CA2762011C - Compositions and methods for control of insect infestations in plants - Google Patents
Compositions and methods for control of insect infestations in plants Download PDFInfo
- Publication number
- CA2762011C CA2762011C CA2762011A CA2762011A CA2762011C CA 2762011 C CA2762011 C CA 2762011C CA 2762011 A CA2762011 A CA 2762011A CA 2762011 A CA2762011 A CA 2762011A CA 2762011 C CA2762011 C CA 2762011C
- Authority
- CA
- Canada
- Prior art keywords
- pest
- sequence
- seq
- dsrna
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000238631 Hexapoda Species 0.000 title claims abstract description 283
- 238000000034 method Methods 0.000 title claims abstract description 145
- 239000000203 mixture Substances 0.000 title claims abstract description 90
- 206010061217 Infestation Diseases 0.000 title claims abstract description 59
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 332
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims abstract description 299
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims abstract description 296
- 230000014509 gene expression Effects 0.000 claims abstract description 105
- 235000005911 diet Nutrition 0.000 claims abstract description 83
- 230000037213 diet Effects 0.000 claims abstract description 83
- 239000000575 pesticide Substances 0.000 claims abstract description 70
- 230000006870 function Effects 0.000 claims abstract description 30
- 230000037406 food intake Effects 0.000 claims abstract description 27
- 108090000623 proteins and genes Proteins 0.000 claims description 393
- 241000196324 Embryophyta Species 0.000 claims description 252
- 102000004169 proteins and genes Human genes 0.000 claims description 148
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 123
- 239000003795 chemical substances by application Substances 0.000 claims description 110
- 150000007523 nucleic acids Chemical group 0.000 claims description 105
- 230000000749 insecticidal effect Effects 0.000 claims description 64
- 230000001629 suppression Effects 0.000 claims description 62
- 241000489947 Diabrotica virgifera virgifera Species 0.000 claims description 47
- 240000008042 Zea mays Species 0.000 claims description 46
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 46
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 45
- 235000005822 corn Nutrition 0.000 claims description 45
- 230000000361 pesticidal effect Effects 0.000 claims description 25
- 241000193388 Bacillus thuringiensis Species 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 19
- 229940097012 bacillus thuringiensis Drugs 0.000 claims description 18
- 239000011248 coating agent Substances 0.000 claims description 14
- 239000002689 soil Substances 0.000 claims description 12
- 241000489975 Diabrotica Species 0.000 claims description 11
- 238000009472 formulation Methods 0.000 claims description 11
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 9
- 108700039887 Essential Genes Proteins 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 8
- 230000008685 targeting Effects 0.000 claims description 7
- 230000009471 action Effects 0.000 claims description 5
- 241000489977 Diabrotica virgifera Species 0.000 claims description 4
- 241000381325 Diabrotica virgifera zeae Species 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 4
- 241000489972 Diabrotica barberi Species 0.000 claims description 3
- 241000489976 Diabrotica undecimpunctata howardi Species 0.000 claims description 3
- 101710197133 Protein TIC 100 Proteins 0.000 claims description 3
- 238000000855 fermentation Methods 0.000 claims description 3
- 230000004151 fermentation Effects 0.000 claims description 3
- 241000489973 Diabrotica undecimpunctata Species 0.000 claims description 2
- 241000916730 Diabrotica viridula Species 0.000 claims description 2
- 241001156075 Cyclocephala Species 0.000 claims 1
- 241001529600 Diabrotica balteata Species 0.000 claims 1
- 241000258915 Leptinotarsa Species 0.000 claims 1
- 241001427555 Polyphaga <Blattaria> Species 0.000 claims 1
- 241000254086 Tribolium <beetle> Species 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 description 346
- 239000002773 nucleotide Substances 0.000 description 338
- 210000004027 cell Anatomy 0.000 description 172
- 229920002477 rna polymer Polymers 0.000 description 164
- 235000018102 proteins Nutrition 0.000 description 120
- 108020004414 DNA Proteins 0.000 description 111
- 108020004459 Small interfering RNA Proteins 0.000 description 101
- 239000004055 small Interfering RNA Substances 0.000 description 98
- 108020004635 Complementary DNA Proteins 0.000 description 95
- 238000010804 cDNA synthesis Methods 0.000 description 94
- 239000002299 complementary DNA Substances 0.000 description 94
- 102000039446 nucleic acids Human genes 0.000 description 89
- 108020004707 nucleic acids Proteins 0.000 description 89
- 230000009261 transgenic effect Effects 0.000 description 68
- 108091093088 Amplicon Proteins 0.000 description 67
- 230000000295 complement effect Effects 0.000 description 60
- 230000005764 inhibitory process Effects 0.000 description 60
- 239000013615 primer Substances 0.000 description 54
- 239000013598 vector Substances 0.000 description 52
- 230000000875 corresponding effect Effects 0.000 description 49
- 230000002441 reversible effect Effects 0.000 description 46
- 108020004511 Recombinant DNA Proteins 0.000 description 43
- 125000003275 alpha amino acid group Chemical group 0.000 description 39
- 230000035897 transcription Effects 0.000 description 39
- 238000013518 transcription Methods 0.000 description 39
- 230000000692 anti-sense effect Effects 0.000 description 37
- 230000015572 biosynthetic process Effects 0.000 description 37
- 241000894007 species Species 0.000 description 34
- 108020004999 messenger RNA Proteins 0.000 description 33
- 230000001276 controlling effect Effects 0.000 description 31
- 230000001747 exhibiting effect Effects 0.000 description 31
- 239000012634 fragment Substances 0.000 description 31
- 239000000523 sample Substances 0.000 description 30
- 230000003321 amplification Effects 0.000 description 29
- 238000003199 nucleic acid amplification method Methods 0.000 description 29
- 230000000694 effects Effects 0.000 description 27
- 239000013612 plasmid Substances 0.000 description 27
- 239000000047 product Substances 0.000 description 27
- 238000004166 bioassay Methods 0.000 description 25
- 108091026890 Coding region Proteins 0.000 description 24
- 230000009466 transformation Effects 0.000 description 23
- 238000011282 treatment Methods 0.000 description 23
- 239000002609 medium Substances 0.000 description 22
- 244000005700 microbiome Species 0.000 description 22
- 241000244206 Nematoda Species 0.000 description 21
- 238000006243 chemical reaction Methods 0.000 description 21
- 230000002401 inhibitory effect Effects 0.000 description 21
- 230000001404 mediated effect Effects 0.000 description 21
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 20
- 230000001580 bacterial effect Effects 0.000 description 20
- 238000000338 in vitro Methods 0.000 description 20
- 230000014616 translation Effects 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 19
- 238000013519 translation Methods 0.000 description 18
- 210000001519 tissue Anatomy 0.000 description 17
- 102000007469 Actins Human genes 0.000 description 16
- 108010085238 Actins Proteins 0.000 description 16
- 241000233866 Fungi Species 0.000 description 15
- 230000001105 regulatory effect Effects 0.000 description 15
- 239000000126 substance Substances 0.000 description 15
- 238000003786 synthesis reaction Methods 0.000 description 15
- 230000006378 damage Effects 0.000 description 14
- 210000001035 gastrointestinal tract Anatomy 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 102100023387 Endoribonuclease Dicer Human genes 0.000 description 13
- 108090000790 Enzymes Proteins 0.000 description 13
- 238000011161 development Methods 0.000 description 13
- 230000018109 developmental process Effects 0.000 description 13
- 101150083707 dicer1 gene Proteins 0.000 description 13
- 230000003828 downregulation Effects 0.000 description 13
- 229930014550 juvenile hormone Natural products 0.000 description 13
- 239000002949 juvenile hormone Substances 0.000 description 13
- 150000003633 juvenile hormone derivatives Chemical class 0.000 description 13
- 102000004190 Enzymes Human genes 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 12
- 229940088598 enzyme Drugs 0.000 description 12
- 230000009467 reduction Effects 0.000 description 12
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 11
- 108091081021 Sense strand Proteins 0.000 description 11
- 230000008827 biological function Effects 0.000 description 11
- 230000002068 genetic effect Effects 0.000 description 11
- 230000009036 growth inhibition Effects 0.000 description 11
- 238000003752 polymerase chain reaction Methods 0.000 description 11
- 125000002652 ribonucleotide group Chemical group 0.000 description 11
- 102000016954 ADP-Ribosylation Factors Human genes 0.000 description 10
- 108010053971 ADP-Ribosylation Factors Proteins 0.000 description 10
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 10
- 102100035172 Glucose-6-phosphate 1-dehydrogenase Human genes 0.000 description 10
- 101710155861 Glucose-6-phosphate 1-dehydrogenase Proteins 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 10
- 108091028664 Ribonucleotide Proteins 0.000 description 10
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 10
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 10
- 230000002939 deleterious effect Effects 0.000 description 10
- 235000013601 eggs Nutrition 0.000 description 10
- 239000002917 insecticide Substances 0.000 description 10
- 238000012423 maintenance Methods 0.000 description 10
- 239000013600 plasmid vector Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 230000033458 reproduction Effects 0.000 description 10
- 239000002336 ribonucleotide Substances 0.000 description 10
- 231100000331 toxic Toxicity 0.000 description 10
- 230000002588 toxic effect Effects 0.000 description 10
- 102000053602 DNA Human genes 0.000 description 9
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 9
- 241001414826 Lygus Species 0.000 description 9
- 101710137500 T7 RNA polymerase Proteins 0.000 description 9
- 230000001332 colony forming effect Effects 0.000 description 9
- 235000013305 food Nutrition 0.000 description 9
- 230000012010 growth Effects 0.000 description 9
- 238000001727 in vivo Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 9
- 108090000704 Tubulin Proteins 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- 239000003184 complementary RNA Substances 0.000 description 8
- 230000034994 death Effects 0.000 description 8
- 230000030279 gene silencing Effects 0.000 description 8
- 239000004009 herbicide Substances 0.000 description 8
- 238000009396 hybridization Methods 0.000 description 8
- 230000001418 larval effect Effects 0.000 description 8
- 239000003550 marker Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 230000035899 viability Effects 0.000 description 8
- 241000255601 Drosophila melanogaster Species 0.000 description 7
- 108700026244 Open Reading Frames Proteins 0.000 description 7
- 102000004243 Tubulin Human genes 0.000 description 7
- 102000011731 Vacuolar Proton-Translocating ATPases Human genes 0.000 description 7
- 108010037026 Vacuolar Proton-Translocating ATPases Proteins 0.000 description 7
- 238000007792 addition Methods 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000015556 catabolic process Effects 0.000 description 7
- 238000006731 degradation reaction Methods 0.000 description 7
- 238000012217 deletion Methods 0.000 description 7
- 230000037430 deletion Effects 0.000 description 7
- 230000002255 enzymatic effect Effects 0.000 description 7
- 238000013412 genome amplification Methods 0.000 description 7
- 230000037361 pathway Effects 0.000 description 7
- 108700012359 toxins Proteins 0.000 description 7
- 241000238876 Acari Species 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 240000001980 Cucurbita pepo Species 0.000 description 6
- 241000282414 Homo sapiens Species 0.000 description 6
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- 210000000349 chromosome Anatomy 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 230000001419 dependent effect Effects 0.000 description 6
- 230000009368 gene silencing by RNA Effects 0.000 description 6
- 210000000087 hemolymph Anatomy 0.000 description 6
- 230000002363 herbicidal effect Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 230000010354 integration Effects 0.000 description 6
- 108010004855 juvenile hormone epoxide hydrolase Proteins 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 108091070501 miRNA Proteins 0.000 description 6
- 239000002679 microRNA Substances 0.000 description 6
- 230000001124 posttranscriptional effect Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 108020005544 Antisense RNA Proteins 0.000 description 5
- 102100031266 Chromodomain-helicase-DNA-binding protein 3 Human genes 0.000 description 5
- 241000206602 Eukaryota Species 0.000 description 5
