BR112012013954B8 - derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico - Google Patents

derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico

Info

Publication number
BR112012013954B8
BR112012013954B8 BR112012013954A BR112012013954A BR112012013954B8 BR 112012013954 B8 BR112012013954 B8 BR 112012013954B8 BR 112012013954 A BR112012013954 A BR 112012013954A BR 112012013954 A BR112012013954 A BR 112012013954A BR 112012013954 B8 BR112012013954 B8 BR 112012013954B8
Authority
BR
Brazil
Prior art keywords
hyaluronic acid
acid derivative
amino
aldehyde
hyaluronan
Prior art date
Application number
BR112012013954A
Other languages
English (en)
Other versions
BR112012013954B1 (pt
BR112012013954A2 (pt
Inventor
Pospisilova Lucie
Berkova Miroslava
Buffa Radovan
Kettou Sofiane
Velebny Vladimir
Original Assignee
Contipro As
Contipro Pharma A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contipro As, Contipro Pharma A S filed Critical Contipro As
Publication of BR112012013954A2 publication Critical patent/BR112012013954A2/pt
Publication of BR112012013954B1 publication Critical patent/BR112012013954B1/pt
Publication of BR112012013954B8 publication Critical patent/BR112012013954B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico e método de modificação do derivado de ácido hialurônico a invenção se refere ao método de preparação e modificação de um derivado de hialuronano com um grupo aldeídico na posição (6) da parte de polissacarídeo glucosamina. a oxidação do ácido hialurônico pode ser realizada por meio do agente periodinano dess-martin (dmp). o aldeído preparado pode ser usado para ligação amina, diamina, arninoácido, peptídeo e outros compostos contendo um grupo amino, por exemplo, por meio da aminação redutiva com nabh3cn em água ou em um sistema de solvente orgânico em água. é possível preparar derivados de hialuronano reticulados quando uma diamina ou compostos contendo três ou mais grupos amino são usados. os derivados reticulados também podem ser preparados pela reação do aldeído com um hialuronano substituído por um grupo amino-alquil ha- alquil-nh2.
BR112012013954A 2009-12-11 2010-12-10 derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico BR112012013954B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20090836A CZ302504B6 (cs) 2009-12-11 2009-12-11 Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZPV2009-836 2009-12-11
PCT/CZ2010/000128 WO2011069474A2 (en) 2009-12-11 2010-12-10 Oxidized derivative of hyaluronic acid, a method of preparation thereof and a method of modification thereof

Publications (3)

Publication Number Publication Date
BR112012013954A2 BR112012013954A2 (pt) 2016-06-07
BR112012013954B1 BR112012013954B1 (pt) 2020-12-22
BR112012013954B8 true BR112012013954B8 (pt) 2021-05-25

Family

ID=43971822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012013954A BR112012013954B8 (pt) 2009-12-11 2010-12-10 derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico

Country Status (11)

Country Link
US (1) US9403918B2 (pt)
EP (1) EP2510017B1 (pt)
JP (1) JP5945504B2 (pt)
KR (1) KR101710432B1 (pt)
BR (1) BR112012013954B8 (pt)
CZ (1) CZ302504B6 (pt)
DK (1) DK2510017T3 (pt)
ES (1) ES2531292T3 (pt)
PL (1) PL2510017T3 (pt)
RU (1) RU2550602C2 (pt)
WO (1) WO2011069474A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZ304072B6 (cs) * 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
CZ201224A3 (cs) * 2012-01-16 2013-04-03 Contipro Biotech S.R.O. Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití
EP2813515B1 (en) 2012-02-07 2019-07-10 PHI Biomed Co., Ltd. Transdermally delivered hyaluronic acid-protein conjugate
CZ303879B6 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
CZ2012282A3 (cs) * 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
CZ304512B6 (cs) * 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ304266B6 (cs) * 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Nekonečná vlákna na bázi hyaluronanu selektivně oxidovaného v poloze 6 N-acetyl-D-glukosaminové části, jejich příprava, použití, nitě, střiže, příze, textilie a způsob jejich úpravy
KR101664444B1 (ko) * 2013-12-13 2016-10-12 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 생분해성 의료용 접착제 또는 실란트 조성물
CZ2014150A3 (cs) * 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
EP3765103A1 (en) 2018-03-12 2021-01-20 Merz Pharma GmbH & Co. KGaA Porous biomaterials for tissue regeneration
WO2023056433A1 (en) * 2021-10-01 2023-04-06 Northwestern University Supramolecular-covalent composite slurry for cartilage repair
CN116789869A (zh) * 2023-06-25 2023-09-22 吉林省奇健生物技术有限公司 一种透明质酸-蛋白偶联体的制备方法及其应用

