SE7508789L - Forfarande for framstellnign av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner, deras syraadditionssalter och anvendning som lekemedel - Google Patents

Forfarande for framstellnign av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner, deras syraadditionssalter och anvendning som lekemedel

Info

Publication number
SE7508789L
SE7508789L SE7508789A SE7508789A SE7508789L SE 7508789 L SE7508789 L SE 7508789L SE 7508789 A SE7508789 A SE 7508789A SE 7508789 A SE7508789 A SE 7508789A SE 7508789 L SE7508789 L SE 7508789L
Authority
SE
Sweden
Prior art keywords
benzomorphanes
tetrahydrofurfuryl
disubstituted
medicines
beta
Prior art date
Application number
SE7508789A
Other languages
Unknown language ( )
English (en)
Other versions
SE425392B (sv
Inventor
H Merz
A Langbein
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of SE7508789L publication Critical patent/SE7508789L/sv
Publication of SE425392B publication Critical patent/SE425392B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE7508789A 1974-08-05 1975-08-04 Forfarande for framstellning av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner eller deras syraadditionssalter SE425392B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
SE7508789L true SE7508789L (sv) 1976-02-10
SE425392B SE425392B (sv) 1982-09-27

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7508789A SE425392B (sv) 1974-08-05 1975-08-04 Forfarande for framstellning av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner eller deras syraadditionssalter

Country Status (27)

Country Link
US (1) US3982005A (sv)
JP (1) JPS60358B2 (sv)
AT (1) AT348140B (sv)
BE (1) BE832099R (sv)
BG (3) BG25090A3 (sv)
CA (1) CA1049008A (sv)
CH (7) CH613963A5 (sv)
CS (1) CS189717B2 (sv)
DD (1) DD122685A5 (sv)
DE (1) DE2437610A1 (sv)
DK (1) DK138992C (sv)
ES (6) ES452764A1 (sv)
FI (1) FI63229C (sv)
FR (1) FR2320096A2 (sv)
GB (1) GB1513950A (sv)
HU (1) HU177952B (sv)
IE (1) IE42216B1 (sv)
IL (1) IL47860A (sv)
LU (1) LU73138A1 (sv)
NL (1) NL7509249A (sv)
NO (1) NO143460C (sv)
PH (1) PH13687A (sv)
PL (3) PL99819B1 (sv)
RO (3) RO67390A (sv)
SE (1) SE425392B (sv)
SU (3) SU591147A3 (sv)
ZA (1) ZA754997B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
CA2697168A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
NZ588954A (en) 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
JP5711115B2 (ja) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
ES2432150T3 (es) 2008-07-25 2013-12-02 Boehringer Ingelheim International Gmbh Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
UY33001A (es) 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives
JPWO2022113437A1 (sv) 2020-11-26 2022-06-02
EP4397695A1 (en) 2021-09-03 2024-07-10 Shin-Etsu Chemical Co., Ltd. Organopolysiloxane compound, room temperature-curable organopolysiloxane composition, and article

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (sv) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (sv) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
FR2320096B2 (sv) 1978-09-01
FI63229C (fi) 1983-05-10
AT348140B (de) 1979-01-25
DD122685A5 (sv) 1976-10-20
CH616420A5 (sv) 1980-03-31
NO143460B (no) 1980-11-10
ES452766A1 (es) 1977-10-01
DK138992C (da) 1979-04-30
DK138992B (da) 1978-11-27
SE425392B (sv) 1982-09-27
CH616421A5 (sv) 1980-03-31
BE832099R (fr) 1976-02-04
CS189717B2 (en) 1979-04-30
FR2320096A2 (fr) 1977-03-04
SU587859A3 (ru) 1978-01-05
CH615679A5 (sv) 1980-02-15
AU8364675A (en) 1977-02-10
ATA523775A (de) 1978-06-15
NO143460C (no) 1981-02-18
JPS60358B2 (ja) 1985-01-07
BG25088A3 (en) 1978-07-12
CA1049008A (en) 1979-02-20
ES452764A1 (es) 1977-10-16
RO72735A (ro) 1982-09-09
GB1513950A (en) 1978-06-14
PL99838B1 (pl) 1978-08-31
ES452767A1 (es) 1977-10-01
BG25089A3 (en) 1978-07-12
CH615678A5 (sv) 1980-02-15
IL47860A (en) 1979-01-31
CH613963A5 (sv) 1979-10-31
DK352875A (da) 1976-02-06
FI752211A (sv) 1976-02-06
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
BG25090A3 (en) 1978-07-12
FI63229B (fi) 1983-01-31
ES452763A1 (es) 1977-10-01
PL99819B1 (pl) 1978-08-31
PL99816B1 (pl) 1978-08-31
ES452768A1 (es) 1977-10-01
DE2437610A1 (de) 1976-02-26
NL7509249A (nl) 1976-02-09
HU177952B (en) 1982-02-28
JPS5139673A (en) 1976-04-02
NO752731L (sv) 1976-02-06
ZA754997B (en) 1977-04-27
ES452765A1 (es) 1977-10-16
IE42216B1 (en) 1980-07-02
CH615677A5 (sv) 1980-02-15
LU73138A1 (sv) 1977-04-13
CH615680A5 (sv) 1980-02-15
IE42216L (en) 1976-02-05
SU587858A3 (ru) 1978-01-05
US3982005A (en) 1976-09-21
SU591147A3 (ru) 1978-01-30
RO72736A (ro) 1982-09-09
IL47860A0 (en) 1975-11-25

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