahren zur Herstellung von dl- 6a-10a-cis-1-Hydroxy-3-alkylsubstituierten-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]-pyran-9-onen
DE1793521A1 (de) Verfahren zur Herstellung basisch substituierter Dibenzo-[b,f]-oxepine sowie von deren nichttoxischen Salzen
DE2227922C3 (de) Spiroverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE1695944A1 (de) Verfahren zur Herstellung neuer 1,3-Aminoalkohole
AT266075B (de) Verfahren zur Herstellung von neuen Sulfonaniliden und deren Säureadditions- und Metallsalzen
AT252246B (de) Verfahren zur Herstellung von neuen Hexahydro-11bH-benzo[a]chinolizinen
AT347423B (de) Verfahren zur herstellung von neuen 7- aminobenzocycloheptenen und von deren salzen
AT373255B (de) Verfahren zur herstellung von neuen 5-subst.-10,11-dihydro-5h-dibenzo(a,d)-cyclohep en-5,10-iminen und von deren salzen sowie optischen isomeren
AT381088B (de) Verfahren zur herstellung von neuen aminen und deren salzen
AT372960B (de) Verfahren zur herstellung von neuen 5-subst.-10,11-dihydro-5h-dibenzo(a,d)-cyclohep en-5,10-iminen und von deren salzen sowie optischen isomeren
AT339322B (de) Verfahren zur herstellung von neuen 1,4-disubstituierten piperazin-derivaten und deren saureadditonsverbindungen

Legal Events

Date Code Title Description
PL Patent ceased