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720662A (en) 1971-09-13 1973-03-13 Nat Starch Chem Corp Preparation of starch esters
US3728223A (en) 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
CH628088A5 (en) 1975-09-17 1982-02-15 Dresden Arzneimittel Process for obtaining streptococcal metabolic products
US4205025A (en) 1975-12-22 1980-05-27 Champion International Corporation Synthetic polymeric fibrids, fibrid products and process for their production
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4716224A (en) 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8519416D0 (en) 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
JPS62104579A (ja) 1985-10-30 1987-05-15 Kyowa Hakko Kogyo Co Ltd ヒアルロニダ−ゼの製造法
JPH0751064B2 (ja) 1986-08-13 1995-06-05 生化学工業株式会社 新規なヒアルロニダ−ゼｓｄ−６７８およびその製造法
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0214019A (ja) 1988-06-30 1990-01-18 Tonen Corp 繊維状成形物及びその製造方法
IT1254704B (it) 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
US5824335A (en) 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
JP2855307B2 (ja) 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
FR2689131B1 (fr) 1992-03-30 1994-05-20 Oreal Procede de preparation de monoesters majoritairement en position 6' du d-maltose et leur utilisation dans les domaines cosmetique, bucco-dentaire, pharmaceutique et alimentaire.
JPH0625306A (ja) 1992-04-21 1994-02-01 Shiseido Co Ltd 溶媒不溶化ヒアルロン酸及びその製造方法
IT1263316B (it) 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
NL9700003A (nl) 1993-09-28 1997-07-01 House Foods Corp Werkwijze voor het inoculeren van Fistulina hepatica.
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
EP0701704B1 (en) 1994-03-14 1999-12-15 Seikagaku Corporation Material to be worn on the eyeball
US5455349A (en) 1994-05-13 1995-10-03 Polaroid Corporation Vinylbenzyl thymine monomers
US6025444A (en) 1994-11-17 2000-02-15 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Cinnamic acid derivative
US5690961A (en) 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
EP0813546B1 (en) 1995-03-07 2002-07-17 Novartis AG Photochemically cross-linked polysaccharide derivatives as supports for the chromatographic separation of enantiomers
WO1997007833A2 (en) 1995-08-29 1997-03-06 Fidia Advanced Biopolymers, S.R.L. Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
EP0763754B1 (en) 1995-09-13 2003-01-08 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Photocured crosslinked-hyaluronic acid contact lens
DE19604706A1 (de) 1996-02-09 1997-08-14 Merck Patent Gmbh Vernetzungsprodukte von Aminogruppen-haltigen Biopolymeren
DE19616010C2 (de) 1996-04-23 1998-07-09 Seitz Filter Werke Verfahren und Vorrichtung zur Herstellung von Fibrets (Fibriden) aus Zellulosederivaten
IT1287698B1 (it) 1996-08-29 1998-08-18 Fidia Advanced Biopolymers Srl Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico
US6632802B2 (en) 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
WO1999001143A1 (en) 1997-07-03 1999-01-14 Orquest, Inc. Cross-linked polysaccharide drug carrier
ATE302785T1 (de) 1998-04-30 2005-09-15 Maruha Corp Verbindungen, deren struktur derivate von glukuronsäure und glukosamin enthält, verfahren zu deren herstellung und deren verwendung
PL188781B1 (pl) * 1998-05-07 2005-04-29 Tno Sposób selektywnego utleniania alkoholi pierwszorzędowych
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6719986B1 (en) 1998-12-23 2004-04-13 Esparma Gmbh Hyaluronate lyase used for promoting penetration in topical agents
DE19917614C2 (de) 1999-04-19 2001-07-05 Thueringisches Inst Textil Verfahren zur Herstellung von cellulosischen Formkörpern mit hohem Adsorptionsvermögen
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6592794B1 (en) 1999-09-28 2003-07-15 Organogenesis Inc. Process of making bioengineered collagen fibrils
WO2001034657A1 (en) 1999-11-08 2001-05-17 Sca Hygiene Products Zeist B.V. Process of oxidising primary alcohols
