AT350737B - Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen - Google Patents

Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen

Info

Publication number
AT350737B
AT350737B AT553976A AT553976A AT350737B AT 350737 B AT350737 B AT 350737B AT 553976 A AT553976 A AT 553976A AT 553976 A AT553976 A AT 553976A AT 350737 B AT350737 B AT 350737B
Authority
AT
Austria
Prior art keywords
noroxymorphones
furfuryl
tetrahydro
acid addition
addition salts
Prior art date
Application number
AT553976A
Other languages
English (en)
Other versions
ATA553976A (de
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to AT605678A priority Critical patent/AT358196B/de
Priority to AT605578A priority patent/AT358195B/de
Priority to AT605378A priority patent/AT358193B/de
Priority to AT605478A priority patent/AT358194B/de
Publication of ATA553976A publication Critical patent/ATA553976A/de
Application granted granted Critical
Publication of AT350737B publication Critical patent/AT350737B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT553976A 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen AT350737B (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT605678A AT358196B (de) 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen
AT605578A AT358195B (de) 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen
AT605378A AT358193B (de) 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen
AT605478A AT358194B (de) 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752538075 DE2538075A1 (de) 1975-08-27 1975-08-27 N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ATA553976A ATA553976A (de) 1978-11-15
AT350737B true AT350737B (de) 1979-06-11

Family

ID=5954931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT553976A AT350737B (de) 1975-08-27 1976-07-28 Verfahren zur herstellung neuer n-tetrahydro- furfuryl-noroxymorphone und deren saeure- additionssalzen

Country Status (33)

Country Link
US (1) US4100288A (de)
JP (1) JPS5231100A (de)
AT (1) AT350737B (de)
AU (1) AU499926B2 (de)
BE (1) BE845563A (de)
BG (2) BG27545A3 (de)
CA (1) CA1068266A (de)
CH (5) CH622521A5 (de)
CS (2) CS192599B2 (de)
DD (1) DD127145A5 (de)
DE (1) DE2538075A1 (de)
DK (1) DK143278C (de)
ES (5) ES450897A1 (de)
FI (1) FI762430A (de)
FR (1) FR2321888A1 (de)
GB (1) GB1519719A (de)
GR (1) GR61158B (de)
HU (1) HU176929B (de)
IE (1) IE44069B1 (de)
IL (1) IL50355A (de)
LU (1) LU75667A1 (de)
MX (1) MX4133E (de)
NL (1) NL7609485A (de)
NO (1) NO145793C (de)
NZ (1) NZ181864A (de)
PH (1) PH13780A (de)
PL (2) PL109091B1 (de)
PT (1) PT65521B (de)
RO (1) RO69457A (de)
SE (1) SE7609495L (de)
SU (2) SU612631A3 (de)
YU (1) YU208176A (de)
ZA (1) ZA765120B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) * 1982-06-03 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
EP2010539B1 (de) * 2006-04-21 2017-06-14 Nektar Therapeutics Stereoselektive reduktion eines morphinons
WO2012005795A1 (en) 2010-07-08 2012-01-12 Alkermes, Inc. Process for the synthesis of substituted morphinans
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
CN111836813A (zh) * 2018-02-23 2020-10-27 罗德科技公司 新型阿片样化合物及其用途
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446370A (de) 1964-03-05 1967-11-15 Hoffmann La Roche Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) * 1972-08-07 1974-02-14 Boehringer Sohn Ingelheim Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
ES454086A1 (es) 1977-11-16
ZA765120B (en) 1978-05-30
NO145793B (no) 1982-02-22
RO69457A (ro) 1981-04-30
ATA553976A (de) 1978-11-15
SU612631A3 (ru) 1978-06-25
IL50355A (en) 1979-11-30
CH624114A5 (de) 1981-07-15
CH624117A5 (de) 1981-07-15
PT65521A (de) 1976-09-01
NZ181864A (en) 1978-06-20
PH13780A (en) 1980-09-26
FI762430A (de) 1977-02-28
IE44069L (en) 1977-02-27
CH624115A5 (de) 1981-07-15
DE2538075A1 (de) 1977-03-17
FR2321888A1 (fr) 1977-03-25
SE7609495L (sv) 1977-02-28
ES454084A1 (es) 1977-11-16
BG27546A4 (en) 1979-11-12
BG27545A3 (en) 1979-11-12
AU499926B2 (en) 1979-05-03
AU1720176A (en) 1978-03-02
CS192599B2 (en) 1979-08-31
MX4133E (es) 1982-01-06
IL50355A0 (en) 1976-10-31
GB1519719A (en) 1978-08-02
NL7609485A (nl) 1977-03-01
CH624116A5 (de) 1981-07-15
NO762932L (de) 1977-03-01
BE845563A (fr) 1977-02-28
ES450897A1 (es) 1977-12-01
SU638262A3 (ru) 1978-12-15
DK143278C (da) 1981-12-07
US4100288A (en) 1978-07-11
HU176929B (hu) 1981-06-28
ES454085A1 (es) 1977-11-16
JPS5231100A (en) 1977-03-09
DD127145A5 (de) 1977-09-07
ES454087A2 (es) 1977-11-16
GR61158B (en) 1978-09-30
CH622521A5 (de) 1981-04-15
PL110724B1 (en) 1980-07-31
DK143278B (da) 1981-08-03
FR2321888B1 (de) 1980-01-11
YU208176A (en) 1982-08-31
PT65521B (de) 1978-07-04
LU75667A1 (de) 1977-09-13
PL192020A1 (pl) 1979-03-12
NO145793C (no) 1982-06-02
DK386876A (da) 1977-02-28
IE44069B1 (en) 1981-08-12
CA1068266A (en) 1979-12-18
CS192564B2 (en) 1979-08-31
PL109091B1 (en) 1980-05-31

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Legal Events

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ELJ Ceased due to non-payment of the annual fee