ES454084A1 - Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas. - Google Patents

Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.

Info

Publication number
ES454084A1
ES454084A1 ES454084A ES454084A ES454084A1 ES 454084 A1 ES454084 A1 ES 454084A1 ES 454084 A ES454084 A ES 454084A ES 454084 A ES454084 A ES 454084A ES 454084 A1 ES454084 A1 ES 454084A1
Authority
ES
Spain
Prior art keywords
tetrahydrofurfuril
noroximorphone
translation
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES454084A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES454084A1 publication Critical patent/ES454084A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES454084A 1975-08-27 1976-12-09 Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas. Expired ES454084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752538075 DE2538075A1 (de) 1975-08-27 1975-08-27 N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES454084A1 true ES454084A1 (es) 1977-11-16

Family

ID=5954931

Family Applications (5)

Application Number Title Priority Date Filing Date
ES450897A Expired ES450897A1 (es) 1975-08-27 1976-08-21 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona.
ES454085A Expired ES454085A1 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454087A Expired ES454087A2 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454084A Expired ES454084A1 (es) 1975-08-27 1976-12-09 Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454086A Expired ES454086A1 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-norosimorfona nuevas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES450897A Expired ES450897A1 (es) 1975-08-27 1976-08-21 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona.
ES454085A Expired ES454085A1 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454087A Expired ES454087A2 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES454086A Expired ES454086A1 (es) 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-norosimorfona nuevas.

Country Status (33)

Country Link
US (1) US4100288A (es)
JP (1) JPS5231100A (es)
AT (1) AT350737B (es)
AU (1) AU499926B2 (es)
BE (1) BE845563A (es)
BG (2) BG27546A4 (es)
CA (1) CA1068266A (es)
CH (5) CH622521A5 (es)
CS (2) CS192564B2 (es)
DD (1) DD127145A5 (es)
DE (1) DE2538075A1 (es)
DK (1) DK143278C (es)
ES (5) ES450897A1 (es)
FI (1) FI762430A7 (es)
FR (1) FR2321888A1 (es)
GB (1) GB1519719A (es)
GR (1) GR61158B (es)
HU (1) HU176929B (es)
IE (1) IE44069B1 (es)
IL (1) IL50355A (es)
LU (1) LU75667A1 (es)
MX (1) MX4133E (es)
NL (1) NL7609485A (es)
NO (1) NO145793C (es)
NZ (1) NZ181864A (es)
PH (1) PH13780A (es)
PL (2) PL109091B1 (es)
PT (1) PT65521B (es)
RO (1) RO69457A (es)
SE (1) SE7609495L (es)
SU (2) SU612631A3 (es)
YU (1) YU208176A (es)
ZA (1) ZA765120B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) * 1982-06-03 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
CN101466381B (zh) * 2006-04-21 2012-11-14 尼克塔治疗公司 吗啡酮的立体选择性还原
ES2708726T3 (es) * 2010-07-08 2019-04-10 Alkermes Pharma Ireland Ltd Proceso para la síntesis de morfinanos sustituidos
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
JP2016519161A (ja) 2013-05-24 2016-06-30 アルカームス ファーマ アイルランド リミテッド モルファン及びモルフィナン類似物及び使用の方法
WO2019165298A1 (en) * 2018-02-23 2019-08-29 Rhodes Technologies Novel opioid compounds and uses thereof
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446370A (de) 1964-03-05 1967-11-15 Hoffmann La Roche Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) * 1972-08-07 1974-02-14 Boehringer Sohn Ingelheim Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
HU176929B (hu) 1981-06-28
IL50355A0 (en) 1976-10-31
ZA765120B (en) 1978-05-30
BE845563A (fr) 1977-02-28
FR2321888A1 (fr) 1977-03-25
SU638262A3 (ru) 1978-12-15
AT350737B (de) 1979-06-11
PL110724B1 (en) 1980-07-31
CH624114A5 (es) 1981-07-15
MX4133E (es) 1982-01-06
IL50355A (en) 1979-11-30
SE7609495L (sv) 1977-02-28
CH624117A5 (es) 1981-07-15
LU75667A1 (es) 1977-09-13
IE44069L (en) 1977-02-27
GR61158B (en) 1978-09-30
US4100288A (en) 1978-07-11
CH624115A5 (es) 1981-07-15
ES454086A1 (es) 1977-11-16
CS192599B2 (en) 1979-08-31
CH622521A5 (es) 1981-04-15
PL192020A1 (pl) 1979-03-12
PL109091B1 (en) 1980-05-31
JPS5231100A (en) 1977-03-09
FI762430A7 (es) 1977-02-28
DK143278B (da) 1981-08-03
CH624116A5 (es) 1981-07-15
AU1720176A (en) 1978-03-02
CA1068266A (en) 1979-12-18
ES450897A1 (es) 1977-12-01
NO762932L (es) 1977-03-01
IE44069B1 (en) 1981-08-12
PT65521A (de) 1976-09-01
DE2538075A1 (de) 1977-03-17
GB1519719A (en) 1978-08-02
NO145793C (no) 1982-06-02
YU208176A (en) 1982-08-31
DK143278C (da) 1981-12-07
ES454085A1 (es) 1977-11-16
NZ181864A (en) 1978-06-20
DK386876A (da) 1977-02-28
SU612631A3 (ru) 1978-06-25
BG27546A4 (bg) 1979-11-12
PT65521B (de) 1978-07-04
FR2321888B1 (es) 1980-01-11
PH13780A (en) 1980-09-26
NO145793B (no) 1982-02-22
BG27545A3 (bg) 1979-11-12
DD127145A5 (es) 1977-09-07
ATA553976A (de) 1978-11-15
ES454087A2 (es) 1977-11-16
RO69457A (ro) 1981-04-30
NL7609485A (nl) 1977-03-01
CS192564B2 (en) 1979-08-31
AU499926B2 (en) 1979-05-03

