SE425392B - Forfarande for framstellning av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner eller deras syraadditionssalter - Google Patents
Forfarande for framstellning av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner eller deras syraadditionssalterInfo
- Publication number
- SE425392B SE425392B SE7508789A SE7508789A SE425392B SE 425392 B SE425392 B SE 425392B SE 7508789 A SE7508789 A SE 7508789A SE 7508789 A SE7508789 A SE 7508789A SE 425392 B SE425392 B SE 425392B
- Authority
- SE
- Sweden
- Prior art keywords
- benzomorphanes
- tetrahydrofurfuryl
- disubstituted
- beta
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2437610A DE2437610A1 (de) | 1974-08-05 | 1974-08-05 | Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7508789L SE7508789L (sv) | 1976-02-10 |
SE425392B true SE425392B (sv) | 1982-09-27 |
Family
ID=5922448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7508789A SE425392B (sv) | 1974-08-05 | 1975-08-04 | Forfarande for framstellning av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner eller deras syraadditionssalter |
Country Status (27)
Country | Link |
---|---|
US (1) | US3982005A (fr) |
JP (1) | JPS60358B2 (fr) |
AT (1) | AT348140B (fr) |
BE (1) | BE832099R (fr) |
BG (3) | BG25088A3 (fr) |
CA (1) | CA1049008A (fr) |
CH (7) | CH613963A5 (fr) |
CS (1) | CS189717B2 (fr) |
DD (1) | DD122685A5 (fr) |
DE (1) | DE2437610A1 (fr) |
DK (1) | DK138992C (fr) |
ES (6) | ES452765A1 (fr) |
FI (1) | FI63229C (fr) |
FR (1) | FR2320096A2 (fr) |
GB (1) | GB1513950A (fr) |
HU (1) | HU177952B (fr) |
IE (1) | IE42216B1 (fr) |
IL (1) | IL47860A (fr) |
LU (1) | LU73138A1 (fr) |
NL (1) | NL7509249A (fr) |
NO (1) | NO143460C (fr) |
PH (1) | PH13687A (fr) |
PL (3) | PL99819B1 (fr) |
RO (3) | RO67390A (fr) |
SE (1) | SE425392B (fr) |
SU (3) | SU591147A3 (fr) |
ZA (1) | ZA754997B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087532A (en) * | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
GB1575009A (en) * | 1976-06-21 | 1980-09-17 | Acf Chemiefarma Nv | 6,7-benzomorphan derivatives |
DE2716687A1 (de) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel |
NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
DE2828039A1 (de) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung |
JPS5636521A (en) * | 1979-08-31 | 1981-04-09 | Shin Etsu Chem Co Ltd | Production of alkenyloxy group-containing organopolysiloxane |
ATE554078T1 (de) | 2007-07-26 | 2012-05-15 | Vitae Pharmaceuticals Inc | Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern |
JP5769970B2 (ja) | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の環状尿素阻害剤 |
TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
CA2712500A1 (fr) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11beta-hydroxysteroide deshydrogenase 1 |
CA2715290A1 (fr) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de la 11 beta-hydroxysteroide dehydrogenase 1 |
JP5538365B2 (ja) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
AR071719A1 (es) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion |
EP2687525B1 (fr) | 2008-07-25 | 2015-09-23 | Boehringer Ingelheim International GmbH | Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
AR078887A1 (es) | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen. |
WO2011159760A1 (fr) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation |
TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物 |
EP2744783A1 (fr) | 2011-08-17 | 2014-06-25 | Boehringer Ingelheim International GmbH | Dérivés d'indénopyridine |
WO2022113437A1 (fr) | 2020-11-26 | 2022-06-02 | 信越化学工業株式会社 | Composition d'organopolysiloxane durcissable à température ambiante, article, composé organosilane hydrolysable et son procédé de production |
JPWO2023032745A1 (fr) | 2021-09-03 | 2023-03-09 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE582575A (fr) * | 1958-09-22 | |||
US3700734A (en) * | 1969-01-23 | 1972-10-24 | Merck & Co Inc | 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan |
DE2105743C3 (de) * | 1971-02-08 | 1979-11-29 | Boehringer Sohn Ingelheim | 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung |
CS166802B2 (fr) * | 1971-02-08 | 1976-03-29 | Boehringer Sohn Ingelheim | |
DE2200596A1 (de) * | 1972-01-07 | 1973-07-12 | Boehringer Sohn Ingelheim | N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
DE2217420C3 (de) * | 1972-04-12 | 1981-03-12 | C.H. Boehringer Sohn, 6507 Ingelheim | N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DE2229695A1 (de) * | 1972-06-19 | 1974-01-31 | Boehringer Sohn Ingelheim | 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
-
1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
-
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 RO RO7583017A patent/RO67390A/fr unknown
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-31 RO RO7593231A patent/RO72736A/fr unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/fr unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-08-01 CA CA75232728A patent/CA1049008A/fr not_active Expired
- 1975-08-02 BG BG7500030726A patent/BG25088A3/xx unknown
- 1975-08-02 BG BG7500031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG7500031842A patent/BG25089A3/xx unknown
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 BE BE158924A patent/BE832099R/fr not_active IP Right Cessation
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
-
1976
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
-
1979
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
Also Published As
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