DK2248809T3 - Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoater som mellemprodukt i fremstilling af Azetidin-3-ol-derivater - Google Patents

Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoater som mellemprodukt i fremstilling af Azetidin-3-ol-derivater

Info

Publication number
DK2248809T3
DK2248809T3 DK10007872.4T DK10007872T DK2248809T3 DK 2248809 T3 DK2248809 T3 DK 2248809T3 DK 10007872 T DK10007872 T DK 10007872T DK 2248809 T3 DK2248809 T3 DK 2248809T3
Authority
DK
Denmark
Prior art keywords
azetidin
ethoxy
propanoates
thiophen
benzo
Prior art date
Application number
DK10007872.4T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of DK2248809T3 publication Critical patent/DK2248809T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
DK10007872.4T 2005-03-28 2006-03-27 Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoater som mellemprodukt i fremstilling af Azetidin-3-ol-derivater DK2248809T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
EP06730075A EP1864978A4 (en) 2005-03-28 2006-03-27 PROCESS FOR PRODUCING 1- (3- (2- (1-BENZOTHIOPHEN-5-YL) -ETHOXY) PROPYL) AZETIDIN-3-OL OR ITS SALTS

Publications (1)

Publication Number Publication Date
DK2248809T3 true DK2248809T3 (da) 2012-06-18

Family

ID=37053344

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10007872.4T DK2248809T3 (da) 2005-03-28 2006-03-27 Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoater som mellemprodukt i fremstilling af Azetidin-3-ol-derivater
DK10002020.5T DK2210884T3 (da) 2005-03-28 2006-03-27 Fremgangsmåde til fremstilling af 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propionsyre eller salte deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10002020.5T DK2210884T3 (da) 2005-03-28 2006-03-27 Fremgangsmåde til fremstilling af 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propionsyre eller salte deraf

Country Status (22)

