CS189717B2 - Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes - Google Patents

Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Info

Publication number
CS189717B2
CS189717B2 CS755425A CS542575A CS189717B2 CS 189717 B2 CS189717 B2 CS 189717B2 CS 755425 A CS755425 A CS 755425A CS 542575 A CS542575 A CS 542575A CS 189717 B2 CS189717 B2 CS 189717B2
Authority
CS
Czechoslovakia
Prior art keywords
benzomorphanes
tetrahydrofurfuryl
disubstituted
beta
producing novel
Prior art date
Application number
CS755425A
Other languages
English (en)
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to CS777329A priority Critical patent/CS189749B2/cs
Priority to CS777330A priority patent/CS189750B2/cs
Publication of CS189717B2 publication Critical patent/CS189717B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS755425A 1974-08-05 1975-08-04 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes CS189717B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS777329A CS189749B2 (en) 1974-08-05 1977-11-09 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes
CS777330A CS189750B2 (en) 1974-08-05 1977-11-09 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
CS189717B2 true CS189717B2 (en) 1979-04-30

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
CS755425A CS189717B2 (en) 1974-08-05 1975-08-04 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Country Status (27)

Country Link
US (1) US3982005A (cs)
JP (1) JPS60358B2 (cs)
AT (1) AT348140B (cs)
BE (1) BE832099R (cs)
BG (3) BG25088A3 (cs)
CA (1) CA1049008A (cs)
CH (7) CH613963A5 (cs)
CS (1) CS189717B2 (cs)
DD (1) DD122685A5 (cs)
DE (1) DE2437610A1 (cs)
DK (1) DK138992C (cs)
ES (6) ES452767A1 (cs)
FI (1) FI63229C (cs)
FR (1) FR2320096A2 (cs)
GB (1) GB1513950A (cs)
HU (1) HU177952B (cs)
IE (1) IE42216B1 (cs)
IL (1) IL47860A (cs)
LU (1) LU73138A1 (cs)
NL (1) NL7509249A (cs)
NO (1) NO143460C (cs)
PH (1) PH13687A (cs)
PL (3) PL99819B1 (cs)
RO (3) RO67390A (cs)
SE (1) SE425392B (cs)
SU (3) SU591147A3 (cs)
ZA (1) ZA754997B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
WO2009017664A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1
JP5769970B2 (ja) 2007-11-16 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
WO2009134400A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2288596B1 (en) 2008-05-13 2016-11-30 Boehringer Ingelheim International GmbH Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
EP4253494A4 (en) 2020-11-26 2024-11-13 Shin-Etsu Chemical Co., Ltd. ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION, ARTICLE, HYDROLYZABLE ORGANOSILANE COMPOUND AND PROCESS FOR PRODUCING THE SAME
JPWO2023032745A1 (cs) 2021-09-03 2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (cs) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (cs) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
PL99838B1 (pl) 1978-08-31
BG25090A3 (en) 1978-07-12
ES452766A1 (es) 1977-10-01
NO143460C (no) 1981-02-18
ES452765A1 (es) 1977-10-16
BG25089A3 (en) 1978-07-12
ES452768A1 (es) 1977-10-01
CH616420A5 (cs) 1980-03-31
CH615677A5 (cs) 1980-02-15
NL7509249A (nl) 1976-02-09
NO143460B (no) 1980-11-10
NO752731L (cs) 1976-02-06
SE425392B (sv) 1982-09-27
FI63229C (fi) 1983-05-10
RO72735A (ro) 1982-09-09
CA1049008A (en) 1979-02-20
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
SU587858A3 (ru) 1978-01-05
US3982005A (en) 1976-09-21
JPS5139673A (en) 1976-04-02
CH615679A5 (cs) 1980-02-15
CH615680A5 (cs) 1980-02-15
PL99819B1 (pl) 1978-08-31
DD122685A5 (cs) 1976-10-20
LU73138A1 (cs) 1977-04-13
SU591147A3 (ru) 1978-01-30
FI63229B (fi) 1983-01-31
RO72736A (ro) 1982-09-09
IE42216B1 (en) 1980-07-02
DK138992B (da) 1978-11-27
CH613963A5 (cs) 1979-10-31
DK352875A (da) 1976-02-06
FR2320096B2 (cs) 1978-09-01
DK138992C (da) 1979-04-30
SE7508789L (sv) 1976-02-10
ES452764A1 (es) 1977-10-16
IE42216L (en) 1976-02-05
HU177952B (en) 1982-02-28
BE832099R (fr) 1976-02-04
FI752211A (cs) 1976-02-06
ZA754997B (en) 1977-04-27
CH616421A5 (cs) 1980-03-31
SU587859A3 (ru) 1978-01-05
PL99816B1 (pl) 1978-08-31
ES452763A1 (es) 1977-10-01
AU8364675A (en) 1977-02-10
AT348140B (de) 1979-01-25
GB1513950A (en) 1978-06-14
CH615678A5 (cs) 1980-02-15
JPS60358B2 (ja) 1985-01-07
BG25088A3 (en) 1978-07-12
IL47860A (en) 1979-01-31
DE2437610A1 (de) 1976-02-26
ATA523775A (de) 1978-06-15
ES452767A1 (es) 1977-10-01
IL47860A0 (en) 1975-11-25
FR2320096A2 (fr) 1977-03-04

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