US472484A
(en)
*
|
|
1892-04-05 |
|
Pneumatic tire |
US633770A
(en)
|
1898-10-15 |
1899-09-26 |
Diven Brothers & Company |
Rotary plow.
|
US3025516A
(en)
*
|
1952-11-03 |
1962-03-13 |
Stewart Warner Corp |
Frequency control system for radio identification apparatus
|
DE3226768A1
(de)
|
1981-11-05 |
1983-05-26 |
Hoechst Ag, 6230 Frankfurt |
Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
|
DE3211676A1
(de)
|
1982-03-30 |
1983-10-06 |
Hoechst Ag |
Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
|
US4499082A
(en)
*
|
1983-12-05 |
1985-02-12 |
E. I. Du Pont De Nemours And Company |
α-Aminoboronic acid peptides
|
FR2575753B1
(fr)
|
1985-01-07 |
1987-02-20 |
Adir |
Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US5496927A
(en)
*
|
1985-02-04 |
1996-03-05 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
DE3683541D1
(de)
|
1985-06-07 |
1992-03-05 |
Ici America Inc |
Selektionierte difluorverbindungen.
|
US5231084A
(en)
*
|
1986-03-27 |
1993-07-27 |
Hoechst Aktiengesellschaft |
Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
|
US5736520A
(en)
*
|
1988-10-07 |
1998-04-07 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
NZ235155A
(en)
|
1989-09-11 |
1993-04-28 |
Merrell Dow Pharma |
Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical
|
DE4019586A1
(de)
*
|
1990-06-20 |
1992-01-02 |
Bosch Gmbh Robert |
Kraftstoffeinspritzsystem fuer brennkraftmaschinen
|
US5371072A
(en)
|
1992-10-16 |
1994-12-06 |
Corvas International, Inc. |
Asp-Pro-Arg α-keto-amide enzyme inhibitors
|
EP0604182B1
(en)
*
|
1992-12-22 |
2000-10-11 |
Eli Lilly And Company |
Inhibitors of HIV protease useful for the treatment of Aids
|
DE69332616T2
(de)
|
1992-12-29 |
2003-11-06 |
Abbott Lab |
Hemmer der retroviralen Protease
|
US5384410A
(en)
*
|
1993-03-24 |
1995-01-24 |
The Du Pont Merck Pharmaceutical Company |
Removal of boronic acid protecting groups by transesterification
|
US5656600A
(en)
|
1993-03-25 |
1997-08-12 |
Corvas International, Inc. |
α-ketoamide derivatives as inhibitors of thrombosis
|
US5672582A
(en)
|
1993-04-30 |
1997-09-30 |
Merck & Co., Inc. |
Thrombin inhibitors
|
IL110752A
(en)
|
1993-09-13 |
2000-07-26 |
Abbott Lab |
Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
|
US5559158A
(en)
|
1993-10-01 |
1996-09-24 |
Abbott Laboratories |
Pharmaceutical composition
|
US5468858A
(en)
|
1993-10-28 |
1995-11-21 |
The Board Of Regents Of Oklahoma State University Physical Sciences |
N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
|
IL111991A
(en)
*
|
1994-01-28 |
2000-07-26 |
Abbott Lab |
Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
|
IL113196A0
(en)
|
1994-03-31 |
1995-06-29 |
Bristol Myers Squibb Co |
Imidazole derivatives and pharmaceutical compositions containing the same
|
US5847135A
(en)
|
1994-06-17 |
1998-12-08 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
US6420522B1
(en)
|
1995-06-05 |
2002-07-16 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
US5716929A
(en)
|
1994-06-17 |
1998-02-10 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
US5756466A
(en)
*
|
1994-06-17 |
1998-05-26 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
US5861267A
(en)
*
|
1995-05-01 |
1999-01-19 |
Vertex Pharmaceuticals Incorporated |
Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
|
US6037157A
(en)
|
1995-06-29 |
2000-03-14 |
Abbott Laboratories |
Method for improving pharmacokinetics
|
EP1019410A1
(en)
*
|
1995-11-23 |
2000-07-19 |
MERCK SHARP & DOHME LTD. |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
US5807876A
(en)
*
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
US6054472A