Similar Documents

Publication Publication Date Title
ES438946A2 (es) Procedimiento de prreparacion de esteres cicloalquil alqui- licos de acidos que el esqueleto de eburnano
DE2963097D1 (en) Process for the preparation of beta-lactam derivatives, the novel derivatives so obtainable and pharmaceutical compositions containing them
ES381894A1 (es) Procedimiento para la preparacion de o-acil-lisegoles.
ES456541A1 (es) Procedimiento para la preparacion de acidos n-fosfonometilen-monoaminoalcanmonofosfonicos y -polifosfonicos yno acidos n-fosfonometilen-diaminoalcanpolifosfonicos.
ES454084A1 (es) Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES8100283A1 (es) Un procedimiento para la preparacion de derivados del acido 4,5-dihidro-4-oxofuran-2-carboxilico
ES469477A1 (es) Procedimiento para preparar productos racemicos u opticamen-te activos pentaciclicos, del grupo del acido apovincaminico
ES449817A1 (es) Procedimiento para producir 2-fenilamino-tiazolinas susti- tuidas.
ES451466A1 (es) Procedimiento para la preparacion de nuevos derivados de 5- tiazol-metanoamina.
ES400790A1 (es) Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4 - hidroxibutiricos, sus esteres o lactonas.
ES429691A1 (es) Proceso para la preparacion del acido p. isobutil-hidratro-pico.
ES440282A1 (es) Procedimiento para la preparacion de piperidina.
ES427869A1 (es) Procedimiento para la preparacion de esteres alcoholicos deacido 5-fenilsulfinil-2-bencimidazol-carbamico.
ES430420A1 (es) Procedimiento para la preparacion de derivados de propanol.
ES402328A1 (es) Procedimiento para preparar 4-hidroxibenzodio-xol.
JPS5283413A (en) Preparation of 3,3-dimethyl-4-pentenoic acid or its esters
ES428011A1 (es) Procedimiento para la preparacion de 2-amino-3,5-dibromo- bencilamina.
DE3062840D1 (en) 10-bromosandwicine and 10-bromoisosandwicine, as well as their additions salts with pharmacolical acceptable acids process for their preparation and their use
ES477163A1 (es) Procedimiento para la preparacion de compuestos de acidos 4-(8x-6,11-dihidro-dibenzo- b.e. -tiepin-11-on-3-il)-4-oxobu- tiricos.
ES423460A1 (es) Procedimiento para la preparacion del acido 7-aminodesace- toxicefalosporanico.
ES471168A1 (es) Un procedimiento para la obtencion de 2-p-clorofenil-1,5,5- trimetil- 4-metilenpiperidina
ES471169A1 (es) Un procedimiento para la obtencion de 2-p-clorofenil-1,3,3- trimetil- 4-metilenpiperidina
ES467136A1 (es) Procedimiento de preparacion de nuevos derivados de alca- loides pentaciclicos.
FI762309A7 (es)
ES443459A1 (es) Un procedimiento para la preparacion de nuevos derivados de 3-cianopiridinas.