Country Link
US (2) US7951963B2 (da)
EP (4) EP2348022B1 (da)
JP (1) JP5031554B2 (da)
KR (2) KR101337382B1 (da)
CN (1) CN101151257B (da)
AT (2) ATE546443T1 (da)
AU (1) AU2006229271B2 (da)
BR (1) BRPI0609496C8 (da)
CA (2) CA2600381C (da)
CY (3) CY1112956T1 (da)
DK (2) DK2248809T3 (da)
ES (3) ES2398934T3 (da)
IL (2) IL186044A (da)
MX (1) MX2007011938A (da)
NO (3) NO340071B1 (da)
NZ (2) NZ583580A (da)
PL (3) PL2348022T3 (da)
PT (3) PT2248809E (da)
SG (1) SG155251A1 (da)
SI (3) SI2210884T1 (da)
WO (1) WO2006104088A1 (da)
ZA (1) ZA200708262B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100956990B1 (ko) 2001-10-19 2010-05-11 토야마 케미칼 컴퍼니 리미티드 알킬에테르유도체 또는 그 염
ES2398934T3 (es) * 2005-03-28 2013-03-22 Toyama Chemical Co., Ltd. Proceso de la producción de1-(3-(2-(1-benzotiofen-5-il)etoxi)propil)acetidin-ol o sales del mismo
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
DK3091011T3 (da) 2006-04-07 2018-02-26 Vertex Pharma Modulatorer af atp-bindende kassette-transportere
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
AU2007279673B2 (en) * 2006-08-04 2012-04-19 Toyama Chemical Co., Ltd. Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG184987A1 (en) * 2010-04-22 2012-11-29 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
JP6100174B2 (ja) 2011-03-02 2017-03-22 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ アリール酢酸誘導体及びヘテロアリール酢酸誘導体を調製する方法
EP2762225B1 (en) 2011-09-30 2018-09-12 Mitsubishi Chemical Corporation Polymerizable inorganic particle-dispersing agent, inorganic/organic composite particles containing said polymerizable inorganic particle-dispersing agent, and inorganic/organic resin composite
US9872914B2 (en) 2012-02-22 2018-01-23 Toyama Chemical Co., Ltd. Solid pharmaceutical composition containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
EP3100725B1 (en) 2014-01-31 2020-05-06 FUJIFILM Toyama Chemical Co., Ltd. Post nerve injury rehabilitation effect-enhancing agent comprising an alkyl ether derivative or a salt thereof
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN109526218B (zh) 2016-03-31 2021-07-06 富士胶片富山化学株式会社 5-溴甲基-1-苯并噻吩的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844616B (en) 1983-06-20 1986-02-26 Merck & Co Inc 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure
NZ208444A (en) 1983-06-20 1987-08-31 Merck & Co Inc 2-thiophene derivatives and pharmaceutical compositions
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
CH673100A5 (da) 1987-08-10 1990-02-15 Josef Paul Huser
JPH04182463A (ja) 1990-11-17 1992-06-30 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノール類およびその誘導体の製造方法
JPH05140086A (ja) 1991-09-26 1993-06-08 Sumitomo Seika Chem Co Ltd ハロゲノチオフエノールの製造方法および精製方法
JPH05178816A (ja) 1991-12-28 1993-07-20 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノールの製造方法
JP2641363B2 (ja) 1992-04-22 1997-08-13 三共株式会社 新規なフェネチルアルコール及びその製法
GB9404775D0 (en) 1994-03-11 1994-04-27 Payne P P Ltd Improvements in or relating to article tagging
JPH08143533A (ja) 1994-11-24 1996-06-04 Sumitomo Seika Chem Co Ltd ハロチオフェノール類の製造方法
JPH1043967A (ja) 1996-08-06 1998-02-17 Calsonic Corp カシメ装置
JP4245668B2 (ja) 1997-03-31 2009-03-25 富山化学工業株式会社 ２−（ベンゾ〔ｂ〕チオフェン−５−イル）−２−ヒドロキシ酢酸誘導体もしくはその光学活性体またはそれらの塩の製造法
GB9706574D0 (en) 1997-04-01 1997-05-21 Zeneca Ltd Cyano substituted cycloalkanes
JPH1112238A (ja) 1997-06-23 1999-01-19 Kao Corp １−（β−ヒドロキシエチル）−２，５−ジアミノベンゼン又はその塩の製造法
JPH1143455A (ja) 1997-07-25 1999-02-16 Mitsubishi Chem Corp ハロゲン化アルコールの製造方法
WO1999031056A1 (fr) * 1997-12-12 1999-06-24 Toyama Chemical Co., Ltd. Derives d'ether alcoylique ou leurs sels, et antagonistes du calcium les contenant
EP0993105B1 (en) 1998-10-07 2003-01-08 STMicroelectronics S.r.l. Control of power transfer in a flyback converter by modulating the off-phase in function of the load
JP4182463B2 (ja) 2000-07-19 2008-11-19 富士電機デバイステクノロジー株式会社 磁気ディスク評価装置およびその方法
WO2002100850A1 (fr) 2001-06-08 2002-12-19 Kuraray Co., Ltd. Procedes de preparation de composes heterocycliques
KR100956990B1 (ko) * 2001-10-19 2010-05-11 토야마 케미칼 컴퍼니 리미티드 알킬에테르유도체 또는 그 염
MXPA05011125A (es) * 2003-04-17 2005-12-14 Toyama Chemical Co Ltd Remedio preventivo para enfermedades del nervio retiniano que contienen derivados de eter de alquilo o sales de los mismos.
JP2005012291A (ja) 2003-06-17 2005-01-13 National Institute Of Information & Communication Technology Ｔｖ会議用モバイル動画通信端末
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005019200A2 (en) 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
ES2398934T3 (es) * 2005-03-28 2013-03-22 Toyama Chemical Co., Ltd. Proceso de la producción de1-(3-(2-(1-benzotiofen-5-il)etoxi)propil)acetidin-ol o sales del mismo
PL2011796T3 (pl) * 2006-04-26 2015-03-31 Toyama Chemical Co Ltd Induktor neurogenezy lub środek terapeutyczny do stosowania w neuropatii zawierający pochodną eteru alkilowego lub jej sól