(en)
*
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
ZA972195B
(en)
*
|
1996-03-15 |
1998-09-14 |
Du Pont Merck Pharma |
Spirocycle integrin inhibitors
|
CN1116288C
(zh)
*
|
1996-04-23 |
2003-07-30 |
沃泰克斯药物股份有限公司 |
用作肌苷-5'-一磷酸脱氢酶抑制剂的脲衍生物
|
US5990276A
(en)
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
WO1997043310A1
(en)
|
1996-05-10 |
1997-11-20 |
Schering Corporation |
Synthetic inhibitors of hepatitis c virus ns3 protease
|
US6153579A
(en)
|
1996-09-12 |
2000-11-28 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
AU723414B2
(en)
*
|
1996-09-25 |
2000-08-24 |
Merck Sharp & Dohme Limited |
Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
|
DE69725023T2
(de)
*
|
1996-10-08 |
2004-08-05 |
Colorado State University Research Foundation, Fort Collins |
Katalytische asymmetrische epoxidierung
|
EE04023B1
(et)
*
|
1996-10-18 |
2003-04-15 |
Vertex Pharmaceuticals Incorporated |
Seriinproteaaside, eriti C-hepatiidi viiruse NS3-proteaasi inhibiitorid
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
DE19648011A1
(de)
*
|
1996-11-20 |
1998-05-28 |
Bayer Ag |
Cyclische Imine
|
AU6701598A
(en)
*
|
1997-03-14 |
1998-09-29 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
GB9708484D0
(en)
*
|
1997-04-25 |
1997-06-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9711114D0
(en)
*
|
1997-05-29 |
1997-07-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
HUP0004853A3
(en)
|
1997-08-11 |
2001-12-28 |
Boehringer Ingelheim Ca Ltd |
Hepatitis c inhibitor peptides, process for preparation thereof, pharmaceutical compositions comprising thereof, their use and their intermediates
|
US6767991B1
(en)
|
1997-08-11 |
2004-07-27 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptides
|
HUP0100100A3
(en)
|
1997-08-11 |
2001-12-28 |
Boehringer Ingelheim Ca Ltd |
Hepatitis c inhibitor peptide analogues, pharmaceutical compositions comprising thereof and their use
|
US6183121B1
(en)
*
|
1997-08-14 |
2001-02-06 |
Vertex Pharmaceuticals Inc. |
Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
|
US20040058982A1
(en)
*
|
1999-02-17 |
2004-03-25 |
Bioavailability System, Llc |
Pharmaceutical compositions
|
US20020017295A1
(en)
*
|
2000-07-07 |
2002-02-14 |
Weers Jeffry G. |
Phospholipid-based powders for inhalation
|
WO1999028482A2
(en)
*
|
1997-11-28 |
1999-06-10 |
Schering Corporation |
Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
EP1066247B1
(en)
|
1998-03-31 |
2006-11-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
|
US6251583B1
(en)
*
|
1998-04-27 |
2001-06-26 |
Schering Corporation |
Peptide substrates for HCV NS3 protease assays
|
GB9812523D0
(en)
*
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
DE19836514A1
(de)
*
|
1998-08-12 |
2000-02-17 |
Univ Stuttgart |
Modifikation von Engineeringpolymeren mit N-basischen Gruppe und mit Ionenaustauschergruppen in der Seitenkette
|
US6117639A
(en)
|
1998-08-31 |
2000-09-12 |
Vertex Pharmaceuticals Incorporated |
Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
|
US6025516A
(en)
|
1998-10-14 |
2000-02-15 |
Chiragene, Inc. |
Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
|
GB9825946D0
(en)
|
1998-11-26 |
1999-01-20 |
Angeletti P Ist Richerche Bio |
Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease
|
ATE400251T1
(de)
*
|
1999-02-09 |
2008-07-15 |
Pfizer Prod Inc |
Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
|
US20020042046A1
(en)
*
|
1999-02-25 |
2002-04-11 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
SK13332001A3
(sk)
|
1999-03-19 |
2002-02-05 |
Vertex Pharmaceuticals Incorporated |
Inhibítory IMPDH enzýmu a ich použitie
