DK138992B - Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditonste heraf - Google Patents

Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditonste heraf

Info

Publication number
DK138992B
DK138992B DK352875A DK352875A DK138992B DK 138992 B DK138992 B DK 138992B DK 352875 A DK352875 A DK 352875A DK 352875 A DK352875 A DK 352875A DK 138992 B DK138992 B DK 138992B
Authority
DK
Denmark
Prior art keywords
additones
benzomorphanes
9beta
tetrahydrofurfuryl
disubstituted
Prior art date
Application number
DK352875A
Other languages
English (en)
Other versions
DK138992C (da
DK352875A (da
Inventor
H Merz
A Langbein
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DK352875A publication Critical patent/DK352875A/da
Publication of DK138992B publication Critical patent/DK138992B/da
Application granted granted Critical
Publication of DK138992C publication Critical patent/DK138992C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK352875A 1974-08-05 1975-08-04 Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf DK138992C (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (3)

Publication Number Publication Date
DK352875A DK352875A (da) 1976-02-06
DK138992B true DK138992B (da) 1978-11-27
DK138992C DK138992C (da) 1979-04-30

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK352875A DK138992C (da) 1974-08-05 1975-08-04 Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf

Country Status (27)

Country Link
US (1) US3982005A (da)
JP (1) JPS60358B2 (da)
AT (1) AT348140B (da)
BE (1) BE832099R (da)
BG (3) BG25088A3 (da)
CA (1) CA1049008A (da)
CH (7) CH613963A5 (da)
CS (1) CS189717B2 (da)
DD (1) DD122685A5 (da)
DE (1) DE2437610A1 (da)
DK (1) DK138992C (da)
ES (6) ES452764A1 (da)
FI (1) FI63229C (da)
FR (1) FR2320096A2 (da)
GB (1) GB1513950A (da)
HU (1) HU177952B (da)
IE (1) IE42216B1 (da)
IL (1) IL47860A (da)
LU (1) LU73138A1 (da)
NL (1) NL7509249A (da)
NO (1) NO143460C (da)
PH (1) PH13687A (da)
PL (3) PL99816B1 (da)
RO (3) RO67390A (da)
SE (1) SE425392B (da)
SU (3) SU591147A3 (da)
ZA (1) ZA754997B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156719B (da) * 1978-06-26 1989-09-25 Boehringer Sohn Ingelheim Analogifremgangsmaade til fremstilling af 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanforbindelser eller syreadditionssalte deraf

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
BRPI0911764A2 (pt) 2008-05-01 2015-10-06 Boehringer Ingelheim Int inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134392A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009138386A2 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
PE20110566A1 (es) 2008-07-25 2011-09-02 Boehringer Ingelheim Int Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
UY33001A (es) * 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives
EP4253494A1 (en) 2020-11-26 2023-10-04 Shin-Etsu Chemical Co., Ltd. Room temperature curable organopolysiloxane composition, article, hydrolyzable organosilane compound and method for producing same
JPWO2023032745A1 (da) 2021-09-03 2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (da) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166802B2 (da) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156719B (da) * 1978-06-26 1989-09-25 Boehringer Sohn Ingelheim Analogifremgangsmaade til fremstilling af 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanforbindelser eller syreadditionssalte deraf

Also Published As

Publication number Publication date
SE425392B (sv) 1982-09-27
AT348140B (de) 1979-01-25
HU177952B (en) 1982-02-28
RO72735A (ro) 1982-09-09
CH615680A5 (da) 1980-02-15
CH615679A5 (da) 1980-02-15
ZA754997B (en) 1977-04-27
ES452765A1 (es) 1977-10-16
ES452764A1 (es) 1977-10-16
DK138992C (da) 1979-04-30
SU587859A3 (ru) 1978-01-05
FI63229C (fi) 1983-05-10
PL99838B1 (pl) 1978-08-31
ATA523775A (de) 1978-06-15
NL7509249A (nl) 1976-02-09
AU8364675A (en) 1977-02-10
NO143460C (no) 1981-02-18
CA1049008A (en) 1979-02-20
BE832099R (fr) 1976-02-04
FI63229B (fi) 1983-01-31
CH613963A5 (da) 1979-10-31
SE7508789L (sv) 1976-02-10
PL99819B1 (pl) 1978-08-31
LU73138A1 (da) 1977-04-13
IL47860A (en) 1979-01-31
BG25088A3 (en) 1978-07-12
CS189717B2 (en) 1979-04-30
FI752211A (da) 1976-02-06
FR2320096A2 (fr) 1977-03-04
JPS60358B2 (ja) 1985-01-07
DE2437610A1 (de) 1976-02-26
FR2320096B2 (da) 1978-09-01
NO143460B (no) 1980-11-10
NO752731L (da) 1976-02-06
US3982005A (en) 1976-09-21
ES452763A1 (es) 1977-10-01
PL99816B1 (pl) 1978-08-31
IE42216L (en) 1976-02-05
JPS5139673A (en) 1976-04-02
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
SU591147A3 (ru) 1978-01-30
RO72736A (ro) 1982-09-09
BG25090A3 (en) 1978-07-12
DK352875A (da) 1976-02-06
IE42216B1 (en) 1980-07-02
DD122685A5 (da) 1976-10-20
BG25089A3 (en) 1978-07-12
CH616420A5 (da) 1980-03-31
CH615678A5 (da) 1980-02-15
CH615677A5 (da) 1980-02-15
CH616421A5 (da) 1980-03-31
SU587858A3 (ru) 1978-01-05
IL47860A0 (en) 1975-11-25
GB1513950A (en) 1978-06-14
ES452767A1 (es) 1977-10-01
ES452766A1 (es) 1977-10-01
ES452768A1 (es) 1977-10-01

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