Also Published As

Publication number Publication date
PT2210884E (pt) 2012-04-10
CA2600381A1 (en) 2006-10-05
JPWO2006104088A1 (ja) 2008-09-04
US7951963B2 (en) 2011-05-31
EP2248809A1 (en) 2010-11-10
PL2348022T3 (pl) 2013-06-28
KR101283930B1 (ko) 2013-07-16
NO340071B1 (no) 2017-03-06
BRPI0609496C8 (pt) 2021-05-25
IL214245A0 (en) 2011-08-31
US8273902B2 (en) 2012-09-25
CY1113571T1 (el) 2016-06-22
CN101151257B (zh) 2012-07-18
EP2248809B1 (en) 2012-05-09
NO20161418A1 (no) 2007-10-25
SI2348022T1 (sl) 2013-05-31
KR20130010090A (ko) 2013-01-25
EP2348022A1 (en) 2011-07-27
IL186044A (en) 2013-12-31
BRPI0609496C1 (pt) 2021-05-11
SI2248809T1 (sl) 2012-09-28
KR20080008334A (ko) 2008-01-23
ZA200708262B (en) 2009-01-28
ATE557020T1 (de) 2012-05-15
EP2348022B1 (en) 2013-01-09
SG155251A1 (en) 2009-09-30
KR101337382B1 (ko) 2013-12-06
AU2006229271A1 (en) 2006-10-05
EP1864978A1 (en) 2007-12-12
JP5031554B2 (ja) 2012-09-19
CA2600381C (en) 2013-11-12
NZ561672A (en) 2010-04-30
WO2006104088A1 (ja) 2006-10-05
NZ583580A (en) 2010-10-29
BRPI0609496A2 (pt) 2011-10-18
NO20161419A1 (no) 2016-06-07
EP2210884A3 (en) 2010-09-22
PL2210884T3 (pl) 2012-07-31
NO340420B1 (no) 2017-04-18
ES2398934T3 (es) 2013-03-22
PL2248809T3 (pl) 2012-10-31
EP1864978A4 (en) 2009-07-01
US20110098484A1 (en) 2011-04-28
CN101151257A (zh) 2008-03-26
IL214245A (en) 2014-12-31
CA2799659C (en) 2014-12-02
PT2348022E (pt) 2013-02-13
ATE546443T1 (de) 2012-03-15
CY1112885T1 (el) 2016-04-13
DK2210884T3 (da) 2012-03-26
IL186044A0 (en) 2008-02-09
EP2210884B1 (en) 2012-02-22
MX2007011938A (es) 2008-03-14
SI2210884T1 (sl) 2012-06-29
AU2006229271B2 (en) 2012-02-09
ES2380443T3 (es) 2012-05-11
CA2799659A1 (en) 2006-10-05
PT2248809E (pt) 2012-07-02
EP2210884A2 (en) 2010-07-28
ES2384312T3 (es) 2012-07-03
BRPI0609496B1 (pt) 2020-11-24
CY1112956T1 (el) 2016-04-13
US20090069576A1 (en) 2009-03-12
NO340366B1 (no) 2017-04-10
NO20074618L (no) 2007-10-25

Similar Documents

Publication Publication Date Title
DK2248809T3 (da) Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoater som mellemprodukt i fremstilling af Azetidin-3-ol-derivater
MY147436A (en) Process for the synthesis of 5-(methyl-1h-imidazol-1-yl)-3-(trifluoromethyl-benzeneamine
MY147389A (en) Phthalazinone derivative
TW200745076A (en) Process for production of methylene disulfonate compound
MX2011009127A (es) Nicotinamidas sustituidas como moduladores de kcnq2/3.
NO20070400L (no) Organiske forbindelser
RS52900B (en) Benzoylpyrazole Compound, Process for Production and Production of Herbicides Containing Them
NO20075626L (no) Heteroarylbenzamid-derivater for anvendelse som GLK-aktivatorer i behandling av diabetes
WO2006092428A3 (de) 2-substituierte 7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
TW200745077A (en) Thiophene compound having sulfonyl group and process for producing the same
MX2010004669A (es) Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.
WO2010015355A3 (en) Acylaminobenzamide derivatives
WO2006114405A3 (de) Verwendung von 5-alkyl-6-phenylalkyl-7-amino-azolopyrimidinen, neue azolopyrimidine, verfahren zu ihrer herstellung und sie enthaltende mittel
WO2006072334A3 (de) Verfahren zur herstellung von thiophenglycosidderivaten
BRPI0810330A2 (pt) "processo para preparar l-tartarato de (r)-2-metil pirrolidina, processo para preparar 6-{4-[3-((r)-2-metil-pirrolidin-1-il)-propoxi] - fenil}-2h-piridazin-3-ona, processo para preparar d-tartarato de (s)-2-metil pirrolidina"
TW200637852A (en) Indole derivatives
PE20081886A1 (es) Proceso e intermediarios para preparar arzoxifeno
TW200604141A (en) Method for producing acetamidopyrrolidine derivative and intermediate compound thereof
MX2010013184A (es) Compuesto heterocíclico.
UA85383C2 (ru) Способ получения меркаптоорганил(алкоксисиланов)
TW200621706A (en) Process for producing azetidinone derivatives