CS189717B2 - Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes - Google Patents

Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Info

Publication number
CS189717B2
CS189717B2 CS755425A CS542575A CS189717B2 CS 189717 B2 CS189717 B2 CS 189717B2 CS 755425 A CS755425 A CS 755425A CS 542575 A CS542575 A CS 542575A CS 189717 B2 CS189717 B2 CS 189717B2
Authority
CS
Czechoslovakia
Prior art keywords
benzomorphanes
tetrahydrofurfuryl
disubstituted
beta
producing novel
Prior art date
Application number
CS755425A
Other languages
English (en)
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to CS777330A priority Critical patent/CS189750B2/cs
Priority to CS777329A priority patent/CS189749B2/cs
Publication of CS189717B2 publication Critical patent/CS189717B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS755425A 1974-08-05 1975-08-04 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes CS189717B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS777330A CS189750B2 (en) 1974-08-05 1977-11-09 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes
CS777329A CS189749B2 (en) 1974-08-05 1977-11-09 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
CS189717B2 true CS189717B2 (en) 1979-04-30

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
CS755425A CS189717B2 (en) 1974-08-05 1975-08-04 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Country Status (27)

Country Link
US (1) US3982005A (cs)
JP (1) JPS60358B2 (cs)
AT (1) AT348140B (cs)
BE (1) BE832099R (cs)
BG (3) BG25088A3 (cs)
CA (1) CA1049008A (cs)
CH (7) CH613963A5 (cs)
CS (1) CS189717B2 (cs)
DD (1) DD122685A5 (cs)
DE (1) DE2437610A1 (cs)
DK (1) DK138992C (cs)
ES (6) ES452765A1 (cs)
FI (1) FI63229C (cs)
FR (1) FR2320096A2 (cs)
GB (1) GB1513950A (cs)
HU (1) HU177952B (cs)
IE (1) IE42216B1 (cs)
IL (1) IL47860A (cs)
LU (1) LU73138A1 (cs)
NL (1) NL7509249A (cs)
NO (1) NO143460C (cs)
PH (1) PH13687A (cs)
PL (3) PL99838B1 (cs)
RO (3) RO67390A (cs)
SE (1) SE425392B (cs)
SU (3) SU591147A3 (cs)
ZA (1) ZA754997B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
AR067673A1 (es) 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
AR069545A1 (es) 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
WO2009102460A2 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134392A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MX2010011935A (es) 2008-05-01 2011-05-19 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11 beta-hidroxiesteroide deshidrogenasa 1.
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5711115B2 (ja) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2324017B1 (en) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) * 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives
JP7574861B2 (ja) 2020-11-26 2024-10-29 信越化学工業株式会社 室温硬化性オルガノポリシロキサン組成物及び物品並びに加水分解性オルガノシラン化合物及びその製造方法
CN117881724A (zh) 2021-09-03 2024-04-12 信越化学工业株式会社 有机聚硅氧烷化合物、室温固化性有机聚硅氧烷组合物和物品

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (cs) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (cs) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
NL7509249A (nl) 1976-02-09
JPS5139673A (en) 1976-04-02
CH615678A5 (cs) 1980-02-15
RO72736A (ro) 1982-09-09
AU8364675A (en) 1977-02-10
BG25089A3 (bg) 1978-07-12
FR2320096B2 (cs) 1978-09-01
IL47860A0 (en) 1975-11-25
ES452765A1 (es) 1977-10-16
FI752211A7 (cs) 1976-02-06
BG25090A3 (bg) 1978-07-12
GB1513950A (en) 1978-06-14
ES452767A1 (es) 1977-10-01
ES452766A1 (es) 1977-10-01
PL99816B1 (pl) 1978-08-31
CH616420A5 (cs) 1980-03-31
CH615677A5 (cs) 1980-02-15
NO143460B (no) 1980-11-10
NO752731L (cs) 1976-02-06
DK352875A (da) 1976-02-06
ATA523775A (de) 1978-06-15
NO143460C (no) 1981-02-18
FR2320096A2 (fr) 1977-03-04
ES452763A1 (es) 1977-10-01
CH616421A5 (cs) 1980-03-31
JPS60358B2 (ja) 1985-01-07
HU177952B (en) 1982-02-28
DD122685A5 (cs) 1976-10-20
IL47860A (en) 1979-01-31
DK138992C (da) 1979-04-30
IE42216L (en) 1976-02-05
CH615680A5 (cs) 1980-02-15
CH615679A5 (cs) 1980-02-15
RO72735A (ro) 1982-09-09
LU73138A1 (cs) 1977-04-13
PL99838B1 (pl) 1978-08-31
DK138992B (da) 1978-11-27
SU591147A3 (ru) 1978-01-30
BG25088A3 (bg) 1978-07-12
DE2437610A1 (de) 1976-02-26
SE7508789L (sv) 1976-02-10
PL99819B1 (pl) 1978-08-31
IE42216B1 (en) 1980-07-02
SU587859A3 (ru) 1978-01-05
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
SE425392B (sv) 1982-09-27
FI63229C (fi) 1983-05-10
FI63229B (fi) 1983-01-31
ZA754997B (en) 1977-04-27
ES452764A1 (es) 1977-10-16
CA1049008A (en) 1979-02-20
ES452768A1 (es) 1977-10-01
AT348140B (de) 1979-01-25
CH613963A5 (cs) 1979-10-31
SU587858A3 (ru) 1978-01-05
US3982005A (en) 1976-09-21
BE832099R (fr) 1976-02-04

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