CY1112956T1 - Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου - Google Patents

Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου

Info

Publication number
CY1112956T1
CY1112956T1 CY20121100434T CY121100434T CY1112956T1 CY 1112956 T1 CY1112956 T1 CY 1112956T1 CY 20121100434 T CY20121100434 T CY 20121100434T CY 121100434 T CY121100434 T CY 121100434T CY 1112956 T1 CY1112956 T1 CY 1112956T1
Authority
CY
Cyprus
Prior art keywords
ethoxy
salts
production
benzoethiophen
propionic acid
Prior art date
Application number
CY20121100434T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1112956T1 publication Critical patent/CY1112956T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Μέθοδος για την παραγωγή 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)αιθοξυ)προπυλ)αζετιδιν-3-όλης ή αλάτων αυτής που περιλαμβάνει τη χρήση ως ενδιάμεσου, ενός παραγώγου εστέρα προπιονικού οξέος που αναπαριστάται από το γενικό τύπο (2):
CY20121100434T 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου CY1112956T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
EP10002020A EP2210884B1 (en) 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propionic acid or salts thereof

Publications (1)

Publication Number Publication Date
CY1112956T1 true CY1112956T1 (el) 2016-04-13

Family

ID=37053344

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20121100434T CY1112956T1 (el) 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου
CY20121100566T CY1112885T1 (el) 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης
CY20131100075T CY1113571T1 (el) 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20121100566T CY1112885T1 (el) 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης
CY20131100075T CY1113571T1 (el) 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Country Status (22)

Country Link
US (2) US7951963B2 (el)
EP (4) EP1864978A4 (el)
JP (1) JP5031554B2 (el)
KR (2) KR101337382B1 (el)
CN (1) CN101151257B (el)
AT (2) ATE557020T1 (el)
AU (1) AU2006229271B2 (el)
BR (1) BRPI0609496C8 (el)
CA (2) CA2799659C (el)
CY (3) CY1112956T1 (el)
DK (2) DK2248809T3 (el)
ES (3) ES2380443T3 (el)
IL (2) IL186044A (el)
MX (1) MX2007011938A (el)
NO (3) NO340071B1 (el)
NZ (2) NZ561672A (el)
PL (3) PL2210884T3 (el)
PT (3) PT2210884E (el)
SG (1) SG155251A1 (el)
SI (3) SI2210884T1 (el)
WO (1) WO2006104088A1 (el)
ZA (1) ZA200708262B (el)

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US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
PL3327016T3 (pl) 2006-04-07 2021-10-04 Vertex Pharmaceuticals Incorporated Wytwarzanie modulatorów transporterów posiadających kasetę wiążącą ATP
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CA2659835A1 (en) * 2006-08-04 2008-02-07 Toyama Chemical Co., Ltd. Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
KR101984225B1 (ko) * 2010-04-22 2019-05-30 버텍스 파마슈티칼스 인코포레이티드 시클로알킬카르복스아미도-인돌 화합물의 제조 방법
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
BR112013022282B1 (pt) * 2011-03-02 2019-03-26 Bayer Intellectual Property Gmbh Processo para a preparação de derivados de ácidos aril- e heteroaril acético
EP2762225B1 (en) 2011-09-30 2018-09-12 Mitsubishi Chemical Corporation Polymerizable inorganic particle-dispersing agent, inorganic/organic composite particles containing said polymerizable inorganic particle-dispersing agent, and inorganic/organic resin composite
KR102070581B1 (ko) 2012-02-22 2020-01-29 후지필름 도야마 케미컬 가부시키가이샤 1－(3－(2－(1－벤조티오펜－5－일)에톡시)프로필)아제티딘－3－올 또는 그 염을 함유하는 고형 의약 조성물
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
ES2792950T3 (es) 2014-01-31 2020-11-12 Fujifilm Toyama Chemical Co Ltd Agente potenciador del efecto de rehabilitación después de una lesión nerviosa que comprende un derivado alquil éter o una sal del mismo
PT3925607T (pt) 2014-04-15 2023-09-26 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
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Also Published As

Publication number Publication date
EP1864978A4 (en) 2009-07-01
BRPI0609496C1 (pt) 2021-05-11
ZA200708262B (en) 2009-01-28
CA2600381C (en) 2013-11-12
PL2348022T3 (pl) 2013-06-28
JP5031554B2 (ja) 2012-09-19
MX2007011938A (es) 2008-03-14
EP2210884B1 (en) 2012-02-22
NO340366B1 (no) 2017-04-10
ATE546443T1 (de) 2012-03-15
WO2006104088A1 (ja) 2006-10-05
NO20074618L (no) 2007-10-25
DK2248809T3 (da) 2012-06-18
EP2248809A1 (en) 2010-11-10
JPWO2006104088A1 (ja) 2008-09-04
EP2348022A1 (en) 2011-07-27
SI2348022T1 (sl) 2013-05-31
CA2799659A1 (en) 2006-10-05
SI2248809T1 (sl) 2012-09-28
PL2248809T3 (pl) 2012-10-31
US8273902B2 (en) 2012-09-25
ATE557020T1 (de) 2012-05-15
NO20161418A1 (no) 2007-10-25
NZ561672A (en) 2010-04-30
CA2799659C (en) 2014-12-02
AU2006229271B2 (en) 2012-02-09
KR20080008334A (ko) 2008-01-23
ES2380443T3 (es) 2012-05-11
EP2210884A3 (en) 2010-09-22
EP2210884A2 (en) 2010-07-28
KR101283930B1 (ko) 2013-07-16
CN101151257B (zh) 2012-07-18
PT2210884E (pt) 2012-04-10
US20110098484A1 (en) 2011-04-28
US7951963B2 (en) 2011-05-31
KR101337382B1 (ko) 2013-12-06
ES2398934T3 (es) 2013-03-22
PT2348022E (pt) 2013-02-13
SG155251A1 (en) 2009-09-30
BRPI0609496B1 (pt) 2020-11-24
PL2210884T3 (pl) 2012-07-31
EP2248809B1 (en) 2012-05-09
IL214245A (en) 2014-12-31
BRPI0609496C8 (pt) 2021-05-25
SI2210884T1 (sl) 2012-06-29
CY1113571T1 (el) 2016-06-22
DK2210884T3 (da) 2012-03-26
IL214245A0 (en) 2011-08-31
KR20130010090A (ko) 2013-01-25
BRPI0609496A2 (pt) 2011-10-18
AU2006229271A1 (en) 2006-10-05
US20090069576A1 (en) 2009-03-12
ES2384312T3 (es) 2012-07-03
EP1864978A1 (en) 2007-12-12
CA2600381A1 (en) 2006-10-05
CN101151257A (zh) 2008-03-26
IL186044A (en) 2013-12-31
NO340071B1 (no) 2017-03-06
PT2248809E (pt) 2012-07-02
NO20161419A1 (no) 2016-06-07
CY1112885T1 (el) 2016-04-13
EP2348022B1 (en) 2013-01-09
NZ583580A (en) 2010-10-29
IL186044A0 (en) 2008-02-09
NO340420B1 (no) 2017-04-18

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