- 241000258937 Hemiptera Species 0.000 description 5
- 101000777071 Homo sapiens Chromodomain-helicase-DNA-binding protein 3 Proteins 0.000 description 5
- 241001414825 Miridae Species 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 230000003466 anti-cipated effect Effects 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 210000002249 digestive system Anatomy 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 230000035772 mutation Effects 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 230000001052 transient effect Effects 0.000 description 5
- 238000011144 upstream manufacturing Methods 0.000 description 5
- 241000589158 Agrobacterium Species 0.000 description 4
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 4
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 4
- 241000244203 Caenorhabditis elegans Species 0.000 description 4
- 101710128223 Chloride channel protein Proteins 0.000 description 4
- 108010077544 Chromatin Proteins 0.000 description 4
- 240000006740 Cichorium endivia Species 0.000 description 4
- 241001672694 Citrus reticulata Species 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 4
- 241000254173 Coleoptera Species 0.000 description 4
- 244000241257 Cucumis melo Species 0.000 description 4
- 235000009854 Cucurbita moschata Nutrition 0.000 description 4
- 235000009852 Cucurbita pepo Nutrition 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 239000005562 Glyphosate Substances 0.000 description 4
- 241001414823 Lygus hesperus Species 0.000 description 4
- 241000255908 Manduca sexta Species 0.000 description 4
- 240000005561 Musa balbisiana Species 0.000 description 4
- 241000242594 Platyhelminthes Species 0.000 description 4
- 241000256248 Spodoptera Species 0.000 description 4
- 108020004566 Transfer RNA Proteins 0.000 description 4
- 108700019146 Transgenes Proteins 0.000 description 4
- 244000078534 Vaccinium myrtillus Species 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000032823 cell division Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 235000003733 chicria Nutrition 0.000 description 4
- 210000003483 chromatin Anatomy 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 238000013500 data storage Methods 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 230000037149 energy metabolism Effects 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 210000004955 epithelial membrane Anatomy 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000002538 fungal effect Effects 0.000 description 4
- 229940097068 glyphosate Drugs 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 229930027917 kanamycin Natural products 0.000 description 4
- 229960000318 kanamycin Drugs 0.000 description 4
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 4
- 229930182823 kanamycin A Natural products 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 239000003090 pesticide formulation Substances 0.000 description 4
- 239000003016 pheromone Substances 0.000 description 4
- 102000040430 polynucleotide Human genes 0.000 description 4
- 108091033319 polynucleotide Proteins 0.000 description 4
- 239000002157 polynucleotide Substances 0.000 description 4
- 230000006798 recombination Effects 0.000 description 4
- 238000005215 recombination Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 3
- 241000566547 Agrotis ipsilon Species 0.000 description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 3
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 3
- 241000239223 Arachnida Species 0.000 description 3
- 235000016068 Berberis vulgaris Nutrition 0.000 description 3
- 241000335053 Beta vulgaris Species 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 3
- 241000242722 Cestoda Species 0.000 description 3
- 240000007154 Coffea arabica Species 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 241000498255 Enterobius vermicularis Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 241000257303 Hymenoptera Species 0.000 description 3
- 108091092195 Intron Proteins 0.000 description 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
- 241000258916 Leptinotarsa decemlineata Species 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- 241001147398 Ostrinia nubilalis Species 0.000 description 3
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 3
- 241000018646 Pinus brutia Species 0.000 description 3
- 235000011613 Pinus brutia Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 102000013009 Pyruvate Kinase Human genes 0.000 description 3
- 108020005115 Pyruvate Kinase Proteins 0.000 description 3
- 108010057163 Ribonuclease III Proteins 0.000 description 3
- 102000003661 Ribonuclease III Human genes 0.000 description 3
- 241000242678 Schistosoma Species 0.000 description 3
- 241000258242 Siphonaptera Species 0.000 description 3
- 108091023040 Transcription factor Proteins 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 3
- 241000254113 Tribolium castaneum Species 0.000 description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 235000021405 artificial diet Nutrition 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 3
- 239000003593 chromogenic compound Substances 0.000 description 3
- 102000038379 digestive enzymes Human genes 0.000 description 3
- 108091007734 digestive enzymes Proteins 0.000 description 3
- 238000004520 electroporation Methods 0.000 description 3
- 206010014881 enterobiasis Diseases 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 208000037824 growth disorder Diseases 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229960000485 methotrexate Drugs 0.000 description 3
- 239000004570 mortar (masonry) Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- -1 pulite Substances 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 238000009331 sowing Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 230000002103 transcriptional effect Effects 0.000 description 3
- 108010020183 3-phosphoshikimate 1-carboxyvinyltransferase Proteins 0.000 description 2
- 108010016281 ADP-Ribosylation Factor 1 Proteins 0.000 description 2
- 102100034341 ADP-ribosylation factor 1 Human genes 0.000 description 2
- 240000004507 Abelmoschus esculentus Species 0.000 description 2
- 241000589220 Acetobacter Species 0.000 description 2
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 2
- 244000298697 Actinidia deliciosa Species 0.000 description 2
- 241000256111 Aedes <genus> Species 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 235000005254 Allium ampeloprasum Nutrition 0.000 description 2
- 240000006108 Allium ampeloprasum Species 0.000 description 2
- 244000291564 Allium cepa Species 0.000 description 2
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 2
- 235000007119 Ananas comosus Nutrition 0.000 description 2
- 241001465677 Ancylostomatoidea Species 0.000 description 2
- 241000254175 Anthonomus grandis Species 0.000 description 2
- 240000007087 Apium graveolens Species 0.000 description 2
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 2
- 235000010591 Appio Nutrition 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 244000003416 Asparagus officinalis Species 0.000 description 2
- 235000005340 Asparagus officinalis Nutrition 0.000 description 2
- 241000223651 Aureobasidium Species 0.000 description 2
- 235000007319 Avena orientalis Nutrition 0.000 description 2
- 241000209763 Avena sativa Species 0.000 description 2
- 235000007558 Avena sp Nutrition 0.000 description 2
- 235000000832 Ayote Nutrition 0.000 description 2
- 241000589151 Azotobacter Species 0.000 description 2
- 241001147758 Bacillus thuringiensis serovar kurstaki Species 0.000 description 2
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 2
- 108010006654 Bleomycin Proteins 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 2
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 2
- 235000006008 Brassica napus var napus Nutrition 0.000 description 2
- 240000000385 Brassica napus var. napus Species 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 2
- 235000004221 Brassica oleracea var gemmifera Nutrition 0.000 description 2
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 2
- 244000308368 Brassica oleracea var. gemmifera Species 0.000 description 2
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 2
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 2
- 241000193417 Brevibacillus laterosporus Species 0.000 description 2
- 235000004936 Bromus mango Nutrition 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- 235000009467 Carica papaya Nutrition 0.000 description 2
- 240000006432 Carica papaya Species 0.000 description 2
- 240000001817 Cereus hexagonus Species 0.000 description 2
- 241001124134 Chrysomelidae Species 0.000 description 2
- 241000668561 Chrysomphalus Species 0.000 description 2
- 244000298479 Cichorium intybus Species 0.000 description 2
- 244000241235 Citrullus lanatus Species 0.000 description 2
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 240000000560 Citrus x paradisi Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 108020004394 Complementary RNA Proteins 0.000 description 2
- 108091035707 Consensus sequence Proteins 0.000 description 2
- 244000018436 Coriandrum sativum Species 0.000 description 2
- 241000238424 Crustacea Species 0.000 description 2
- 101710151559 Crystal protein Proteins 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 description 2
- 235000015001 Cucumis melo var inodorus Nutrition 0.000 description 2
- 240000002495 Cucumis melo var. inodorus Species 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 2
- 241000219130 Cucurbita pepo subsp. pepo Species 0.000 description 2
- 241000254171 Curculionidae Species 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 2
- 244000019459 Cynara cardunculus Species 0.000 description 2
- 235000019106 Cynara scolymus Nutrition 0.000 description 2
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 2
- 239000003155 DNA primer Substances 0.000 description 2
- 235000002767 Daucus carota Nutrition 0.000 description 2
- 244000000626 Daucus carota Species 0.000 description 2
- 235000011511 Diospyros Nutrition 0.000 description 2
- 244000236655 Diospyros kaki Species 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- 241001057636 Dracaena deremensis Species 0.000 description 2
- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 2
- 244000024675 Eruca sativa Species 0.000 description 2
- 235000014755 Eruca sativa Nutrition 0.000 description 2
- 241000588698 Erwinia Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 244000004281 Eucalyptus maculata Species 0.000 description 2
- 108091029865 Exogenous DNA Proteins 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 240000006927 Foeniculum vulgare Species 0.000 description 2
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- 108700007698 Genetic Terminator Regions Proteins 0.000 description 2
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 241000219146 Gossypium Species 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 244000020551 Helianthus annuus Species 0.000 description 2
- 235000003222 Helianthus annuus Nutrition 0.000 description 2
- 108090000353 Histone deacetylase Proteins 0.000 description 2
- 102000003964 Histone deacetylase Human genes 0.000 description 2
- 101100220555 Homo sapiens CHD3 gene Proteins 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 235000002678 Ipomoea batatas Nutrition 0.000 description 2
- 244000017020 Ipomoea batatas Species 0.000 description 2
- 235000003228 Lactuca sativa Nutrition 0.000 description 2
- 240000008415 Lactuca sativa Species 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- 241000208682 Liquidambar Species 0.000 description 2
- 235000006552 Liquidambar styraciflua Nutrition 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 241000220225 Malus Species 0.000 description 2
- 235000011430 Malus pumila Nutrition 0.000 description 2
- 235000015103 Malus silvestris Nutrition 0.000 description 2
- 235000014826 Mangifera indica Nutrition 0.000 description 2
- 240000007228 Mangifera indica Species 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 2
- 108091027974 Mature messenger RNA Proteins 0.000 description 2
- 240000004658 Medicago sativa Species 0.000 description 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 102000029749 Microtubule Human genes 0.000 description 2
- 108091022875 Microtubule Proteins 0.000 description 2
- 235000003805 Musa ABB Group Nutrition 0.000 description 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 244000061176 Nicotiana tabacum Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 235000001591 Pachyrhizus erosus Nutrition 0.000 description 2
- 244000215747 Pachyrhizus erosus Species 0.000 description 2
- 235000018669 Pachyrhizus tuberosus Nutrition 0.000 description 2
- 241001310339 Paenibacillus popilliae Species 0.000 description 2
- 241000721454 Pemphigus Species 0.000 description 2
- 239000006002 Pepper Substances 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 description 2
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 description 2
- 244000025272 Persea americana Species 0.000 description 2
- 235000008673 Persea americana Nutrition 0.000 description 2
