CA2828861A1 - Oral care product and methods of use and manufacture thereof - Google Patents
Oral care product and methods of use and manufacture thereof Download PDFInfo
- Publication number
- CA2828861A1 CA2828861A1 CA2828861A CA2828861A CA2828861A1 CA 2828861 A1 CA2828861 A1 CA 2828861A1 CA 2828861 A CA2828861 A CA 2828861A CA 2828861 A CA2828861 A CA 2828861A CA 2828861 A1 CA2828861 A1 CA 2828861A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- fluoride
- salt
- basic amino
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 58
- 238000004519 manufacturing process Methods 0.000 title description 12
- 239000000203 mixture Substances 0.000 claims abstract description 405
- 150000001413 amino acids Chemical class 0.000 claims abstract description 117
- 150000003839 salts Chemical class 0.000 claims abstract description 84
- 239000011236 particulate material Substances 0.000 claims abstract description 10
- 239000004475 Arginine Substances 0.000 claims description 69
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 69
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 68
- 229940091249 fluoride supplement Drugs 0.000 claims description 53
- 210000000214 mouth Anatomy 0.000 claims description 53
- -1 sodium fluorosilicate Chemical compound 0.000 claims description 41
- 239000002253 acid Substances 0.000 claims description 34
- 241000894006 Bacteria Species 0.000 claims description 31
- 239000000551 dentifrice Substances 0.000 claims description 29
- 208000002925 dental caries Diseases 0.000 claims description 23
- 150000004715 keto acids Chemical class 0.000 claims description 23
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 22
- 239000000606 toothpaste Substances 0.000 claims description 22
- 229940034610 toothpaste Drugs 0.000 claims description 21
- 210000003298 dental enamel Anatomy 0.000 claims description 19
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 18
- 239000011575 calcium Substances 0.000 claims description 18
- 229910052791 calcium Inorganic materials 0.000 claims description 18
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 18
- 229960003500 triclosan Drugs 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000003082 abrasive agent Substances 0.000 claims description 17
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 16
- 230000003902 lesion Effects 0.000 claims description 16
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 15
- 230000001013 cariogenic effect Effects 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 15
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 102000004190 Enzymes Human genes 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 14
- 239000003945 anionic surfactant Substances 0.000 claims description 14
- 230000002328 demineralizing effect Effects 0.000 claims description 14
- 229910019142 PO4 Inorganic materials 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- 238000005115 demineralization Methods 0.000 claims description 13
- 239000003906 humectant Substances 0.000 claims description 13
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 12
- 230000036541 health Effects 0.000 claims description 12
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 12
- 230000009885 systemic effect Effects 0.000 claims description 11
- 229920001577 copolymer Polymers 0.000 claims description 10
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 10
- 235000000346 sugar Nutrition 0.000 claims description 10
- 239000010452 phosphate Substances 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 9
- 239000011775 sodium fluoride Substances 0.000 claims description 9
- 235000013024 sodium fluoride Nutrition 0.000 claims description 9
- 206010020751 Hypersensitivity Diseases 0.000 claims description 7
- 208000026935 allergic disease Diseases 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 claims description 7
- 239000004599 antimicrobial Substances 0.000 claims description 7
- 208000007565 gingivitis Diseases 0.000 claims description 7
- 230000009610 hypersensitivity Effects 0.000 claims description 7
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims description 7
- 230000008439 repair process Effects 0.000 claims description 7
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 7
- 229960002799 stannous fluoride Drugs 0.000 claims description 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
- 230000036996 cardiovascular health Effects 0.000 claims description 6
- 206010013781 dry mouth Diseases 0.000 claims description 6
- 230000035876 healing Effects 0.000 claims description 6
- 230000000813 microbial effect Effects 0.000 claims description 6
- 230000007406 plaque accumulation Effects 0.000 claims description 6
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical group [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 230000032770 biofilm formation Effects 0.000 claims description 5
- 238000004040 coloring Methods 0.000 claims description 5
- 230000003628 erosive effect Effects 0.000 claims description 5
- 239000004088 foaming agent Substances 0.000 claims description 5
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 claims description 5
- 229960001245 olaflur Drugs 0.000 claims description 5
- 239000011698 potassium fluoride Substances 0.000 claims description 5
- 235000003270 potassium fluoride Nutrition 0.000 claims description 5
- 229940088594 vitamin Drugs 0.000 claims description 5
- 229930003231 vitamin Natural products 0.000 claims description 5
- 235000013343 vitamin Nutrition 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 4
- 229920006318 anionic polymer Polymers 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 4
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- 239000004323 potassium nitrate Substances 0.000 claims description 3
- 235000010333 potassium nitrate Nutrition 0.000 claims description 3
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 claims description 2
- 210000004268 dentin Anatomy 0.000 claims description 2
- XROWMBWRMNHXMF-UHFFFAOYSA-J titanium tetrafluoride Chemical compound [F-].[F-].[F-].[F-].[Ti+4] XROWMBWRMNHXMF-UHFFFAOYSA-J 0.000 claims description 2
- 238000005299 abrasion Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000004673 fluoride salts Chemical class 0.000 abstract description 38
- 229940024606 amino acid Drugs 0.000 description 111
- 235000001014 amino acid Nutrition 0.000 description 111
- 238000009472 formulation Methods 0.000 description 71
- 229960003121 arginine Drugs 0.000 description 68
- 235000009697 arginine Nutrition 0.000 description 67
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 66
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 52
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 49
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 48
- 150000007522 mineralic acids Chemical class 0.000 description 29
- 235000011007 phosphoric acid Nutrition 0.000 description 26
- 239000000377 silicon dioxide Substances 0.000 description 25
- 229910021529 ammonia Inorganic materials 0.000 description 24
- 239000001506 calcium phosphate Substances 0.000 description 21
- 239000000047 product Substances 0.000 description 20
