CY1113571T1 - Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης - Google Patents

Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Info

Publication number
CY1113571T1
CY1113571T1 CY20131100075T CY131100075T CY1113571T1 CY 1113571 T1 CY1113571 T1 CY 1113571T1 CY 20131100075 T CY20131100075 T CY 20131100075T CY 131100075 T CY131100075 T CY 131100075T CY 1113571 T1 CY1113571 T1 CY 1113571T1
Authority
CY
Cyprus
Prior art keywords
azetidin
ethoxy
propyl
salts
production
Prior art date
Application number
CY20131100075T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1113571T1 publication Critical patent/CY1113571T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση παρέχει μία μέθοδο για την παραγωγή 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)αιθοξυ)προπυλ)αζετιδιν-3-όλης ή αλάτων αυτής χαρακτηριζόμενη από υποβολή της 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)αιθοξυ)προπιονυλ)αζετιδιν-3-όλης σε αντίδραση αναγωγής με την προσθήκη ενεργοποιητή παρουσία βοριοϋδριδίου αλκαλίου.
CY20131100075T 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης CY1113571T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
EP11002265A EP2348022B1 (en) 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof

Publications (1)

Publication Number Publication Date
CY1113571T1 true CY1113571T1 (el) 2016-06-22

Family

ID=37053344

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20121100434T CY1112956T1 (el) 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου
CY20121100566T CY1112885T1 (el) 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης
CY20131100075T CY1113571T1 (el) 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20121100434T CY1112956T1 (el) 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου
CY20121100566T CY1112885T1 (el) 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης

Country Status (22)

Country Link
US (2) US7951963B2 (el)
EP (4) EP1864978A4 (el)
JP (1) JP5031554B2 (el)
KR (2) KR101337382B1 (el)
CN (1) CN101151257B (el)
AT (2) ATE557020T1 (el)
AU (1) AU2006229271B2 (el)
BR (1) BRPI0609496C8 (el)
CA (2) CA2799659C (el)
CY (3) CY1112956T1 (el)
DK (2) DK2248809T3 (el)
ES (3) ES2380443T3 (el)
IL (2) IL186044A (el)
MX (1) MX2007011938A (el)
NO (3) NO340071B1 (el)
NZ (2) NZ561672A (el)
PL (3) PL2248809T3 (el)
PT (3) PT2248809E (el)
SG (1) SG155251A1 (el)
SI (3) SI2210884T1 (el)
WO (1) WO2006104088A1 (el)
ZA (1) ZA200708262B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL215264B1 (pl) 2001-10-19 2013-11-29 Toyama Chemical Co Ltd Pochodne eteru alkilowego lub ich sole, sposób ich wytwarzania oraz kompozycja farmaceutyczna
SI2210884T1 (sl) * 2005-03-28 2012-06-29 Toyama Chemical Co Ltd Postopek izdelave 1-(3-(2-(1-benzotiofen-5-il)-etoksi)propionske kisline ali soli le-te
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
SI2674428T1 (sl) 2006-04-07 2016-07-29 Vertex Pharmaceuticals Incorporated Modulatorji transporterjev atp-vezavne kasete
ATE491705T1 (de) * 2006-08-04 2011-01-15 Toyama Chemical Co Ltd Verstärker der aktivität von proteinkinase c, enthaltend ein alkyletherderivat oder ein salz davon
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CN103038214B (zh) * 2010-04-22 2015-09-30 弗特克斯药品有限公司 制备环烷基甲酰胺基-吲哚化合物的方法
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
MX341269B (es) 2011-03-02 2016-08-09 Bayer Ip Gmbh Proceso para preparar derivados de acido arilacetico y heteroarilacetico.
KR20140072061A (ko) 2011-09-30 2014-06-12 니폰 가세이 가부시키가이샤 중합성 무기 입자 분산제, 그 중합성 무기 입자 분산제를 포함하는 무기 유기 복합 입자, 및 무기 유기 수지 복합재
ES2721666T3 (es) 2012-02-22 2019-08-02 Fujifilm Toyama Chemical Co Ltd Composición farmacéutica sólida que contiene 1-(3-(2-(1-benzotiofen-5-il)etoxi)propil)azetidin-3-ol o una sal del mismo
CA2878057A1 (en) 2012-07-16 2014-01-23 Rossitza Gueorguieva Alargova Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
PT3100725T (pt) 2014-01-31 2020-06-17 Fujifilm Toyama Chemical Co Ltd Agente de melhoria do efeito de reabilitação após uma lesão de um nervo, compreendendo um derivado de éter de alquilo ou um seu sal
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
AU2017239816B9 (en) 2016-03-31 2020-09-24 Fujifilm Corporation Method for producing 5-(bromomethyl)-1-benzothiophene