- 244000062780 Petroselinum sativum Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- IAJOBQBIJHVGMQ-UHFFFAOYSA-N Phosphinothricin Natural products CP(O)(=O)CCC(N)C(O)=O IAJOBQBIJHVGMQ-UHFFFAOYSA-N 0.000 description 2
- 241001674048 Phthiraptera Species 0.000 description 2
- 241001236219 Pinus echinata Species 0.000 description 2
- 235000005018 Pinus echinata Nutrition 0.000 description 2
- 235000017339 Pinus palustris Nutrition 0.000 description 2
- 241000218679 Pinus taeda Species 0.000 description 2
- 235000008566 Pinus taeda Nutrition 0.000 description 2
- 235000016761 Piper aduncum Nutrition 0.000 description 2
- 240000003889 Piper guineense Species 0.000 description 2
- 235000017804 Piper guineense Nutrition 0.000 description 2
- 235000008184 Piper nigrum Nutrition 0.000 description 2
- 241000219843 Pisum Species 0.000 description 2
- 235000010582 Pisum sativum Nutrition 0.000 description 2
- 108700001094 Plant Genes Proteins 0.000 description 2
- 235000015266 Plantago major Nutrition 0.000 description 2
- 241000219000 Populus Species 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 description 2
- 244000018633 Prunus armeniaca Species 0.000 description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 description 2
- 244000294611 Punica granatum Species 0.000 description 2
- 235000014360 Punica granatum Nutrition 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 240000001987 Pyrus communis Species 0.000 description 2
- 244000088415 Raphanus sativus Species 0.000 description 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 2
- 241000589180 Rhizobium Species 0.000 description 2
- 241000223252 Rhodotorula Species 0.000 description 2
- 235000017848 Rubus fruticosus Nutrition 0.000 description 2
- 240000007651 Rubus glaucus Species 0.000 description 2
- 235000011034 Rubus glaucus Nutrition 0.000 description 2
- 235000009122 Rubus idaeus Nutrition 0.000 description 2
- 240000000111 Saccharum officinarum Species 0.000 description 2
- 235000007201 Saccharum officinarum Nutrition 0.000 description 2
- 241000209056 Secale Species 0.000 description 2
- 235000007238 Secale cereale Nutrition 0.000 description 2
- 241000607720 Serratia Species 0.000 description 2
- 241000147799 Serratia entomophila Species 0.000 description 2
- 241000607714 Serratia sp. Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- 235000002597 Solanum melongena Nutrition 0.000 description 2
- 244000061458 Solanum melongena Species 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 240000006394 Sorghum bicolor Species 0.000 description 2
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
- 235000009337 Spinacia oleracea Nutrition 0.000 description 2
- 244000300264 Spinacia oleracea Species 0.000 description 2
- 235000009184 Spondias indica Nutrition 0.000 description 2
- 235000021536 Sugar beet Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 241001414989 Thysanoptera Species 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 240000006909 Tilia x europaea Species 0.000 description 2
- 241000255993 Trichoplusia ni Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 244000098338 Triticum aestivum Species 0.000 description 2
- 108090000848 Ubiquitin Proteins 0.000 description 2
- 102000044159 Ubiquitin Human genes 0.000 description 2
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 241000500606 Xenorhabdus sp. Species 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 230000035508 accumulation Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 229960000723 ampicillin Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 235000016520 artichoke thistle Nutrition 0.000 description 2
- 235000000183 arugula Nutrition 0.000 description 2
- 210000003578 bacterial chromosome Anatomy 0.000 description 2
- 208000036815 beta tubulin Diseases 0.000 description 2
- 235000021029 blackberry Nutrition 0.000 description 2
- 229960001561 bleomycin Drugs 0.000 description 2
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
- 235000021014 blueberries Nutrition 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 230000009087 cell motility Effects 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 244000038559 crop plants Species 0.000 description 2
- 238000002716 delivery method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 235000004879 dioscorea Nutrition 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 230000035611 feeding Effects 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000012226 gene silencing method Methods 0.000 description 2
- 230000035784 germination Effects 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 230000002414 glycolytic effect Effects 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 210000004688 microtubule Anatomy 0.000 description 2
- 230000000394 mitotic effect Effects 0.000 description 2
- 230000009753 muscle formation Effects 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000014571 nuts Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 235000011197 perejil Nutrition 0.000 description 2
- 235000015136 pumpkin Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
- 230000000754 repressing effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 108020004418 ribosomal RNA Proteins 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000020354 squash Nutrition 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000005062 synaptic transmission Effects 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 230000005030 transcription termination Effects 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 241001515965 unidentified phage Species 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 235000020985 whole grains Nutrition 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- FCHBECOAGZMTFE-ZEQKJWHPSA-N (6r,7r)-3-[[2-[[4-(dimethylamino)phenyl]diazenyl]pyridin-1-ium-1-yl]methyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=CC=[N+]1CC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CC=3SC=CC=3)[C@H]2SC1 FCHBECOAGZMTFE-ZEQKJWHPSA-N 0.000 description 1
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 description 1
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- UPMXNNIRAGDFEH-UHFFFAOYSA-N 3,5-dibromo-4-hydroxybenzonitrile Chemical compound OC1=C(Br)C=C(C#N)C=C1Br UPMXNNIRAGDFEH-UHFFFAOYSA-N 0.000 description 1
- CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 description 1
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 1
- BIRSGZKFKXLSJQ-SQOUGZDYSA-N 6-Phospho-D-gluconate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O BIRSGZKFKXLSJQ-SQOUGZDYSA-N 0.000 description 1
- 102100021206 60S ribosomal protein L19 Human genes 0.000 description 1
- 101710187808 60S ribosomal protein L19 Proteins 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 244000235858 Acetobacter xylinum Species 0.000 description 1
- 235000002837 Acetobacter xylinum Nutrition 0.000 description 1
- 108010000700 Acetolactate synthase Proteins 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 241001204086 Acleris Species 0.000 description 1
- 101710197637 Actin-3 Proteins 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 241001136265 Agriotes Species 0.000 description 1
- 241000589156 Agrobacterium rhizogenes Species 0.000 description 1
- 241000218473 Agrotis Species 0.000 description 1
- 241000588986 Alcaligenes Species 0.000 description 1
- 241000307865 Aleurothrixus floccosus Species 0.000 description 1
- 241000107983 Aleyrodes proletella Species 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 1
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 description 1
- 102100026277 Alpha-galactosidase A Human genes 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000546288 Alysia lucicola Species 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 241000244021 Anisakis simplex Species 0.000 description 1
- 241000256186 Anopheles <genus> Species 0.000 description 1
- 241000256182 Anopheles gambiae Species 0.000 description 1
- 241001427556 Anoplura Species 0.000 description 1
- 241000254177 Anthonomus Species 0.000 description 1
- 241000625764 Anticarsia gemmatalis Species 0.000 description 1
- 241001414827 Aonidiella Species 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 241001600407 Aphis <genus> Species 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 241000219195 Arabidopsis thaliana Species 0.000 description 1
- 241000384127 Argyrotaenia Species 0.000 description 1
- 241000186063 Arthrobacter Species 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000387313 Aspidiotus Species 0.000 description 1
- 241001174347 Atomaria Species 0.000 description 1
- 241000726103 Atta Species 0.000 description 1
- 241001367049 Autographa Species 0.000 description 1
- 241000589154 Azotobacter group Species 0.000 description 1
- 241001112741 Bacillaceae Species 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 241000193363 Bacillus thuringiensis serovar aizawai Species 0.000 description 1
- 241000193368 Bacillus thuringiensis serovar berliner Species 0.000 description 1
- 241001147757 Bacillus thuringiensis serovar galleriae Species 0.000 description 1
- 241000193367 Bacillus thuringiensis serovar san diego Species 0.000 description 1
- 241001147766 Bacillus thuringiensis serovar sotto Species 0.000 description 1
- 241000193369 Bacillus thuringiensis serovar tenebrionis Species 0.000 description 1
- 241000193364 Bacillus thuringiensis serovar thuringiensis Species 0.000 description 1
- 108700003860 Bacterial Genes Proteins 0.000 description 1
- 241001142392 Bibio Species 0.000 description 1
- 241000238658 Blattella Species 0.000 description 1
- 241000929635 Blissus Species 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 241000142468 Bracon Species 0.000 description 1
- 241000131971 Bradyrhizobiaceae Species 0.000 description 1
- 239000005489 Bromoxynil Substances 0.000 description 1
- 241000661267 Busseola Species 0.000 description 1
- 108091007914 CDKs Proteins 0.000 description 1
- 101100220553 Caenorhabditis elegans chd-3 gene Proteins 0.000 description 1
- 241000257160 Calliphora Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 241001347512 Carposina Species 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 241000717851 Cephus Species 0.000 description 1
- 241000255580 Ceratitis <genus> Species 0.000 description 1
- 241001098608 Ceratophyllus Species 0.000 description 1
- 241001087583 Chaetocnema tibialis Species 0.000 description 1
- 102000012286 Chitinases Human genes 0.000 description 1
- 108010022172 Chitinases Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 241000255945 Choristoneura Species 0.000 description 1
- 102100031235 Chromodomain-helicase-DNA-binding protein 1 Human genes 0.000 description 1
- 241001414836 Cimex Species 0.000 description 1
- 241000098277 Cnaphalocrocis Species 0.000 description 1
- 241001350387 Cnephasia Species 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 241001362579 Cochylis Species 0.000 description 1
- 241000689390 Coleophora Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241001212536 Cosmopolites Species 0.000 description 1
- 241000907509 Cowbone Ridge virus Species 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 235000003954 Cucurbita pepo var melopepo Nutrition 0.000 description 1
- 241000256054 Culex <genus> Species 0.000 description 1
- 241000692095 Cuterebra Species 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 description 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 description 1
- 241001634817 Cydia Species 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- 101150074155 DHFR gene Proteins 0.000 description 1
- 230000005971 DNA damage repair Effects 0.000 description 1
- 108090000133 DNA helicases Proteins 0.000 description 1
- 102000003844 DNA helicases Human genes 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 230000004568 DNA-binding Effects 0.000 description 1
- 241000157278 Dacus <genus> Species 0.000 description 1
- 241000252212 Danio rerio Species 0.000 description 1
- 241001631715 Dendrolimus Species 0.000 description 1
- 241000605716 Desulfovibrio Species 0.000 description 1
- 241000916731 Diabrotica speciosa Species 0.000 description 1
- 241000122105 Diatraea Species 0.000 description 1
- 102000016680 Dioxygenases Human genes 0.000 description 1
- 108010028143 Dioxygenases Proteins 0.000 description 1
- 241000511318 Diprion Species 0.000 description 1
- 241000511320 Diprionidae Species 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 241000321929 Dothiorella pretoriensis Species 0.000 description 1
- 235000014466 Douglas bleu Nutrition 0.000 description 1
- 101100054775 Drosophila melanogaster Act42A gene Proteins 0.000 description 1
- 101100220554 Drosophila melanogaster Chd3 gene Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241001425477 Dysdercus Species 0.000 description 1
- 101150013191 E gene Proteins 0.000 description 1
- 241000241133 Earias Species 0.000 description 1
- 101710103942 Elongation factor 1-alpha Proteins 0.000 description 1
- 241000995023 Empoasca Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 241000546351 Ephedrus persicae Species 0.000 description 1
- 241000630736 Ephestia Species 0.000 description 1
