BRPI0609496C8 - derivado do éster do ácido propiônico - Google Patents

derivado do éster do ácido propiônico

Info

Publication number
BRPI0609496C8
BRPI0609496C8 BRPI0609496A BRPI0609496A BRPI0609496C8 BR PI0609496 C8 BRPI0609496 C8 BR PI0609496C8 BR PI0609496 A BRPI0609496 A BR PI0609496A BR PI0609496 A BRPI0609496 A BR PI0609496A BR PI0609496 C8 BRPI0609496 C8 BR PI0609496C8
Authority
BR
Brazil
Prior art keywords
acid ester
propionic acid
ester derivative
benzothiophen
azetidin
Prior art date
Application number
BRPI0609496A
Other languages
English (en)
Inventor
Saitoh Akihito
Yonezawa Kenji
Kawamura Mitsuhide
Kusanagi Takahiko
Nakai Takashi
Suzuki Yoshiaki
Original Assignee
Fujifilm Toyama Chemical Co Ltd
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Toyama Chemical Co Ltd, Toyama Chemical Co Ltd filed Critical Fujifilm Toyama Chemical Co Ltd
Publication of BRPI0609496A2 publication Critical patent/BRPI0609496A2/pt
Publication of BRPI0609496B1 publication Critical patent/BRPI0609496B1/pt
Publication of BRPI0609496C1 publication Critical patent/BRPI0609496C1/pt
Publication of BRPI0609496C8 publication Critical patent/BRPI0609496C8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para a produção de um composto, e, derivados de diidrobenzotiofeno, de benzotiofeno ou sais do mesmo, e do éster do ácido propiônico. um processo para a produção de 1-(3-(2-(1-benzotiofen-5-il)etóxi)propil)azetidin-3-ol ou sais do mesmo, que compreende o uso, como composto de partida, de um derivado do ácido (feniltio)acético, representado pela fórmula geral [1] ou um sal do mesmo: [fórmula química 1] (em que x1 é halogênio) é útil como um processo seguro para a produção em massa de 1 -(3 -(2-( 1 -benzotiofen-5 -il)etóxi)propil)azetidin-3-ol ou sais do mesmo, que é útil como um remédio para doenças do sistema nervoso central e doenças do nervo periférico.
BRPI0609496A 2005-03-28 2006-03-27 derivado do éster do ácido propiônico BRPI0609496C8 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2005-090831 2005-03-28
JP2005090831 2005-03-28
JP2005-174738 2005-06-15
JP2005174738 2005-06-15
JP2005-206808 2005-07-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
PCT/JP2006/306127 WO2006104088A1 (ja) 2005-03-28 2006-03-27 １－（３－（２－（１－ベンゾチオフェン－５－イル）エトキシ）プロピル）アゼチジン－３－オールまたはその塩の製造法

Publications (4)

Publication Number Publication Date
BRPI0609496A2 BRPI0609496A2 (pt) 2011-10-18
BRPI0609496B1 BRPI0609496B1 (pt) 2020-11-24
BRPI0609496C1 BRPI0609496C1 (pt) 2021-05-11
BRPI0609496C8 true BRPI0609496C8 (pt) 2021-05-25

Family

ID=37053344

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609496A BRPI0609496C8 (pt) 2005-03-28 2006-03-27 derivado do éster do ácido propiônico

Country Status (22)

Country Link
US (2) US7951963B2 (pt)
EP (4) EP2348022B1 (pt)
JP (1) JP5031554B2 (pt)
KR (2) KR101337382B1 (pt)
CN (1) CN101151257B (pt)
AT (2) ATE546443T1 (pt)
AU (1) AU2006229271B2 (pt)
BR (1) BRPI0609496C8 (pt)
CA (2) CA2600381C (pt)
CY (3) CY1112956T1 (pt)
DK (2) DK2248809T3 (pt)
ES (3) ES2398934T3 (pt)
IL (2) IL186044A (pt)
MX (1) MX2007011938A (pt)
NO (3) NO340071B1 (pt)
NZ (2) NZ583580A (pt)
PL (3) PL2348022T3 (pt)
PT (3) PT2248809E (pt)
SG (1) SG155251A1 (pt)
SI (3) SI2210884T1 (pt)
WO (1) WO2006104088A1 (pt)
ZA (1) ZA200708262B (pt)

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KR100956990B1 (ko) 2001-10-19 2010-05-11 토야마 케미칼 컴퍼니 리미티드 알킬에테르유도체 또는 그 염
ES2398934T3 (es) * 2005-03-28 2013-03-22 Toyama Chemical Co., Ltd. Proceso de la producción de1-(3-(2-(1-benzotiofen-5-il)etoxi)propil)acetidin-ol o sales del mismo
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
DK3091011T3 (en) 2006-04-07 2018-02-26 Vertex Pharma MODULATORS OF ATP BINDING CASSETTE TRANSPORT
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
AU2007279673B2 (en) * 2006-08-04 2012-04-19 Toyama Chemical Co., Ltd. Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG184987A1 (en) * 2010-04-22 2012-11-29 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
JP6100174B2 (ja) 2011-03-02 2017-03-22 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ アリール酢酸誘導体及びヘテロアリール酢酸誘導体を調製する方法
EP2762225B1 (en) 2011-09-30 2018-09-12 Mitsubishi Chemical Corporation Polymerizable inorganic particle-dispersing agent, inorganic/organic composite particles containing said polymerizable inorganic particle-dispersing agent, and inorganic/organic resin composite
US9872914B2 (en) 2012-02-22 2018-01-23 Toyama Chemical Co., Ltd. Solid pharmaceutical composition containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
EP3100725B1 (en) 2014-01-31 2020-05-06 FUJIFILM Toyama Chemical Co., Ltd. Post nerve injury rehabilitation effect-enhancing agent comprising an alkyl ether derivative or a salt thereof
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN109526218B (zh) 2016-03-31 2021-07-06 富士胶片富山化学株式会社 5-溴甲基-1-苯并噻吩的制备方法

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MXPA05011125A (es) * 2003-04-17 2005-12-14 Toyama Chemical Co Ltd Remedio preventivo para enfermedades del nervio retiniano que contienen derivados de eter de alquilo o sales de los mismos.
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Also Published As

Publication number Publication date
PT2210884E (pt) 2012-04-10
CA2600381A1 (en) 2006-10-05
JPWO2006104088A1 (ja) 2008-09-04
US7951963B2 (en) 2011-05-31
EP2248809A1 (en) 2010-11-10
PL2348022T3 (pl) 2013-06-28
KR101283930B1 (ko) 2013-07-16
NO340071B1 (no) 2017-03-06
IL214245A0 (en) 2011-08-31
US8273902B2 (en) 2012-09-25
CY1113571T1 (el) 2016-06-22
CN101151257B (zh) 2012-07-18
EP2248809B1 (en) 2012-05-09
NO20161418A1 (no) 2007-10-25
SI2348022T1 (sl) 2013-05-31
KR20130010090A (ko) 2013-01-25
EP2348022A1 (en) 2011-07-27
IL186044A (en) 2013-12-31
BRPI0609496C1 (pt) 2021-05-11
SI2248809T1 (sl) 2012-09-28
KR20080008334A (ko) 2008-01-23
ZA200708262B (en) 2009-01-28
ATE557020T1 (de) 2012-05-15
EP2348022B1 (en) 2013-01-09
SG155251A1 (en) 2009-09-30
KR101337382B1 (ko) 2013-12-06
AU2006229271A1 (en) 2006-10-05
EP1864978A1 (en) 2007-12-12
JP5031554B2 (ja) 2012-09-19
CA2600381C (en) 2013-11-12
NZ561672A (en) 2010-04-30
WO2006104088A1 (ja) 2006-10-05
DK2248809T3 (da) 2012-06-18
NZ583580A (en) 2010-10-29
BRPI0609496A2 (pt) 2011-10-18
NO20161419A1 (no) 2016-06-07
EP2210884A3 (en) 2010-09-22
PL2210884T3 (pl) 2012-07-31
NO340420B1 (no) 2017-04-18
ES2398934T3 (es) 2013-03-22
PL2248809T3 (pl) 2012-10-31
EP1864978A4 (en) 2009-07-01
US20110098484A1 (en) 2011-04-28
CN101151257A (zh) 2008-03-26
IL214245A (en) 2014-12-31
CA2799659C (en) 2014-12-02
PT2348022E (pt) 2013-02-13
ATE546443T1 (de) 2012-03-15
CY1112885T1 (el) 2016-04-13
DK2210884T3 (da) 2012-03-26
IL186044A0 (en) 2008-02-09
EP2210884B1 (en) 2012-02-22
MX2007011938A (es) 2008-03-14
SI2210884T1 (sl) 2012-06-29
AU2006229271B2 (en) 2012-02-09
ES2380443T3 (es) 2012-05-11
CA2799659A1 (en) 2006-10-05
PT2248809E (pt) 2012-07-02
EP2210884A2 (en) 2010-07-28
ES2384312T3 (es) 2012-07-03
BRPI0609496B1 (pt) 2020-11-24
CY1112956T1 (el) 2016-04-13
US20090069576A1 (en) 2009-03-12
NO340366B1 (no) 2017-04-10
NO20074618L (no) 2007-10-25

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B25A Requested transfer of rights approved

Owner name: FUJIFILM TOYAMA CHEMICAL CO., LTD. (JP)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
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