ES452763A1 - Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. - Google Patents
Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta.Info
- Publication number
- ES452763A1 ES452763A1 ES452763A ES452763A ES452763A1 ES 452763 A1 ES452763 A1 ES 452763A1 ES 452763 A ES452763 A ES 452763A ES 452763 A ES452763 A ES 452763A ES 452763 A1 ES452763 A1 ES 452763A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- salts
- phenyl
- benzomorphans
- tetrahydrofurfuryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2437610A DE2437610A1 (de) | 1974-08-05 | 1974-08-05 | Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES452763A1 true ES452763A1 (es) | 1977-10-01 |
Family
ID=5922448
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES452764A Expired ES452764A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5,9-beta. |
ES452766A Expired ES452766A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
ES452763A Expired ES452763A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
ES452768A Expired ES452768A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
ES452765A Expired ES452765A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5,9-beta. |
ES452767A Expired ES452767A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES452764A Expired ES452764A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5,9-beta. |
ES452766A Expired ES452766A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES452768A Expired ES452768A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
ES452765A Expired ES452765A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5,9-beta. |
ES452767A Expired ES452767A1 (es) | 1974-08-05 | 1976-10-27 | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta. |
Country Status (27)
Country | Link |
---|---|
US (1) | US3982005A (es) |
JP (1) | JPS60358B2 (es) |
AT (1) | AT348140B (es) |
BE (1) | BE832099R (es) |
BG (3) | BG25090A3 (es) |
CA (1) | CA1049008A (es) |
CH (7) | CH613963A5 (es) |
CS (1) | CS189717B2 (es) |
DD (1) | DD122685A5 (es) |
DE (1) | DE2437610A1 (es) |
DK (1) | DK138992C (es) |
ES (6) | ES452764A1 (es) |
FI (1) | FI63229C (es) |
FR (1) | FR2320096A2 (es) |
GB (1) | GB1513950A (es) |
HU (1) | HU177952B (es) |
IE (1) | IE42216B1 (es) |
IL (1) | IL47860A (es) |
LU (1) | LU73138A1 (es) |
NL (1) | NL7509249A (es) |
NO (1) | NO143460C (es) |
PH (1) | PH13687A (es) |
PL (3) | PL99816B1 (es) |
RO (3) | RO67390A (es) |
SE (1) | SE425392B (es) |
SU (3) | SU591147A3 (es) |
ZA (1) | ZA754997B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087532A (en) * | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
GB1575009A (en) * | 1976-06-21 | 1980-09-17 | Acf Chemiefarma Nv | 6,7-benzomorphan derivatives |
DE2716687A1 (de) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel |
NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
DE2828039A1 (de) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung |
JPS5636521A (en) * | 1979-08-31 | 1981-04-09 | Shin Etsu Chem Co Ltd | Production of alkenyloxy group-containing organopolysiloxane |
US8329897B2 (en) | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2254872A2 (en) | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
TW200950780A (en) | 2008-05-13 | 2009-12-16 | Boehringer Ingelheim Int | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
AU2009274567B2 (en) | 2008-07-25 | 2013-04-04 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
TWI531571B (zh) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜芳基羰基衍生物 |
EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物 |
JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
WO2022113437A1 (ja) | 2020-11-26 | 2022-06-02 | 信越化学工業株式会社 | 室温硬化性オルガノポリシロキサン組成物及び物品並びに加水分解性オルガノシラン化合物及びその製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE582575A (es) * | 1958-09-22 | |||
US3700734A (en) * | 1969-01-23 | 1972-10-24 | Merck & Co Inc | 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan |
DE2105743C3 (de) * | 1971-02-08 | 1979-11-29 | Boehringer Sohn Ingelheim | 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung |
CS166802B2 (es) * | 1971-02-08 | 1976-03-29 | Boehringer Sohn Ingelheim | |
DE2200596A1 (de) * | 1972-01-07 | 1973-07-12 | Boehringer Sohn Ingelheim | N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
DE2217420C3 (de) * | 1972-04-12 | 1981-03-12 | C.H. Boehringer Sohn, 6507 Ingelheim | N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DE2229695A1 (de) * | 1972-06-19 | 1974-01-31 | Boehringer Sohn Ingelheim | 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
-
1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
-
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG7500031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG7500030726A patent/BG25088A3/xx unknown
- 1975-08-02 BG BG7500031842A patent/BG25089A3/xx unknown
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
-
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
-
1979
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES452764A1 (es) | Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5,9-beta. | |
ES431510A1 (es) | Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. | |
ES431054A1 (es) | Procedimiento para la preparacion de nuevos n-(metoximetil-furlmetil)-6,7-benzomorfanos y -mofinanos. | |
ES465528A1 (es) | Procedimiento para la obtencion de nuevas feniletilaminas. | |
ES439927A1 (es) | Procedimiento para la obtencion de 7-metoxi-6-tiatetracicli-nas. | |
ES425010A1 (es) | Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas. | |
ES437869A1 (es) | Un procedimiento para preparar nuevos 5,6 dimetoxiindazoles sustituidos en 2. | |
ES424309A1 (es) | Procedimiento para la preparacion de n-(heteroarilmetil)-7 -acil-6,14-endoetenotetrahidronororipavinas y -tebainas. | |
ES436317A1 (es) | Procedimiento para la preparacion de nuevas isoquinoleinas. | |
ES430199A1 (es) | Procedimiento para la preparacion de n-(heteroarilmetil - delta7-desoxi-normorfinas y -norcodeinas. | |
ES441437A1 (es) | Procedimiento para la preparacion de crotonanilidas susti- tuidas. | |
ES440905A1 (es) | Un procedimiento para la preparacion de una composicion her-bicida. | |
ES440252A1 (es) | Procedimiento para la preparacion de dienilfosfatos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980302 |