ATE557020T1 - Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen - Google Patents

Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen

Info

Publication number
ATE557020T1
ATE557020T1 AT10007872T AT10007872T ATE557020T1 AT E557020 T1 ATE557020 T1 AT E557020T1 AT 10007872 T AT10007872 T AT 10007872T AT 10007872 T AT10007872 T AT 10007872T AT E557020 T1 ATE557020 T1 AT E557020T1
Authority
AT
Austria
Prior art keywords
production
ethoxyü
benzoäbuthiophen
propanoate
azetidine
Prior art date
Application number
AT10007872T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of ATE557020T1 publication Critical patent/ATE557020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT10007872T 2005-03-28 2006-03-27 Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen ATE557020T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09

Publications (1)

Publication Number Publication Date
ATE557020T1 true ATE557020T1 (de) 2012-05-15

Family

ID=37053344

Family Applications (2)

Application Number Title Priority Date Filing Date
AT10002020T ATE546443T1 (de) 2005-03-28 2006-03-27 Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze
AT10007872T ATE557020T1 (de) 2005-03-28 2006-03-27 Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT10002020T ATE546443T1 (de) 2005-03-28 2006-03-27 Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze

Country Status (22)

Country Link
US (2) US7951963B2 (de)
EP (4) EP2348022B1 (de)
JP (1) JP5031554B2 (de)
KR (2) KR101337382B1 (de)
CN (1) CN101151257B (de)
AT (2) ATE546443T1 (de)
AU (1) AU2006229271B2 (de)
BR (1) BRPI0609496C8 (de)
CA (2) CA2600381C (de)
CY (3) CY1112956T1 (de)
DK (2) DK2248809T3 (de)
ES (3) ES2398934T3 (de)
IL (2) IL186044A (de)
MX (1) MX2007011938A (de)
NO (3) NO340071B1 (de)
NZ (2) NZ583580A (de)
PL (3) PL2348022T3 (de)
PT (3) PT2248809E (de)
SG (1) SG155251A1 (de)
SI (3) SI2210884T1 (de)
WO (1) WO2006104088A1 (de)
ZA (1) ZA200708262B (de)

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ES2398934T3 (es) * 2005-03-28 2013-03-22 Toyama Chemical Co., Ltd. Proceso de la producción de1-(3-(2-(1-benzotiofen-5-il)etoxi)propil)acetidin-ol o sales del mismo
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DK3091011T3 (en) 2006-04-07 2018-02-26 Vertex Pharma MODULATORS OF ATP BINDING CASSETTE TRANSPORT
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
AU2007279673B2 (en) * 2006-08-04 2012-04-19 Toyama Chemical Co., Ltd. Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG184987A1 (en) * 2010-04-22 2012-11-29 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
JP6100174B2 (ja) 2011-03-02 2017-03-22 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ アリール酢酸誘導体及びヘテロアリール酢酸誘導体を調製する方法
EP2762225B1 (de) 2011-09-30 2018-09-12 Mitsubishi Chemical Corporation Polymerisierbares dispergiermittel für anorganische partikel, anorganische/organische verbundpartikel mit diesem dispergiermittel für anorganische partikel und anorganischer/organischer harzverbundstoff
US9872914B2 (en) 2012-02-22 2018-01-23 Toyama Chemical Co., Ltd. Solid pharmaceutical composition containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
EP3100725B1 (de) 2014-01-31 2020-05-06 FUJIFILM Toyama Chemical Co., Ltd. Rehabilitationswirkungsverstärkendes mittel nach einer nervenverletzung enthaltend einen alkyletherderivat oder dessen salz
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN109526218B (zh) 2016-03-31 2021-07-06 富士胶片富山化学株式会社 5-溴甲基-1-苯并噻吩的制备方法

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Also Published As

Publication number Publication date
PT2210884E (pt) 2012-04-10
CA2600381A1 (en) 2006-10-05
JPWO2006104088A1 (ja) 2008-09-04
US7951963B2 (en) 2011-05-31
EP2248809A1 (de) 2010-11-10
PL2348022T3 (pl) 2013-06-28
KR101283930B1 (ko) 2013-07-16
NO340071B1 (no) 2017-03-06
BRPI0609496C8 (pt) 2021-05-25
IL214245A0 (en) 2011-08-31
US8273902B2 (en) 2012-09-25
CY1113571T1 (el) 2016-06-22
CN101151257B (zh) 2012-07-18
EP2248809B1 (de) 2012-05-09
NO20161418A1 (no) 2007-10-25
SI2348022T1 (sl) 2013-05-31
KR20130010090A (ko) 2013-01-25
EP2348022A1 (de) 2011-07-27
IL186044A (en) 2013-12-31
BRPI0609496C1 (pt) 2021-05-11
SI2248809T1 (sl) 2012-09-28
KR20080008334A (ko) 2008-01-23
ZA200708262B (en) 2009-01-28
EP2348022B1 (de) 2013-01-09
SG155251A1 (en) 2009-09-30
KR101337382B1 (ko) 2013-12-06
AU2006229271A1 (en) 2006-10-05
EP1864978A1 (de) 2007-12-12
JP5031554B2 (ja) 2012-09-19
CA2600381C (en) 2013-11-12
NZ561672A (en) 2010-04-30
WO2006104088A1 (ja) 2006-10-05
DK2248809T3 (da) 2012-06-18
NZ583580A (en) 2010-10-29
BRPI0609496A2 (pt) 2011-10-18
NO20161419A1 (no) 2016-06-07
EP2210884A3 (de) 2010-09-22
PL2210884T3 (pl) 2012-07-31
NO340420B1 (no) 2017-04-18
ES2398934T3 (es) 2013-03-22
PL2248809T3 (pl) 2012-10-31
EP1864978A4 (de) 2009-07-01
US20110098484A1 (en) 2011-04-28
CN101151257A (zh) 2008-03-26
IL214245A (en) 2014-12-31
CA2799659C (en) 2014-12-02
PT2348022E (pt) 2013-02-13
ATE546443T1 (de) 2012-03-15
CY1112885T1 (el) 2016-04-13
DK2210884T3 (da) 2012-03-26
IL186044A0 (en) 2008-02-09
EP2210884B1 (de) 2012-02-22
MX2007011938A (es) 2008-03-14
SI2210884T1 (sl) 2012-06-29
AU2006229271B2 (en) 2012-02-09
ES2380443T3 (es) 2012-05-11
CA2799659A1 (en) 2006-10-05
PT2248809E (pt) 2012-07-02
EP2210884A2 (de) 2010-07-28
ES2384312T3 (es) 2012-07-03
BRPI0609496B1 (pt) 2020-11-24
CY1112956T1 (el) 2016-04-13
US20090069576A1 (en) 2009-03-12
NO340366B1 (no) 2017-04-10
NO20074618L (no) 2007-10-25

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