|
US6608027B1
(en)
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
UA74546C2
(en)
*
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
AU6371900A
(en)
|
1999-07-26 |
2001-02-13 |
Du Pont Pharmaceuticals Company |
Lactam inhibitors of hepatitis c virus ns3 protease
|
US7122627B2
(en)
|
1999-07-26 |
2006-10-17 |
Bristol-Myers Squibb Company |
Lactam inhibitors of Hepatitis C virus NS3 protease
|
US20020183249A1
(en)
|
1999-08-31 |
2002-12-05 |
Taylor Neil R. |
Method of identifying inhibitors of CDC25
|
GB9925955D0
(en)
|
1999-11-02 |
1999-12-29 |
Angeletti P Ist Richerche Bio |
Hcv n33 protease inhibitors
|
AU2055301A
(en)
|
1999-12-03 |
2001-06-12 |
Bristol-Myers Squibb Pharma Company |
Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease
|
US6624290B2
(en)
|
2000-02-08 |
2003-09-23 |
Schering Corporation |
Azapeptides useful in the treatment of Hepatitis C
|
JP2003525294A
(ja)
|
2000-02-29 |
2003-08-26 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
C型肝炎ウイルスns3プロテアーゼの阻害剤
|
EP1268519B1
(en)
|
2000-04-03 |
2005-06-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
|
CN1441806A
(zh)
*
|
2000-04-05 |
2003-09-10 |
先灵公司 |
包含n-环p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
|
AU2001253621A1
(en)
|
2000-04-19 |
2001-11-07 |
Schering Corporation |
Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
|
AU2001267886A1
(en)
|
2000-06-30 |
2002-01-14 |
Seikagaku Corporation |
Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
|
JP2004504356A
(ja)
|
2000-07-20 |
2004-02-12 |
メルク エンド カムパニー インコーポレーテッド |
C型肝炎ウイルスのプロセシングおよび複製の抑制
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
CZ303213B6
(cs)
|
2000-07-21 |
2012-05-23 |
Schering Corporation |
Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostredek
|
AU2001277967A1
(en)
*
|
2000-07-21 |
2002-02-05 |
Corvas International, Inc. |
Peptides as ns3-serine protease inhibitors of hepatitis c virus
|
CA2410682A1
(en)
|
2000-07-21 |
2002-01-31 |
Schering Corporation |
Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
|
AR034127A1
(es)
*
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
AR029851A1
(es)
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
US6777400B2
(en)
|
2000-08-05 |
2004-08-17 |
Smithkline Beecham Corporation |
Anti-inflammatory androstane derivative compositions
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
US6939692B2
(en)
|
2000-09-12 |
2005-09-06 |
Degussa Ag |
Nucleotide sequences coding for the pknB gene
|
US6846806B2
(en)
|
2000-10-23 |
2005-01-25 |
Bristol-Myers Squibb Company |
Peptide inhibitors of Hepatitis C virus NS3 protein
|
MXPA03004299A
(es)
|
2000-11-20 |
2004-02-12 |
Bristol Myers Squibb Co |
Inhibidores de tripeptido de hepatitis c.
|
IL155842A0
(en)
*
|
2000-12-12 |
2003-12-23 |
Schering Corp |
Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus
|
WO2002048116A2
(en)
|
2000-12-13 |
2002-06-20 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
AU2002230764A1
(en)
*
|
2000-12-13 |
2002-06-24 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
|
US6653295B2
(en)
*
|
2000-12-13 |
2003-11-25 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus NS3 protease
|
CA2434386C
(en)
*
|
2001-01-22 |
2006-12-05 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
WO2002061149A2
(en)
|
2001-01-30 |
2002-08-08 |
Vertex Pharmaceuticals Incorporated |
A quantitative assay for nucleic acids
|
GB0102342D0
(en)
*
|
2001-01-30 |
2001-03-14 |
Smithkline Beecham Plc |
Pharmaceutical formulation
|
MXPA03008882A
(es)
|
2001-03-27 |
2003-12-08 |
Vertex Pharma |
Composiciones y metodos utiles para la infeccion por hcv.