DE10003397A1 (de) 2000-01-27 2001-08-09 Hartmann Paul Ag Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband
IT1317359B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
US6498269B1 (en) 2000-10-17 2002-12-24 The University Of Connecticut Method for the oxidation of aldehydes, hemiacetals and primary alcohols
WO2002048197A1 (en) 2000-12-13 2002-06-20 Sca Hygiene Products Zeist B.V. Process for oxidising primary alcohols
DE60117502T2 (de) 2000-12-19 2006-08-24 Seikagaku Corp. Photohärtbare Derivate von Hyaluronsäure, Verfahren zu deren Herstellung, vernetztes und photogehärtetes Derivat der Hyaluronsäure und diese enthaltendes medizinisches Material
FR2819808B1 (fr) * 2001-01-19 2003-04-18 Simafex Compositions stabilisees d'acide o-iodoxybenzoique et leur procede de preparation
AU2002230102B9 (en) 2001-01-31 2008-05-01 Seikagaku Corporation Crosslinked polysaccharide sponge
US6902548B1 (en) 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US6673919B2 (en) 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
US6946284B2 (en) 2001-11-16 2005-09-20 University Of Massachusetts Solubilizing cross-linked polymers with photolyase
US20060189516A1 (en) 2002-02-19 2006-08-24 Industrial Technology Research Institute Method for producing cross-linked hyaluronic acid-protein bio-composites
US6762327B2 (en) * 2002-04-29 2004-07-13 Wyeth Selective oxidation process with enhanced safety
JP3975267B2 (ja) 2002-06-03 2007-09-12 独立行政法人産業技術総合研究所 多糖物質のアシル化方法
US20040101546A1 (en) 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
US7550136B2 (en) 2002-12-20 2009-06-23 University Of Massachusetts Photo-reactive polymers and devices for use in hair treatments
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
FR2852012B1 (fr) 2003-03-04 2006-06-23 Oreal Procede de preparation de derives o-acyles du glucose
WO2004081054A1 (ja) 2003-03-11 2004-09-23 Seikagaku Corporation 光架橋多糖組成物およびその製造方法
DE10331342B4 (de) 2003-07-11 2009-03-12 Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. Thermostabile Form- oder Spinnmasse
CA2538793C (en) 2003-09-19 2011-01-11 Colorado State University Research Foundation (Csurf) Hyaluronan (ha) esterification via acylation technique for moldable devices
GB2408741B (en) 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US20100330143A1 (en) 2003-12-04 2010-12-30 University Of Utah Research Foundation Modified macromolecules and methods of making and using thereof
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
JP2008505716A (ja) 2004-07-09 2008-02-28 ザ クリーヴランド クリニック ファウンデーション ヒドロキシフェニル架橋高分子ネットワーク及びその用途
US7323425B2 (en) 2004-08-27 2008-01-29 Stony Brook Technology And Applied Research Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom
US8481080B2 (en) 2004-11-24 2013-07-09 Novozymes Biopolymer A/S Method of cross-linking hyaluronic acid with divinulsulfone
US7214759B2 (en) * 2004-11-24 2007-05-08 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
US7680038B1 (en) 2005-04-25 2010-03-16 Electronic Arts, Inc. Dynamic bandwidth detection and response for online games
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
EP1905456A4 (en) 2005-07-06 2010-12-22 Seikagaku Kogyo Co Ltd PHARMACEUTICAL LIGHT-NETWORKED HYALURONIC DERIVATIVE GEL
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
ITMI20051415A1 (it) 2005-07-22 2007-01-23 Fidia Advanced Biopolymers Srl Biomateriali a base di corbossimetilcellulosa salificata con zinco associata a derivati dell'acido ialuronico da impiegarsi come dispositivi medici con attivita' antimicrobica ed antifungina e loro processo di produzione
US7993678B2 (en) 2005-09-26 2011-08-09 Novozymes Biopolymer A/S Hyaluronic acid derivatives
WO2007070617A1 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
US20070202570A1 (en) 2006-02-24 2007-08-30 Kikkoman Corporation Enzyme composition, low molecular weight hyaluronan and process for preparing the same
JP4892679B2 (ja) 2006-03-27 2012-03-07 国立大学法人弘前大学 ゲル紡糸によるヒアルロン酸繊維およびその製造方法
