BRPI0508263A - derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina - Google Patents

derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina

Info

Publication number
BRPI0508263A
BRPI0508263A BRPI0508263-3A BRPI0508263A BRPI0508263A BR PI0508263 A BRPI0508263 A BR PI0508263A BR PI0508263 A BRPI0508263 A BR PI0508263A BR PI0508263 A BRPI0508263 A BR PI0508263A
Authority
BR
Brazil
Prior art keywords
tetrahydro
isoquinoline
derivatives
pharmaceutical composition
derivative
Prior art date
Application number
BRPI0508263-3A
Other languages
English (en)
Inventor
Thomas Weller
Ralf Koberstein
Hamed Aissaoui
Martine Clozel
Walter Fischli
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0508263A publication Critical patent/BRPI0508263A/pt
Publication of BRPI0508263B1 publication Critical patent/BRPI0508263B1/pt
Publication of BRPI0508263B8 publication Critical patent/BRPI0508263B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Veterinary Medicine (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

DERIVADOS DE 1,2,3,4-TETRA-HIDRO-ISOQUINOLINA,COMPOSIçãOFARMACê UTICA,E,USODEDERIVADODE1,2,3,4-TETRA-HIDRO-ISOQUIN OLINA A invenção refere-se aos novos derivados de 1,2,3,4-tetra-hidro-isoquinolina de f-ormula (I) na qual R¬ 1¬, R¬ 2¬, R¬ 3¬ e X são como definidos nas reivindicações, e ao seu uso como ingredientes ativos na preparação de composições farmacêuticas. A invenção também se refere aos aspectos relacionados incluindo processos para a preparação dos compostos, composições farmacêuticas contendo um ou mais daqueles compostos e métodos de tratamento compreendendo a administração de citados compostos a um mamífero.
BRPI0508263-3 2004-03-01 2005-02-23 derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina BRPI0508263B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2004002020 2004-03-01
EPPCT/EP2004/002020 2004-03-01
PCT/EP2005/001879 WO2005118548A1 (en) 2004-03-01 2005-02-23 Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

Publications (3)

Publication Number Publication Date
BRPI0508263A true BRPI0508263A (pt) 2007-07-31
BRPI0508263B1 BRPI0508263B1 (pt) 2018-08-21
BRPI0508263B8 BRPI0508263B8 (pt) 2021-05-25

Family

ID=34960649

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508263-3 BRPI0508263B8 (pt) 2004-03-01 2005-02-23 derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina

Country Status (24)

Country Link
US (2) US7763638B2 (pt)
EP (1) EP1751111B1 (pt)
JP (1) JP4094050B2 (pt)
KR (1) KR100848747B1 (pt)
CN (1) CN1926109B (pt)
AR (1) AR047823A1 (pt)
AU (1) AU2005250077B2 (pt)
BR (1) BRPI0508263B8 (pt)
CA (1) CA2557163C (pt)
CY (1) CY1116103T1 (pt)
DK (1) DK1751111T3 (pt)
ES (1) ES2533389T3 (pt)
HR (1) HRP20150371T1 (pt)
IL (1) IL177798A (pt)
MY (1) MY144992A (pt)
NO (1) NO337299B1 (pt)
NZ (1) NZ550216A (pt)
PL (1) PL1751111T3 (pt)
PT (1) PT1751111E (pt)
RU (1) RU2378257C2 (pt)
SI (1) SI1751111T1 (pt)
TW (1) TWI301129B (pt)
WO (1) WO2005118548A1 (pt)
ZA (1) ZA200606974B (pt)

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AU2007226203A1 (en) * 2006-03-15 2007-09-20 Actelion Pharmaceuticals Ltd Tetrahydroisoquinoline derivatives to enhance memory function
CN101460453B (zh) 2006-04-11 2012-10-03 埃科特莱茵药品有限公司 磺酰胺化合物
CA2647077A1 (en) * 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
CA2657623A1 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
MX2009006553A (es) 2006-12-22 2009-06-26 Actelion Pharmaceuticals Ltd Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
ATE512963T1 (de) * 2007-04-04 2011-07-15 Hoffmann La Roche Heterocyclen als orexinantagonisten
WO2008143856A1 (en) 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
US8242121B2 (en) 2007-05-23 2012-08-14 Merck Sharp & Dohme Corp. Pyridyl piperidine orexin receptor antagonists
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
PE20091010A1 (es) * 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
JP5100298B2 (ja) * 2007-10-11 2012-12-19 株式会社トクヤマ 光学活性α−スルホニルオキシカルボン酸アミド誘導体及びその製造方法
EP2231155A4 (en) * 2007-12-18 2011-09-14 Concert Pharmaceuticals Inc Tetrahydroisoquinoline DERIVATIVES
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