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72070A (en) 1983-06-20 1988-11-30 Merck & Co Inc 2-sulfamoylbenzo(b)-thiophene derivatives,their preparation and pharmaceutical compositions containing them
ZA844616B (en) 1983-06-20 1986-02-26 Merck & Co Inc 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
CH673100A5 (el) 1987-08-10 1990-02-15 Josef Paul Huser
JPH04182463A (ja) 1990-11-17 1992-06-30 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノール類およびその誘導体の製造方法
JPH05140086A (ja) 1991-09-26 1993-06-08 Sumitomo Seika Chem Co Ltd ハロゲノチオフエノールの製造方法および精製方法
JPH05178816A (ja) 1991-12-28 1993-07-20 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノールの製造方法
JP2641363B2 (ja) 1992-04-22 1997-08-13 三共株式会社 新規なフェネチルアルコール及びその製法
GB9404775D0 (en) 1994-03-11 1994-04-27 Payne P P Ltd Improvements in or relating to article tagging
JPH08143533A (ja) 1994-11-24 1996-06-04 Sumitomo Seika Chem Co Ltd ハロチオフェノール類の製造方法
JPH1043967A (ja) 1996-08-06 1998-02-17 Calsonic Corp カシメ装置
AU6519798A (en) 1997-03-31 1998-10-22 Toyama Chemical Co. Ltd. Process for producing 2-(benzo{b}thiophen-5-yl)-2-hydroxyacetic acid derivatives, optically active compounds thereof, or salts of both
GB9706574D0 (en) 1997-04-01 1997-05-21 Zeneca Ltd Cyano substituted cycloalkanes
JPH1112238A (ja) 1997-06-23 1999-01-19 Kao Corp １−（β−ヒドロキシエチル）−２，５−ジアミノベンゼン又はその塩の製造法
JPH1143455A (ja) 1997-07-25 1999-02-16 Mitsubishi Chem Corp ハロゲン化アルコールの製造方法
WO1999031056A1 (fr) 1997-12-12 1999-06-24 Toyama Chemical Co., Ltd. Derives d'ether alcoylique ou leurs sels, et antagonistes du calcium les contenant
EP0993105B1 (en) 1998-10-07 2003-01-08 STMicroelectronics S.r.l. Control of power transfer in a flyback converter by modulating the off-phase in function of the load
JP4182463B2 (ja) 2000-07-19 2008-11-19 富士電機デバイステクノロジー株式会社 磁気ディスク評価装置およびその方法
WO2002100850A1 (fr) 2001-06-08 2002-12-19 Kuraray Co., Ltd. Procedes de preparation de composes heterocycliques
PL215264B1 (pl) * 2001-10-19 2013-11-29 Toyama Chemical Co Ltd Pochodne eteru alkilowego lub ich sole, sposób ich wytwarzania oraz kompozycja farmaceutyczna
CN100353942C (zh) 2003-04-17 2007-12-12 富山化学工业株式会社 用于视网膜神经疾病的含有烷基醚衍生物或其盐的预防剂/治疗剂
JP2005012291A (ja) 2003-06-17 2005-01-13 National Institute Of Information & Communication Technology Ｔｖ会議用モバイル動画通信端末
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005019200A2 (en) * 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
SI2210884T1 (sl) 2005-03-28 2012-06-29 Toyama Chemical Co Ltd Postopek izdelave 1-(3-(2-(1-benzotiofen-5-il)-etoksi)propionske kisline ali soli le-te
BRPI0710239A2 (pt) 2006-04-26 2011-08-09 Toyama Chemical Co Ltd indutor de neurogênese, e, agente terapêutico para distúrbio mental.

Also Published As

Publication number Publication date
IL186044A0 (en) 2008-02-09
EP2210884A2 (en) 2010-07-28
MX2007011938A (es) 2008-03-14
PT2248809E (pt) 2012-07-02
NO20161418A1 (no) 2007-10-25
NO340366B1 (no) 2017-04-10
PT2348022E (pt) 2013-02-13
WO2006104088A1 (ja) 2006-10-05
BRPI0609496A2 (pt) 2011-10-18
AU2006229271A1 (en) 2006-10-05
IL186044A (en) 2013-12-31
SI2348022T1 (sl) 2013-05-31
NO340071B1 (no) 2017-03-06
CA2799659A1 (en) 2006-10-05
ES2398934T3 (es) 2013-03-22
KR20130010090A (ko) 2013-01-25
EP2210884B1 (en) 2012-02-22
CY1112885T1 (el) 2016-04-13
DK2210884T3 (da) 2012-03-26
PT2210884E (pt) 2012-04-10
BRPI0609496C1 (pt) 2021-05-11
NO20074618L (no) 2007-10-25
EP2348022B1 (en) 2013-01-09
IL214245A (en) 2014-12-31
SI2210884T1 (sl) 2012-06-29
NZ561672A (en) 2010-04-30
US20090069576A1 (en) 2009-03-12
ATE557020T1 (de) 2012-05-15
ATE546443T1 (de) 2012-03-15
PL2248809T3 (pl) 2012-10-31
CA2600381A1 (en) 2006-10-05
EP2248809B1 (en) 2012-05-09
DK2248809T3 (da) 2012-06-18
CN101151257A (zh) 2008-03-26
ES2380443T3 (es) 2012-05-11
CY1112956T1 (el) 2016-04-13
EP1864978A4 (en) 2009-07-01
EP2348022A1 (en) 2011-07-27
BRPI0609496C8 (pt) 2021-05-25
SG155251A1 (en) 2009-09-30
CA2799659C (en) 2014-12-02
EP2210884A3 (en) 2010-09-22
CN101151257B (zh) 2012-07-18
ES2384312T3 (es) 2012-07-03
CA2600381C (en) 2013-11-12
IL214245A0 (en) 2011-08-31
KR20080008334A (ko) 2008-01-23
NO340420B1 (no) 2017-04-18
EP1864978A1 (en) 2007-12-12
AU2006229271B2 (en) 2012-02-09
PL2348022T3 (pl) 2013-06-28
NO20161419A1 (no) 2016-06-07
KR101337382B1 (ko) 2013-12-06
ZA200708262B (en) 2009-01-28
EP2248809A1 (en) 2010-11-10
US20110098484A1 (en) 2011-04-28
JPWO2006104088A1 (ja) 2008-09-04
NZ583580A (en) 2010-10-29
JP5031554B2 (ja) 2012-09-19
PL2210884T3 (pl) 2012-07-31
US8273902B2 (en) 2012-09-25
US7951963B2 (en) 2011-05-31
SI2248809T1 (sl) 2012-09-28
BRPI0609496B1 (pt) 2020-11-24
KR101283930B1 (ko) 2013-07-16

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