- 241000917109 Eriosoma Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- BHTWZQKERRCPRZ-RYRKJORJSA-N Estra-4,9-diene-3,17-dione Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)(C(CC3)=O)CC3)C3=C21 BHTWZQKERRCPRZ-RYRKJORJSA-N 0.000 description 1
- 241001362584 Eupoecilia Species 0.000 description 1
- 241000060469 Eupoecilia ambiguella Species 0.000 description 1
- 241001331999 Euproctis Species 0.000 description 1
- 241000515838 Eurygaster Species 0.000 description 1
- 241001585293 Euxoa Species 0.000 description 1
- 241000371383 Fannia Species 0.000 description 1
- 108700005088 Fungal Genes Proteins 0.000 description 1
- 101150038242 GAL10 gene Proteins 0.000 description 1
- 108091092584 GDNA Proteins 0.000 description 1
- 102100024637 Galectin-10 Human genes 0.000 description 1
- 241001660203 Gasterophilus Species 0.000 description 1
- 208000031448 Genomic Instability Diseases 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 241000258727 Gilpinia Species 0.000 description 1
- 241000257324 Glossina <genus> Species 0.000 description 1
- 102000030595 Glucokinase Human genes 0.000 description 1
- 108010021582 Glucokinase Proteins 0.000 description 1
- 239000005561 Glufosinate Substances 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 241001150406 Grapholita Species 0.000 description 1
- 241000190714 Gymnosporangium clavipes Species 0.000 description 1
- 241000790933 Haematopinus Species 0.000 description 1
- 241001201676 Hedya nubiferana Species 0.000 description 1
- 241000255990 Helicoverpa Species 0.000 description 1
- 241001147381 Helicoverpa armigera Species 0.000 description 1
- 241000255967 Helicoverpa zea Species 0.000 description 1
- 241000256257 Heliothis Species 0.000 description 1
- 241001581044 Hellula undalis Species 0.000 description 1
- 241001659689 Hercinothrips Species 0.000 description 1
- 241001466007 Heteroptera Species 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 241000546300 Histeromerus mystacinus Species 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 102000006947 Histones Human genes 0.000 description 1
- 101000718525 Homo sapiens Alpha-galactosidase A Proteins 0.000 description 1
- 101000777047 Homo sapiens Chromodomain-helicase-DNA-binding protein 1 Proteins 0.000 description 1
- 101000907904 Homo sapiens Endoribonuclease Dicer Proteins 0.000 description 1
- 101000702559 Homo sapiens Probable global transcription activator SNF2L2 Proteins 0.000 description 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 description 1
- 241001417351 Hoplocampa Species 0.000 description 1
- GRRNUXAQVGOGFE-UHFFFAOYSA-N Hygromycin-B Natural products OC1C(NC)CC(N)C(O)C1OC1C2OC3(C(C(O)C(O)C(C(N)CO)O3)O)OC2C(O)C(CO)O1 GRRNUXAQVGOGFE-UHFFFAOYSA-N 0.000 description 1
- 241001531327 Hyphantria cunea Species 0.000 description 1
- 241000257176 Hypoderma <fly> Species 0.000 description 1
- 108700001097 Insect Genes Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 241001495069 Ischnocera Species 0.000 description 1
- 241000256602 Isoptera Species 0.000 description 1
- 241000400431 Keiferia lycopersicella Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 101100288095 Klebsiella pneumoniae neo gene Proteins 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241001468155 Lactobacillaceae Species 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001470016 Laodelphax Species 0.000 description 1
- 241000256686 Lasius <genus> Species 0.000 description 1
- 241000669027 Lepidosaphes Species 0.000 description 1
- 241000500881 Lepisma Species 0.000 description 1
- 241000661345 Leptocorisa Species 0.000 description 1
- 241000192132 Leuconostoc Species 0.000 description 1
- 241001578972 Leucoptera malifoliella Species 0.000 description 1
- 241000209510 Liliopsida Species 0.000 description 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
- 241000322707 Liposcelis Species 0.000 description 1
- 241000396080 Lissorhoptrus Species 0.000 description 1
- 241001261104 Lobesia botrana Species 0.000 description 1
- 241000254023 Locusta Species 0.000 description 1
- 241000257162 Lucilia <blowfly> Species 0.000 description 1
- 241000257166 Lucilia cuprina Species 0.000 description 1
- 241000258912 Lygaeidae Species 0.000 description 1
- 241000501345 Lygus lineolaris Species 0.000 description 1
- 241000721696 Lymantria Species 0.000 description 1
- 241001190211 Lyonetia Species 0.000 description 1
- 241000193386 Lysinibacillus sphaericus Species 0.000 description 1
- LTGPFZWZZNUIIK-LURJTMIESA-N Lysol Chemical compound NCCCC[C@H](N)CO LTGPFZWZZNUIIK-LURJTMIESA-N 0.000 description 1
- 108091077621 MAPRE family Proteins 0.000 description 1
- 241000255676 Malacosoma Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000256010 Manduca Species 0.000 description 1
- 101001077853 Manduca sexta Juvenile hormone epoxide hydrolase Proteins 0.000 description 1
- 241000824682 Melanagromyza Species 0.000 description 1
- 241001599018 Melanogaster Species 0.000 description 1
- 241000254071 Melolontha Species 0.000 description 1
- 241000002163 Mesapamea fractilinea Species 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 241000257229 Musca <genus> Species 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- 241000721623 Myzus Species 0.000 description 1
- 229920002274 Nalgene Polymers 0.000 description 1
- 241000406465 Neodiprion Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 241001671714 Nezara Species 0.000 description 1
- 241001556090 Nilaparvata Species 0.000 description 1
- 108010033272 Nitrilase Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 241000257191 Oestridae Species 0.000 description 1
- 241001491890 Operophtera Species 0.000 description 1
- 241001465829 Orseolia Species 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 241000975417 Oscinella frit Species 0.000 description 1
- 241000131737 Otiorhynchus Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001441428 Pandemis Species 0.000 description 1
- 241000370704 Papaipema Species 0.000 description 1
- 241000222051 Papiliotrema laurentii Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 101710091688 Patatin Proteins 0.000 description 1
- 241000721451 Pectinophora gossypiella Species 0.000 description 1
- 241000320508 Pentatomidae Species 0.000 description 1
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 1
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 1
- 241000238661 Periplaneta Species 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 241000607568 Photobacterium Species 0.000 description 1
- 241001148062 Photorhabdus Species 0.000 description 1
- 241001439019 Phthorimaea operculella Species 0.000 description 1
- 241001516577 Phylloxera Species 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 241000255972 Pieris <butterfly> Species 0.000 description 1
- 241000907661 Pieris rapae Species 0.000 description 1
- 235000008577 Pinus radiata Nutrition 0.000 description 1
- 241000218621 Pinus radiata Species 0.000 description 1
- 241000193804 Planococcus <bacterium> Species 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 241000254103 Popillia Species 0.000 description 1
- 241001201614 Prays Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 235000005805 Prunus cerasus Nutrition 0.000 description 1
- 241000668989 Pseudaulacaspis Species 0.000 description 1
- 241000722234 Pseudococcus Species 0.000 description 1
- 241000947836 Pseudomonadaceae Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 241000589615 Pseudomonas syringae Species 0.000 description 1
- 240000001416 Pseudotsuga menziesii Species 0.000 description 1
- 235000005386 Pseudotsuga menziesii var menziesii Nutrition 0.000 description 1
- 241001415024 Psocoptera Species 0.000 description 1
- 241000526145 Psylla Species 0.000 description 1
- 241001160824 Psylliodes Species 0.000 description 1
- 241000531582 Pulvinaria <Pelagophyceae> Species 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 102000004879 Racemases and epimerases Human genes 0.000 description 1
- 108090001066 Racemases and epimerases Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 241001136852 Rhagoletis Species 0.000 description 1
- 241000722251 Rhodnius Species 0.000 description 1
- 241000158450 Rhodobacter sp. KYW73 Species 0.000 description 1
- 241000191043 Rhodobacter sphaeroides Species 0.000 description 1
- 241000223253 Rhodotorula glutinis Species 0.000 description 1
- 241000223254 Rhodotorula mucilaginosa Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000700685 Saccoglossus kowalevskii Species 0.000 description 1
- 241000914334 Sahlbergella singularis Species 0.000 description 1
- 241001450655 Saissetia Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000254026 Schistocerca Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 241001635185 Sciara Species 0.000 description 1
- 241001249127 Scirpophaga Species 0.000 description 1
- 241000924322 Scirtothrips aurantii Species 0.000 description 1
- 241000893388 Scotinophara Species 0.000 description 1
- 241001479507 Senecio odorus Species 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 241000931987 Sesamia Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000180197 Sitobion Species 0.000 description 1
- 241000254181 Sitophilus Species 0.000 description 1
- 241000753143 Sitotroga Species 0.000 description 1
- 241001492664 Solenopsis <angiosperm> Species 0.000 description 1
- 241000592344 Spermatophyta Species 0.000 description 1
- 241000253368 Spirillaceae Species 0.000 description 1
- 241000256251 Spodoptera frugiperda Species 0.000 description 1
- 241000222068 Sporobolomyces <Sporidiobolaceae> Species 0.000 description 1
- 241000567442 Spragueia leo Species 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 241000258128 Strongylocentrotus purpuratus Species 0.000 description 1
- 241001528589 Synanthedon Species 0.000 description 1
- 241000255626 Tabanus <genus> Species 0.000 description 1
- 241000189578 Taeniothrips Species 0.000 description 1
- 241000254105 Tenebrio Species 0.000 description 1
- 241000255588 Tephritidae Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 240000006474 Theobroma bicolor Species 0.000 description 1
- 241000339374 Thrips tabaci Species 0.000 description 1
- 241000131345 Tipula <genus> Species 0.000 description 1
- 241001238452 Tortrix Species 0.000 description 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 description 1
- 241001259047 Trichodectes Species 0.000 description 1
- 241000462092 Trioza erytreae Species 0.000 description 1
- 239000007984 Tris EDTA buffer Substances 0.000 description 1
- 241000267823 Trogoderma Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 description 1
- 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 description 1
- 241000368303 Unaspis citri Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- 235000013447 Xanthosoma atrovirens Nutrition 0.000 description 1
- 240000001781 Xanthosoma sagittifolium Species 0.000 description 1
- 241000353224 Xenopsylla Species 0.000 description 1
- 241000482268 Zea mays subsp. mays Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000012871 anti-fungal composition Substances 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000010310 bacterial transformation Effects 0.000 description 1
- 101150103518 bar gene Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- GINJFDRNADDBIN-FXQIFTODSA-N bilanafos Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCP(C)(O)=O GINJFDRNADDBIN-FXQIFTODSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 239000012681 biocontrol agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 230000006652 catabolic pathway Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 108091092328 cellular RNA Proteins 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000005058 diapause Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 230000000967 entomopathogenic effect Effects 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 230000008571 general function Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- IAJOBQBIJHVGMQ-BYPYZUCNSA-N glufosinate-P Chemical compound CP(O)(=O)CC[C@H](N)C(O)=O IAJOBQBIJHVGMQ-BYPYZUCNSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
- 229940097277 hygromycin b Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical group CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000009571 larval growth Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 229960005287 lincomycin Drugs 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 235000020888 liquid diet Nutrition 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 210000004334 malpighian tubule Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 230000007658 neurological function Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N o-dihydroxy-benzene Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 238000012015 optical character recognition Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000021962 pH elevation Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- 230000032361 posttranscriptional gene silencing Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 244000062645 predators Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002987 primer (paints) Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 230000019617 pupation Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000019745 retinal vasculopathy with cerebral leukodystrophy Diseases 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 238000010845 search algorithm Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000014639 sexual reproduction Effects 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 230000003584 silencer Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005029 transcription elongation Effects 0.000 description 1
