ATA523775A - Verfahren zur herstellung neuer, 5,9-beta-disubstituierter 2-tetrahydrofurfuryl-6,7-benzomorphane und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung neuer, 5,9-beta-disubstituierter 2-tetrahydrofurfuryl-6,7-benzomorphane und deren saeureadditionssalzen

Info

Publication number
ATA523775A
ATA523775A AT523775A AT523775A ATA523775A AT A523775 A ATA523775 A AT A523775A AT 523775 A AT523775 A AT 523775A AT 523775 A AT523775 A AT 523775A AT A523775 A ATA523775 A AT A523775A
Authority
AT
Austria
Prior art keywords
benzomorphanes
tetrahydrofurfuryl
disubstituted
beta
acid addition
Prior art date
Application number
AT523775A
Other languages
English (en)
Other versions
AT348140B (de
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of ATA523775A publication Critical patent/ATA523775A/de
Application granted granted Critical
Publication of AT348140B publication Critical patent/AT348140B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT523775A 1974-08-05 1975-07-08 Verfahren zur herstellung neuer, 5,9-beta- disubstituierter 2-tetrahydrofurfuryl-6,7-benzomorphane und deren saeureadditionssalzen AT348140B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ATA523775A true ATA523775A (de) 1978-06-15
AT348140B AT348140B (de) 1979-01-25

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT523775A AT348140B (de) 1974-08-05 1975-07-08 Verfahren zur herstellung neuer, 5,9-beta- disubstituierter 2-tetrahydrofurfuryl-6,7-benzomorphane und deren saeureadditionssalzen

Country Status (27)

Country Link
US (1) US3982005A (de)
JP (1) JPS60358B2 (de)
AT (1) AT348140B (de)
BE (1) BE832099R (de)
BG (3) BG25089A3 (de)
CA (1) CA1049008A (de)
CH (7) CH613963A5 (de)
CS (1) CS189717B2 (de)
DD (1) DD122685A5 (de)
DE (1) DE2437610A1 (de)
DK (1) DK138992C (de)
ES (6) ES452766A1 (de)
FI (1) FI63229C (de)
FR (1) FR2320096A2 (de)
GB (1) GB1513950A (de)
HU (1) HU177952B (de)
IE (1) IE42216B1 (de)
IL (1) IL47860A (de)
LU (1) LU73138A1 (de)
NL (1) NL7509249A (de)
NO (1) NO143460C (de)
PH (1) PH13687A (de)
PL (3) PL99838B1 (de)
RO (3) RO67390A (de)
SE (1) SE425392B (de)
SU (3) SU591147A3 (de)
ZA (1) ZA754997B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
ATE554078T1 (de) 2007-07-26 2012-05-15 Vitae Pharmaceuticals Inc Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern
WO2009063061A2 (en) 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
EP2254872A2 (de) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyllactamderivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
EP2300461B1 (de) 2008-05-01 2013-04-17 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2724214A1 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
DK2324018T3 (da) 2008-07-25 2013-10-14 Boehringer Ingelheim Int Cykliske inhibitorer af 11 beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
EP2440537A1 (de) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclische hemmer der 11beta-hydroxysteroiddehydrogenase 1 auf basis der 1,3 -oxazinan- 2 -on-struktur
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
WO2022113437A1 (ja) 2020-11-26 2022-06-02 信越化学工業株式会社 室温硬化性オルガノポリシロキサン組成物及び物品並びに加水分解性オルガノシラン化合物及びその製造方法
JPWO2023032745A1 (de) 2021-09-03 2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (de) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (de) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
AT348140B (de) 1979-01-25
ES452768A1 (es) 1977-10-01
SU587858A3 (ru) 1978-01-05
DK352875A (da) 1976-02-06
HU177952B (en) 1982-02-28
JPS60358B2 (ja) 1985-01-07
ZA754997B (en) 1977-04-27
PL99816B1 (pl) 1978-08-31
FR2320096B2 (de) 1978-09-01
CA1049008A (en) 1979-02-20
CH615677A5 (de) 1980-02-15
BG25090A3 (en) 1978-07-12
SE7508789L (sv) 1976-02-10
SU587859A3 (ru) 1978-01-05
IL47860A0 (en) 1975-11-25
CH613963A5 (de) 1979-10-31
LU73138A1 (de) 1977-04-13
CH615678A5 (de) 1980-02-15
DD122685A5 (de) 1976-10-20
CH616421A5 (de) 1980-03-31
NL7509249A (nl) 1976-02-09
DE2437610A1 (de) 1976-02-26
FI63229B (fi) 1983-01-31
BE832099R (fr) 1976-02-04
ES452765A1 (es) 1977-10-16
US3982005A (en) 1976-09-21
CH615679A5 (de) 1980-02-15
DK138992C (da) 1979-04-30
ES452764A1 (es) 1977-10-16
NO143460C (no) 1981-02-18
RO72736A (ro) 1982-09-09
CH616420A5 (de) 1980-03-31
ES452763A1 (es) 1977-10-01
PL99819B1 (pl) 1978-08-31
DK138992B (da) 1978-11-27
JPS5139673A (en) 1976-04-02
NO143460B (no) 1980-11-10
NO752731L (de) 1976-02-06
GB1513950A (en) 1978-06-14
CH615680A5 (de) 1980-02-15
BG25088A3 (en) 1978-07-12
BG25089A3 (en) 1978-07-12
FR2320096A2 (fr) 1977-03-04
ES452766A1 (es) 1977-10-01
IE42216B1 (en) 1980-07-02
PL99838B1 (pl) 1978-08-31
SE425392B (sv) 1982-09-27
FI63229C (fi) 1983-05-10
IE42216L (en) 1976-02-05
IL47860A (en) 1979-01-31
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
ES452767A1 (es) 1977-10-01
SU591147A3 (ru) 1978-01-30
AU8364675A (en) 1977-02-10
FI752211A (de) 1976-02-06
CS189717B2 (en) 1979-04-30
RO72735A (ro) 1982-09-09

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Legal Events

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ELJ Ceased due to non-payment of the annual fee