|
GB0107924D0
(en)
|
2001-03-29 |
2001-05-23 |
Angeletti P Ist Richerche Bio |
Inhibitor of hepatitis C virus NS3 protease
|
JP2005500322A
(ja)
*
|
2001-07-03 |
2005-01-06 |
アルタナ ファルマ アクチエンゲゼルシャフト |
3−フェニルイソセリンの製法
|
CN100402549C
(zh)
|
2001-07-11 |
2008-07-16 |
沃泰克斯药物股份有限公司 |
桥连二环的丝氨酸蛋白酶抑制剂
|
JP2003055389A
(ja)
|
2001-08-09 |
2003-02-26 |
Univ Tokyo |
錯体及びそれを用いたエポキシドの製法
|
US6824769B2
(en)
|
2001-08-28 |
2004-11-30 |
Vertex Pharmaceuticals Incorporated |
Optimal compositions and methods thereof for treating HCV infections
|
NZ531681A
(en)
|
2001-10-24 |
2007-05-31 |
Vertex Pharma |
Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system
|
HUP0501067A2
(en)
*
|
2001-11-14 |
2006-02-28 |
Teva Pharma |
Amorphous and crystalline forms of losartan potassium and process for their preparation
|
ATE443703T1
(de)
|
2002-01-23 |
2009-10-15 |
Schering Corp |
Prolinderivate als ns3-serine protease hemmer, zur verwendung bei der bekämpfung von hepatitis c virusinfektion
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
AR038375A1
(es)
|
2002-02-01 |
2005-01-12 |
Pfizer Prod Inc |
Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
CA2369970A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
CN100381440C
(zh)
|
2002-04-11 |
2008-04-16 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶、特别是丙型肝炎病毒ns3-ns4蛋白酶的抑制剂
|
ES2361011T3
(es)
|
2002-05-20 |
2011-06-13 |
Bristol-Myers Squibb Company |
Inhibidores del virus de la hepatitis c.
|
KR20050040912A
(ko)
*
|
2002-08-01 |
2005-05-03 |
파마셋 인코포레이티드 |
플라비비리다에 감염 치료용의 비사이클로[4.2.1]노난시스템을 가지는 화합물
|
AU2003277891A1
(en)
|
2002-09-23 |
2004-04-08 |
Medivir Ab |
Hcv ns-3 serine protease inhibitors
|
US20040138109A1
(en)
|
2002-09-30 |
2004-07-15 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Potent inhibitor of HCV serine protease
|
US20050075279A1
(en)
*
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
US20050159345A1
(en)
|
2002-10-29 |
2005-07-21 |
Boehringer Ingelheim International Gmbh |
Composition for the treatment of infection by Flaviviridae viruses
|
CA2413705A1
(en)
*
|
2002-12-06 |
2004-06-06 |
Raul Altman |
Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
|
US7601709B2
(en)
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
US7098231B2
(en)
|
2003-01-22 |
2006-08-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
EP1590442A4
(en)
|
2003-02-07 |
2007-07-18 |
Enanta Pharm Inc |
MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS
|
US20040180815A1
(en)
|
2003-03-07 |
2004-09-16 |
Suanne Nakajima |
Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
|
JP2006517960A
(ja)
|
2003-02-18 |
2006-08-03 |
ファイザー インコーポレイテッド |
C型肝炎ウイルスの阻害剤、それを使用する組成物および治療法
|
JP4550824B2
(ja)
|
2003-03-05 |
2010-09-22 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎抑制化合物
|
CA2516018C
(en)
|
2003-03-05 |
2011-08-23 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibitor peptide analogs
|
KR20060008877A
(ko)
|
2003-04-10 |
2006-01-27 |
베링거 인겔하임 인터내셔날 게엠베하 |
