CH616421A5 - - Google Patents

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Publication number
CH616421A5
CH616421A5 CH393579A CH393579A CH616421A5 CH 616421 A5 CH616421 A5 CH 616421A5 CH 393579 A CH393579 A CH 393579A CH 393579 A CH393579 A CH 393579A CH 616421 A5 CH616421 A5 CH 616421A5
Authority
CH
Switzerland
Prior art keywords
compounds
formula
tetrahydrofurfuryl
acid
benzomorphan
Prior art date
Application number
CH393579A
Other languages
German (de)
English (en)
Inventor
Herbert Dr Merz
Adolf Dr Langbein
Gerhard Dr Walther
Klaus Dr Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of CH616421A5 publication Critical patent/CH616421A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH393579A 1974-08-05 1979-04-26 CH616421A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
CH616421A5 true CH616421A5 (fr) 1980-03-31

Family

ID=5922448

Family Applications (7)

Application Number Title Priority Date Filing Date
CH1002475A CH613963A5 (fr) 1974-08-05 1975-07-31
CH393179A CH615677A5 (fr) 1974-08-05 1979-04-26
CH393679A CH615680A5 (fr) 1974-08-05 1979-04-26
CH393579A CH616421A5 (fr) 1974-08-05 1979-04-26
CH393279A CH615678A5 (fr) 1974-08-05 1979-04-26
CH393479A CH615679A5 (fr) 1974-08-05 1979-04-26
CH393379A CH616420A5 (fr) 1974-08-05 1979-04-26

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CH1002475A CH613963A5 (fr) 1974-08-05 1975-07-31
CH393179A CH615677A5 (fr) 1974-08-05 1979-04-26
CH393679A CH615680A5 (fr) 1974-08-05 1979-04-26

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH393279A CH615678A5 (fr) 1974-08-05 1979-04-26
CH393479A CH615679A5 (fr) 1974-08-05 1979-04-26
CH393379A CH616420A5 (fr) 1974-08-05 1979-04-26

Country Status (27)

Country Link
US (1) US3982005A (fr)
JP (1) JPS60358B2 (fr)
AT (1) AT348140B (fr)
BE (1) BE832099R (fr)
BG (3) BG25090A3 (fr)
CA (1) CA1049008A (fr)
CH (7) CH613963A5 (fr)
CS (1) CS189717B2 (fr)
DD (1) DD122685A5 (fr)
DE (1) DE2437610A1 (fr)
DK (1) DK138992C (fr)
ES (6) ES452765A1 (fr)
FI (1) FI63229C (fr)
FR (1) FR2320096A2 (fr)
GB (1) GB1513950A (fr)
HU (1) HU177952B (fr)
IE (1) IE42216B1 (fr)
IL (1) IL47860A (fr)
LU (1) LU73138A1 (fr)
NL (1) NL7509249A (fr)
NO (1) NO143460C (fr)
PH (1) PH13687A (fr)
PL (3) PL99819B1 (fr)
RO (3) RO67390A (fr)
SE (1) SE425392B (fr)
SU (3) SU591147A3 (fr)
ZA (1) ZA754997B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
AR067673A1 (es) 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
AR069545A1 (es) 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (fr) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CA2723034A1 (fr) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-beta-hydroxysteroide dehydrogenase 1
ES2421537T3 (es) 2008-05-01 2013-09-03 Vitae Pharmaceuticals Inc Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
PL2324018T3 (pl) 2008-07-25 2014-02-28 Boehringer Ingelheim Int Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
UY33001A (es) * 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (fr) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Dérivés d'indénopyridine
EP4253494A1 (fr) 2020-11-26 2023-10-04 Shin-Etsu Chemical Co., Ltd. Composition d'organopolysiloxane durcissable à température ambiante, article, composé organosilane hydrolysable et son procédé de production
JPWO2023032745A1 (fr) 2021-09-03 2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (fr) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (fr) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
DK138992C (da) 1979-04-30
FI752211A (fr) 1976-02-06
IL47860A0 (en) 1975-11-25
BG25090A3 (en) 1978-07-12
ATA523775A (de) 1978-06-15
DK138992B (da) 1978-11-27
CS189717B2 (en) 1979-04-30
FI63229B (fi) 1983-01-31
DE2437610A1 (de) 1976-02-26
JPS60358B2 (ja) 1985-01-07
AT348140B (de) 1979-01-25
FR2320096A2 (fr) 1977-03-04
BG25088A3 (en) 1978-07-12
GB1513950A (en) 1978-06-14
CH615679A5 (fr) 1980-02-15
SU591147A3 (ru) 1978-01-30
DD122685A5 (fr) 1976-10-20
CH615680A5 (fr) 1980-02-15
IL47860A (en) 1979-01-31
NO143460C (no) 1981-02-18
ES452763A1 (es) 1977-10-01
CH615678A5 (fr) 1980-02-15
CH613963A5 (fr) 1979-10-31
JPS5139673A (en) 1976-04-02
PL99816B1 (pl) 1978-08-31
ES452768A1 (es) 1977-10-01
ES452765A1 (es) 1977-10-16
NO143460B (no) 1980-11-10
NO752731L (fr) 1976-02-06
SU587859A3 (ru) 1978-01-05
ES452764A1 (es) 1977-10-16
PL99819B1 (pl) 1978-08-31
BG25089A3 (en) 1978-07-12
FI63229C (fi) 1983-05-10
ZA754997B (en) 1977-04-27
HU177952B (en) 1982-02-28
ES452767A1 (es) 1977-10-01
DK352875A (da) 1976-02-06
PL99838B1 (pl) 1978-08-31
CH616420A5 (fr) 1980-03-31
NL7509249A (nl) 1976-02-09
US3982005A (en) 1976-09-21
AU8364675A (en) 1977-02-10
CA1049008A (fr) 1979-02-20
BE832099R (fr) 1976-02-04
ES452766A1 (es) 1977-10-01
LU73138A1 (fr) 1977-04-13
RO72735A (fr) 1982-09-09
SE425392B (sv) 1982-09-27
SE7508789L (sv) 1976-02-10
IE42216B1 (en) 1980-07-02
PH13687A (en) 1980-09-01
RO67390A (fr) 1981-06-30
RO72736A (fr) 1982-09-09
SU587858A3 (ru) 1978-01-05
CH615677A5 (fr) 1980-02-15
FR2320096B2 (fr) 1978-09-01
IE42216L (en) 1976-02-05

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Legal Events

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PL Patent ceased