- 238000011426 transformation method Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 101150101900 uidA gene Proteins 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000007279 water homeostasis Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8275—Glyphosate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Virology (AREA)
- Dentistry (AREA)
- Insects & Arthropods (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Catching Or Destruction (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56084204P | 2004-04-09 | 2004-04-09 | |
US60/560,842 | 2004-04-09 | ||
US56563204P | 2004-04-27 | 2004-04-27 | |
US60/565,632 | 2004-04-27 | ||
US57906204P | 2004-06-11 | 2004-06-11 | |
US60/579,062 | 2004-06-11 | ||
US60342104P | 2004-08-20 | 2004-08-20 | |
US60/603,421 | 2004-08-20 | ||
US61726104P | 2004-10-11 | 2004-10-11 | |
US60/617,261 | 2004-10-11 | ||
US66917505P | 2005-04-07 | 2005-04-07 | |
US60/669,175 | 2005-04-07 | ||
CA2562022A CA2562022C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2562022A Division CA2562022C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2762011A1 CA2762011A1 (en) | 2005-11-24 |
CA2762011C true CA2762011C (en) | 2019-05-07 |
Family
ID=35394619
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2762011A Expired - Lifetime CA2762011C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
CA2562022A Expired - Lifetime CA2562022C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
CA2693280A Expired - Lifetime CA2693280C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2562022A Expired - Lifetime CA2562022C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
CA2693280A Expired - Lifetime CA2693280C (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
Country Status (14)
Country | Link |
---|---|
US (10) | US20060021087A1 (forum.php) |
EP (4) | EP1732379B1 (forum.php) |
CN (2) | CN102524294B (forum.php) |
AR (1) | AR048685A1 (forum.php) |
AU (2) | AU2005244258B2 (forum.php) |
BR (1) | BRPI0509743A (forum.php) |
CA (3) | CA2762011C (forum.php) |
EC (1) | ECSP066908A (forum.php) |
ES (2) | ES2439696T3 (forum.php) |
MX (1) | MXPA06011694A (forum.php) |
PL (2) | PL1732379T3 (forum.php) |
PT (2) | PT1818405E (forum.php) |
WO (1) | WO2005110068A2 (forum.php) |
ZA (1) | ZA200607995B (forum.php) |
Families Citing this family (227)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9322031B2 (en) | 1999-05-06 | 2016-04-26 | Monsanto Technology Llc | Transgenic plants with enhanced agronomic traits |
US20090044297A1 (en) * | 1999-05-06 | 2009-02-12 | Andersen Scott E | Transgenic plants with enhanced agronomic traits |
US20090241217A9 (en) * | 2001-05-22 | 2009-09-24 | Jingrui Wu | Yield-improved transgenic plants |
US7612194B2 (en) * | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
US20090183270A1 (en) | 2002-10-02 | 2009-07-16 | Adams Thomas R | Transgenic plants with enhanced agronomic traits |
US20090049573A1 (en) * | 2002-10-02 | 2009-02-19 | Dotson Stanton B | Transgenic plants with enhanced agronomic traits |
AU2004268196B2 (en) | 2003-08-21 | 2010-03-04 | Monsanto Technology Llc | Fatty acid desaturases from primula |
ATE526407T1 (de) * | 2003-11-17 | 2011-10-15 | Commw Scient Ind Res Org | Insektenresistenz durch inhibierung von genexpression |
CA2762011C (en) * | 2004-04-09 | 2019-05-07 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
US20160230185A1 (en) | 2013-03-14 | 2016-08-11 | Monsanto Technology Llc | Compositions and methods for controlling diabrotica |
US20070199095A1 (en) | 2005-10-13 | 2007-08-23 | Edwards Allen | Methods for producing hybrid seed |
US8404927B2 (en) | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
US8314290B2 (en) | 2004-12-21 | 2012-11-20 | Monsanto Technology Llc | Temporal regulation of gene expression by MicroRNAs |
CN101213301B (zh) * | 2005-05-31 | 2013-02-27 | 德福根有限公司 | 用于防治昆虫和蜘蛛类动物的RNAi |
AU2006335978B2 (en) | 2005-09-16 | 2014-02-20 | Devgen Nv | Methods for controlling pests using RNAI |
PT2295584E (pt) * | 2005-09-16 | 2015-09-22 | Devgen Nv | Métodos com base em plantas transgénicas para infestações em plantas utilizando arn de interferência |
AP2008004416A0 (en) | 2005-09-16 | 2008-04-30 | Monsanto Technology Llc | Methods for genetic control of insect infestationsin plants and compositions thereof |
US8906876B2 (en) | 2006-01-12 | 2014-12-09 | Devgen Nv | Methods for controlling pests using RNAi |
BRPI0706266A2 (pt) * | 2006-01-12 | 2009-02-25 | Devgen Nv | mÉtodos para controle de pragas usando a rnai |
CA2633576A1 (en) * | 2006-01-12 | 2007-07-19 | Devgen N.V. | Dsrna as insect control agent |
EP2426206B8 (en) * | 2006-02-13 | 2018-10-31 | Monsanto Technology LLC | Selecting and stabilizing dsRNA constructs |
CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
CL2007001851A1 (es) * | 2006-06-23 | 2008-01-18 | Monsanto Technology Llc Socedad Anonima Organizada Bajo Las Leyes Del Estado De Delaware | Segmento de adn de planta que comprende una secuencia recombinante de un factor de transcripcion nuclear y (nf-yb), celula vegetal que lo comprende y metodo para elaborar semillas que comprende seleccionar plantas que comprendan dicho adn. |
EP2059596B1 (en) | 2006-08-31 | 2017-10-04 | Monsanto Technology, LLC | Phased small rnas |
EP3378953A1 (en) | 2006-10-12 | 2018-09-26 | Monsanto Technology LLC | Plant micrornas and methods of use thereof |
CN101195821A (zh) | 2006-12-04 | 2008-06-11 | 中国科学院上海生命科学研究院 | 利用RNAi技术改良植物抗虫性的方法 |
WO2008103643A1 (en) | 2007-02-20 | 2008-08-28 | Monsanto Technology, Llc | Invertebrate micrornas |
US8609936B2 (en) * | 2007-04-27 | 2013-12-17 | Monsanto Technology Llc | Hemipteran-and coleopteran active toxin proteins from Bacillus thuringiensis |
MX2009013064A (es) * | 2007-06-15 | 2010-01-18 | Basf Plant Science Gmbh | Composiciones y metodos de uso de la interferencia de arn para el control de nematodos. |
US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
US8847013B2 (en) * | 2008-01-17 | 2014-09-30 | Pioneer Hi Bred International Inc | Compositions and methods for the suppression of target polynucleotides from lepidoptera |
US20090188008A1 (en) * | 2008-01-17 | 2009-07-23 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides |
US8809625B2 (en) | 2008-01-17 | 2014-08-19 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides from Lygus |
US8367895B2 (en) * | 2008-01-17 | 2013-02-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides from the family aphididae |
WO2009103808A2 (en) * | 2008-02-20 | 2009-08-27 | Devgen N.V. | Methods and compositions for increasing rna interference |
US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
WO2010002984A1 (en) | 2008-07-01 | 2010-01-07 | Monsanto Technology, Llc | Recombinant dna constructs and methods for modulating expression of a target gene |
AU2009285624B2 (en) | 2008-08-29 | 2013-12-05 | Monsanto Technology Llc | Novel Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis |
US11414664B2 (en) * | 2008-12-18 | 2022-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
US20100257634A1 (en) * | 2009-04-03 | 2010-10-07 | Venganza Inc. | Bioassay for gene silencing constructs |
WO2010141294A1 (en) * | 2009-06-01 | 2010-12-09 | North Carolina State University | Insecticidal target genes identified from bug whole body and digestive system transcriptomes |
MX351822B (es) | 2009-08-28 | 2017-10-30 | Du Pont | Composicicones y métodos para controlar plagas de insectos. |
JP5396353B2 (ja) * | 2009-09-17 | 2014-01-22 | 日本碍子株式会社 | 静電チャック及びその製法 |
US10017774B2 (en) | 2009-09-29 | 2018-07-10 | Temasek Life Sciences Laboratory Limited | Control of pests in plants |
US8962584B2 (en) * | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
US20110165561A1 (en) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Direct and continuous root alone or root/shoot production from transgenic events derived from green regenerative tissues and its applications |
US20110183369A1 (en) * | 2010-01-28 | 2011-07-28 | Monsanto Technology Llc | Plant infesting systems and methods |
US8735560B1 (en) | 2010-03-02 | 2014-05-27 | Monsanto Technology Llc | Multiple domain lepidopteran active toxin proteins |
CN102948425B (zh) * | 2010-03-05 | 2014-10-22 | 广州市锐博生物科技有限公司 | 一种生物农药和昆虫防治方法 |
MX2012010479A (es) | 2010-03-08 | 2012-10-09 | Monsanto Technology Llc | Moleculas polinucleotidicas para regulacion genetica en plantas. |
JP5732687B2 (ja) * | 2010-03-19 | 2015-06-10 | エルジー ケム. エルティーディ. | ポーチ型ケース及びこれを含む電池パック |
US8530440B2 (en) * | 2010-05-03 | 2013-09-10 | Board Of Regents Of The University Of Nebraska | dsRNA delivery composition and methods of use |
CA2799453A1 (en) | 2010-06-04 | 2011-12-08 | Pioneer Hi-Bred International, Inc. | Compositions and methods for insecticidal control of stinkbugs |
ES2607059T3 (es) | 2010-09-20 | 2017-03-29 | Wisconsin Alumni Research Foundation | Xenorhabdus, lipopéptido y procedimientos mosquitocidas |
CN107287235B (zh) | 2010-10-27 | 2021-07-09 | 德福根有限公司 | 下调昆虫害虫中的基因表达 |
AU2011352005B2 (en) * | 2010-12-30 | 2017-03-16 | Dow Agrosciences Llc | Nucleic acid molecules that confer resistance to coleopteran pests |
NZ612405A (en) | 2010-12-30 | 2015-12-24 | Dow Agrosciences Llc | Nucleic acid molecules that target the vacuolar atpase c subunit and confer resistance to coleopteran pests |
MX2013007678A (es) * | 2010-12-30 | 2013-07-30 | Dow Agrosciences Llc | Moleculas de acido nucleico dirigidas ala pequeña proteina de union de gtp rho1 y que confieren resistencia a las plagas de coleopteros. |
EP2698379A4 (en) * | 2011-03-18 | 2015-04-29 | Shanghai Inst Biol Sciences | INSECTROSIVE PREPARATION AND METHODS BASED ON RNAI TECHNOLOGY |
CN110452908A (zh) * | 2011-04-20 | 2019-11-15 | 德福根有限公司 | 在昆虫害虫中下调基因表达 |
US8841272B2 (en) * | 2011-05-31 | 2014-09-23 | Kansas State University Research Foundation | Double-stranded RNA-based nanoparticles for insect gene silencing |
CN102866220B (zh) * | 2011-07-08 | 2014-07-23 | 中国科学院大连化学物理研究所 | 一种基于化学衍生的飞蝗血淋巴代谢物的检测方法 |
RU2014105825A (ru) * | 2011-07-18 | 2015-08-27 | Девген Нв | Растения, устойчивые к насекомым-вредителям |
CN103748230B (zh) * | 2011-08-16 | 2016-09-28 | 先正达参股股份有限公司 | 外源双链rna导入植物细胞的方法和组合物 |
UA116089C2 (uk) | 2011-09-13 | 2018-02-12 | Монсанто Текнолоджи Ллс | Спосіб та композиція для боротьби з бур'янами (варіанти) |
US9840715B1 (en) | 2011-09-13 | 2017-12-12 | Monsanto Technology Llc | Methods and compositions for delaying senescence and improving disease tolerance and yield in plants |
US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
MX343072B (es) | 2011-09-13 | 2016-10-21 | Monsanto Technology Llc | Metodos y composiciones para controlar malezas. |
CA2848685A1 (en) | 2011-09-13 | 2013-03-21 | Monsanto Technology Llc | Methods and compositions for weed control comprising topical application of a glutamine synthetase polynucleotide |
UY34328A (es) | 2011-09-13 | 2013-04-30 | Monsanto Technology Llc | ?composiciones y métodos para controlar malezas comprendiendo un polinucleótido y agente de transferencia, y que modulan protoporfirinógeno ix oxidasa?. |
US9920326B1 (en) | 2011-09-14 | 2018-03-20 | Monsanto Technology Llc | Methods and compositions for increasing invertase activity in plants |
US9534232B2 (en) | 2011-10-06 | 2017-01-03 | Dow Agrosciences Llc | Nucleic acid molecules that target RPS6 and confer resistance to coleopteran pests |
AR088261A1 (es) * | 2011-10-06 | 2014-05-21 | Dow Agrosciences Llc | Moleculas de acido nucleico que se dirigen al gen pp1-87b y confieren resistencia a plagas de coleopteros |
TW201321508A (zh) * | 2011-10-06 | 2013-06-01 | Dow Agrosciences Llc | 靶定rpa70且賦予對鞘翅目害蟲抗性之核酸分子 |
GB201202119D0 (en) * | 2012-02-08 | 2012-03-21 | Univ Swansea | Pest and pathogen control |
CA2978081C (en) | 2012-04-06 | 2021-11-23 | Monsanto Technology Llc | Proteins toxic to hemipteran insect species |
WO2013158966A1 (en) * | 2012-04-20 | 2013-10-24 | Futuragene Israel Ltd. | Bronze bug control agents |
WO2013163085A2 (en) * | 2012-04-23 | 2013-10-31 | Futuragene Israel Ltd. | Glycaspis brimblecombei control agents |
RU2648155C2 (ru) | 2012-05-08 | 2018-03-22 | Монсанто Текнолоджи Ллс | Объект кукурузы mon 87411 |
UY34822A (es) | 2012-05-24 | 2013-12-31 | Seeds Ltd Ab | Composiciones y métodos para silenciar la expresión genética |
US9657293B2 (en) * | 2012-06-22 | 2017-05-23 | Sygenta Participations Ag | Biological control of coleopteran pests |
RU2015114446A (ru) * | 2012-09-20 | 2016-11-10 | Е.И.Дюпон Де Немур Энд Компани | Борьба со злаковым корневым червем и другими насекомыми-вредителями |
US10004236B2 (en) * | 2012-09-24 | 2018-06-26 | Lincoln University | Biocontrol compositions |