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 19
- 159000000007 calcium salts Chemical class 0.000 description 19
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 17
- 239000004615 ingredient Substances 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 15
- 229910052708 sodium Inorganic materials 0.000 description 15
- 239000011734 sodium Substances 0.000 description 15
- 229940083542 sodium Drugs 0.000 description 15
- 235000015424 sodium Nutrition 0.000 description 15
- 229960005069 calcium Drugs 0.000 description 14
- 239000002245 particle Substances 0.000 description 14
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 13
- 229930064664 L-arginine Natural products 0.000 description 13
- 235000014852 L-arginine Nutrition 0.000 description 13
- 229940088598 enzyme Drugs 0.000 description 13
- 230000007935 neutral effect Effects 0.000 description 13
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 12
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 12
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 12
- 229940038472 dicalcium phosphate Drugs 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 12
- 229910052500 inorganic mineral Inorganic materials 0.000 description 12
- 235000010755 mineral Nutrition 0.000 description 12
- 239000011707 mineral Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 238000011282 treatment Methods 0.000 description 12
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 description 11
- 239000002585 base Substances 0.000 description 11
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 11
- 239000000796 flavoring agent Substances 0.000 description 11
- 239000000543 intermediate Substances 0.000 description 11
- 239000002324 mouth wash Substances 0.000 description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 9
- 108010082340 Arginine deiminase Proteins 0.000 description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- 150000007513 acids Chemical class 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 8
- 229910000389 calcium phosphate Inorganic materials 0.000 description 8
- 235000011010 calcium phosphates Nutrition 0.000 description 8
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
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- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 6
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- 230000002401 inhibitory effect Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
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- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
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- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 3
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
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- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
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- 238000005728 strengthening Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
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- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 description 1
- CDVLCTOFEIEUDH-UHFFFAOYSA-K tetrasodium;phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O CDVLCTOFEIEUDH-UHFFFAOYSA-K 0.000 description 1
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- WBGSMIRITKHZNA-UHFFFAOYSA-M trisodium;dioxido(oxidooxy)borane Chemical compound [Na+].[Na+].[Na+].[O-]OB([O-])[O-] WBGSMIRITKHZNA-UHFFFAOYSA-M 0.000 description 1
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- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Landscapes
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- Public Health (AREA)
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- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
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| US2742008P | 2008-02-08 | 2008-02-08 | |
| US2743108P | 2008-02-08 | 2008-02-08 | |
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| US61/027,420 | 2008-02-08 | ||
| US61/027,431 | 2008-02-08 | ||
| US61/027,432 | 2008-02-08 | ||
| CA2710650A CA2710650C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2710650A Division CA2710650C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
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| CA2828861A1 true CA2828861A1 (en) | 2009-08-13 |
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| CA2710650A Active CA2710650C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
| CA2711414A Expired - Fee Related CA2711414C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
| CA2707084A Expired - Fee Related CA2707084C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
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| CA2710650A Active CA2710650C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
| CA2711414A Expired - Fee Related CA2711414C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
| CA2707084A Expired - Fee Related CA2707084C (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
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| US11857588B2 (en) | 2005-04-05 | 2024-01-02 | Membrane Protective Technologies, Inc. | Reproductive cell maintenance system |
| US9919014B2 (en) * | 2005-04-05 | 2018-03-20 | Membrane Protective Technologies, Inc. | Reproductive cell maintenance system |
| CN101801521B (zh) | 2007-05-14 | 2015-06-17 | 纽约州立大学研究基金会 | 生物膜中细菌细胞内的生理学分散响应诱导 |
| CN107080702A (zh) | 2008-02-08 | 2017-08-22 | 高露洁-棕榄公司 | 口腔护理产品及其使用和制备方法 |
| US9376722B2 (en) | 2008-02-08 | 2016-06-28 | Colgate-Palmolive Company | Oral care methods and systems |
| US8568697B2 (en) | 2008-03-21 | 2013-10-29 | Colgate-Palmolive Company | High fluoride ion recovery compositions |
| US20090238769A1 (en) * | 2008-03-21 | 2009-09-24 | Colgate-Palmolive Company | Compositions Comprising Nonionic And Zwittterionic Surfactants |
| EP3409324B1 (en) | 2010-01-29 | 2023-11-29 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
| SG183905A1 (en) | 2010-03-31 | 2012-10-30 | Colgate Palmolive Co | Oral care composition |
| MX343209B (es) | 2010-03-31 | 2016-10-27 | Colgate-Palmolive Company * | Composicion para el cuidado oral. |
| BR112012027179B1 (pt) * | 2010-06-01 | 2017-12-05 | Colgate-Palmolive Company | Microbial growth resistant compositions of body hygiene |
| CN105748305A (zh) * | 2010-06-23 | 2016-07-13 | 高露洁-棕榄公司 | 治疗用口腔组合物 |
| MX2012013955A (es) | 2010-06-23 | 2013-01-24 | Colgate Palmolive Co | Composiciones terapeuticas bucales. |
| KR102120160B1 (ko) | 2010-08-07 | 2020-06-08 | 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 | 구강용 조성물 |
| BR112013003722A2 (pt) * | 2010-08-18 | 2016-08-02 | Colgate Palmolive Co | produtos para cuidado e métodos de uso e fabricação dos mesmos |
| MX350073B (es) * | 2010-10-27 | 2017-08-25 | Colgate Palmolive Co | Composicion del cuidado oral que comprende arginina y carbonato de calcio. |
| AU2010363656C1 (en) | 2010-11-12 | 2015-07-30 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| WO2012064341A1 (en) * | 2010-11-12 | 2012-05-18 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
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