루테늄 착물 촉매 존재하의 복분해 반응에 의한거대사이클릭 화합물의 제조방법
|
ES2381548T3
(es)
|
2003-04-11 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de serina proteasas, particularmente de la proteasa VHC NS3-NS4A
|
EP1613620A1
(en)
|
2003-04-11 |
2006-01-11 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
EP1629000B1
(en)
|
2003-04-16 |
2009-02-18 |
Bristol-Myers Squibb Company |
Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus
|
PL1615613T3
(pl)
|
2003-04-18 |
2010-04-30 |
Enanta Pharm Inc |
Chinoksalinylowe makrocykliczne inhibitory proteazy serynowej zapalenia wątroby typu C
|
PE20050204A1
(es)
*
|
2003-05-21 |
2005-05-04 |
Boehringer Ingelheim Int |
Compuestos inhibidores de la hepatitis c
|
WO2004113365A2
(en)
|
2003-06-05 |
2004-12-29 |
Enanta Pharmaceuticals, Inc. |
Hepatitis c serine protease tri-peptide inhibitors
|
US7125845B2
(en)
|
2003-07-03 |
2006-10-24 |
Enanta Pharmaceuticals, Inc. |
Aza-peptide macrocyclic hepatitis C serine protease inhibitors
|
NZ544789A
(en)
|
2003-07-18 |
2010-01-29 |
Vertex Pharma |
Dithia-azaspiro-nonane and decane derivatives as inhibitors of serine proteases
|
WO2005018330A1
(en)
*
|
2003-08-18 |
2005-03-03 |
Pharmasset, Inc. |
Dosing regimen for flaviviridae therapy
|
EP1664090A2
(en)
|
2003-08-26 |
2006-06-07 |
Schering Corporation |
Novel peptidomimetic ns3-serine protease inhibitors of hepatitis c virus
|
UY28500A1
(es)
*
|
2003-09-05 |
2005-04-29 |
Vertex Pharma |
Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
|
US20050120398A1
(en)
*
|
2003-09-12 |
2005-06-02 |
Vertex Pharmaceuticals Incorporated |
Animal model for HCV infection
|
TW200526686A
(en)
|
2003-09-18 |
2005-08-16 |
Vertex Pharma |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
US6933760B2
(en)
*
|
2003-09-19 |
2005-08-23 |
Intel Corporation |
Reference voltage generator for hysteresis circuit
|
CA2536182C
(en)
|
2003-09-22 |
2012-07-24 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis c virus
|
TWI280964B
(en)
|
2003-09-26 |
2007-05-11 |
Schering Corp |
Macrocyclic inhibitors of hepatitis C virus NS3 serine protease
|
RU2006115558A
(ru)
|
2003-10-10 |
2007-11-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы
|
AR045870A1
(es)
*
|
2003-10-11 |
2005-11-16 |
Vertex Pharma |
Terapia de combinacion para la infeccion de virus de hepatitis c
|
WO2005037214A2
(en)
|
2003-10-14 |
2005-04-28 |
Intermune, Inc. |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
|
PT1677827E
(pt)
*
|
2003-10-27 |
2009-03-13 |
Vertex Pharma |
Associações para o tratamento do vhc
|
US8187874B2
(en)
*
|
2003-10-27 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Drug discovery method
|
EP1678202B1
(en)
*
|
2003-10-27 |
2012-06-13 |
Vertex Pharmaceuticals Incorporated |
Hcv ns3-ns4a protease resistance mutants
|
ES2330944T3
(es)
|
2003-10-28 |
2009-12-17 |
Vertex Pharmaceuticals Incorporated |
Preparacion de derivados del acido 4,5-dialquil-3-acil-pirrol-2-carboxilico mediante sintesis de tipo fischer-fink y acilacion subsiguiente.