MX364070B (es) | 2012-10-18 | 2019-04-10 | Monsanto Technology Llc | Métodos y composiciones para el control de plagas vegetales. |
DE102012110664A1 (de) * | 2012-11-07 | 2014-05-08 | Henkel Ag & Co. Kgaa | In Beschichtungsmitteln, Haftvermittlern oder Klebstoffen für oxidische Oberflächen einsetzbare Peptide |
US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
UY35252A (es) * | 2013-01-01 | 2014-07-31 | Seeds Ltd Ab | MÉTODOS PARA INTRODUCIR dsRNA EN SEMILLAS DE PLANTAS PARA MODULAR LA EXPRESIÓN GENÉTICA |
US10000767B2 (en) | 2013-01-28 | 2018-06-19 | Monsanto Technology Llc | Methods and compositions for plant pest control |
UY35385A (es) | 2013-03-13 | 2014-09-30 | Monsanto Technology Llc | ?métodos y composiciones para el control de malezas?. |
EP3604535A3 (en) | 2013-03-13 | 2020-04-22 | Monsanto Technology LLC | Methods and compositions for weed control |
EP2970363B1 (en) * | 2013-03-14 | 2020-07-08 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
US9920316B2 (en) | 2013-03-14 | 2018-03-20 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
US20140283211A1 (en) | 2013-03-14 | 2014-09-18 | Monsanto Technology Llc | Methods and Compositions for Plant Pest Control |
CA2901316A1 (en) | 2013-03-15 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Phi-4 polypeptides and methods for their use |
US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
US9365863B2 (en) | 2013-05-08 | 2016-06-14 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge seed blend |
US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
RU2703498C2 (ru) | 2013-07-19 | 2019-10-17 | Монсанто Текнолоджи Ллс | Композиции и способы борьбы с leptinotarsa |
BR112016003225B1 (pt) | 2013-08-16 | 2022-10-25 | Pioneer Hi-Bred International, Inc. | Polipeptídeo pip-47, polipeptídeo pip-47 quimérico, composição, proteína de fusão, método para controlar uma população de inseto-praga, método para inibir o crescimento ou matar um inseto-praga, construto de dna, polinucleotídeo isolado, cassete de expressão, método de obtenção de uma planta transgênica e método para controlar infestação de inseto |
CA3223359A1 (en) | 2013-09-13 | 2015-03-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US10329560B2 (en) | 2013-09-23 | 2019-06-25 | Georgia Tech Research Corporation | Targeting non-coding RNA for RNA interference |
CA2929533C (en) | 2013-11-04 | 2023-06-06 | Monsanto Technology Llc | Compositions and methods for controlling arthropod parasite and pest infestations |
CN104630275A (zh) * | 2013-11-12 | 2015-05-20 | 中国科学院上海生命科学研究院 | 一种通过灌溉防治害虫的RNAi技术及其应用 |
CA2929703C (en) | 2013-12-04 | 2022-05-10 | Stoller Enterprises, Inc. | Methods for applying diformylurea to crops |
UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
BR102014031844A2 (pt) * | 2013-12-20 | 2015-10-06 | Dow Agrosciences Llc | ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros |
UA121462C2 (uk) | 2014-01-15 | 2020-06-10 | Монсанто Текнолоджі Елелсі | Спосіб та композиція для боротьби із бур'янами з використанням полінуклеотидів epsps |
CN106536545A (zh) | 2014-02-07 | 2017-03-22 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
CN106535642A (zh) * | 2014-02-10 | 2017-03-22 | 爱贝克斯生态学有限责任公司 | 用于农业的生物衍生组合物 |
US20170029835A1 (en) | 2014-03-12 | 2017-02-02 | The University Of Sydney | Rna production in higher plants |
CN103828721B (zh) * | 2014-03-20 | 2016-03-02 | 北京农学院 | 地衣芽孢杆菌在促进蓝莓组培苗生根或生长中的应用 |
EP3122882A4 (en) | 2014-03-28 | 2018-02-28 | Monsanto Technology LLC | Pesticidal toxin proteins active against coleopteran insects |
CN106413390B (zh) * | 2014-04-01 | 2019-09-27 | 孟山都技术公司 | 用于控制虫害的组合物和方法 |
CA2947756A1 (en) | 2014-05-07 | 2015-11-12 | Dow Agrosciences Llc | Dre4 nucleic acid molecules that confer resistance to coleopteran pests |
CA2953347A1 (en) | 2014-06-23 | 2015-12-30 | Monsanto Technology Llc | Compositions and methods for regulating gene expression via rna interference |
WO2015200539A1 (en) | 2014-06-25 | 2015-12-30 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
CN104170557B (zh) * | 2014-07-24 | 2016-06-29 | 四川农业大学 | 一种促进中国樱桃种子快速高效萌发成苗的方法 |
RU2754955C2 (ru) * | 2014-07-29 | 2021-09-08 | Монсанто Текнолоджи Ллс | Композиции и способы борьбы с насекомыми-вредителями |
US20170247719A1 (en) * | 2014-09-17 | 2017-08-31 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
JP2017532039A (ja) * | 2014-10-13 | 2017-11-02 | ダウ アグロサイエンシィズ エルエルシー | 鞘翅目および半翅目害虫に対する抵抗性を付与するcopiコートマーガンマサブユニット核酸分子 |
MX2017004452A (es) * | 2014-10-13 | 2017-12-14 | Dow Agrosciences Llc | Moléculas de ácido nucleico de la subunida alfa del coatómero copi que confiere resistencia contra plagas de coleoóteros y hemípteros. |
KR102127552B1 (ko) | 2014-10-16 | 2020-06-26 | 몬산토 테크놀로지 엘엘씨 | 인시류-활성 cry1da1 아미노산 서열 변이 단백질 |
US10316329B2 (en) | 2014-10-16 | 2019-06-11 | Monsanto Technology Llc | Proteins toxic or inhibitory to lepidopteran insects |
US10487123B2 (en) | 2014-10-16 | 2019-11-26 | Monsanto Technology Llc | Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests |
KR102208978B1 (ko) | 2014-10-16 | 2021-01-27 | 몬산토 테크놀로지 엘엘씨 | 인시류 해충에 대해서 유독성이거나 저해성인 신규한 키메릭 살곤충 단백질 |
EP3207143B1 (en) | 2014-10-16 | 2023-11-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3218497A1 (en) | 2014-11-12 | 2017-09-20 | NMC Inc. | Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same |
BR122020006737B1 (pt) | 2014-11-20 | 2024-01-23 | Monsanto Technology Llc | Cassete de expessão, célula hospedeira bacteriana, composição inibidora de inseto, método para controlar uma praga de espécie coleoptera, e vetor recombinante |
AR103043A1 (es) * | 2014-12-16 | 2017-04-12 | Dow Agrosciences Llc | Supresión de arni parental de gen kruppel para el control de las plagas de hemípteros |
MX369475B (es) | 2015-01-15 | 2019-11-08 | Pioneer Hi Bred Int | Proteinas insecticidas y metodos para sus usos. |
MX2017009239A (es) * | 2015-01-16 | 2018-03-23 | Emekatech Llc | Sistemas, métodos y composiciones para la supresión efectiva de una población de insectos. |
BR112017015705A2 (pt) | 2015-01-22 | 2018-03-20 | Monsanto Technology Llc | composições e métodos para controle de leptinotarsa |
MX2017010745A (es) * | 2015-02-27 | 2018-04-30 | Pioneer Hi Bred Int | Composiciones y metodos para controlar plagas de insectos. |
EA038923B1 (ru) | 2015-03-11 | 2021-11-10 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидная днк-конструкция и способы её применения |
WO2016186986A1 (en) | 2015-05-19 | 2016-11-24 | Pioneer Hi Bred International Inc | Insecticidal proteins and methods for their use |
BR112017024832A2 (pt) * | 2015-05-27 | 2018-08-07 | Dow Agrosciences Llc | moléculas de ácido nucleico thread que conferem resistência a pragas de hemípteros |
US10883103B2 (en) | 2015-06-02 | 2021-01-05 | Monsanto Technology Llc | Compositions and methods for delivery of a polynucleotide into a plant |
WO2016196782A1 (en) | 2015-06-03 | 2016-12-08 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
GB201510154D0 (en) * | 2015-06-11 | 2015-07-29 | Univ Swansea | Pest control system |
EA201890066A1 (ru) | 2015-06-16 | 2018-06-29 | Пайонир Хай-Бред Интернэшнл, Инк. | Композиции и способы контроля насекомых-вредителей |
RU2765310C2 (ru) | 2015-07-30 | 2022-01-28 | Монсанто Текнолоджи Ллс | Новые белки, проявляющие ингибирующую активность по отношению к насекомым |
MX382456B (es) | 2015-08-06 | 2025-03-13 | Corteva Agriscience Llc | Proteinas insecticidas derivadas de plantas y metodos para su uso. |
CA2996295A1 (en) | 2015-08-27 | 2017-03-02 | Monsanto Technology Llc | Novel insect inhibitory proteins |
AU2016326588A1 (en) * | 2015-09-25 | 2018-04-05 | Dow Agrosciences Llc | Shibire/dynamin nucleic acid molecules to control coleopteran and hemipteran pests |
RU2018116201A (ru) * | 2015-10-05 | 2019-11-07 | Зингента Партисипейшнс Аг | Способы сохранения биологической активности рибонуклеиновых кислот |
EP3922100A1 (en) | 2015-10-12 | 2021-12-15 | Pioneer Hi-Bred International, Inc. | Biologicals and their use in plants |
BR112018007396A2 (pt) | 2015-10-12 | 2018-10-16 | Droneseed Co | sistemas e métodos de gestão de informação florestal aperfeiçoados por hierarquização automática de dados biométricos |
CA3001162A1 (en) | 2015-10-12 | 2017-04-20 | Dow Agrosciences Llc | Wupa nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
US10212876B2 (en) | 2015-10-12 | 2019-02-26 | Droneseed Co. | Aerial deployment planting methods and systems |
CN108350413A (zh) * | 2015-11-02 | 2018-07-31 | 美国陶氏益农公司 | 赋予对鞘翅目和半翅目害虫的抗性的rab5核酸分子 |
BR112018011174A2 (pt) | 2015-11-30 | 2018-11-21 | Du Pont | polinucleotídeo recombinante, construto de dna, célula heteróloga, planta transgênica ou célula de planta, semente da planta transgênica, método para expressar um polinucleotídeo em uma planta e método para aprimorar a transcrição de um polinucleotídeo em uma célula hospedeira |
US9856291B2 (en) * | 2015-12-08 | 2018-01-02 | Agricultural Technology Research Institute | Cancer stem cell targeting peptide and use thereof |
US11134675B2 (en) | 2015-12-14 | 2021-10-05 | Monsanto Technology Llc | Methods and compositions for delivery of polynucleotides |
WO2017105987A1 (en) | 2015-12-18 | 2017-06-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US10329581B2 (en) | 2015-12-18 | 2019-06-25 | Dow Agrosciences Llc | Ribosomal protein L40 (RPL40) nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
CN105543224B (zh) * | 2016-01-04 | 2020-01-14 | 北京大北农科技集团股份有限公司 | 用于控制昆虫侵袭的核苷酸序列及其方法 |
EP3408390A4 (en) * | 2016-01-26 | 2019-10-09 | Monsanto Technology LLC | COMPOSITIONS AND METHODS FOR COMBATING INSECTS |
BR112018070404A2 (pt) * | 2016-04-05 | 2019-02-05 | Dow Agrosciences Llc | moléculas de ácido nucleico de fsh para controlar pragas de inseto |
BR112018072417B1 (pt) | 2016-05-04 | 2023-03-14 | E. I. Du Pont De Nemours And Company | Polipeptídeo inseticida recombinante, polipeptídeo quimérico, composição, polinucleotídeo recombinante, construtos de dna, métodos para obter uma planta transgênica, métodos para inibir o crescimento ou extermínio de uma praga de inseto ou população de praga, método para obter uma célula procariótica transformada, célula procariótica transformada e método para modificar geneticamente o polipeptídeo inseticida |
US11248204B2 (en) | 2016-05-16 | 2022-02-15 | Danisco Us Inc | Biologicals and their use in plants |
WO2017205751A1 (en) * | 2016-05-27 | 2017-11-30 | Provivi, Inc. | Improved insect control strategies utilizing pheromones and rnai |
BR112018076047A2 (pt) | 2016-06-16 | 2019-03-26 | Pioneer Hi Bred Int | elemento de silenciamento, construto de dna, cassete de expressão, célula hospedeira, composição, célula vegetal, planta ou parte de planta, semente transgênica, método para controlar um inseto-praga de planta e kit |
US10612037B2 (en) | 2016-06-20 | 2020-04-07 | Monsanto Technology Llc | Insecticidal proteins toxic or inhibitory to hemipteran pests |
WO2017222867A1 (en) * | 2016-06-22 | 2017-12-28 | Dow Agrosciences Llc | Cactus nucleic acid molecules to control coleopteran pests |
UA127388C2 (uk) | 2016-06-24 | 2023-08-09 | Піонір Хай-Бред Інтернешнл, Інк. | Регуляторний елемент рослини і спосіб його застосування |
CA3026113A1 (en) | 2016-07-01 | 2018-01-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
US20210292778A1 (en) | 2016-07-12 | 2021-09-23 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
US20180023076A1 (en) * | 2016-07-25 | 2018-01-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Double strand rna delivery system for plant-sap-feeding insects |
AR109205A1 (es) * | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
AR109206A1 (es) * | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
CA3036620A1 (en) * | 2016-10-05 | 2018-04-12 | Syngenta Participations Ag | Methods of preserving the biological activity of ribonucleic acids |
CN107058466A (zh) * | 2016-10-20 | 2017-08-18 | 中国农业科学院植物保护研究所 | 玉米根萤叶甲特异性ss‑coi引物及检测方法和应用 |
CA3038806A1 (en) | 2016-11-01 | 2018-05-11 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018106847A1 (en) * | 2016-12-06 | 2018-06-14 | Pebble Labs, Inc. | System and methods for the biocontrol of plant pathogens |
CN110088123B (zh) | 2016-12-14 | 2023-10-20 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
MX2019007491A (es) | 2016-12-22 | 2019-09-06 | Pioneer Hi Bred Int | Proteinas insecticidas y metodos para su uso. |
WO2018140214A1 (en) | 2017-01-24 | 2018-08-02 | Pioneer Hi-Bred International, Inc. | Nematicidal protein from pseudomonas |
CA3052794A1 (en) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International, Inc. | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
CA3057314A1 (en) * | 2017-03-21 | 2018-09-27 | Dow Agrosciences Llc | Pre-mrna processing factor 19 (prp19) nucleic acid molecules to control insect pests |
US20200181639A1 (en) * | 2017-05-01 | 2020-06-11 | Donald Danforth Plant Science Center | Rnai approach for crop pest protection |
WO2018208882A1 (en) | 2017-05-11 | 2018-11-15 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CA3057444A1 (en) * | 2017-05-18 | 2018-11-22 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Structure specific recognition protein 1 (ssrp1) nucleic acid molecules to control insect pests |