KR20070118730A (ko) 2006-06-13 2007-12-18 주식회사 코오롱 보습성이 우수한 창상피복재 및 그의 제조방법
US20080124395A1 (en) 2006-06-22 2008-05-29 Weiliam Chen Formulations and devices for treatment or prevention of neural ischemic damage
US20080063617A1 (en) * 2006-09-07 2008-03-13 Abrahams John M Cosmetics formulations
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CZ302856B6 (cs) 2006-09-27 2011-12-14 Cpn Spol. S R. O. Zpusob prípravy derivátu polysacharidu
ATE545436T1 (de) 2006-12-22 2012-03-15 Croma Pharma Ges M B H Verwendung von thiolierten polysacchariden zum gewebeaufbau
KR20080062092A (ko) 2006-12-29 2008-07-03 주식회사 핸슨바이오텍 세포전달체로서의 히알루론산 유도체 및 이의 제조 방법
JP5329767B2 (ja) 2007-02-26 2013-10-30 帝人株式会社 芳香族コポリアミド繊維の製造装置
RU2350625C2 (ru) * 2007-04-04 2009-03-27 Институт нефтехимии и катализа РАН Производные гиалуроновой кислоты с пониженной биодеградируемостью
CZ2007299A3 (cs) 2007-04-24 2009-02-04 Cpn Spol. S R. O. Príprava nanovláken z polysacharidu a jejich smesí s polyvinylalkoholem
JP5165281B2 (ja) * 2007-06-01 2013-03-21 株式会社バイオベルデ ２反応剤型の医療用含水ゲル形成剤、及び、これより得られるヒアルロン酸ゲル
US8288142B2 (en) 2007-06-19 2012-10-16 Uvarkina Tamara P Hyaluronidase and method of use thereof
FR2921675B1 (fr) 2007-09-28 2010-03-19 Univ Claude Bernard Lyon Filament a base d'acide hyaluronique et son procede d'obtention.
MX2010008667A (es) 2008-02-11 2010-09-24 Basf Se Metodo para producir estructuras porosas de polimericos sinteticos.
US9585987B2 (en) 2008-02-29 2017-03-07 Pvac Medical Technologies Ltd Composition for the formation of gels
JP5544107B2 (ja) * 2008-03-31 2014-07-09 花王株式会社 高分子ビルダー
WO2009148405A1 (en) 2008-06-05 2009-12-10 Agency For Science, Technology And Research Formation of hydrogel in the presence of peroxidase and low concentration of hydrogen peroxide
FR2934999B1 (fr) 2008-08-13 2011-07-29 Adocia Polysaccharides fonctionnalises par des derives du tryptophane
EP3184552B1 (en) 2008-09-02 2020-08-12 Tautona Group LP Threads of hyaluronic acid, methods of making thereof and uses thereof
CZ2008705A3 (cs) 2008-11-06 2010-04-14 Cpn S. R. O. Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
JP2010138276A (ja) 2008-12-11 2010-06-24 Nipro Corp ヒアルロン酸単糸の製造方法
AU2010215196B2 (en) 2009-02-21 2015-04-16 Covidien Lp Crosslinked fibers and method of making same by extrusion
US8969473B2 (en) 2009-02-21 2015-03-03 Sofradim Production Compounds and medical devices activated with solvophobic linkers
US9273191B2 (en) 2009-02-21 2016-03-01 Sofradim Production Medical devices with an activated coating
CZ301899B6 (cs) 2009-03-17 2010-07-21 Contipro C, A.S. Zpusob prípravy derivátu kyseliny hyaluronové pomocí O-acyl-O´-alkylkarbonátu v prítomnosti substituovaného pyridinu
US8551378B2 (en) 2009-03-24 2013-10-08 North Carolina State University Nanospinning of polymer fibers from sheared solutions
IT1396003B1 (it) 2009-05-14 2012-11-09 Fidia Farmaceutici Ialuronidasi extracellulare da streptomyces koganeiensis
WO2010138074A1 (en) 2009-05-29 2010-12-02 Hilborn Joens Hyaluronic acid based delivery systems
CN102573941B (zh) 2009-07-30 2014-10-29 卡比兰生物外科公司 改性透明质酸聚合物组合物和相关的方法
KR101103423B1 (ko) 2009-09-04 2012-01-06 아주대학교산학협력단 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
EP2498824B1 (en) 2009-11-11 2016-04-20 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers
WO2011059325A2 (en) 2009-11-11 2011-05-19 University Of Twente, Institute For Biomedical Technology And Technical Medicine (Mira) Dextran-hyaluronic acid based hydrogels
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
US8197849B2 (en) 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
CN101897976A (zh) 2010-07-16 2010-12-01 沈阳药科大学 一种药物增溶载体及其制备方法和应用
CZ20101001A3 (cs) 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
CN102154738B (zh) 2011-05-10 2012-08-01 青岛大学 一种红藻琼胶纤维的制备方法
US9920454B2 (en) 2011-10-18 2018-03-20 Heiq Pty Ltd Fibre-forming process and fibres produced by the process
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití

Also Published As

Publication number Publication date
JP5945504B2 (ja) 2016-07-05
RU2550602C2 (ru) 2015-05-10
US20120245323A1 (en) 2012-09-27
WO2011069474A2 (en) 2011-06-16
PL2510017T3 (pl) 2015-06-30
EP2510017A2 (en) 2012-10-17
CZ2009836A3 (cs) 2011-06-22
BR112012013954B1 (pt) 2020-12-22
KR20120091449A (ko) 2012-08-17
JP2013513671A (ja) 2013-04-22
ES2531292T3 (es) 2015-03-12
RU2012122313A (ru) 2014-01-20
US9403918B2 (en) 2016-08-02
EP2510017B1 (en) 2015-01-21
WO2011069474A3 (en) 2013-03-14
CZ302504B6 (cs) 2011-06-22
DK2510017T3 (en) 2015-03-23
BR112012013954A2 (pt) 2016-06-07
KR101710432B1 (ko) 2017-02-27

Similar Documents

Publication Publication Date Title
BR112012013954B8 (pt) derivado de ácido hialurônico, método de preparação do derivado de ácido hialurônico
JP2013513671A5 (pt)
BRPI0706947B8 (pt) método de preparação de uma composição de micropartícula
CZ2012537A3 (cs) Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
JP2013513672A5 (pt)
BRPI0806318B8 (pt) sacarídeo capsular modificado, processo para modificar um sacarídeo, conjugado proteína sacarídea, molécula e composição farmacêutica
WO2008143240A1 (ja) 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法
AR088296A1 (es) Citramida de rasagilina, proceso de preparación y composicion farmaceutica
BR112018010535A2 (pt) compostos peptídicos e conjugados peptídicos para o tratamento de câncer por quimioterapia com mediação por um receptor
BR112015011896A2 (pt) derivado fotorreativo de ácido hialurônico, método de preparação do derivado fotorreativo, método de preparação de derivados 3d reticulados de ácido hialurônico, derivado 3d reticulado de ácido hialurônico e uso do derivado 3d reticulado
BRPI1015447A8 (pt) Soluções pediátricas compreendendo um bloqueador beta
WO2007090749A3 (en) Benzamide and heteroarene derivatives as cetp inhibitors
CU24030B1 (es) Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen
BR112012021094A2 (pt) método para separar partículas de polímero superabsorvente a partir de uma composição temoplástica solidificada compreendendo polímeros
WO2010035122A3 (fr) Complexe constitue d'un polysaccharide et d'une hpb
BR112017023749A2 (pt) um método para marcação especificamente de micro-organismos vivos que compreende o uso de compostos monossacarídicos modificados
IL276043B1 (en) Process for preparing GALNAC oligonucleotide conjugates
JP2011513304A5 (pt)
BR112013005823A2 (pt) compostos heterocíclicos para o tratamento ou prevenção de distúrbios causados pela neurotransmissão reduzida de serotonima, norefnefrina ou dopamina
CL2008002777A1 (es) Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
BRPI0616169B8 (pt) cloridrato de lercanidipina na forma polimorfa v, composição farmacêutica compreendendo dito composto e processos para preparação de cloridrato de lercanidipina
CA2606799A1 (en) Process for synthesis of proton pump inhibitors
RU2017107144A (ru) Способы химического синтеза филлирина
WO2009047699A8 (en) An improved process for the preparation of an amorphous form of pentosan polysulfate or salts thereof
RU2018102154A (ru) Производные сульфатированных полисахаридов, их способ получения, модификация и применение

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: CONTIPRO A.S. (CZ)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/12/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF