SI2348022T1 - Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega - Google Patents

Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega

Info

Publication number
SI2348022T1
SI2348022T1 SI200631556T SI200631556T SI2348022T1 SI 2348022 T1 SI2348022 T1 SI 2348022T1 SI 200631556 T SI200631556 T SI 200631556T SI 200631556 T SI200631556 T SI 200631556T SI 2348022 T1 SI2348022 T1 SI 2348022T1
Authority
SI
Slovenia
Prior art keywords
benzothiophen
azetidin
ethoxy
propyl
salts
Prior art date
Application number
SI200631556T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of SI2348022T1 publication Critical patent/SI2348022T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200631556T 2005-03-28 2006-03-27 Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega SI2348022T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
EP11002265A EP2348022B1 (en) 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof

Publications (1)

Publication Number Publication Date
SI2348022T1 true SI2348022T1 (sl) 2013-05-31

Family

ID=37053344

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200631383T SI2248809T1 (sl) 2005-03-28 2006-03-27 Alkil-3-(2-(benzo(b)tiofen-5-il)-etoksi)-propanoati kot vmesniki v proizvodnji derivatov azetidin-3-ola
SI200631324T SI2210884T1 (sl) 2005-03-28 2006-03-27 Postopek izdelave 1-(3-(2-(1-benzotiofen-5-il)-etoksi)propionske kisline ali soli le-te
SI200631556T SI2348022T1 (sl) 2005-03-28 2006-03-27 Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200631383T SI2248809T1 (sl) 2005-03-28 2006-03-27 Alkil-3-(2-(benzo(b)tiofen-5-il)-etoksi)-propanoati kot vmesniki v proizvodnji derivatov azetidin-3-ola
SI200631324T SI2210884T1 (sl) 2005-03-28 2006-03-27 Postopek izdelave 1-(3-(2-(1-benzotiofen-5-il)-etoksi)propionske kisline ali soli le-te

Country Status (22)

Country Link
US (2) US7951963B2 (sl)
EP (4) EP2210884B1 (sl)
JP (1) JP5031554B2 (sl)
KR (2) KR101283930B1 (sl)
CN (1) CN101151257B (sl)
AT (2) ATE546443T1 (sl)
AU (1) AU2006229271B2 (sl)
BR (1) BRPI0609496C8 (sl)
CA (2) CA2600381C (sl)
CY (3) CY1112956T1 (sl)
DK (2) DK2248809T3 (sl)
ES (3) ES2380443T3 (sl)
IL (2) IL186044A (sl)
MX (1) MX2007011938A (sl)
NO (3) NO340071B1 (sl)
NZ (2) NZ561672A (sl)
PL (3) PL2210884T3 (sl)
PT (3) PT2348022E (sl)
SG (1) SG155251A1 (sl)
SI (3) SI2248809T1 (sl)
WO (1) WO2006104088A1 (sl)
ZA (1) ZA200708262B (sl)

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BRPI0213393B8 (pt) 2001-10-19 2021-05-25 Fujifilm Toyama Chemical Co Ltd derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica
PT2348022E (pt) * 2005-03-28 2013-02-13 Toyama Chemical Co Ltd Processo para a produção de 1-(3-(2-(1- benzotiofen-5-il)etoxi)propil)azetidin-3-ol ou dos seus sais
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CA2869945C (en) 2006-04-07 2018-01-23 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
JP5255441B2 (ja) * 2006-08-04 2013-08-07 富山化学工業株式会社 アルキルエーテル誘導体またはその塩を含有するプロテインキナーゼｃ活性促進剤
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2858351T3 (es) * 2010-04-22 2021-09-30 Vertex Pharma Compuesto intermedio para proceso de producción de compuestos de cicloalquilcaraboxamido-indol
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
MX341269B (es) * 2011-03-02 2016-08-09 Bayer Ip Gmbh Proceso para preparar derivados de acido arilacetico y heteroarilacetico.
JP6438199B2 (ja) 2011-09-30 2018-12-12 三菱ケミカル株式会社 重合性無機粒子分散剤、該重合性無機粒子分散剤を含む無機有機複合粒子、および無機有機樹脂複合材
CN104159583B (zh) * 2012-02-22 2018-04-13 富山化学工业株式会社 含有1‑(3‑(2‑(1‑苯并噻吩‑5‑基)乙氧基)丙基)氮杂环丁烷‑3‑醇或其盐的固体药物组合物
EP2872122A1 (en) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
LT3100725T (lt) 2014-01-31 2020-08-10 Fujifilm Toyama Chemical Co., Ltd. Reabilitacijos poveikį po nervo pažeidimo sustiprinanti priemonė, apimanti alkileterio darinį arba jo druską
RU2744460C2 (ru) 2014-04-15 2021-03-09 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
EP3444243B1 (en) 2016-03-31 2020-09-02 FUJIFILM Toyama Chemical Co., Ltd. Method for producing 5-(bromomethyl)-1-benzothiophene

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Also Published As

Publication number Publication date
CA2600381A1 (en) 2006-10-05
PL2248809T3 (pl) 2012-10-31
NO20161418A1 (no) 2007-10-25
CY1112956T1 (el) 2016-04-13
CA2799659A1 (en) 2006-10-05
ATE557020T1 (de) 2012-05-15
AU2006229271A1 (en) 2006-10-05
IL186044A0 (en) 2008-02-09
US20110098484A1 (en) 2011-04-28
SG155251A1 (en) 2009-09-30
PL2348022T3 (pl) 2013-06-28
JP5031554B2 (ja) 2012-09-19
CA2600381C (en) 2013-11-12
CY1112885T1 (el) 2016-04-13
EP2248809A1 (en) 2010-11-10
EP2248809B1 (en) 2012-05-09
CA2799659C (en) 2014-12-02
EP2210884B1 (en) 2012-02-22
CN101151257A (zh) 2008-03-26
NO20161419A1 (no) 2016-06-07
IL214245A0 (en) 2011-08-31
ES2380443T3 (es) 2012-05-11
EP2348022B1 (en) 2013-01-09
ES2384312T3 (es) 2012-07-03
IL214245A (en) 2014-12-31
AU2006229271B2 (en) 2012-02-09
PT2248809E (pt) 2012-07-02
PL2210884T3 (pl) 2012-07-31
BRPI0609496B1 (pt) 2020-11-24
CN101151257B (zh) 2012-07-18
EP1864978A1 (en) 2007-12-12
EP2210884A2 (en) 2010-07-28
MX2007011938A (es) 2008-03-14
EP1864978A4 (en) 2009-07-01
NO340420B1 (no) 2017-04-18
IL186044A (en) 2013-12-31
EP2348022A1 (en) 2011-07-27
US8273902B2 (en) 2012-09-25
BRPI0609496C8 (pt) 2021-05-25
NZ583580A (en) 2010-10-29
SI2248809T1 (sl) 2012-09-28
ZA200708262B (en) 2009-01-28
ES2398934T3 (es) 2013-03-22
KR20130010090A (ko) 2013-01-25
PT2210884E (pt) 2012-04-10
DK2248809T3 (da) 2012-06-18
KR101283930B1 (ko) 2013-07-16
WO2006104088A1 (ja) 2006-10-05
KR101337382B1 (ko) 2013-12-06
US7951963B2 (en) 2011-05-31
NO340366B1 (no) 2017-04-10
CY1113571T1 (el) 2016-06-22
PT2348022E (pt) 2013-02-13
SI2210884T1 (sl) 2012-06-29
US20090069576A1 (en) 2009-03-12
NO340071B1 (no) 2017-03-06
JPWO2006104088A1 (ja) 2008-09-04
KR20080008334A (ko) 2008-01-23
NO20074618L (no) 2007-10-25
ATE546443T1 (de) 2012-03-15
EP2210884A3 (en) 2010-09-22
NZ561672A (en) 2010-04-30
BRPI0609496C1 (pt) 2021-05-11
DK2210884T3 (da) 2012-03-26
BRPI0609496A2 (pt) 2011-10-18

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