|
US20050119318A1
(en)
*
|
2003-10-31 |
2005-06-02 |
Hudyma Thomas W. |
Inhibitors of HCV replication
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
CN1902216A
(zh)
|
2003-11-20 |
2007-01-24 |
先灵公司 |
丙肝病毒ns3蛋白酶的去肽化抑制剂
|
US7309708B2
(en)
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
CA2547787A1
(en)
|
2003-12-01 |
2005-06-16 |
Vertex Pharmaceuticals Incorporated |
Compositions comprising fetal liver cells and methods useful for hcv infection
|
WO2005058821A1
(en)
|
2003-12-11 |
2005-06-30 |
Schering Corporation |
Inhibitors of hepatitis c virus ns3/ns4a serine protease
|
EP1730167B1
(en)
|
2004-01-21 |
2011-01-12 |
Boehringer Ingelheim International GmbH |
Macrocyclic peptides active against the hepatitis c virus
|
EP1713822B1
(en)
|
2004-01-30 |
2010-03-17 |
Medivir AB |
Hcv ns-3 serine protease inhibitors
|
US7683033B2
(en)
|
2004-02-04 |
2010-03-23 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
US20050187192A1
(en)
|
2004-02-20 |
2005-08-25 |
Kucera Pharmaceutical Company |
Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
|
CN102911161A
(zh)
|
2004-02-20 |
2013-02-06 |
贝林格尔.英格海姆国际有限公司 |
病毒聚合酶抑制剂
|
DE602005015093D1
(de)
|
2004-02-27 |
2009-08-06 |
Schering Corp |
Neue verbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
|
US7173057B2
(en)
|
2004-02-27 |
2007-02-06 |
Schering Corporation |
Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus
|
US7205330B2
(en)
|
2004-02-27 |
2007-04-17 |
Schering Corporation |
Inhibitors of hepatitis C virus NS3 protease
|
DE602005021760D1
(de)
|
2004-02-27 |
2010-07-22 |
Schering Corp |
Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
|
ATE438622T1
(de)
|
2004-02-27 |
2009-08-15 |
Schering Corp |
3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
|
JP2007525510A
(ja)
|
2004-02-27 |
2007-09-06 |
シェーリング コーポレイション |
C型肝炎ウイルスns3セリンプロテアーゼのインヒビターとしての化合物
|
EP1725548B1
(en)
*
|
2004-03-12 |
2015-01-14 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
|
AU2005228894B9
(en)
|
2004-03-30 |
2011-10-13 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
US20050249702A1
(en)
|
2004-05-06 |
2005-11-10 |
Schering Corporation |
(1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease
|
WO2005113581A1
(en)
|
2004-05-20 |
2005-12-01 |
Schering Corporation |
Substituted prolines as inhibitors of hepatitis c virus ns3 serine protease
|
KR101370580B1
(ko)
*
|
2004-06-08 |
2014-03-06 |
버텍스 파마슈티칼스 인코포레이티드 |
약학 조성물
|
WO2006000085A1
(en)
|
2004-06-28 |
2006-01-05 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibitor peptide analogs
|
UY29016A1
(es)
|
2004-07-20 |
2006-02-24 |
Boehringer Ingelheim Int |
Analogos de dipeptidos inhibidores de la hepatitis c
|
ATE512971T1
(de)
|
2004-07-20 |
2011-07-15 |
Boehringer Ingelheim Int |
Peptidanaloga als hepatitis c-hemmer
|
US7423113B2
(en)
*
|
2004-08-25 |
2008-09-09 |
Vib Vzw |
Leptin antagonist
|
CN101068828A
(zh)
|
2004-08-27 |
2007-11-07 |
先灵公司 |
用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的酰基磺酰胺化合物
|
EP1804821A4
(en)
|
2004-10-01 |
2009-07-15 |
Vertex Pharma |
INHIBITION OF HCV NS3-NS4A PROTEASE
|
TW201424733A
(zh)
*
|
2004-10-29 |
2014-07-01 |
Vertex Pharma |
劑量型式
|
US7863274B2
(en)
|
2005-07-29 |
2011-01-04 |
Concert Pharmaceuticals Inc. |
Deuterium enriched analogues of tadalafil as PDE5 inhibitors
|
EP2402331A1
(en)
*
|
2005-08-02 |
2012-01-04 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases
|
EP2357170A1
(en)
*
|
2005-08-19 |
2011-08-17 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates
|
AR055395A1
(es)
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
US7705138B2
(en)
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
WO2007098270A2
(en)
|
2006-02-27 |
2007-08-30 |
Vertex Pharmaceuticals Incorporated |
Co-crystals comprising vx-950 and pharmaceutical compositions comprising the same
|
CA2646229A1
(en)
*
|
2006-03-16 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Deuterated hepatitis c protease inhibitors
|
US20070244334A1
(en)
|
2006-03-16 |
2007-10-18 |
Tanoury Gerald J |
Processes and intermediates for preparing steric compounds
|
CN101494979A
(zh)
|
2006-03-20 |
2009-07-29 |
沃泰克斯药物股份有限公司 |
药物组合物
|
CA2646335A1
(en)
|
2006-03-20 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions
|
PT2037887E
(pt)
*
|
2006-05-31 |
2010-12-07 |
Vertex Pharma |
Formulações orais de libertação controlada de um inibidor da enzima conversora de interleucina-1 beta
|