US11484030B2 (en) | 2017-10-02 | 2022-11-01 | Syngenta Participations Ag | Engineered pesticidal proteins and methods of controlling plant pests |
WO2019074598A1 (en) | 2017-10-13 | 2019-04-18 | Pioneer Hi-Bred International, Inc. | VIRUS-INDUCED GENETIC SILENCING TECHNOLOGY FOR THE CONTROL OF INSECTS IN MAIZE |
GB201718701D0 (en) | 2017-11-13 | 2017-12-27 | Syngenta Participations Ag | Improvements in or relating to gene silencing |
GB201719680D0 (en) * | 2017-11-27 | 2018-01-10 | Devgen Nv | Improvements in or relating to gene silencing |
DK3740070T3 (da) | 2018-01-18 | 2025-01-20 | Pioneer Hi Bred Int | Alginat-indkapsling af fungale mikrosklerotier |
US20210002657A1 (en) | 2018-03-02 | 2021-01-07 | Pioneer Hi-Bred International, Inc. | Plant health assay |
CA3092075A1 (en) | 2018-03-14 | 2019-09-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
WO2019178042A1 (en) | 2018-03-14 | 2019-09-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
WO2019200016A1 (en) | 2018-04-10 | 2019-10-17 | President And Fellows Of Harvard College | Aav vectors encoding clarin-1 or gjb2 and uses thereof |
US11702668B2 (en) | 2018-05-22 | 2023-07-18 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
EP3817558A4 (en) | 2018-07-18 | 2021-12-15 | PlantArcBio Ltd. | COMPOSITIONS AND METHODS FOR THE MITIGATION OF AN INFESTATION WITH THE PEST RHYNCHOPHORUS FERRUGINEUS |
WO2020046701A1 (en) | 2018-08-29 | 2020-03-05 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
JP2022502018A (ja) * | 2018-09-24 | 2022-01-11 | オルタ ドグ テクニク ユニヴェルシテシ | 改変されたaox1プロモータバリアント |
US11375656B2 (en) | 2018-11-06 | 2022-07-05 | Droneseed Co. | Remote drone configuration systems and methods |
KR20210091243A (ko) | 2018-11-15 | 2021-07-21 | 퀀텀-에스아이 인코포레이티드 | 단백질 시퀀싱을 위한 방법 및 조성물 |
US20220015372A1 (en) | 2018-12-14 | 2022-01-20 | Pioneer Hi-Bred International, Inc. | Biologicals and their use in plants |
CN109337884B9 (zh) * | 2018-12-21 | 2021-10-29 | 中国农业科学院北京畜牧兽医研究所 | 一种丙酮酸激酶基因及其应用 |
US11266151B2 (en) | 2019-01-22 | 2022-03-08 | Monsanto Technology Llc | Insect inhibitory proteins |
AR118136A1 (es) | 2019-02-20 | 2021-09-22 | Syngenta Crop Protection Ag | Proteínas pesticidas modificadas y métodos para controlar las plagas de plantas |
MX2021011701A (es) * | 2019-03-28 | 2021-12-10 | Massachusetts Gen Hospital | Vectores adenoasociados fabricados por ingenieria (aav) para expresion transgenica. |
AU2020262444A1 (en) * | 2019-04-24 | 2021-11-25 | University Of Manitoba | Flea beetle-specific RNAi-based pesticides |
CN110117606A (zh) * | 2019-04-29 | 2019-08-13 | 贵州大学 | 一种马铃薯蚜虫效应蛋白Me10基因的重组载体和表达方法 |
TW202142114A (zh) | 2020-02-04 | 2021-11-16 | 美商陶氏農業科學公司 | 具有殺有害生物效用之組成物及與其相關之方法 |
IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
CN116134046A (zh) * | 2020-05-20 | 2023-05-16 | 宽腾矽公司 | 用于蛋白质测序的方法及组合物 |
CA3186978A1 (en) | 2020-07-14 | 2022-01-20 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
TWI784298B (zh) * | 2020-08-06 | 2022-11-21 | 大江生醫股份有限公司 | 生物活性物質用於製備促進肌膚膠原蛋白質生成及提升肌膚膠原蛋白質密度的組合物的用途 |
WO2022035649A1 (en) | 2020-08-10 | 2022-02-17 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
EP4262400A4 (en) | 2020-12-21 | 2025-01-08 | Monsanto Technology LLC | NEW INSECT INHIBITORY PROTEINS |
UY39585A (es) | 2020-12-23 | 2022-07-29 | Monsanto Technology Llc | Proteínas que exhiben actividad inhibidora de insectos frente a plagas con importancia agrícola de plantas de cultivo y semillas |
MX2023007858A (es) | 2020-12-31 | 2023-07-07 | Monsanto Technology Llc | Novedosas proteinas inhibidoras de insectos. |
WO2022212926A1 (en) * | 2021-04-01 | 2022-10-06 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
AU2022306570A1 (en) | 2021-07-08 | 2024-01-18 | Monsanto Technology Llc | Novel insect inhibitory proteins |
US11807685B2 (en) * | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
WO2023034849A2 (en) | 2021-08-31 | 2023-03-09 | nanoSUR LLC | HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS |
MX2024002927A (es) | 2021-09-08 | 2024-05-29 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
TW202345696A (zh) | 2022-05-18 | 2023-12-01 | 美商科迪華農業科技有限責任公司 | 具有殺有害生物效用之組成物及與其相關的方法 |
CN117025618B (zh) * | 2023-07-24 | 2024-07-05 | 西南大学 | 一种对番茄红螨高效致死的靶标基因及其应用 |
WO2025038870A1 (en) * | 2023-08-16 | 2025-02-20 | Rnaissance Ag Llc | Double stranded rna methods and compositions for insecticide |
CN117187278B (zh) * | 2023-10-17 | 2024-11-12 | 河北农业大学 | 一种用于防控蛴螬的dsHpVAA、dsRNA纳米复合物及其应用 |
WO2025103765A1 (en) * | 2023-11-17 | 2025-05-22 | Novozymes A/S | Lytic polysaccharide monooxygenases and their use in detergent |
Family Cites Families (175)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3937813A (en) * | 1974-02-20 | 1976-02-10 | Abbott Laboratories | Insecticidal compositions comprising mixtures of bacillus thuringiensis and chlordimeform |
US4272417A (en) | 1979-05-22 | 1981-06-09 | Cargill, Incorporated | Stable protective seed coating |
US4245432A (en) | 1979-07-25 | 1981-01-20 | Eastman Kodak Company | Seed coatings |
US4339456A (en) | 1980-01-14 | 1982-07-13 | Gustafson, Inc. | Peanut seed treating |
US4383391A (en) | 1981-09-21 | 1983-05-17 | Celanese Corporation | Seed coating composition based on carbamate pesticide and non-alkaline amorphous carbon |
US4634587A (en) | 1982-07-09 | 1987-01-06 | Key Pharmaceuticals, Inc. | Sustained release quinidine dosage form |
US4693977A (en) | 1982-08-23 | 1987-09-15 | Queen's University At Kingston | Enzyme immobilization for producing cephalosporin antibiotics |
US4536475A (en) | 1982-10-05 | 1985-08-20 | Phytogen | Plant vector |
US4876197A (en) | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
US4465017A (en) | 1983-03-09 | 1984-08-14 | Simmons John J | Seed coating machine |
NZ207765A (en) | 1983-04-15 | 1987-03-06 | Lubrizol Genetics Inc | Plant expression of transferred dna(t-dna)from plasmids associated with agrobacterium sp |
JPS59205983A (ja) | 1983-04-28 | 1984-11-21 | ジエネツクス・コ−ポレイシヨン | 異種遺伝子を原核微生物で発現させる方法 |
US4735015A (en) | 1983-11-25 | 1988-04-05 | Basf Corporation | Seed protective coating |
US4880734A (en) | 1984-05-11 | 1989-11-14 | Chiron Corporation | Eukaryotic regulatable transcription |
ATE102250T1 (de) | 1984-05-11 | 1994-03-15 | Chiron Corp | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
US4886937A (en) | 1985-05-20 | 1989-12-12 | North Carolina State University | Method for transforming pine |
CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
DE3616010A1 (de) | 1986-05-13 | 1987-11-19 | Bayer Ag | Verfahren zum beizen und/oder inkrustieren von saatgutkoernern |
US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
DE3703584A1 (de) | 1987-02-06 | 1988-08-18 | Consortium Elektrochem Ind | Aldehyde und alkohole mit 3-methyl- oder 3,5-dimethylphenylgruppen, deren herstellung und verwendung als duftstoffe |
ATE103333T1 (de) | 1987-03-23 | 1994-04-15 | Zymogenetics Inc | Hohe proteinsyntheserate in hefe. |
TR27832A (tr) | 1987-04-29 | 1995-08-31 | Monsanto Co | Zararli ucucu hasarata mukavim bitkiler. |
WO1988010469A1 (en) | 1987-06-18 | 1988-12-29 | Unisys Corporation | Intercomputer communication control apparatus and method |
FR2618041B1 (fr) | 1987-07-16 | 1991-06-21 | Ceres Ets | Dispositif pour le traitement des semences |
US4948734A (en) | 1987-08-12 | 1990-08-14 | Mycogen Corporation | Novel isolates of bacillus thuringiensis having activity against nematodes |
EP0315447A3 (en) | 1987-11-06 | 1990-07-18 | Teijin Limited | Method of immunological measurement of human protein s and reagent and kit therefor |
US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
US5789214A (en) | 1988-03-08 | 1998-08-04 | Novartis Finance Corporation | Method of inducing gene transcription in a plant |
US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
JPH0646887B2 (ja) | 1988-11-08 | 1994-06-22 | 矢崎総業株式会社 | 種子のゲル被覆装置 |
US5300127A (en) | 1989-01-06 | 1994-04-05 | Agricultural Genetics Company Limited | Seed coatings |
AU638438B2 (en) | 1989-02-24 | 1993-07-01 | Monsanto Technology Llc | Synthetic plant genes and method for preparation |
US5231020A (en) | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
EP0400246A1 (en) | 1989-05-31 | 1990-12-05 | Plant Genetic Systems, N.V. | Prevention of Bt resistance development |
US5501967A (en) | 1989-07-26 | 1996-03-26 | Mogen International, N.V./Rijksuniversiteit Te Leiden | Process for the site-directed integration of DNA into the genome of plants |
US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
CA2074355C (en) | 1990-01-22 | 2008-10-28 | Ronald C. Lundquist | Method of producing fertile transgenic corn plants |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5837848A (en) | 1990-03-16 | 1998-11-17 | Zeneca Limited | Root-specific promoter |
US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
US5633435A (en) | 1990-08-31 | 1997-05-27 | Monsanto Company | Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases |
JP3234598B2 (ja) | 1990-11-23 | 2001-12-04 | プラント・ジエネテイツク・システムズ・エヌ・ベー | 単子葉植物の形質転換方法 |
JP3605411B2 (ja) | 1991-05-15 | 2004-12-22 | モンサント・カンパニー | 形質転換された稲植物の製法 |
EP0595894B1 (en) | 1991-07-19 | 1995-12-20 | UNIROYAL CHEMICAL COMPANY, Inc. | Seed film compositions |
AU664392B2 (en) | 1991-10-18 | 1995-11-16 | Monsanto Technology Llc | Fungicides for the control of take-all disease of plants |
US5593874A (en) | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
CA2094658A1 (en) | 1992-04-23 | 1993-10-24 | Martin Sumner-Smith | Intracellular delivery of biochemical agents |
CZ333294A3 (en) | 1992-07-02 | 1995-07-12 | Hybridon | Self-stabilized oligonucleotide and inhibition method of virus gene or pathogenic organism or cellular gene expression |
DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
FI93687C (fi) | 1992-07-29 | 1995-05-26 | Novasso Oy | Menetelmä siementen päällystämiseksi |
US5661103A (en) | 1992-11-05 | 1997-08-26 | Donlar Corporation | Seed treatment composition and method |
US5527695A (en) | 1993-01-29 | 1996-06-18 | Purdue Research Foundation | Controlled modification of eukaryotic genomes |
US6118047A (en) | 1993-08-25 | 2000-09-12 | Dekalb Genetic Corporation | Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction |
US5629469A (en) | 1994-03-10 | 1997-05-13 | Sandoz Ltd. | Thiol protease inhibitor |
US5882713A (en) | 1994-04-26 | 1999-03-16 | The United States Of America As Represented By The Secretary Of Agriculture | Non-separable compositions of starch and water-immiscible organic materials |
US5662897A (en) | 1994-07-27 | 1997-09-02 | U. Of Ga Research Foundation | Insect viruses, sequences, insecticidal compositions and methods of use |
US5631152A (en) | 1994-10-26 | 1997-05-20 | Monsanto Company | Rapid and efficient regeneration of transgenic plants |
US5716837A (en) | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
US5580544A (en) | 1995-03-29 | 1996-12-03 | Uniroyal Chemical Company, Inc. | Paste formulation useful for seed treatment and foliar treatment of plants |
JP3125847B2 (ja) | 1995-06-15 | 2001-01-22 | 矢崎総業株式会社 | ゲル被覆種子のゲル層易崩壊処理方法 |
US5622003A (en) | 1995-07-11 | 1997-04-22 | Isp Investments Inc. | Seed coating containing Mn (NO3)2 ·6H2 O |
US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
US5876739A (en) | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
US5849320A (en) | 1996-06-13 | 1998-12-15 | Novartis Corporation | Insecticidal seed coating |
US5939356A (en) | 1996-06-21 | 1999-08-17 | Southwest Research Institute | Controlled release coated agricultural products |
DE19631919C2 (de) | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
US6603063B1 (en) * | 1999-05-07 | 2003-08-05 | Mycogen Corp. | Plants and cells transformed with a nucleic acid from Bacillus thuringiensis strain KB59A4-6 encoding a novel SUP toxin |
US5942664A (en) | 1996-11-27 | 1999-08-24 | Ecogen, Inc. | Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants |
JP3185133B2 (ja) | 1997-02-13 | 2001-07-09 | タキイ種苗株式会社 | 造粒コーティング種子およびその製造方法 |
KR20010006015A (ko) | 1997-04-03 | 2001-01-15 | 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 | 식물 해충 방제 방법 |
GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
KR100664331B1 (ko) | 1997-07-28 | 2007-01-02 | 메디칼 바이오시스템스 리미티드 | 핵산 서열 분석 |
US5891246A (en) | 1997-08-15 | 1999-04-06 | Gustafson, Inc. | Seed coating apparatus |
US5879827A (en) | 1997-10-10 | 1999-03-09 | Minnesota Mining And Manufacturing Company | Catalyst for membrane electrode assembly and method of making |
US20090077685A1 (en) | 1998-06-16 | 2009-03-19 | Buehler Robert E | Nucleic acid molecules and other molecules associated with plants |
AUPP058797A0 (en) | 1997-11-28 | 1997-12-18 | Commonwealth Scientific And Industrial Research Organisation | Novel gene |
US6037160A (en) | 1997-12-12 | 2000-03-14 | Heska Corporation | Flea epoxide hydrolase nucleic acid molecules, proteins and uses thereof |
US6060594A (en) | 1997-12-18 | 2000-05-09 | Ecogen, Inc. | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
ATE241151T1 (de) | 1998-01-09 | 2003-06-15 | Novartis Pharma Gmbh | Beschichtung von polymeren |
AUPP135698A0 (en) | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
KR20010042069A (ko) | 1998-03-20 | 2001-05-25 | 베니텍 오스트레일리아 리미티드 | 유전자 발현 조절방법 |
DE69923546T2 (de) | 1998-03-23 | 2006-02-16 | Devgen N.V. | Verfahren zur ballistischen transformation von caenorhabditis elegans |
ATE507299T1 (de) | 1998-04-08 | 2011-05-15 | Commw Scient Ind Res Org | Verfahren und mittel zum erhalt von veränderten phänotypen |
AR020078A1 (es) * | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
GB9827152D0 (en) * | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
EP1104481B1 (en) | 1998-08-19 | 2011-04-20 | Monsanto Technology LLC | Plant expression vectors |
US6506599B1 (en) | 1999-10-15 | 2003-01-14 | Tai-Wook Yoon | Method for culturing langerhans islets and islet autotransplantation islet regeneration |
US6489542B1 (en) | 1998-11-04 | 2002-12-03 | Monsanto Technology Llc | Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids |
GB9826890D0 (en) | 1998-12-07 | 1999-01-27 | Devgen Nv | Method for screening compounds |
AU2848800A (en) | 1999-01-14 | 2000-08-01 | Monsanto Technology Llc | Soybean transformation method |
US6417208B1 (en) | 1999-02-05 | 2002-07-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of identification of inhibitors of PDE1C |
GB9906018D0 (en) | 1999-03-16 | 1999-05-12 | Devgen Nv | Expression of DNA or proteins in C.elegans |
US6511824B1 (en) | 1999-03-17 | 2003-01-28 | Exelixis, Inc. | Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use |
US6703491B1 (en) | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
EP1169343B1 (en) | 1999-04-09 | 2006-05-24 | Heska Corporation | Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof |
GB9908676D0 (en) | 1999-04-15 | 1999-06-09 | Devgen Nv | Method for screening compounds |
GB9908677D0 (en) | 1999-04-15 | 1999-06-09 | Devgen Nv | Compound assay |
PL353437A1 (en) | 1999-05-04 | 2003-11-17 | Monsanto Technology Llc | Coleopteran-toxic polypeptide compositions and insect-resistant transgenic plants |
US6551800B1 (en) * | 1999-10-26 | 2003-04-22 | The Board Of Regents, The University Texas System | Recombinant materials for production of a protein toxic to fire ants |
GB9925459D0 (en) | 1999-10-27 | 1999-12-29 | Plant Bioscience Ltd | Gene silencing |
US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
WO2001037654A2 (en) | 1999-11-24 | 2001-05-31 | Dna Plant Technology Corporation | METHOD OF EXPRESSING dsRNA IN PLANTS TO INHIBIT INSECT PESTS |
GB9930691D0 (en) | 1999-12-24 | 2000-02-16 | Devgen Nv | Improvements relating to double-stranded RNA inhibition |
RU2157644C1 (ru) | 2000-01-21 | 2000-10-20 | Авакян Юрий Арамович | Пищевой и кормовой продукт с повышенным содержанием балластных веществ и способ его получения |
ES2336641T3 (es) * | 2000-02-11 | 2010-04-15 | Metabolix, Inc. | Constructos de expresion multigenicos que contienen inteinas modificadas. |
AU2001247587A1 (en) | 2000-03-20 | 2001-10-03 | Arch Development Corporation | Transgenic plants containing heat shock protein |
EP1268856A2 (de) | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
US20110131679A2 (en) | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
AU2001259260A1 (en) | 2000-05-15 | 2001-11-26 | Monsanto Technology Llc | Polypeptide composionns toxic to anthonomus insects, and use thereof |
GB0012233D0 (en) | 2000-05-19 | 2000-07-12 | Devgen Nv | Vector constructs |
WO2001091559A2 (en) | 2000-05-30 | 2001-12-06 | Pieter Lodewikus Steyn | Bacillus thuringiensis as insect repellent |
GB0014009D0 (en) | 2000-06-08 | 2000-08-02 | Devgen Nv | Compound screens relating to insulin deficiency or insulin resistance |
GB0017224D0 (en) * | 2000-07-14 | 2000-08-30 | Crocker John G | Hand and wrist support |
WO2002013609A1 (en) * | 2000-08-11 | 2002-02-21 | The Regents Of The University Of California | METHODS FOR BLOCKING RESISTANCE TO Bt TOXINS IN INSECTS AND NEMATODES |
US7109393B2 (en) | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
US20020048814A1 (en) | 2000-08-15 | 2002-04-25 | Dna Plant Technology Corporation | Methods of gene silencing using poly-dT sequences |
US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
US6660690B2 (en) | 2000-10-06 | 2003-12-09 | Monsanto Technology, L.L.C. | Seed treatment with combinations of insecticides |
US6586365B2 (en) | 2000-10-06 | 2003-07-01 | Monsanto Technology, Llc | Method for reducing pest damage to corn by treating transgenic corn seeds with clothianidin pesticide |
US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
AU2002218457A1 (en) | 2000-10-18 | 2002-04-29 | Devgen N.V. | Methods for identifying pesticidal compounds |
EP1210875A1 (en) | 2000-12-04 | 2002-06-05 | Aventis CropScience GmbH | Modulating gene expression in insects by using double-stranded RNA (dsRNA) |
WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
AUPR621501A0 (en) * | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
US7612194B2 (en) | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
US7230167B2 (en) | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
EP1440151B1 (en) * | 2001-09-05 | 2008-02-27 | Monsanto Technology LLC | Seed specific 7s alpha promoter for expressing genes in plants |
WO2003031577A2 (en) * | 2001-10-10 | 2003-04-17 | Heska Corporation | Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof |
US20030150017A1 (en) | 2001-11-07 | 2003-08-07 | Mesa Jose Ramon Botella | Method for facilitating pathogen resistance |
US6766613B2 (en) | 2001-11-16 | 2004-07-27 | University Of Florida Research Foundation, Inc. | Materials and methods for controlling pests |
US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
AU2003209814B2 (en) | 2002-03-14 | 2008-12-04 | Commonwealth Scientific & Industrial Research Organisation | Modified gene-silencing RNA and uses thereof |
US20040053876A1 (en) | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
AU2003251579B2 (en) | 2002-06-21 | 2008-04-03 | Monsanto Technology Llc | Intron double stranded RNA constructs and uses thereof |
US7803984B2 (en) | 2002-07-10 | 2010-09-28 | Kansas State University Research Foundation | Compositions and methods for controlling plant parasitic nematodes |
MEP35008A (en) * | 2002-07-29 | 2011-02-10 | Monsanto Technology | Corn event pv-zmir13 (mon863) plants and compositions and methods for detection thereof |
US7205454B2 (en) | 2002-07-31 | 2007-04-17 | Bayer Bioscience N.V. | Corn root preferential promoters and uses thereof |
US20040053289A1 (en) | 2002-09-09 | 2004-03-18 | The Regents Of The University Of California | Short interfering nucleic acid hybrids and methods thereof |
US20040048261A1 (en) | 2002-09-11 | 2004-03-11 | Klaus Raming | Invertebrate choline transporter nucleic acids, polypeptides and uses thereof |
AU2003284323A1 (en) | 2002-10-18 | 2004-05-04 | Alnylam Pharmaceuticals Inc | Double-stranded rna structures and constructs, and methods for generating and using the same |
US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
CN1412311A (zh) | 2002-11-26 | 2003-04-23 | 西南农业大学 | 利用侵染相关基因的协同作用提高微生物杀虫效果的方法 |
ATE528402T1 (de) | 2003-02-19 | 2011-10-15 | Commw Scient Ind Res Org | Effiziente genabschaltung in pflanzen unter verwendung von kurzen dsrna-sequenzen |
AU2004245998A1 (en) | 2003-06-04 | 2004-12-16 | The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention | PNI microarray and uses |
RU2382822C2 (ru) | 2003-07-07 | 2010-02-27 | Монсанто Текнолоджи, Ллс | ИНСЕКТИЦИДНЫЕ БЕЛКИ, ВЫДЕЛЕННЫЕ ИЗ ВИДОВ БАКТЕРИЙ Bacillus, И ИХ ПРИМЕНЕНИЕ |
IL157538A0 (en) | 2003-08-21 | 2004-03-28 | Bar Ilan Res & Dev Company Ltd | Plant resistant to cytoplasm-feeding parasites |
US7266831B2 (en) * | 2003-10-14 | 2007-09-04 | Byeong-Seon Bak | Insertion type compact disc case |
ATE526407T1 (de) * | 2003-11-17 | 2011-10-15 | Commw Scient Ind Res Org | Insektenresistenz durch inhibierung von genexpression |
MXPA06007005A (es) | 2003-12-16 | 2008-02-14 | Monsanto Technology Llc | Composiciones de proteinas y genes secretados de bacillus thuringiensis y usos de las mismas. |
BRPI0416713B8 (pt) | 2003-12-23 | 2020-02-04 | Bayer Sas | métodos de produção de uma planta ou de uma célula vegetal resistente a um fungo fitopatogênico, métodos para inibir ou reduzir a expressão de um gene de fungo e uso de uma construção |
US7622301B2 (en) | 2004-02-24 | 2009-11-24 | Basf Plant Science Gmbh | Compositions and methods using RNA interference for control of nematodes |
CA2762011C (en) | 2004-04-09 | 2019-05-07 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
CN1997737B (zh) | 2004-04-09 | 2018-11-30 | 孟山都技术有限公司 | 用于在植物中控制昆虫侵袭的组合物和方法 |
WO2006070227A2 (en) | 2004-10-04 | 2006-07-06 | Devgen Nv | Method for down-regulating gene expression in fungi |
WO2006046148A2 (en) | 2004-10-25 | 2006-05-04 | Devgen Nv | Rna constructs |
WO2006045591A2 (en) | 2004-10-25 | 2006-05-04 | Devgen N.V. | Method and constructs for delivering double stranded rna to pest organisms |
BRPI0516329A (pt) | 2004-10-25 | 2008-03-11 | Devgen Nv | moléculas de rna de multidomìnio que compreendem pelo menos um aptámero para a aplicação de rna de cordão duplo a organismos de pestes |
US8404927B2 (en) | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
US8030473B2 (en) | 2005-01-07 | 2011-10-04 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Method to trigger RNA interference |
US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
CN101213301B (zh) | 2005-05-31 | 2013-02-27 | 德福根有限公司 | 用于防治昆虫和蜘蛛类动物的RNAi |
PT2295584E (pt) | 2005-09-16 | 2015-09-22 | Devgen Nv | Métodos com base em plantas transgénicas para infestações em plantas utilizando arn de interferência |
AP2008004416A0 (en) | 2005-09-16 | 2008-04-30 | Monsanto Technology Llc | Methods for genetic control of insect infestationsin plants and compositions thereof |
AU2006335978B2 (en) | 2005-09-16 | 2014-02-20 | Devgen Nv | Methods for controlling pests using RNAI |
EP2426206B8 (en) | 2006-02-13 | 2018-10-31 | Monsanto Technology LLC | Selecting and stabilizing dsRNA constructs |
WO2007098001A2 (en) | 2006-02-16 | 2007-08-30 | The Texas A & M University System | Cotton plant with seed-specific reduction in gossypol |
US20110131668A1 (en) | 2007-08-14 | 2011-06-02 | Commonwealth Scientific And Industrial Research Organisation | Improved gene silencing methods |
-
2005
- 2005-04-08 CA CA2762011A patent/CA2762011C/en not_active Expired - Lifetime
- 2005-04-08 US US11/102,026 patent/US20060021087A1/en not_active Abandoned
- 2005-04-08 EP EP05777174.3A patent/EP1732379B1/en not_active Expired - Lifetime
- 2005-04-08 PL PL05777174T patent/PL1732379T3/pl unknown
- 2005-04-08 US US11/547,764 patent/US8946510B2/en active Active
- 2005-04-08 ES ES05777174.3T patent/ES2439696T3/es not_active Expired - Lifetime
- 2005-04-08 CN CN201110393140.6A patent/CN102524294B/zh not_active Expired - Lifetime
- 2005-04-08 ES ES07104762.5T patent/ES2547381T3/es not_active Expired - Lifetime
- 2005-04-08 PL PL07104762T patent/PL1818405T3/pl unknown
- 2005-04-08 PT PT71047625T patent/PT1818405E/pt unknown
- 2005-04-08 BR BRPI0509743-6A patent/BRPI0509743A/pt not_active Application Discontinuation
- 2005-04-08 CN CN201510472024.1A patent/CN105002208A/zh active Pending
- 2005-04-08 WO PCT/US2005/011816 patent/WO2005110068A2/en active Application Filing
- 2005-04-08 PT PT57771743T patent/PT1732379E/pt unknown
- 2005-04-08 CA CA2562022A patent/CA2562022C/en not_active Expired - Lifetime
- 2005-04-08 EP EP11183161A patent/EP2402441A1/en not_active Ceased
- 2005-04-08 EP EP10185197.0A patent/EP2308971B1/en not_active Expired - Lifetime
- 2005-04-08 EP EP07104762.5A patent/EP1818405B2/en not_active Expired - Lifetime
- 2005-04-08 MX MXPA06011694A patent/MXPA06011694A/es active IP Right Grant
- 2005-04-08 AR ARP050101401A patent/AR048685A1/es not_active Application Discontinuation
- 2005-04-08 CA CA2693280A patent/CA2693280C/en not_active Expired - Lifetime
- 2005-04-08 AU AU2005244258A patent/AU2005244258B2/en not_active Expired
-
2006
- 2006-09-26 ZA ZA2006/07995A patent/ZA200607995B/en unknown
- 2006-10-06 EC EC2006006908A patent/ECSP066908A/es unknown
-
2007
- 2007-11-30 US US11/948,759 patent/US7812219B2/en not_active Expired - Lifetime
-
2010
- 2010-09-30 AU AU2010226899A patent/AU2010226899B2/en not_active Expired
-
2011
- 2011-09-06 US US13/226,353 patent/US9238822B2/en not_active Expired - Lifetime
-
2013
- 2013-03-01 US US13/783,125 patent/US9340797B2/en not_active Expired - Lifetime
-
2016
- 2016-04-15 US US15/130,684 patent/US10167484B2/en not_active Expired - Lifetime
-
2017
- 2017-09-19 US US15/709,291 patent/US11492638B2/en not_active Expired - Lifetime
-
2019
- 2019-12-16 US US16/716,281 patent/US10787680B2/en not_active Expired - Lifetime
-
2020
- 2020-08-07 US US16/988,589 patent/US11685930B2/en not_active Expired - Lifetime
-
2022
- 2022-03-08 US US17/689,613 patent/US12077770B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US12077770B2 (en) | Compositions and methods for control of insect infestations in plants | |
AU2011253615B2 (en) | Compositions and methods for control of insect infestations in plants | |
AU2007214372B2 (en) | Compositions and methods for control of insect infestations in plants | |
HK1106790B (en) | Compositions and methods for control of insect infestations in plants | |
HK1098014B (en) | Compositions and methods for control of insect infestations in plants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |